Genes asparagine. Medical search. Frequent questions

Asparagine synthetase deficiency is a condition that causes neurological problems in affected individuals starting soon after birth. (medlineplus.gov)
Most individuals with asparagine synthetase deficiency have exaggerated reflexes (hyperreflexia) and weak muscle tone (hypotonia). (medlineplus.gov)
People with asparagine synthetase deficiency may have an exaggerated startle reaction (hyperekplexia) to unexpected stimuli. (medlineplus.gov)
People with asparagine synthetase deficiency typically do not survive past childhood. (medlineplus.gov)
Asparagine synthetase deficiency is thought to be a rare condition. (medlineplus.gov)
Asparagine synthetase deficiency is caused by mutations in a gene called ASNS . (medlineplus.gov)
This gene provides instructions for making an enzyme called asparagine synthetase. (medlineplus.gov)
Mutations in the ASNS gene that cause asparagine synthetase deficiency lead to a decrease or loss of functional enzyme. (medlineplus.gov)
As a result, brain cells in people with asparagine synthetase deficiency have a shortage (deficiency) of this amino acid. (medlineplus.gov)
The exact effect of asparagine synthetase deficiency on brain cells is unknown, but because of the severe features of this condition, it is clear that asparagine is necessary for normal brain development. (medlineplus.gov)
Asparagine synthetase uses ATP to activate aspartate, forming β-aspartyl-AMP. (wikipedia.org)
Asparagine synthetase is required for normal development of the brain. (wikipedia.org)
Similarly, low expression of the metabolic protein asparagine synthetase (ASNS) in ovarian cancers predicts response to IPN60090 in preclinical models. (mdanderson.org)
A second mutant, designated Tox-10, has a mutation in a DNA region having a high degree of homology with asnB, a gene that encodes for an asparagine synthetase. (usda.gov)
The team identified the gene affected by the mutation code for asparagine synthetase, the enzyme responsible for synthesizing the amino acid asparagine. (healthnewstrack.com)
In healthy subjects, it seems that the level of asparagine synthetase in the brain is sufficient to supply neurons," Michaud said. (healthnewstrack.com)
Asparagine synthetase catalyses the transfer of an amino group from glutamine to aspartate to form glutamate and asparagine. (grassroots.tools)

which means both copies of the gene in each cell have mutations. (medlineplus.gov)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
From Genes to Genetic Diseases: What Kinds of Mutations Matter? (sciencebuddies.org)
In this science project, you will explore online genetic databases to identify how a mutation in a gene can result in a dysfunctional protein, and how other mutations may have no effect at all. (sciencebuddies.org)
Determine why some gene mutations cause genetic diseases, but others do not. (sciencebuddies.org)
Based on these previous analyses and clinical findings, CLRN1 was directly sequenced in 17 patients susceptible to carrying mutations in this gene. (molvis.org)
In lung cancers, mutations in the KEAP1 and NFE2L2 genes, which regulate response to oxidative stress, sensitize cells to treatment with IPN60090. (mdanderson.org)
All three resistant mutants carried mutations in their polymerase gene. (springer.com)
Relevant large fragments of mutations and methylation abnormalities were not found in the associated genes. (spandidos-publications.com)
The data further revealed absence of 25‑bp repeat mutations at the shear mutation site of exon 1 of the small nuclear ribonucleoprotein polypeptide N gene in the subjects examined. (spandidos-publications.com)
The aim of this study is to investigate both novel and proven mutations of 11 MODY genes in Turkish children by using targeted next generation sequencing. (degruyter.com)
Eighteen patients have GCK mutations, four have HNF1A , one has HNF4A , one has HNF1B , two have NEUROD1 , one has PDX1 gene variations and one patient has both HNF1A and HNF4A heterozygote mutations. (degruyter.com)
Two other mutants, designated Tox-17 and Tox-18, have mutations in genes with very high homology to the gacS and gacA genes that encode a two-component regulatory system. (usda.gov)
Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. (thermofisher.com)
Knowledge about gene mutations can be used to develop treatments. (healthnewstrack.com)
The inclusion of prognostic gene mutations would enhance the predictive efficacy. (bvsalud.org)
Mutations can occur in any area of the gene. (medscape.com)
Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)

