AlleleMonoclonal AntibodyAllelesPeptideAntibodiesGenotypeHeterodimericHumanCounterpartsChainsStructuralClassImmuneCellsPositiveAnalysisHistocompatibilityHaplotypeSusceptibilityCeliacDQA1ChromosomeVariantsGravesBiomarkersDiseasesFrequenciesMolecularBody'sProteinsInfectionsDeficiencyPatientsRiskPresentRoleNormalAssociationTypesCasesFound
Allele3
- Here is a map showing the allele frequency of HLA-DR14. (eupedia.com)
- Here is a map showing the allele frequency of HLA-DR10. (eupedia.com)
- Here is a map showing the allele frequency of HLA-A3, which is divided in two subtypes : A3:01 and A3:02. (eupedia.com)
Monoclonal Antibody3
- The following product was used in this experiment: HLA-DR Monoclonal Antibody (LN3), Super Bright™ 436, eBioscience™ from Thermo Fisher Scientific, catalog # 62-9956-42, RRID AB_2744822. (thermofisher.com)
- Immunohistochemistry-Paraffin: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
- This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
Alleles2
- In addition to influencing immune response patterns, many of these alleles are associated with susceptibility to a wide spectrum of autoimmune diseases, making the MHC an essential starting point for anyone wanting to understand the genetics of rheumatic diseases. (musculoskeletalkey.com)
- In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)
Peptide3
- Modified peptides showed enhanced binding to HLA-A2 compared with the native sequences and immunization of HLA-A2 transgenic mice generated high avidity modification specific CD8 responses that killed peptide expressing target cells. (bmj.com)
- In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. (novusbio.com)
- The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
Antibodies1
- Following this model, the human immune system is divided into two major classes: Cellular Immunity, located in the mucous membranes of the gastrointestinal and respiratory tracts and their respective lymph nodes (outer defenses), and Humoral Immunity, with production of antigen-specific antibodies by plasma cells in the bone marrow (inner defenses). (medicalveritas.org)
Genotype1
- The analysis of genetic factors other than CFTR may help our understanding of genotype-phenotype relationships in CF. As human leukocyte antigen (HLA) class II polymorphism has been associated with a number of diseases including autoimmune and inflammatory diseases, asthma, and allergy, we investigated the possibility that HLA polymorphism contributes to CF-associated pulmonary inflammation. (nih.gov)
Heterodimeric2
- HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
- HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. (novusbio.com)
Human5
- Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
- Methods Homocitrullinated peptides were identified and assessed in vitro for HLA-A2 binding and in vivo in human leukocyte antigen (HLA) transgenic mouse models for immunogenicity. (bmj.com)
- During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
- Flow Cytometry: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Flow Cytometric Analysis of Human Raji cells using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
- The MHC, one of the most gene-rich regions in the human genome, has identified more than 200 genes. (musculoskeletalkey.com)
Counterparts2
- HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
- The HLA molecules and their counterparts in rodents were subsequently shown to be directly responsible for immune response differences between individuals and for determining the likelihood of graft rejection. (musculoskeletalkey.com)
Chains1
- HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
Structural1
- Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
Class5
- HLA class II polymorphism in cystic fibrosis. (nih.gov)
- HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
- Background Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. (bmj.com)
- HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
- HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)
Immune1
- The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
Cells6
- During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
- Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
- HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
- During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)
- Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
- In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
Positive1
- Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
Analysis1
- Western Blot: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Western Blot Analysis of Ramos cell lysate using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
Histocompatibility1
- 19. Distribution of human Class I ( hla-a ,B,C) histocompatibility antigens in normal and malignant tissues of nonlymphoid origin. (nih.gov)
Haplotype2
Susceptibility5
- The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
- HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects. (cdc.gov)
- HLA class II high-resolution genotyping in Greek children with celiac disease and impact on disease susceptibility. (cdc.gov)
- HLA Genotyping: Methods for the Identification of the HLA-DQ2,-DQ8 Heterodimers Implicated in Celiac Disease (CD) Susceptibility. (cdc.gov)
- Celiac disease is a multifactorial disorder resulting from the interaction of HLA-DQA1 and HLA-DQB1 allelic variants known to be associated with celiac disease susceptibility, less well-recognized variants in non-HLA genes, gliadin (a subcomponent of gluten), and other environmental factors. (nih.gov)
Celiac8
- Celiac disease (gluten allergy) : 95% of all celiacs have HLA-DQ2. (eupedia.com)
- Influence of HLA-DQ2 and DQ8 on severity in celiac Disease. (cdc.gov)
