Gene transmembrane protein. Medical search. Frequent questions

CF is caused by mutations of the gene for the CF transmembrane conductance regulator (CFTR) protein. (karger.com)
For example, in cystic fibrosis, a mutation in the gene that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein causes the disease. (sciencedaily.com)
An individual with cystic fibrosis has a specific mutation in a gene and protein called cystic fibrosis transmembrane conductance regulator (CFTR). (bartleby.com)
mRNA therapy is one way to deliver the correct genetic instructions to cells, which would allow them to make functional CFTR protein regardless of an individual's CF mutations. (cff.org)
Cystic fibrosis is caused by mutations in both copies of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. (cff.org)
Cystic fibrosis is caused by mutations in the gene responsible for producing the cystic fibrosis transmembrane conductance regulator (CFTR) protein. (cff.org)
Every person has two copies of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. (cff.org)
A person must inherit two copies of the CFTR gene that contain mutations - one copy from each parent - to have cystic fibrosis. (cff.org)
In an international research project, scientists are examining cystic fibrosis transmembrane conductance regulator (CFTR) mutations to determine which ones cause CF and to provide additional information associated with these mutations. (cff.org)
CF results from mutations (changes) in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene , which has instructions for making the CFTR protein. (cdc.gov)
Everyone has two copies of the CFTR gene, one copy inherited from their mother and one from their father. (cdc.gov)
Because different CFTR mutations have different effects on the CFTR protein, these medicines can only be used to treat people with certain CFTR mutations. (cdc.gov)

This record is derived from a genomic sequence (NC_036886.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. (genscript.com)
Characterization of the desmosomal cadherin gene family: genomic organization of two desmoglein genes on human chromosome 18q12. (cdlib.org)
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl.de)
An evolutionary genomic analysis of these genes suggests the genes are IFITM3 duplications not found in humans that are both within the IFITM locus and also dispersed elsewhere in the Ptm genome . (bvsalud.org)

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. (nih.gov)
Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. (consensus.app)
This gene spans approximately 14 kb and encodes a 1.8-kb mRNA detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. (consensus.app)
Mutations in four genes have been identified in familial hemiplegic migraine (FHM), from which CACNA1A (FHM type 1) and SCN1A (FHM type 3) code for neuronal voltage-gated calcium or sodium channels, respectively, while ATP1A2 (FHM type 2) encodes the α 2 isoform of the Na + ,K + -ATPase's catalytic subunit, thus classifying FHM primarily as an ion channel/ion transporter pathology. (frontiersin.org)
FHM type 4 is attributed to mutations in the PRRT2 gene, which encodes a proline-rich transmembrane protein of as yet unknown function. (frontiersin.org)
which encodes a proline-rich transmembrane protein of still unknown function. (frontiersin.org)
The Mucin 1 (MUC1) gene encodes a membrane bound glycosylated phosphoprotein, belonging to the family of mucins which are heavily glycosylated proteins. (sigmaaldrich.com)
Recent investigations have identified a gene cluster on human chromosome 18q1 that encodes the desmosomal transmembrane proteins, desmocollins and desmogleins 1-3. (cdlib.org)
For example, Streptomyces griseus encodes in the following order: an ABC-2 type transporter, an ABC-type ATPase (see TC#3.A.1.105.11), a S2P-M50 peptidase with a CBS domain (see 9.B.149.1.1), a lantibiotic synthesis protein and a lantibiotic dehydratase. (tcdb.org)
Some bacteria have the bioY gene clustering with bioB , which encodes biotin synthase, an enzyme that converts dethiobiotin to biotin. (tcdb.org)

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (nih.gov)

Muc1 is a type I transmembrane glycoprotein with a unique extracellular domain containing 20 amino acid variable number tandem repeat (VNTR) domain. (sigmaaldrich.com)
Immunoglobulin superfamily, member 1 (IGSF1) is a transmembrane glycoprotein highly expressed in the mammalian pituitary gland. (medscape.com)

Nearly 1 in every 30 Americans are a carrier of the recessive gene that leads to CF (About Cystic Fibrosis, n.d. (bartleby.com)

