Gene via protein. Medical search. Frequent questions

The M protein gene ( emm) encodes the cell surface M virulence protein responsible for at least 100 Streptococcus pyogenes M serotypes. (cdc.gov)
NUTM1 gene) encodes (i.e. directs the synthesis of) a 1,132-amino acid protein termed NUT that is expressed almost exclusively in the testes, ovaries, and ciliary ganglion (i.e. a parasympathetic ganglion of nerve cells located just behind the eye). (wikipedia.org)
The BRD4-NUTM1 fusion gene is a translocation that encodes a fusion protein that has merged most of the protein coding region of the NUTM1 gene with a large part of the BRD4 gene located in band 13 on the short (i.e. "q") arm of chromosome 19. (wikipedia.org)
The aim of this study was to investigate the expression and silencing of the S100A8 gene, which encodes the S100 calcium-binding protein A8 (S100A8), and apoptosis and phosphorylation of protein kinase B (Akt) in tissue samples of endometrial carcinoma and HEC-1A endometrial adenocarcinoma cells in vitro . (medscimonit.com)
The HSP70 gene family encodes the major heat shock protein of molecular weight 70,000. (blogspot.com)
The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. (rupress.org)
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and the cytoplasm. (wikipedia.org)
This gene encodes the protein FIC1, also known as ATP8B1. (medscape.com)
PFIC2 is caused by a mutation in the ABCB11 gene on chromosome 2q24 that encodes the bile salt export pump (BSEP). (medscape.com)

Hammill JT, Miyake-Stoner S, Hazen JL, Jackson JC, Mehl RA (2007) Preparation of site-specifically labeled fluorinated proteins for 19 F-NMR structural characterization. (springer.com)
Cloning and characterization of SREHP gene from an Iranian E. histolytica isolate was also studied (Rasti et al . (scialert.net)
Here, we describe the characterization of one of these mutants, per8, and the cloning of the PER8 gene. (rupress.org)
Molecular characterization of the immune system: emergence of proteins, processes, and domains. (lu.se)

De Iaco also found that when DUX4 is forcibly produced in muscle cells, it turns on a whole set of genes that are expressed during zygotic genome activation. (news-medical.net)
They found that DUX4 is one of the very first genes expressed at this stage, releasing a high concentration of its protein product just before zygotic genome activation. (news-medical.net)
In line with this lead, the scientists could show that the DUX4 protein binds to the regulatory region of genes that are induced during zygotic genome activation, stimulating their expression. (news-medical.net)
The final piece of evidence came when the EPFL scientists removed the DUX gene from fertilized mouse oocytes using CRISPR/Cas9 genome editing. (news-medical.net)
The study points to DUX4, and by extension the DUX family of proteins, as the master regulator responsible for kick-starting genome expression at the earliest stage of embryonic life in humans, mouse and probably all placental mammals. (news-medical.net)
With the exception of the first and last exons of genes, every other exon in the genome has splicing signals at its 5' and 3' ends and theoretically can circularize. (bcm.edu)
Lentiviral (LV) vectors of the Retroviridae family show interesting properties for monogenic gene therapy, since they integrate into the host genome and allow long-lasting gene expression 22 . (nature.com)
In humans, only about 1.5 percent of the human genome or DNA consists of protein-coding genes. (indiavision.com)
Researchers have now presented a new proteogenomics method, which makes it possible to track down protein coding genes in the remaining 98.5 percent of the genome, something that until now has been an impossible task to pursue. (indiavision.com)
Associate Professor and study leader Janne Lehtio's team found evidence for almost one hundred new protein-coding regions in the human genome. (indiavision.com)
Many of the new proteins encoded by pseudogenes could also be traced in other cancer cell lines, and the next objective on the researchers' agenda is to investigate if these genes in the "junkyard" of the genome play a role in cancer or other diseases. (indiavision.com)
Dr Lethio said that their study challenges the old theory that pseudogenes don't code for proteins, asserting that their method allows for protein based genome annotation in organism with complex genomes and can lead to discovery of many novel protein coding genes, not only in humans but in any species with a known DNA sequence. (indiavision.com)
The human genome contains about 20,000 protein-coding genes and about 5,000 genes that specify functional RNAs. (blogspot.com)
I hope it's just sloppy thinking when they say that their 1800 essential "genes" represent 9.2% of all genes in the genome (Wang et al. (blogspot.com)
With the accumulation of genome sequences of related species, there has been a growing demand for better and faster homology-based gene prediction programs. (sfu.ca)
First, local alignments between the query protein and the genome are assembled into gene regions where potential homologous genes are located. (sfu.ca)
The experimental and computational techniques for capturing information about protein structures and genetic variation within the human genome have advanced dramatically in the past 20 years, generating extensive new data resources . (bvsalud.org)