- A new PCR-SSP method for HLA DR-DQ risk assessment for celiac disease. (cdc.gov)
- Human leukocyte antigen DQ2.2 and celiac disease. (cdc.gov)
- HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing. (cdc.gov)
- The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. (cdc.gov)
- HLA genotyping in pediatric celiac disease patients. (cdc.gov)
- HLA-DQ2/DQ8 and HLA-DQB1*02 homozygosity typing by real-time polymerase chain reaction for the assessment of celiac disease genetic risk: evaluation of a Spanish celiac population. (cdc.gov)
DQA12
- There is a suspected link with HLA-Cw4, DR7, DR11 and DQA1, among others. (eupedia.com)
- weakly associated with HLA DR3, DR4, DR15 and DQA1. (eupedia.com)
Chromosome1
- HLA types are encoded in the HLA gene on chromosome 6. (eupedia.com)
Variants1
- Among 1,213 patients with NDDs, 477 were genetically diagnosed by exome sequencing, and 168 had epilepsy and causative variants in 129 genes. (bvsalud.org)
Graves1
- 8. Gene Map of the HLA Region, Graves' Disease and Hashimoto thyroid itis, and Hematopoietic Stem Cell Transplantation. (nih.gov)
Biomarkers2
- The study aimed to identify genetic susceptible biomarkers associated with the TCE-induced hypersensitivity dermatitis in genes located in the human leukocyte antigen (HLA) region. (nih.gov)
- 3. Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroid itis-related papillary thyroid cancer . (nih.gov)
Diseases2
- Other concomitant immune defects may be required to increase the risk for respiratory and GI infections and various autoimmune diseases frequently described in patients with IgA deficiency. (medscape.com)
- Some HLA types are known to attack the body's own cells, causing what is known as autoimmune diseases , in other words diseases caused by one's immune system attacking one's own body. (eupedia.com)
Frequencies1
- Here is a very useful website that gives HLA allelle frequencies in worldwide populations (must be registered). (eupedia.com)
Molecular1
- Conclusion: We demonstrated a similar clinical presentation of different gene groups regarding biological/molecular processes in a large NDDs cohort with epilepsy. (bvsalud.org)
Body's1
- Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
Proteins2
- Although this article discusses agammaglobulinemia and hypogammaglobulinemia, the emphasis is on selective Ig deficiencies, including the decreased production of IgA and the various IgG subclasses and impaired antibody responses to specific antigens such as polysaccharide proteins present on certain bacteria. (medscape.com)
- The similarity between antigens of Streptococcus pyogenes and multiple cardiac proteins can cause a life-threatening type II hypersensitivity reaction. (wikipedia.org)
Infections1
- There are tens of thousands of possible combinations of HLA, which is why some people never get sick, while other constantly have a cold, or are prone to some types of infections, depending on what HLA combination they have. (eupedia.com)
Deficiency1
- The importance of IgG-subclass deficiency is reflected in the isotypes of IgG antibodies produced against microbial antigens. (medscape.com)
Patients2
- Causative genes were classified into two groups: (i) the "epilepsy-genes" group resulting in epilepsy as the main phenotype listed in OMIM, Epi25, and ClinGen (67 patients) and (ii) the "NDD-genes" group not included in the "epilepsy-genes" group (101 patients). (bvsalud.org)
- Results: Patients in the "epilepsy-genes" group started having seizures, often characterized by epilepsy syndrome, at a younger age. (bvsalud.org)
Risk4
- The combination HLA-B7/B*2705 heterozygotes exhibited the highest risk for disease. (eupedia.com)
- the main risk factors are HLA B8 and DR3 with DR1. (eupedia.com)
- HLA-Cw*0602 is the main risk factor. (eupedia.com)
- 14. High risk of squamous cell carcinoma of the cervix for women with HLA-DQw3. (nih.gov)
Present1
- During a streptococcal infection, mature antigen-presenting cells such as B cells present the bacterial antigen to CD4+T cells which differentiate into helper T2 cells. (wikipedia.org)
Role3
- HLA-DR3 plays a significant role in the disease. (eupedia.com)
- HLA-DRB1*1501 plays a role in the disease. (eupedia.com)
- HLA DR1 and DR7 may also play a role. (eupedia.com)
Normal1
- 2] They did have normal responses to immunization with protein and polysaccharide antigens. (medscape.com)
Association3
- There is also an association with HLA DR2 and HLA DQ1. (eupedia.com)
- 10. Association of HLA-B*51:01 with papillary thyroid carcinoma in the Chinese Han population of the Shandong coastal areas. (nih.gov)
- 18. Association of differentiated thyroid carcinoma with HLA-DR7. (nih.gov)
Types7
- Contrarily to ABO blood types people do not have just one HLA type, but many (about 8 per person). (eupedia.com)
- There are 3 major types of class I HLA (HLA-A, HLA-B, HLA-C) and 3 major types of class II HLA (HLA-DP, HLA-DQ and HLA-DR). Each type comprises hundreds of subtype (e.g. (eupedia.com)
- People will usually have 2 types of HLA-A, 2 of HLA-B, and 2 of HLA-C as well as 1 or 2 other types. (eupedia.com)
- HLA types are therefore hereditary, just like the ABO blood type. (eupedia.com)
- HLA types found in tropical countries tend to differ a lot from those in temperate parts of the world, because the viruses found there are different. (eupedia.com)
- The HLA types DR2, DR6 and DR11 are protective against Type 1 diabetes. (eupedia.com)
- 5. HLA Class I Expression Changes in Different Types of Cultured Para thyroid Cells. (nih.gov)
Cases1
- Ankylosing spondylitis (arthritis of the spine and sacroiliac joint) : caused by HLA-B27 in 95% of the cases. (eupedia.com)
Found1
- In addition, we compared and analyzed the structure character of amino acid residues of HLA molecules found in participants. (nih.gov)