aspartic acid to the amino acid asparagine. (medlineplus.gov)
Asparagine from the diet likely makes up for the enzyme's inability to produce the amino acid in most cells. (medlineplus.gov)
Asparagine (symbol Asn or N) is an α-amino acid that is used in the biosynthesis of proteins. (wikipedia.org)
Typically, a carbohydrate tree can solely be added to an asparagine residue if the latter is flanked on the C side by X-serine or X-threonine, where X is any amino acid with the exception of proline. (wikipedia.org)
In a gene, if a single DNA nucleotide is mutated, for example from an adenine (A) to a guanine (G), this may cause the wrong amino acid to be made. (sciencebuddies.org)
The government has approved a series of field trials of the CRISPR-edited wheat, which has been bred to have lower levels of the amino acid asparagine. (nfuonline.com)
This mutation leads to the conversion of the amino acid asparagine to aspartate at position 40 (N40D) on the extracellular N-terminal domain, which affects a putative glycosylation site of the receptor ( 5 ). (spandidos-publications.com)
The BTK gene is large and consists of 19 exons that encode the 659 amino acids that form the Btk cytosolic tyrosine kinase. (medscape.com)
Analysis of this HA gene shows that it is closely related to avian A(H5) viruses in HA clade 2.3.4.4b and lacked amino acid changes that improve recognition of mammalian receptors or fusion of the viral membrane with the host endosomal membranes. (cdc.gov)

The nucleotide sequences of Serine-Rich Entamoeba histolytica Protein (SREHP) gene have already exhibited stable and significant polymorphism in the gene studies. (scialert.net)
The polymorphism of the Serine-Rich Entamoeba dispar Protein (SREDP) gene among 8 isolates obtained from Iranian cyst carriers were analyzed by a nested PCR-RFLP followed by sequencing of the PCR products. (scialert.net)
Genetic diversity of Iranian E. dispar isolates based on the SREDP was more polymorphic in comparison of Serine-Rich Entamoeba histolytica Protein (SREHP) of the E. histolytica isolates as well as were different from a few known SREDP genes. (scialert.net)
The first nucleotide sequences have been shown the stable and significant polymorphism in the Strain Specific Gene (SSG) and the Serine-Rich E. histolytica Protein (SREHP) gene. (scialert.net)
It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. (thermofisher.com)
Rather than a cysteine residue, which is highly conserved in [4Fe-4S] clusters, or alanine or glycine residues, which are common in [3Fe-4S] ferredoxins, these genes encode at this position histidine, asparagine, tyrosine, serine, threonine or phenylalanine. (rsc.org)

In reaction that is the reverse of its biosynthesis, asparagine is hydrolyzed to aspartate by asparaginase. (wikipedia.org)
Two coding single nucleotide polymorphisms (SNPs) supposedly affect their functions: GSTO1*C419A (rs4925) causing alanine to aspartate substitution (*A140D) and GSTO2*A424G (rs156697) causing asparagine to aspartate substitution (*N142D), and have been associated with several neurodegenerative diseases and cancers. (cancerindex.org)

While the wild-type CGTase from the same bacterium produces a mixture of mainly alpha-, beta- and gamma-cyclodextrins, catalyzing the conversion of starch into cyclic or linear alpha-1,4-linked glucopyranosyl chains, site-directed mutation of histidine-233 to asparagine changed the nature of the enzyme such that it no longer produced alpha-cyclodextrin. (rcsb.org)
For example, in cystic fibrosis there is a mutation in a gene, called the CFTR gene, that encodes for a channel that controls the flow of particles in cells. (sciencebuddies.org)
Cystic fibrosis is caused by a mutation in the CFTR gene, which encodes for a chloride channel that is important for regulating water flow into, and out of, the cells. (sciencebuddies.org)
We also analyzed the tumor-infiltrating immune cells, immune-related gene expression, tumor mutation burden, and drug sensitivity of patients with HNSCC in the high- and low-risk groups. (frontiersin.org)
One mutant, designated Tox-9, has a mutation in a DNA region having a high degree of homology with exbD, a gene that encodes for an auxiliary protein in the TonB/ExbD/ExbB membrane transport system. (usda.gov)
A third mutant, designated Tox-12, has a mutation in a DNA region having a high degree of homology with cysD, a gene that encodes for a sulfate adenylate transferase. (usda.gov)
The patient has a mutation on exon 15, A504T, which changed an asparagine residue to a valine residue. (medscape.com)

