Several commonly used laboratory mouse strains such as BALB/c, SJL, AKR, CBA, C3H and A do not express the NK1.1 antigen. (thermofisher.com)
Monoclonal3
The following product was used in this experiment: NK1.1 Monoclonal Antibody (PK136), Functional Grade, eBioscience™ from Thermo Fisher Scientific, catalog # 16-5941-82, RRID AB_469159. (thermofisher.com)
Description: The PK136 monoclonal antibody reacts with mouse NK1.1, an antigen expressed by natural killer cells and a subset of T cells in the NK1.1 mouse strains including C57BL and NZB. (thermofisher.com)
For detection of NK cells in these strains the monoclonal antibody DX5 (Cat. (thermofisher.com)
Mice3
1939 International Committee on Standardized Nomenclature for Mice begins, bringing order to the naming of mice and their genes. (jax.org)
Western blot hybridization studies showed that T2CA downregulates the expression of total gal 3 proteins and extended the survival of AKR/J mice injected with Ehrlich ascites tumor cells in the Kepler-Meier survival curve analysis. (arjournals.org)
Tumor2
Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. (arjournals.org)
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. (academicinfluence.com)
Antigen2
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. (lookformedical.com)
Here, we use a BCR light chain neoepitope defined by a characteristic point mutation (IGLV3-21R110) for selective targeting of a poor-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells. (bvsalud.org)
Receptor2
NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. (thermofisher.com)
Recognition of a virus-encoded ligand by a natural killer cell activation receptor. (arjournals.org)
Proteins4
Retroviral proteins, often glycosylated, coded by the envelope (env) gene. (lookformedical.com)
The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. (lookformedical.com)
Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)
Type2
Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. (thermofisher.com)
Effect of host strain and H-2 type on spontaneous regression of murine leukemia. (jax.org)
Fundamental1
As a graduate student he worked on fundamental aspects of regulation of expression of genes. (wikipedia.org)
Cells1
We develop murine and humanized CAR constructs expressed in T cells from healthy donors and CLL patients that eradicate IGLV3-21R110 expressing cell lines and primary CLL cells, but neither cells expressing the non-pathogenic IGLV3-21G110 light chain nor polyclonal healthy B cells. (bvsalud.org)
Cell1
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Expression1
He interrupted his postdoctoral studies at MIT briefly the summer of 1973 to serve as a visiting professor at the University of Copenhagen Faculty of Health and Medical Sciences, where he continued his work on the regulation of gene expression in bacteria. (wikipedia.org)
Products1
The env genes contain a cis-acting RNA target sequence for the rev protein (= GENE PRODUCTS, REV ), termed the rev-responsive element (RRE). (lookformedical.com)
At least 10 antibody specificities were detected on the 13 tumours investigated, allowing separation of the MAbs into three classes: (i) those recognizing the autologous tumour, heterologous tumours as well as normal thymic tissue, (ii) those specific for the autologous tumour, and (iii) those specific for one tumour, but not ones of autologous origin. (microbiologyresearch.org)
Mammary1
different populations of wild mice (mus musculus domesticus) in los angeles and ventura counties were observed over their lifespan in captivity for expression of infectious murine leukemia virus (mulv) and murine mammary tumor virus (mmtv) and for the occurrence of cancer and other diseases. (liverpool.ac.uk)
Antigens2
Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene. (microbiologyresearch.org)
Antibody-induced loss of Friend virus leukemia cell surface antigens occurs during progression of erythroleukemia in F1 mice. (microbiologyresearch.org)
Vitro2
AB - Peripheral blood mononuclear cells from donors of known serological status with respect to EB virus were exposed to the virus in vitro and then cultured at various cell concentrations. (nih.gov)
The results strongly suggest that the regression phenomenon is an in vitro expression of long-term T-cell-mediated immunity to EB virus which the large majority, if not all, infected individuals possess. (nih.gov)
Serological2
Serological characterization of C-type retroviruses endogenous to the C57BL/6 mouse and isolated in tumours induced by radiation leukaemia virus (RadLV-Rs). (microbiologyresearch.org)
Serological characterization of B-tropic viruses of C57BL mice: possible origin by recombination of endogenous N-tropic and xenotropic viruses. (microbiologyresearch.org)
Characterization1
PMID- 214398 TI - Characterization of an adenosine triphosphatase of the avian myeloblastosis virus and the virus-infected myeloblast. (nih.gov)
Radiation2
She went back home and they said, after that, that that radiation virus turned out to be a virus. (nih.gov)
He was at the National Institute of Allergy and Infectious Diseases and had a Branch, or a Laboratory, consisting of a number of well known investigators, amongst which was Wally Rowe and, in his lab, Janet Hartley, who were pretty well known for work in some of the murine viruses. (nih.gov)
And up until I knew Bob from the Cancer Institute, I had been at the Public Health Service in Cincinnati and knew him more in terms of Adenoviruses and a variety of enteric viruses which his laboratory had been very instrumental in discovering, developing and, in fact, he supplied us with Adenovirus Type 3, which we used in disinfection studies and things like that. (nih.gov)
tcrg gene polymorphism was investigated by southern blot analysis on a panel of laboratory and wild mouse strains using a set of probes which identify all known tcrg-v and -c genes. (liverpool.ac.uk)
only three haplotypes are found in laboratory mice: ga, gb, and gc which are represented by balb/c, akr, and dba/2 prototypes respectively. (liverpool.ac.uk)
Friend2
Well, it was right about that time that Charlotte Friend came up with her virus. (nih.gov)
Huebner: Was that the Friend virus that she was talking about? (nih.gov)
Time4
Stevenson: Before we get started on that, maybe we could go back in time and kind of pick up where Bob Huebner got started with virus cancer type investigations. (nih.gov)
We were doing work on enteric viruses in water and sewage and, at that time, I was also collecting fecal specimens from Albert Sabin's polio vaccine experiments to determine what quantities of Poliovirus were in feces, and we were using his vaccine strains in his volunteers as some indication of what you could find in raw feces. (nih.gov)
Do you recall when Bob got interested in tumor viruses for the first time? (nih.gov)
They were ubiquitous and they hung around for a long time and they had qualities that some of the other DNA viruses he was aware of did not. (nih.gov)
Production1
The present findings suggest that the detection of immune complexes in unfractionated samples of late tumour-bearer serum using a C1q-binding assay is masked by the increasing production of tumour-specific antibodies and by a shift from complement fixing to non-complement-fixing tumour-specific antibodies. (nih.gov)
Mouse2
polymorphism of the mouse transcription factor-encoding gene e2a. (liverpool.ac.uk)
cloning and sequence analysis of the gene and cdna encoding mouse spermidine/spermine n1-acetyltransferase--a gene uniquely regulated by polyamines and their analogs. (liverpool.ac.uk)
Type1
The type-specific antibodies were assayed by IHA inhibition test. (nih.gov)