Transmembrane protein 53 , or TMEM53 , is a protein that is encoded on chromosome 1 in humans. (wn.com)
The AMN gene is found on chromosome 14 . (medlineplus.gov)
The investigation of a DNase-hypersensitive site upstream of the CD7 gene on chromosome 17q25 has led to the discovery of a novel human gene designated K12 (SECTM1, the HGMW assignment). (consensus.app)
The MUC1 gene is mapped to human chromosome 1q22. (sigmaaldrich.com)
Localization of a locus for the striated form of palmoplantar keratoderma to chromosome 18q near the desmosomal cadherin gene cluster. (cdlib.org)
1989) refined the assignment of the lymphocyte homing receptor gene to 11pter-p13 by study of Chinese hamster-human cell hybrids in which the human parent cells had various deletions of human chromosome 11. (wdv.com)

The expansion of protein families through gene and whole genome duplication provides raw material for adaptive evolution via mutation and selection and is considered a driving force in the development of biological novelty and complexity (28-30). (healthcarecoremeasures.com)
SUMMARY A direct correlation between HIV infection and mutation in the chemokine receptor ( CCR5 ) gene has been established. (who.int)
HIV-1 is influenced by a mutation in the 1 infection with a typical delay of 2-4 years chemokine receptor ( CCR5 ) gene [ 3,4 ]. (who.int)

These ATG proteins also perform an important parallel role in 'noncanonical' autophagy, a lysosome-associated signaling pathway with key functions in immunity, inflammation, cancer, and neurodegeneration. (babraham.ac.uk)
The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. (cancerindex.org)

These transmembrane domains consist primarily of uncharged amino acids in predicted alpha helices. (wikipedia.org)
The protein product of the translocase gene demonstrated characteristics typical for members in this family of proteins, including 12 transmembrane helices and an isoelectric point of 9.4. (usda.gov)
Bioinformatic analysis of the protein revealed 12 transmembrane helices and an isoelectric point of 9.4, both of which are characteristic of this family of proteins. (usda.gov)
We found 147 genes that were significantly upregulated upon IFN treatment in Ptm lymphocytes and 31/147 were identified as genes that encode transmembrane helices and thus are likely present in membranes where interaction with viral Env is plausible. (bvsalud.org)

Please note that proteins can be included in multiple pathways, ie. (embl.de)
What pathways are this gene/protein implicaed in? (cancerindex.org)

Recent work published in The EMBO Journal and EMBO Reports reveals a novel role for the protein TECPR1 as a sensor for stressed membranes and regulator of lysosomal membrane repair. (babraham.ac.uk)

Mutations in the gene encoding the neuronal transmembrane protein stargazin bring about recessively inherited epilepsy and ataxia in "stargazer" mice. (healthcarecoremeasures.com)
Mutations in the gene encoding desmoplakin, a desmosomal plaque protein, have also been described in the pathogenesis of striate palmoplantar keratoderma. (cdlib.org)
In the autosomal dominant form,whichcomprises about 25% of total cases, approximately 30% of familieshave mutations in the gene encoding the rod photoreceptor-specificprotein rhodopsin. (prosci-inc.com)
Congenital hypophosphatasia is absence or low levels of serum alkaline phosphatase due to mutations in the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). (msdmanuals.com)

This protein isoform has a predicted weight of 26.6 kDa and isoelectric point at a pH of 9.3. (wikipedia.org)

A transmembrane protein (TP) is a type of membrane protein spanning the entirety of the biological membrane to which it is permanently attached . (wn.com)
Originally copurified using the 1 4 receptor (L-type Ca2+ route) from skeletal muscle tissue (1-3) early research focused specifically on the power from the glycosylated 32-kDa transmembrane γ subunit to modulate the electrophysiological properties from the route. (healthcarecoremeasures.com)
Hansen (26) showed that coexpression of γ6 significantly decreased currents through recombinant T-type Ca2+ channels (CaV3.1) in HEK-293 cells and native T-type Ca2+ channels in atrial HL-1 cells and that this effect did not accompany any decrease in the level of CaV3.1 mRNA or protein. (healthcarecoremeasures.com)
The open reading frame predicts a 248-amino-acid protein with the hydropathic characteristics of a type 1a membrane protein. (consensus.app)
To further validate the results pathway study was performed to identify the involvement of the coding genes in type II diabetes. (researchgate.net)
We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)
ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. (thermofisher.com)
This Type I membrane protein is expressed at high levels during early embryonic development. (thermofisher.com)
The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain. (thermofisher.com)
When evidence suggests that homologous membrane transport proteins of the ABC2 type couple transport to ATP hydrolysis using a homologue of the ABC-type ATPases, we list these proteins in the ABC superfamily. (tcdb.org)
Axl2p is predicted to be a type I transmembrane protein. (embl.de)
The KLRB1/NKR-P1 family of proteins are type-II-transmembrane C-type lectin receptors. (bdbiosciences.com)
Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. (cancerindex.org)
Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). (cancerindex.org)