In addition to being a component of proteins, asparagine helps to break down toxic ammonia within cells, is important for protein modification, and is needed for making a molecule that transmits signals in the brain (a neurotransmitter). (medlineplus.gov)
Basic understanding of what genes, DNA, and proteins are. (sciencebuddies.org)
The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. (thermofisher.com)
Asn1 , Ppo5 , PhL , R1 , and VInv ), which results in the reduced level of mRNA transcripts (and subsequently expressed proteins) for those same genes using the RNA interference (RNAi) pathway. (canada.ca)
There are many possible applications for these genes: you could try to recreate essential gene pathways in-vitro, or purify the proteins for functional studies, or create a synthetic MoClo-compatible Bacillus subtilis genome using these genes and the sgRNAs available from the Bacillus Genetic Stock Center. (freegenes.org)
The codon table used was the FreqB table from " Design Parameters to Control Synthetic Gene Expression in Escherichia coli ", which was used because it was shown to express proteins well and was recommended to us by JCVI. (freegenes.org)

G, which results in asparagine replacement by lysine at position 382 (p.Asn382Lys) in exon 7. (spandidos-publications.com)

The active site cleft was filled with several water molecules, forming a hydrogen bond network with various polar side chains of the enzyme, but not with asparagine-233. (rcsb.org)
This enzyme is coded on human chromosome 9, where a 63-kb gene comprising 14 exons is located. (nih.gov)
In individuals with the disability, the enzyme is not produced in sufficient quantity, and the resulting asparagine depletion affects the proliferation and survival of cells during brain development. (healthnewstrack.com)
The petitioner has provided information describing the methods used to develop Simplot Innate® potato events Gen2-W8, Gen2-X17, and Gen2-Y9 and the molecular biology data that characterize the genetic change, which results in reduced levels of free asparagine in tubers, lower levels of reducing sugars (i.e., glucose and fructose) in tubers, reduced expression of polyphenol oxidase 5 enzyme (Ppo5), and expression of the VNT1 protein. (canada.ca)

The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)

The human UBE3A gene encodes an E3 ubiquitin ligase, which exhibits three known protein subtypes ( 1 , 8 ). (spandidos-publications.com)
The human mu-opioid receptor gene (OPRM1) encodes the μ -opioid receptor protein, which is the main target of the analgesic, fentanyl. (spandidos-publications.com)
The neuraminidase (NA) gene encodes the other surface protein of the virus. (cdc.gov)

The mutated genes characterized represent genes that may be involved in several aspects of tagetitoxin production, such as regulation, biosynthesis (the structure contains a sulphur molecule in one ring and two nitrogen moieties attached to the rings), and transport. (usda.gov)

Asparagine is not essential for humans, which means that it can be synthesized from central metabolic pathway intermediates and is not required in the diet. (wikipedia.org)

The gene for this deficiency is located on band 21q22.3. (medscape.com)

This now enables investigation of how parameters such as clonal expansion relate to gene expression phenotypes [ 28 ], thereby providing novel insights not accessible by bulk sequencing (e.g. (nature.com)

The spreadsheet BBF_to_uniprot.csv contains links from our genes to outside resources like uniprot, as well as detailed descriptions. (freegenes.org)
A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. (ensembl.org)

80%) and biological pathways (such as adipocytokine, Notch, Hedgehog and NOD-like receptor signaling) were not identified by previous gene array studies. (mdpi.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)

The Human Genome Project has estimated that the human genome contains around 20,000 to 25,000 genes . (sciencebuddies.org)
This new technology will allow us to sequence all the genes in the genome and obtain a genetic portrait of the children more quickly to know which disease they suffer from and to provide treatment, if available, or when it becomes available. (healthnewstrack.com)