These sequences are usually linked to M protein genes rather than the similar mrp or enn genes. (cdc.gov)
This helps to avoid confounding of the 180-base M protein gene segment by the similar emm- like mrp and enn sequences (see CDC Streptococcus Laboratory GAS bioinformatic pipeline for S. pyogenes external icon ). (cdc.gov)
The reports on base sequences of spider silk protein genes have gained importance as the mechanical properties of silk fibers have been revealed. (bioone.org)
This binding puts these ssDNA sequences into optimal conformations for interacting with DNA polymerases and other replication proteins. (qiagen.com)
To identify the proteins containing the corresponding amino acid sequences, we determined the N-terminal amino acid sequence of 12 spots of LMW-GSs of Norin 61 separated by two-dimensional gel electrophoresis (2DE). (unboundmedicine.com)
The N-terminal sequences of the LMW-GS spots showed that 10 of 12 groups of LMW-GSs were expressed as protein products, which included LMW-i, LMW-m, and LMW-s types. (unboundmedicine.com)
The nucleotide sequences of Serine-Rich Entamoeba histolytica Protein (SREHP) gene have already exhibited stable and significant polymorphism in the gene studies. (scialert.net)
The first nucleotide sequences have been shown the stable and significant polymorphism in the Strain Specific Gene (SSG) and the Serine-Rich E. histolytica Protein (SREHP) gene. (scialert.net)
New emm (M protein gene) sequences of group A streptococci isolated from Malaysian patients. (cdc.gov)

Here you can search for genes and proteins by GenBank gi numbers, accession numbers or UniProt accession numbers. (lu.se)

How do genes direct the production of proteins? (medlineplus.gov)

emm typing is based on sequence analysis of the portion of the emm gene that dictates the M serotype. (cdc.gov)
The 180 bp subtype-encoding sequence consists of 60 codons encoding signal sequence (10 codons) plus the mature M protein (50 codons). (cdc.gov)
This database of trimmed 180 base entries corresponds to the first 50 residues of the mature M protein and the adjacent 10 C terminal residues of the signal sequence. (cdc.gov)
Protein assembly continues until the ribosome encounters a "stop" codon (a sequence of three nucleotides that does not code for an amino acid). (medlineplus.gov)
Zoghbi and collaborator Richard Gibbs propose to sequence these 500 genes in DNA samples from individuals with autism enrolled in the Simons Simplex Collection. (sfari.org)
Using these genetic techniques, Zoghbi and colleagues aim to pinpoint genes in which sequence variations or defects are linked to autism and determine whether these events are heritable or occur spontaneously. (sfari.org)
The sequence of PER8 predicts that its product (Per8p) is a novel polypeptide of 34 kD, and antibodies against Per8p recognize a protein of 31 kD. (rupress.org)
One of the most important steps towards the understanding of genomes is gene prediction, which is determining the positions of genes and their components (including exons and introns) on the DNA sequence. (sfu.ca)
A protein sequence (the product of gene) is used as a query to help in finding genes that are homologous to the query protein. (sfu.ca)
The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)
While nine spCas9 gene editing sites surround the Arc start codon, the accuracy of the editing was highly sequence-dependent, with only a single target resulting in an in-frame reporter integration. (lu.se)
Integration of Protein Structure and Population-Scale DNA Sequence Data for Disease Gene Discovery and Variant Interpretation. (bvsalud.org)

Immumome contains information about immunity related proteins, their domain structure and the related ontology terms. (lu.se)
Here you can search for group of genes e.g. by protein domains or ontology terms. (lu.se)