The following TMEM60 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
These sequences represent the protein coding region of the TMEM60 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
2004). RseP (YaeL), an Escherichia coli RIP protease, cleaves transmembrane sequences. (tcdb.org)
Four isoforms of DMT1 have been identified in mammalian cells encoded by a single gene that differ both in their N- and C-terminal sequences with two mRNA isoforms possessing an iron response element (IRE) motif downstream from the stop codon on the message. (cdc.gov)

Transmembrane protein 88 inhibits transforming growth factor-β1-induced-extracellular matrix accumulation and epithelial-mesenchymal transition program in human pleural mesothelial cells through modulating TGF-β1/Smad pathway. (nih.gov)
There are also two highly conserved cysteine residues, which have the potential to form a disulfide bond in the extracellular space between the first and second transmembrane domains. (wikipedia.org)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
The gene tends to have expression correlated to lymphatic system, vascular/arterial endothelial tissue, and notable expression in the bladder based on expression profiles and microarray analysis. (wikipedia.org)
No known function has been attributed to TMEM217, however a co-expression analysis in dermal fibroblasts has predicted the protein to have a potential association with the cytoskeleton. (wikipedia.org)
Unexpectedly the mechanism of inhibition in this case appeared to be a reduction of α1 subunit protein expression by γ7 rather than modulation of existing channels (25). (healthcarecoremeasures.com)
Based on its range of expression, its broad structural characteristics that resemble cytokines and growth factors, and the chromosomal location of the gene in an area already associated with myelogenous leukemias and other malignant neoplasms, this study concludes that K12 is a novel molecule with potential importance in hematopoietic and/or immune system processes. (consensus.app)
Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below. (jax.org)
GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. (genscript.com)
Protein expression is influenced by many factors that may vary between experiments or laboratories. (genscript.com)
How do post-transcriptional events modulate the expression of functional macromolecules, including proteins and non-coding RNAs? (nih.gov)
NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
How do numerous non-coding variations in the human genome affect gene expression in the retina? (nih.gov)
By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. (aacrjournals.org)
In silico transcriptomic survey revealed increased levels of expression of all three PA-regulatory genes in pollen development (particularly the DGKs). (frontiersin.org)
Expression of truncated bio transport operons, each with one gene deleted, resulted in stable BioMN complexes but revealed only low amounts of BioMY and BioNY aggregates in the absence of the respective third partner. (tcdb.org)
MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
Expression of KLRB1C/NKR-P1C protein is correlated with the ability to lyse tumor cells in vitro and to mediate rejection of bone marrow allografts. (bdbiosciences.com)
We evaluated the expression and activation of Notch pathway genes in the adult human and murine corneal epithelium during proliferation. (molvis.org)
The expression of Notch pathway genes in the limbal and central human corneal epithelium was compared by reverse transcription polymerase chain reaction (RT-PCR). (molvis.org)
MicroRNAs (miRNAs) serve a role in gene expression, primarily by interacting with messenger RNAs, and may be potential biomarkers for detecting cancer. (spandidos-publications.com)
Expression of this gene is induced by TGFBR1. (cancerindex.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
In order to identify the IFN-induced host factor(s) that could contribute to the inhibition of SHIVs in macaque lymphocytes , we measured IFN-induced gene expression in immortalized pig-tailed macaque (Ptm) lymphocytes using RNA-Seq . (bvsalud.org)
The host genetic factors are assumed to play a critical role in tuberculosis pathogenesis, through impact on the gene expression of cytokines and chemokines, which are implicated in the host immune response. (cdc.gov)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

Western Blot was performed using Anti-ROR2 Monoclonal Antibody (OTI3H3) (Product # MA5-27244) and a 130 kDa band corresponding to Tyrosine-protein kinase transmembrane receptor ROR2 was observed across tested cell lines. (thermofisher.com)
Like sorafenib, lapatinib is a protein kinase inhibitor shown to decrease tumor-causing breast cancer stem cells. (hmdb.ca)