This disorder is now formally referred to as X-linked agammaglobulinemia (XLA), and the gene defect has been mapped to the gene that codes for Bruton tyrosine kinase (Btk) at band Xq21.3. (medscape.com)
Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia. (cancercentrum.se)

The loss of the expression of the maternal allele of the UBE3A gene is typically associated with the four following mechanisms: Deletion at the 15q11.2-q13 locus, UBE3A functional loss variation, presence of paternal parthenogenetic double chromosome or genomic imprinting defect ( 4 ). (spandidos-publications.com)
Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)

Glutamine donates an ammonium group, which reacts with β-aspartyl-AMP to form asparagine and free AMP. (wikipedia.org)

Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)

Animal cells undergo fundamental shifts in gene expression when there are changes in the oxygen levels around them. (nobelprize.org)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
However, for most of the 20th century, it was not clear how adaptations to oxygen flux were regulated at the fundamental level of gene expression. (nobelprize.org)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
DNA damage affects the expression of a variety of genes, including proto-oncogenes and cancer suppressor genes. (frontiersin.org)
In agreement with GSS activity localization in vivo , we identified six genes encoding arylsulfatase-like enzymes with a predicted C-terminal transmembrane domain, of which five showed GSS activity upon heterologous expression in insect cells. (nature.com)
Among the various genetic metabolic disorders, Angelman syndrome (AS) has attracted considerable attention due to the abnormal expression of the ubiquitin-protein ligase E3A (UBE3A) gene ( 1 ). (spandidos-publications.com)
UBE3A is the only gene in the 15q11-q13 region that indicates biased expression from the maternal allele ( 6 ). (spandidos-publications.com)
The expression levels of these genes are tissue-specific and depend on the origin of the parent. (spandidos-publications.com)
To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
Gene expression profiles from 128 adult patients with newly diagnosed ALL were characterized using high-density oligonucleotide microarrays. (aacrjournals.org)
T-lineage ALL was characterized by a homogeneous gene expression pattern, whereas several subgroups of B-lineage ALL were evident. (aacrjournals.org)
BCR/ABL + gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. (aacrjournals.org)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
All the essential genes have been recorded for expression in Escherichia coli and have been made MoClo compatible. (freegenes.org)

Since the asparagine side-chain can form hydrogen bond interactions with the peptide backbone, asparagine residues are often found near the beginning of alpha-helices as asx turns and asx motifs, and in similar turn motifs, or as amide rings, in beta sheets. (wikipedia.org)

Asparagine also provides key sites for N-linked glycosylation, modification of the protein chain with the addition of carbohydrate chains. (wikipedia.org)

With the exception of late blight resistance, the other novel traits (i.e. reduced asparagine levels, lower levels of reducing sugars, and reduced black spot bruising) are achieved through the transcription of inverted repeat sequences containing small fragments of DNA from five different endogenous genes (i.e. (canada.ca)
Phylogenetic analysis of the hemagglutinin (A) and neuraminidase (B) gene sequences of the H5N1 influenza virus isolated from a dog´s lung. (flu.org.cn)
The main module page also shows the location of these motifs within the upstream sequences of the module member genes. (systemsbiology.net)
cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. (systemsbiology.net)

The UBE3A gene is located on the 15q11-q13 locus of chromosome 15. (spandidos-publications.com)
OTC is coded on band p21.1 of the X chromosome, where the gene contains 8 exons and spans 85 kb of DNA. (nih.gov)

Cloning and characterization of SREHP gene from an Iranian E. histolytica isolate was also studied (Rasti et al . (scialert.net)

The UBE3A gene plays a regulatory role on the function of specific monoamine transmitters, which are associated with the dynamics of synaptic plasticity. (spandidos-publications.com)

Heating a mixture of asparagine and reducing sugars or other source of carbonyls produces acrylamide in food. (wikipedia.org)
These potato events exhibit reduced levels of free asparagine in tubers, as well as lower levels of reducing sugars (i.e., glucose and fructose) in tubers. (canada.ca)
The reduction in asparagine alone significantly decreases acrylamide formation in tubers when subjected to various forms of thermal processing (e.g., baking, frying, etc.) however lower levels of reducing sugars further decreases acrylamide formation and limit heat-induced browning. (canada.ca)

