• How are genetic conditions and genes named? (nih.gov)
  • Viral vectors are most commonly used for clinical gene therapy resulting in the marketing authorization approval for several products to treat genetic diseases and cancer [ 1 , 2 ]. (bioscirep.org)
  • Some possible genetic contributions include the role of polymorphisms in genes associated with serotonin, noradrenalin, and dopamine neurotransmission, such as variants of the.serotonin transporter genes which inhibit serotonin reuptake, leading to insufficiency of monoamines in the brain and thus predisposing to depression. (news-medical.net)
  • Genes that regulate the circadian rhythm are another potential cause of genetic predisposition to depression by interfering with normal sleep and other body functions that depend on the circadian pacemaker. (news-medical.net)
  • GENES-R-US is a genetic counseling service created and designed by a high school biology class and offered to high school health class (or home economics class) "couples expecting a child" as part of a family living project. (accessexcellence.org)
  • The program asks the student couple if they would like to subscribe to the GENES-R-US genetic counseling service. (accessexcellence.org)
  • Global Genes is a global non-profit advocacy organization for individuals and families fighting rare and genetic diseases. (wikipedia.org)
  • The organization is associated with a blue denim "Genes Ribbon" that is intended to raise awareness of patients affected by rare and genetic diseases. (wikipedia.org)
  • They explain exactly how genomic sequence encodes the regulation of expression of the sets of genes that progressively generate developmental patterns and execute the construction of multiple states of differentiation. (pnas.org)
  • Among the genes identified was CD276, a gene that encodes a protein located on the cell surface, as well as other known and previously undescribed genes. (nih.gov)
  • The oncogene ETS‑related gene (ERG) encodes a transcription factor with roles in the regulation of haematopoiesis, angiogenesis, vasculogenesis, inflammation, migration and invasion. (spandidos-publications.com)
  • The most commonly implicated gene is MC4R , which encodes the melanocortin 4 receptor. (cdc.gov)
  • Proneural genes encode transcription factors of the basic helix-loop-helix (bHLH) class which are responsible for the development of neuroectodermal progenitor cells. (wikipedia.org)
  • Nevertheless, on average, having one copy of some of the newly identified genes raises a person's chances of developing one of the seven studied diseases by 20 to 40 percent, and those with two copies face nearly double that risk, researchers say. (scientificamerican.com)
  • Proneural bHLH transcription factors, not only drive neurogenesis by activating the expression of a cascade of neuronal genes, but they inhibit the expression of glial genes. (wikipedia.org)
  • Proneural genes promote neurogenesis and inhibit gliogenesis but some neurogenic factors can regulate both of these processes, depending on the proneural genes concentration. (wikipedia.org)
  • Input entire protein-encoding gene or transcript repertoires from genomes of interest, and cluster homologs (orthologs and paralogs). (cyverse.org)
  • Vaccination with irradiated granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting gene-transduced cancer vaccines induces tumoricidal immune responses. (aacrjournals.org)
  • These data suggest that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines. (aacrjournals.org)
  • In addition, the maximum cargo size of viral vectors is restricted, hampering gene transfer of larger therapeutic genes. (bioscirep.org)
  • A variety of non-viral gene delivery methods have been developed to improve the efficacy of gene transfer. (bioscirep.org)
  • They injected trout with the genes for antibodies against viral haemorrhagic septicaemia virus. (newscientist.com)
  • Despite their promise, the main limitation is their immunogenicity when administered directly in vivo , that may curtail long-term gene expression and/or prevent vector re-administration. (bioscirep.org)
  • A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. (nih.gov)
  • Researchers at Cell Therapeutics in Seattle have discovered a gene linked to several cancers in humans - including breast, lung, prostate, and ovarian. (wired.com)
  • Functional linkages between these particular genes, and their associated regulatory modules, define the core networks underlying development. (pnas.org)
  • But gene regulatory network architecture can be authenticated only by experimental molecular biology in which the functional meaning of given regulatory sequences is directly determined. (pnas.org)
  • It is most important to determine regulatory network architecture, and this can be done by experimental perturbation followed by measurement of the effects on function of many individual genes. (pnas.org)
  • Although some housekeeping genes (such as LDHA, NONO, PGK1, PPIH,) are expressed at relatively constant levels in most non-pathological situations, other housekeeping genes may vary depending on experimental conditions. (wikipedia.org)
  • Gene regulatory networks explicitly represent the causality of developmental processes. (pnas.org)
  • Many personal characteristics, such as height, are determined by more than 1 gene. (medlineplus.gov)