Upregulation of this gene, abnormal intracellular localization and varied glycosylation of Muc1 has been associated with carcinomas. (sigmaaldrich.com)

Search on a gene symbol or gene name keyword(s). (jax.org)

Due to an inability to genetically manipulate Las at the present time, the translocase (tlc) open reading frame was cloned and expressed in Escherichia coli to determine if this putative gene was in fact functional. (usda.gov)
Within this group of upregulated genes with putative membrane -localized proteins , we identified several interferon -induced transmembrane protein (IFITM) genes , including several previously uncharacterized Ptm IFITM3-related genes . (bvsalud.org)

Some transporters have a conserved transmembrane protein and two nucleotide binding proteins similar to those of ABC transporters. (tcdb.org)
The nucleotide sequence of CD44 cDNAs predicts a 37-kD polypeptide with homology to cartilage link protein (115435) in a phylogenetically conserved amino-terminal domain. (wdv.com)

By proximity ligation assay (PLA), we demonstrated that the mCherry-Arc fusion protein retains the Arc function by interacting with the transmembrane protein stargazin in postsynaptic spines. (lu.se)

This domain has not been found in proteins other than TMEM53 and its orthologs. (wn.com)

Transmembrane protein 131 (TMEM131) is a protein that is encoded by the TMEM131 gene in humans. (wn.com)
Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)

Amnionless attaches (binds) to another protein called cubilin, anchoring cubilin to the cell membrane. (medlineplus.gov)
PRR is a single trans-membrane protein that binds prorenin and renin with comparable affinity, facilitating local AngII generation. (mtu.edu)
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. (cancerindex.org)

This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. (nih.gov)
In mice, there are two CD63 gene loci, of which only one is functional. (biolegend.com)

We hope to provide a concise review of the literature and genes involved within our deletion sequence in the hope that it will contribute to creating a phenotypic profile for this patient population. (hindawi.com)
3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)
Using the amino acid sequence from the Las encoded translocase, a homologous protein was identified in Ca. Liberibacter solanacearum (Lso), the bacterium associated with zebra chip disease. (usda.gov)
The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)
While nine spCas9 gene editing sites surround the Arc start codon, the accuracy of the editing was highly sequence-dependent, with only a single target resulting in an in-frame reporter integration. (lu.se)

Additional experiments proven that γ2 coimmunoprecipitates with GluR1 -2 and -4 AMPAR subunits indicated in heterologous COS cells which the postsynaptic denseness proteins PSD-95 must translocate the γ2-AMPAR complicated to neuronal postsynaptic membranes (10). (healthcarecoremeasures.com)

All transmembrane proteins are integral membrane proteins (IMPs), but not all IMPs are transmembrane proteins. (wn.com)
However, unlike typical ABC transporters (E.I. Sun & M.H. Saier, unpublished results), they use small integral membrane proteins that are postulated to capture specific substrates. (tcdb.org)
These membrane proteins are homologues to ABC-2 exporters. (tcdb.org)

The longest polypeptide of transmembrane protein 217 consists of 229 amino acids. (wikipedia.org)

Canis lupus familiaris transmembrane protein 53 (TMEM53), transcript variant X1, mRNA. (genscript.com)

In animals, cadherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell polarization and migration but they have also been identified in yeast and magnetotactic bacteria. (embl.de)

The gene product is a 6,657 base pair mRNA with 41 predicted exons in the human gene. (wn.com)
Pan troglodytes transmembrane protein 60 (TMEM60), mRNA. (genscript.com)

A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)
How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? (nih.gov)

These transport proteins appear to be unique to mitochondria, plant plastids, and obligate-intracellular bacteria. (usda.gov)
In the most well characterized "canonical" pathway in mammalian cells, the Notch intracellular domain (NotchIC) translocates to the nucleus where it mostly associates with the recombination signal binding protein for the immunoglobulin kappa J region (RBPJκ). (molvis.org)

In non-canonical Atg8-family protein lipidation they become conjugated to single membranes. (babraham.ac.uk)
Biochemical assays revealed that the BioM, N, and Y proteins form stable complexes in membranes of the heterologous host. (tcdb.org)

This may be described if loss of γ2 is functionally rescued by compensating proteins or alternatively if γ2 is not required as a Ca2+ channel subunit and (18-20). (healthcarecoremeasures.com)