The multiplex ligation‑dependent probe amplification project of the Angel/chubby and copy number variation (CNV) sequencing were assessed concomitantly to identify the pathogenic genes responsible for the development of AS. (spandidos-publications.com)
Similar ferredoxin encoding genes were identified across Mycobacterium species, including in the pathogenic M. tuberculosis and M. ulcerans , as well as in a wide range of other bacteria such as Rhodococcus and Streptomyces . (rsc.org)

Here we demonstrate that many bacteria contain a set of unfamiliar ferredoxin encoding genes which are associated with those of cytochrome P450 (CYP) monooxygenases and as such are involved in anabolic and catabolic metabolism. (rsc.org)

There are gene-editing applications in at least 46 different crop species, with rice, tobacco, tomato, maize, wheat and soybean among the most cited. (nfuonline.com)
The hemagglutinin (HA) gene codes for one of the two surface glycoproteins and is central to species specificity because it is responsible for virus attachment and fusion with host cells. (cdc.gov)

We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. (aacrjournals.org)

Four transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)
Therefore, we aimed to assess the effect of specific GSTO1 and GSTO2 gene variants, independently and in interaction with established risk factors (smoking, obesity and hypertension) on the risk for the most aggressive RCC subtype, the clear cell RCC (ccRCC). (cancerindex.org)

Table: Relationship of Codon Changes in the PNRP Gene to Scrapie Susceptibility or Resistance in Sheep and Goats. (msdvetmanual.com)
Multidrug and carbapenem-resistant K. pneumoniae (CR- Kp ) are considered critical threats to global health and key traffickers of resistance genes to other pathogens. (biorxiv.org)
High resistance to most of the antibiotics tested was observed among the isolates, five ST25, three ST11, one ST45, and one ST505, which harbored a total of 44 plasmids, many of them predicted to be conjugative and carrying genes conferring resistance to a variety of antibiotic, metals, and disinfectants. (biorxiv.org)
261 essential genes from Bacillus subtilis , codon optimized for Escherichia coli in MoClo-compatible high-copy ampicillin resistance backbones. (freegenes.org)

In the present study, the genetic variability of E. dispar strains based on the SREDP gene locus was analyzed using RFLP-nested PCR and sequencing of the obtained genes. (scialert.net)

The differences in hydrogen bonds in the neighborhood of asparagine-233, maintaining the architecture of the active site cleft, seem to be responsible for the change in molecular recognition of both substrate and product of the mutant CGTase. (rcsb.org)

Find out more about our proposed trials of gene edited (GE) wheat. (rothamsted.ac.uk)
Watch wheat geneticist Cristobal Uauy explaining crop breeding and gene editing to the 2019 Oxford Farming Conference. (nfuonline.com)
Most recently, scientists at Rothamsted Research and the University of Bristol have used gene editing to develop a type of wheat that is less likely to produce carcinogenic acrylamide when baked . (nfuonline.com)
The first trial started in autumn 2021 , the first such trial of gene-edited wheat to be carried out anywhere in Europe. (nfuonline.com)

In the training set, 13 DNA repair genes were screened using univariate proportional hazard (Cox) regression analysis and least absolute shrinkage and selection operator (LASSO) Cox regression analysis to construct a risk model, which was validated in the testing set. (frontiersin.org)
METHODS: In the screening cohorts, univariable Cox regression analysis was applied to investigate the effect of individual mutant genes on overall survival (OS). (bvsalud.org)

The aim of this study was to investigate the effect of the µ-opioid receptor gene (OPRM1) A118G polymorphism on the requirement for post-operative fentanyl analgesia in patients undergoing radical gastrectomy. (spandidos-publications.com)
Functional relevance of yet another GSTO2 polymorphism, identified at the 5' untranslated (5'UTR) gene region (GSTO2*A183G, rs2297235), has not been clearly discerned so far. (cancerindex.org)