Neumann H, Peak-Chew SY, Chin JW (2008) Genetically encoding N(epsilon)-acetyllysine in recombinant proteins. (springer.com)
In this study, we showed that the human RFC (hRFC) gene can serve as a novel selectable marker for the overproduction of recombinant proteins. (aspetjournals.org)
These results establish a novel RFC-based metabolic selection system for the efficient overexpression of recombinant proteins. (aspetjournals.org)

Overexpression of the MYC and SOX2 genes can also act to maintain cells in an undifferentiated stem cell-like state similar to the cells in the neoplasms driven by the BRD4-NUTM1 fusion gene. (wikipedia.org)
Therefore, the overexpression of p53 does not always indicate a mutation in the TP53 gene. (spandidos-publications.com)

A fusion gene is an abnormal gene consisting of parts from two different genes that form as a result of a large scale gene mutation such as a chromosomal translocation, interstitial deletion, or inversion. (wikipedia.org)
Because of their distribution in the nervous system and because n-syb, synaptotagmin, and drab3 do not appear to be in a family of functionally redundant homologs, we predict that mutation of these genes will have a profound neurological phenotype and that they are therefore good candidates for a genetic dissection in Drosophila. (jneurosci.org)
The TP53 gene mutation is the most common gene alteration in many tumors, including esophageal cancer. (spandidos-publications.com)
Although the biological significance of TP53 gene mutation is well characterized, its clinical significance in esophageal cancer remains controversial, especially as a prognostic biomarker. (spandidos-publications.com)
Similarly, TP53 mutation does not always lead to the accumulation of p53 protein in cells. (spandidos-publications.com)
PFIC1 is caused by a genetic mutation in the ATP8B1 gene on chromosome 18q21-22. (medscape.com)
The mechanism whereby the loss of FIC1 activity results in defective bile salts excretion is unknown, but it has been hypothesized that a mutation in this protein causes phospholipid membrane instability leading to reduced function of bile acid transporters. (medscape.com)
Direct oral anticoagulants (DOACs) or warfarin can be used for prevention and treatment of venous thrombosis in patients with one (heterozygosity) or two (homozygosity) copies of the prothrombin 20210 gene mutation. (msdmanuals.com)

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
The protein is associated with microtubules , and Chatterjee and colleagues silenced the gene via short interfering RNA (siRNA) a molecular biological mechanism to study genes, targeting the CKAP5 encapsulated in lipid nanoparticles for in vivo delivery. (medicalxpress.com)
Some of them are the protein-coding genes for RNA polymerase subunits, ribosomal proteins, enzymes of lipid metabolism, and many other enzymes. (blogspot.com)

One such protein is the cytoskeleton-associated protein 5 (CKAP5), widely expressed in a variety of cells to regulate the dynamics of microtubules in human cells. (medicalxpress.com)
Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
In the cytoplasm, the encoded protein may function to regulate apoptosis. (wikipedia.org)

The type of RNA that contains the information for making a protein is called messenger RNA (mRNA) because it carries the information, or message, from the DNA out of the nucleus into the cytoplasm. (medlineplus.gov)
For some genes, the abundance of the circular RNA exceeds that of the associated linear mRNA by a factor of 10, raising the interesting possibility that the function of some protein-coding genes may actually be to produce circular noncoding RNAs, not proteins. (bcm.edu)
In total, these results indicate that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state output of protein-coding genes towards circular RNAs, which likely helps explain why and how circular RNAs show tissue-specific expression profiles. (bcm.edu)
In particular, we are interested in determining how cellular cues can alter the ratio of linear mRNA to circular RNA for a given gene. (bcm.edu)
After differentiating the mutant and corrected cells into lung organoids, we show expression of SFTPB mRNA during endodermal and organoid differentiation but the protein product only after organoid differentiation. (nature.com)
Northern analysis and in situ hybridizations to mRNA indicate that the novel vamp, as well as the genes for synaptotagmin (syt) and rab3 (drab3), is expressed in the Drosophila nervous system. (jneurosci.org)
S100A8 mRNA and S100A8 protein levels were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting. (medscimonit.com)