  • They are essentially hardwired genomic regulatory codes, the role of which is to specify the sets of genes that must be expressed in specific spatial and temporal patterns. (pnas.org)
  • Caption: Genes control Flowering Development in Plants: Mendelian Genes Define the Commitment to Flowering- Understanding Plant Genes-The Cauliflower Gene-The "fruit-full" gene. (nsf.gov)
  • We think this (gene) will define a new class of anti-cancer compounds, which are selective for specific types of cancer and will have less toxicity than traditional cancer drug (genes),' said Dr. Jack Singer, research program chairman at Cell Therapeutics . (wired.com)
  • Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease. (nih.gov)
  • Rarely, obesity occurs in families according to a clear inheritance pattern caused by changes in a single gene. (cdc.gov)
  • Other genes are also being studied, and some think that depression occurs across a wide spectrum of severity, various forms being only different subtypes of the same disease. (news-medical.net)
  • However, some diseases, such as sickle cell anemia , can be caused by a change in a single gene. (medlineplus.gov)
  • These differences may explain why no single PSEN1 gene mutation has been reported to cause the signs and symptoms of both diseases. (nih.gov)
  • That is because genes, although potent predictors, are not always the sole cause of particular diseases. (scientificamerican.com)
  • Later on, in the 1970s, the achaete-scute complex, a complex of genes that are involved in regulating the early steps of neural development in Drosophila, were identified[by whom? (wikipedia.org)
  • Using molecular tools it was possible to isolate the first four genes of this complex: achaete (ac), scute (sc), lethal of scute (lsc) and asense (ase). (wikipedia.org)
  • The Special Feature on gene regulatory networks in this issue of PNAS highlights an emerging field in the biosciences: gene regulatory networks that control animal development. (pnas.org)
  • The end result is the precise transcriptional control of the associated genes. (pnas.org)
  • Reengineering genomic control systems: To redesign these most potent of all biological control systems, to both intellectual and practical ends, it is necessary to understand thoroughly the flow of causality in a genomically encoded gene regulatory network. (pnas.org)
  • How do genes control energy balance? (cdc.gov)
  • Proneural genes have multiple functions in neural development. (wikipedia.org)
  • These populations may best represent the paternal gene pool of the ancient Jewish/Hebrew population dating back to the First Temple period, before the Babylonian exile (approx. (aish.com)
  • This is a list of recommended housekeeping genes that may be used for reference purposes: The following represent genes that should probably not be used for reference purposes:GUSB,RPLP0, and TFRC.GAPDH, HSP90, and β-actin. (wikipedia.org)
  • carriers of the common FTO gene variant most consistently associated with obesity were able to reduce their risk through physical activity. (cdc.gov)
  • The results support the hypothesis that the paternal gene pools of Jewish communities from Europe, North Africa and the Middle East descended from a common Middle Eastern ancestral population, and suggest that most Jewish communities have remained relatively isolated from neighboring non-Jewish communities during and after the Diaspora. (aish.com)
  • The researchers proposed to answer the question whether the scattered groups of modern Jews can be identified as the descendants of the ancient Hebrews of the Bible, or whether their common ancestry has been diluted through influx of converts and through intermarriage so that little remains of their 'Jewish genes. (aish.com)
  • This article discusses the specific topic of reference genes. (wikipedia.org)
  • The identified mutation deletes a single DNA building block (nucleotide) from the PSEN1 gene, written as 725delC. (nih.gov)
  • Doctors say the same gene may play a role in patients' response to treatment for other forms of malignancy, including lymphoma and cancer of the lung, colon and head and neck. (wired.com)
  • A University of Edinburgh study has shown that genes play a major role in depression. (news-medical.net)
  • The program is organized by the Department of Film, Video, New Media, and Animation at the School of the Art Institute of Chicago in collaboration with the Gene Siskel Film Center and the Video Data Bank . (siskelfilmcenter.org)
  • People whose MGMT genes are altered that way respond much better to carmustine and similar chemotherapy drugs. (wired.com)
  • A gene is a short piece of DNA. (medlineplus.gov)
  • Furthermore, the short version of the gene, called the 'S allele', has been linked to a heightened risk of depression, especially if the person has been through adverse childhood events. (news-medical.net)
  • Definitive regulatory functions emerge only from the architecture of intergenic linkages, and these functions are not visible at the level of any individual genes. (pnas.org)
  • Neural bHLH genes have different functions depending on: the sensitivity to lateral inhibition, which determines if a cell becomes epidermal or neuronal, and whether the gene is expressed in the CNS before or after the terminal mitosis. (wikipedia.org)
  • The company hopes to develop drugs to block the gene, called LPAAT-B, in cancer patients who test positive for it. (wired.com)