Asparagine can be hydroxylated in the HIF1 hypoxia inducible transcription factor. (wikipedia.org)

The addition of N-acetylglucosamine to asparagine is performed by oligosaccharyltransferase enzymes in the endoplasmic reticulum. (wikipedia.org)

Many things can happen during this process to prevent a gene from turning into protein or to have a non-functional protein created. (sciencebuddies.org)
A roadmap for gene functional characterisation in crops with large genomes: L. (grassroots.tools)

However, asparagine cannot cross the protective barrier that allows only certain substances to pass between blood vessels and the brain (the blood-brain barrier). (medlineplus.gov)
In normal brain tissues, the maternal UBE3A gene is actively expressed, whereas the paternal UBE3A gene is not. (spandidos-publications.com)
In normal brain tissues, the maternally inherited UBE3A allele is actively expressed ( 7 ), while the paternally inherited UBE3A gene is not. (spandidos-publications.com)
Asparagine, however, is not well transported to the brain via the blood-brain barrier," said senior co-author of the study Dr. Jacques Michaud, who found that brain cells depend on the local synthesis of asparagine to function properly. (healthnewstrack.com)
For example, asparagine supplement could be given to infants to ensure an adequate level of asparagine in the brain and the latter's normal development. (healthnewstrack.com)

Our genes are made up of hundreds to millions of building blocks, called DNA nucleotides, and if just a single nucleotide of DNA becomes mutated it might cause a devastating genetic disease. (sciencebuddies.org)
To identify the genetic defect in Spanish families with Usher syndrome (USH) and probable involvement of the CLRN1 gene. (molvis.org)
Gene editing is a group of technologies that make the changes within the organism's own DNA by moving, adding or deleting precise pieces of genetic material. (nfuonline.com)
To further elucidate how the genetic variability in the OPRM1 gene contributes to opioid efficacy and side-effects, further studies are required in different races or ethnicities and in different types of pain or surgery with sufficient sample sizes ( 18 ). (spandidos-publications.com)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
All the sgRNAs are available through the Bacillus Genetic Stock Center , which would allow for knockdown of native-sequence essential genes. (freegenes.org)

The Bacillus subtilis community has done an amazing job in curating a list of essential genes , and while the first published list goes back to 2003, the Bacillus subtilis community has continuously updated this list with results from new experiments. (freegenes.org)
In 2016, a paper was published using a CRISPR-based method for knocking down essential genes in Bacillus subtilis . (freegenes.org)

Numerous single nucleotide polymorphisms (SNPs) have been identified in the OPRM1 gene [ http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?locusId=4988 ]. (spandidos-publications.com)
Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma. (cancerindex.org)

To construct a prognostic signature composed of DNA repair genes to effectively predict the prognosis of patients with head and neck squamous cell carcinoma (HNSCC). (frontiersin.org)
In this study, we aimed to establish a prognostic prediction model for HNSCC based on DNA repair genes. (frontiersin.org)
The results showed that the risk model composed of DNA repair genes could effectively distinguish patients with different clinical outcomes and has independent predictive prognostic ability. (frontiersin.org)

The protein encoded by this gene is an omega class glutathione S-transferase (GST). (cancerindex.org)

William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)

Anatomy1

Organisms1

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes26

Information Science4

Synthetase17

Mutations18

Amino9

Serine6

Aspartate2

Mutation7

Proteins6

Lysine1

Enzyme4

Synthase1

Encodes3

Biosynthesis1

Pathway1

Deficiency1

Phenotypes1

UniProt2

Pathways2

Genome2

Tyrosine kinase2

Genomic2

Glutamine1

Kinase1

Expression17

Residues1

Glycosylation1

Sequences4

Chromosome2

Characterization1

Regulatory1

Sugars3

Pathogenic2

Metabolism1

Species2

Abnormalities1

Variants2

Resistance4

Locus1

Hydrogen1

Wheat4

Regression2

Polymorphism2

Transcription factor1

Enzymes1

Functional2

Brain5

Genetic6

Bacillus2

Polymorphisms2

Prognostic3

Protein encoded1

Mutant1