Most genes contain the information needed to make functional molecules called proteins. (medlineplus.gov)
Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell cycle. (nih.gov)
Our results lend support to the concept of post-transcriptional RNA operons, but we further present evidence that nuclear proximity of genes may provide substantial functional regulation in mammalian single cells. (nih.gov)
The database for annotation, visualization and integrated discovery (DAVID), which can be freely accessed at http://david.abcc.ncifcrf.gov/, is a web-based online bioinformatics resource that aims to provide tools for the functional interpretation of large lists of genes/proteins. (nih.gov)
Pseudogenes have been considered as non-functional genes, which are believed to be gene remnants that lost their function during evolution. (indiavision.com)
The study of protein complexes and protein functional modules has become an important method to further understand the mechanism and organization of life activities. (biomedcentral.com)
The clustering algorithms used to analyze the information contained in protein-protein interaction network are effective ways to explore the characteristics of protein functional modules. (biomedcentral.com)
This paper conducts an intensive study on the problems of low recognition efficiency and noise in the overlapping structure of protein functional modules, based on topological characteristics of PPI network. (biomedcentral.com)
The experimental results show that the ECTG algorithm can detect protein functional modules better. (biomedcentral.com)
We find that topological structure and attribute information are very effective in identifying protein complexes by analyzing the existing mainstream PPI network methods for identifying protein functional modules [ 12 , 13 ], even though there are not much approaches take both information into consideration. (biomedcentral.com)
Calculating the similarity between gene expression patterns (co-expression degree) by using gene expression data has an important guiding function in understanding the relationship between the corresponding proteins of the gene, and can help to identify whether different proteins have same or similar functions and whether they can be composed as protein complexes or functional modules. (biomedcentral.com)
Also list of proteins for functional categories, e.g. (lu.se)

Furthermore, the possible implications to subcellular transporter localization and restoration of MTX sensitivity in drug-resistant tumors by RFC-based gene therapy are discussed. (aspetjournals.org)
The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. (wikipedia.org)
We focus on the potential of new methods that integrate human genetic variation into protein structures to discover relationships to disease , including the discovery of mutational hotspots in cancer -related proteins , the localization of protein -altering variants within protein regions for common complex diseases , and the assessment of variants of unknown significance for Mendelian traits. (bvsalud.org)

BRD4 protein recognizes acetylated lysine residues on proteins and by doing so participates in the regulation of DNA replication, DNA transcription, and thereby key cellular processes involved in the development of neoplasms (i.e. malignant or benign tissue growths). (wikipedia.org)
This involves actions such as the autolytic removal of residues to generate the mature form of the protein. (yeastrc.org)

Deep sequencing has revealed thousands of eukaryotic protein-coding genes that defy the central dogma, producing circular noncoding RNAs rather than linear messenger RNAs. (bcm.edu)
Some of these genes are the genes for ribosomal RNA, tRNAs, the RNAs involved in splicing, and many other types of RNA. (blogspot.com)

The flow of information from DNA to RNA to proteins is one of the fundamental principles of molecular biology. (medlineplus.gov)
The T4 Gene 32 Protein is intended for molecular biology applications. (qiagen.com)
Here, we present a compilation of DNA and protein databases, as well as bioinformatic tools for phylogenetic reconstruction and a wide range of studies on molecular evolution. (lu.se)
The researchers reason that autism-related molecular pathways, such as those involved in the functioning of neuronal networks, are a good starting point in their search for potential autism genes. (sfari.org)
To characterize the low-molecular-weight glutenin subunit (LMW-GS), we developed specific PCR primer sets to distinguish 12 groups of LMW-GS genes of Norin 61 and to decide their loci with nullisomic-tetrasomic lines of Chinese Spring. (unboundmedicine.com)
Theoretische und angewandte Genetik JO - Theor Appl Genet VL - 112 IS - 2 N2 - To characterize the low-molecular-weight glutenin subunit (LMW-GS), we developed specific PCR primer sets to distinguish 12 groups of LMW-GS genes of Norin 61 and to decide their loci with nullisomic-tetrasomic lines of Chinese Spring. (unboundmedicine.com)
Fluorescence in situ hybridization (FISH) is a molecular pathological method with high sensitivity and specificity, which uses specific DNA probes to detect chromosomal aberrations, as well as gene deletion and amplification ( 21 , 22 ). (spandidos-publications.com)
PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. (neuromics.com)
There will be involved gene engineering and molecular biology methods such as PCR, SDS-PAGE, qPCR, western blot, DNA-protein interaction assays, flow cytometry etc. (lu.se)

The ability to knock out human genes using CRISPR technology has opened to door to testing for essential genes in tissue culture cells. (blogspot.com)
Upon depletion of RBPJ using CRISPR/Cas9, we observed specific upregulation of Notch target gene expression. (mdpi.com)
To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). (lu.se)

ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)

Our project offers a unique opportunity for Master's student to gain hands-on experience focused on transcriptional regulators with importance in expression of genes of outer membrane proteins that are essential in host-pathogen interaction. (lu.se)

Mutations in specific genes - such as neuroligins, which help relay signals between neurons - have also been linked to autism. (sfari.org)
I want to know about specific genes so I can see if the results conform to expectations. (blogspot.com)

Altogether, these results demonstrate that SARS-CoV-2 could induce HERV-W envelope protein expression and suggest its involvement in the immunopathogenesis of certain COVID-19-associated syndromes and thereby its relevance in the development of personalized treatment of patients. (unmc.edu)

DRB2 has been remarkably conserved throughout plant evolution, raising the possibility that translational repression is the ancient form of miRNA-directed gene regulation in plants, and that Dicer partnering proteins, such as human TRBP, might play a similar role in other eukaryotic systems. (nature.com)
The microarray analysis of drb2 also revealed a large set of gene transcripts that were significantly different from wild-type levels, but which are not thought to be the primary targets of miRNA-directed regulation ( Supplementary Fig. 3 ). (nature.com)
Figure 4: Translational and post-translational regulation of DRB1 and DCL1, and evolutionary conservation of DRB1 and DRB2 proteins. (nature.com)
For example, viral infection, stress and the regulation of other proteins can also change the aggregation of p53 protein ( 20 ). (spandidos-publications.com)
SAA protein is an acute phase reactant, like C-reactive protein (CRP), and is synthesized by hepatocytes under the transcriptional regulation of cytokines, including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF). (medscape.com)
2022 ) Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media. (lu.se)

It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (ETS1). (wikipedia.org)

Silks are composed principally of proteins with a predominance of alanine, serine and glycine and silk proteins are able to undergo irreversible transformations from soluble protein to insoluble fibres. (bioone.org)
Amyloidosis comprises a heterogeneous group of diseases in which normally soluble plasma proteins are deposited in the extracellular space in an abnormal, insoluble, fibrillar form. (medscape.com)

The TP53 gene plays an important role in regulating the cell cycle, apoptosis and DNA damage repair ( 8 , 9 ). (spandidos-publications.com)

Overall, more than 20 genes and chromosomal regions are known to cause autism when defective but together, these account for only around 10 percent of cases. (sfari.org)

A few genes produce regulatory molecules that help the cell assemble proteins. (medlineplus.gov)
Here we show that the form of regulatory action directed by a plant miRNA is determined by DRB2, a DICER-LIKE1 (DCL1) partnering protein. (nature.com)

Using RNAi screening in Drosophila cells, we identified many hnRNPs, SR proteins, core spliceosome, and transcription termination factors that control the outputs of reporter and endogenous genes. (bcm.edu)
Because synaptic transmission is fundamentally similar between vertebrates and invertebrates, vesicle proteins from vertebrates that are important for synaptic transmission should be present in Drosophila as well. (jneurosci.org)
One previously reported candidate (syb), a Drosophila homolog of the vamp or synaptobrevin proteins, has been shown to be expressed at very low levels in neurons and is most abundant in the gut. (jneurosci.org)

It seemed possible that these genes are regulated by transcription factors that are themselves regulated by miRNAs, and at a translational level by a process involving DRB2. (nature.com)
Gene expression is regulated by proteins known as transcription factors. (ku.edu)
Gene reporter technology (GRT) has opened several new avenues for monitoring biological events including the activation of transcription factors, which are central to the study of nutrigenomics. (oregonstate.edu)
In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. (wikipedia.org)

The researchers hope that the identification of new autism genes will pave the way for studies of protein function that may help better understand the mechanics of autism at the cellular level. (sfari.org)
The Cusack group uses X-ray crystallography and cryo electron-microscopy (cryoEM) to study the structural biology of protein-RNA complexes involved in RNA virus replication, innate immunity and cellular RNA metabolism. (embl.org)
Here we present Aura®+ , a USP 1788 compatible, low-volume, high throughput particle imaging system that can rapidly size, count, and characterize biological particles and identify them as proteins, non-proteins, cellular aggregates, or other types of molecules. (livestorm.co)

RNA-silencing requires an Argonaute protein and guide RNA called microRNA. (isaaa.org)
Though Argonaute2 is not the only type of Argonaute protein, it appears to be the only Argonaute protein capable of terminating target RNA directly. (isaaa.org)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and infection-independent manner. (unmc.edu)

A portion of human INGAP gene was cloned and appears to be highly homologous to the hamster gene. (jci.org)
The homology-based methods, on the other hand, usually have higher specificity, but are limited to finding genes that have homologous partners. (sfu.ca)

Daxx, a Death domain-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. (wikipedia.org)

A type of RNA called transfer RNA (tRNA) assembles the protein, one amino acid at a time. (medlineplus.gov)
Previously, we worked on aminoacyl-tRNA synthetases, which play an essential role in protein synthesis by charging specifically their cognate tRNA(s) with the correct amino acid and editing mischarged amino acids if necessary (Palencia et al . (embl.org)

Transmembrane protein 88 inhibits transforming growth factor-β1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-β1/Smad pathway. (nih.gov)
Transmembrane protein 88 exerts a tumor-inhibitory role in thyroid cancer through restriction of Wnt/β-catenin signaling. (nih.gov)
Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer. (nih.gov)
COV00401 The SARS-CoV-2 transmembrane spike glycoprotein (S Protein) forms homotrimers that protrude from the Coronavirus surface and mediates the entry of Coronavirus into host cells. (topsan.org)
By proximity ligation assay (PLA), we demonstrated that the mCherry-Arc fusion protein retains the Arc function by interacting with the transmembrane protein stargazin in postsynaptic spines. (lu.se)

Alberto de Iaco, a postdoc in the lab of Didier Trono at EPFL, drew upon a seemingly irrelevant study of patients suffering from a form of muscular dystrophy where mutations lead to the production in muscle cells of a protein called DUX4, which is normally detected only at the earliest stage of human embryonic development. (news-medical.net)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)

Sushmita Chatterjee and a research team in nanomedicine, materials science, nanotechnology and biology at the Tel Aviv University in Israel studied the therapeutic capacity of cytoskeleton-associated protein 5 , hitherto abbreviated as CKAP5. (medicalxpress.com)
The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. (lu.se)

Upon inhibiting RNA polymerase II termination, circular RNA levels were similarly increased due to readthrough transcripts extending into downstream genes and being subjected to backsplicing. (bcm.edu)
The update on RNA-silencing focused on Argonaute2, which is a protein that can switch-off a gene by intercepting and slicing the gene's RNA transcripts before they are translated as proteins. (isaaa.org)

Several additional interacting proteins are known, but not always is there an understanding of the specific function and relevance of this interaction. (wikipedia.org)
Finally, we recorded mCherry-Arc interaction with presynaptic protein Bassoon in mCherry-negative surrounding neurons at close proximity to mCherry-positive spines of edited neurons. (lu.se)

These covariations form a network with biological properties, outlining known and novel gene interactions. (nih.gov)
COV00701 The SARS-CoV-2 membrane protein (M Protein) is the most abundantly expressed Coronavirus structural protein in host cells, and mediates viral assembly via interactions with other viral proteins. (topsan.org)

The NUTM1 gene is located in band 14 on the long (or "q") arm of chromosome 15. (wikipedia.org)
Tumor protein 53 ( TP53 ) is a recognized tumor suppressor gene located on chromosome 17q13.1. (spandidos-publications.com)

COV00601 The SARS-CoV-2 envelope protein (E Protein) is the smallest of the four main structural proteins and is abundantly expressed in host cells during the viral replication phase. (topsan.org)

More and more clustering algorithms are proposed to identify protein complexes with the constantly development of proteomics. (biomedcentral.com)
The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)

Washington - Researchers have found close to one hundred novel human gene regions that code for proteins and a number of these regions are so-called pseudogenes, which may be linked to cancer. (indiavision.com)
They have assembled a collection of proteins known to be implicated in these pathways and then screened a library of all human brain proteins to find other proteins that interact with those in the collection. (sfari.org)
Sandwalk: How many human protein-coding genes are essential for cell survival? (blogspot.com)
Three-dimensional atomic structure of a human protein which is mainly involved in regulating the activities of cells has been identified by the Scripps Research Institute. (isaaa.org)
Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers. (nih.gov)
In summary, our results showed that IGFBP-3 methylation played an important role in the silencing of its expression, suggesting that IGFBP-3 may act as a tumor suppressor gene in several human cancers examined. (nih.gov)
2022 ) Protein domain-dependent vesiculation of Lipoprotein A, a protein that is important in cell wall synthesis and fitness of the human respiratory pathogen Haemophilus influenzae . (lu.se)

Deletion of histidine-rich protein genes pfhrp2/3 in Plasmodium falciparum causes infections to go undetected by HRP2-based malaria rapid diagnostic tests. (cdc.gov)
The gene deletion proportions signify a risk of false-negative HRP2-RDT results. (cdc.gov)
Parasite deletion of the genes pfhrp2 and pfhrp3 has been implicated in false-negative results using HRP2-based RDTs. (cdc.gov)
The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)
Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) were performed to detect the expression of p53 protein and gene deletion in ESCC tissue samples from different ethnic groups in Xinjiang, in order to analyze their association with clinicopathological characteristics and patient prognosis, as well as the sensitivity and specificity of the two methods. (spandidos-publications.com)

The T4 Gene 32 Protein has exhibited an ability to enhance the performance of several DNA synthesis-related activities in secondary-structure rich regions, including PCR amplification and DNA sequencing. (qiagen.com)
Improved yields and quality of templates may be achieved with the use of DNA-binding proteins in amplification and sequencing reactions. (qiagen.com)

Immunohistochemistry (IHC) was used to detect expression of the S100A8 protein in 74 tissue samples of endometrial cancer and 22 normal endometrial tissue samples. (medscimonit.com)
Expression Atlas ( http://www.ebi.ac.uk/gxa ) is an added value database that provides information about gene and protein expression in different species and contexts, such as tissue, developmental stage, disease or cell type. (oregonstate.edu)
[ 1 ] It is characterized by extracellular tissue deposition of fibrils that are composed of fragments of serum amyloid A (SAA) protein, a major acute-phase reactant protein, produced predominantly by hepatocytes. (medscape.com)
The tissue fibril involved in AA amyloidosis consists of a 7500-dalton cleavage product of the SAA protein. (medscape.com)

The ab initio methods are usually sensitive in finding genes in novel genomes but often produce many false positives. (sfu.ca)

The two main categories of gene prediction methods are ab initio methods and homology-based methods. (sfu.ca)
In this thesis, I present a homology-based gene prediction framework that utilizes protein homology in determining positions of protein-coding genes. (sfu.ca)
In particular, it runs hundreds of times faster than GeneWise, a popular homology-based gene prediction program, while being competitive in accuracy. (sfu.ca)

Once the abnormal gene products are better understood, specific medical treatments may emerge. (medscape.com)

One of the annoying things about all three papers is that they use the words "gene" and "protein-coding gene" as synonyms. (blogspot.com)

Developing a protein function module recognition method ECTG based on Topological Features and Gene expression data for Protein Complex Identification. (biomedcentral.com)
ECTG(Evolutionary Clustering Algorithm Based on Topological Features and Gene expression data for Protein Complex Identification). (biomedcentral.com)

The positive rate of p53 protein expression was 54.5% (201/369) in the multi‑ethnic group, and was significantly different between sex (P=0.026) and between tumor differentiation groups (P=0.032). (spandidos-publications.com)

Through the processes of transcription and translation, information from genes is used to make proteins. (medlineplus.gov)
The conserved structure and neuronal expression pattern of these genes indicate that they may function in processes that are required for both vertebrate and invertebrate synaptic transmission. (jneurosci.org)

They collected data from 229 individuals with Parkinson's (21 of whom had a known genetic variation in their GBA gene). (cureparkinsons.org.uk)
This last finding is particularly important as it may be able to help explain why some individuals without a genetic variation in their GBA gene can have reduced levels of the GCase protein in parts of the brain that are affected by Parkinson's. (cureparkinsons.org.uk)

In the early 1990's, this gene was implicated in the development of certain epithelial cell cancers that: a) occurred in the midline structures of young people, b) were rapidly fatal, and c) consisted of poorly differentiated (i.e. not resembling any particular cell type), immature-appearing cells containing a BRD4-NUTM1 fusion gene. (wikipedia.org)

Next, they looked at mouse embryonic stem cells, which contain the mouse version of the DUX4 gene (called simply DUX). (news-medical.net)
We apply a tailored experimental design that eliminates these confounders, and report thousands of intrinsically covarying gene pairs in mouse embryonic stem cells. (nih.gov)
Other studies showed that lack of Daxx gene caused a higher apoptotic rate in embryonic stem cells. (wikipedia.org)

In the present study, the genetic variability of E. dispar strains based on the SREDP gene locus was analyzed using RFLP-nested PCR and sequencing of the obtained genes. (scialert.net)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

The T4 Gene 32 Protein also stimulates the rate of synthesis of T4 DNA Polymerase on primed-single-stranded substrates showing a 5-10-fold increase in synthesis rate. (qiagen.com)
The ability of T4 Gene 32 Protein to enhance the performance of several DNA synthesis-related activities is based on its essential function in the replication of bacteriophage T4. (qiagen.com)

We investigated the hypothesis that a novel gene encoding a constituent of Ilotropin was expressed in the hamster pancreas undergoing islet neogenesis. (jci.org)
This data suggests that the INGAP gene is a novel pancreatic gene expressed during islet neogenesis whose protein product is a constituent of Ilotropin and is capable of initiating duct cell proliferation, a prerequisite for islet neogenesis. (jci.org)

But when the EPFL researchers deleted the DUX gene, this process stopped, the appearance of the 2-cell stage-like subpopulation was suppressed. (news-medical.net)
It has been used by researchers from more than 5000 institutes worldwide, with a daily submission rate of ∼1200 gene lists from ∼400 unique researchers, and has been cited by more than 6000 scientific publications. (nih.gov)
The researchers screened 20 solid cancer cell lines relative to gene silencing to identify a highly responsive chemo-resistant ovarian cancer cell line that underwent significant depletion in mitotic spindle-dynamics for effective experimental cancer treatment. (medicalxpress.com)
The researchers sought to better understand how the GBA gene affects the variability between individuals with Parkinson's. (cureparkinsons.org.uk)

Toward this end, a hemagglutinin (HA) epitope tagged hRFC (hRFC-HA) was introduced into a bicistronic vector (pIRES2-EGFP), upstream of an enhanced green fluorescent protein (EGFP) reporter gene. (aspetjournals.org)
Plasmid transfection in bovine cells: Optimization using a realtime monitoring of green fluorescent protein and effect on gene reporter assay. (oregonstate.edu)

Daxx interacts with the TGF-β type II receptor by binding of C-terminal domain of the protein. (wikipedia.org)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

Encodes9

Characterization4

Genome17

Sequences9

UniProt1

Production of proteins1

Sequence12

Ontology2

Recombinant proteins3

Overexpression2

Mutation8

Lipid4

Regulate3

MRNA7

Functional12

Localization3

Residues2

RNAs2

Molecular9

CRISPR3

Abstract1

Host-pathogen1

Specific genes2

Induce1

Regulation6

Centromere protein1

Soluble2

Apoptosis1

Chromosomal1

Regulatory2

Drosophila3

Transcription factors4

Cellular3

ARGONAUTE2

Endogenous2

Homologous2

Cytoplasmic1

Amino acid2

Transmembrane5

Mutations3

Cytoskeleton-associated2

Transcripts2

Interaction2

Interactions2

Chromosome2

Structural1

Proteomics2

Human7

Deletion5

Amplification2

Tissue4

Genomes1

Homology3

Abnormal1

Synonyms1

Identification2

Tumor1

Processes2

Genetic Variation2

Epithelial1

Embryonic stem3

Strains2

Synthesis2

Constituent2

Researchers4

Reporter2

Receptor2