The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). (nih.gov)

miRNAs regulate proteins expressions by arresting or degrading the mRNAs. (cancerindex.org)
Two distinct promoter sites regulate production of the 1A or 1B isoforms (translation starts at exon 2) for both the +IRE or -IRE species of the transporter resulting in the generation of four distinct configurations of this protein. (cdc.gov)

Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognitively normal participants who are APOE ε4 carriers. (lu.se)

To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
The present review focuses on circulating miRNAs in patients with TNBC, with an emphasis on their interaction with the immune response checkpoint genes PD‑1, PD‑L1 and CTLA4. (spandidos-publications.com)

Western blots show that the K12 protein exists as a cluster of bands around 27 kDa, and extractions using nonionic detergents or high pH conditions demonstrate that it behaves as an integral membrane protein. (consensus.app)
They are integral membrane zinc metaloprotease that cleave transmembrane domains in proteins. (tcdb.org)
Both of the integral membrane protein constituents of these systems may be distantly related, and in this respect they resemble typical ABC porters. (tcdb.org)

Absence of extracytoplasmic solute-binding proteins among the members of this group, however, is a distinctive feature. (tcdb.org)

Several transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)

Replication of 15 loci involved in human plasma protein N-glycosylation in 4802 samples from four cohorts. (nih.gov)
There are several predicted phosphorylation and glycosylation sites on transmembrane protein 217 in highly conserved parts of the protein, where the phosphorylation sites are located primarily on the C-terminal tail. (wikipedia.org)

This protein is involved in the uptake of vitamin B12 (also called cobalamin) from food. (medlineplus.gov)
The Las gene encoding the translocase (tlc) was subsequently expressed in Escherichia coli and shown to enable E.coli to uptake ATP directly into the cell. (usda.gov)
Divalent metal transporter 1 (DMT1) is generally considered to be the major transmembrane protein responsible for the uptake of a variety of divalent cations. (cdc.gov)

Many bioY genes are located at loci encoding biotin biosynthesis or are unlinked to either biotin synthesis or other biotin transport genes. (tcdb.org)

In the present study, we have revised the structure of the USH3 gene, including a new translation start site, 5' untranslated region, and a transcript encoding a 232-amino acid protein. (nih.gov)

The exocrine pancreas produces three main types of enzymes: amylase, protease, and lipase, which are responsible for the digestion of carbohydrates, protein, and fat. (medscape.com)
prevents proteins needed for digestion from reaching the intestines, which decreases the body's ability to absorb nutrients from food. (cdc.gov)
Whereas protein and carbohydrate begin to undergo digestion in the stomach, triglycerides remain mostly unchanged until they reach the small intestine. (medscape.com)

2023 ). (1) the BioMNY complex with ATPase (BioM) and transmembrane protein (BioN). (tcdb.org)

Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. (embl.de)
Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins. (embl.de)

The gene consists of 46,857 base pairs and is flanked by TBC1D22B (TBC1 Domain Family Member 22B) and PIM1. (wikipedia.org)
The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment. (babraham.ac.uk)
Conjugation of the Atg8 (autophagy related 8) family of ubiquitin-like proteins to phospholipids of the phagophore is a hallmark of macroautophagy/autophagy. (babraham.ac.uk)
However, the Atg8 family of proteins are not found solely attached to double-membrane autophagosomes. (babraham.ac.uk)
The M50 Peptidase (S2P-M50) family includes proteins frequently of 700-800 aas in length with six N-terminal or centrally located TMSs. (tcdb.org)
However, the VUT family member, TrpP of Bacillus subtilis (2.A.88.4.1) and the ThiW ABC membrane protein homologue, 3.A.1.26.2, are clearly related by common descent. (tcdb.org)
[ 7 ] Connexins are a family of transmembrane proteins that assemble into hexameric hemichannels and form gated intercellular gap junction channels. (medscape.com)

Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner. (bvsalud.org)

Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer. (nih.gov)
Furthermore, because MGMT protein loss may be a result of promoter hypermethylation, it was reported that methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness to alkylating agents ( 7 ). (aacrjournals.org)

2000). Membrane-fusion protein homologues in gram-positive bacteria. (tcdb.org)

To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). (lu.se)

1983) used a murine monoclonal antibody (A3D8) to identify an erythrocyte antigen inhibited by the In(Lu) gene. (wdv.com)
1983) showed that the antigens defined by monoclonal antibodies A3D8 and A1G3 are determined by genes on 11p. (wdv.com)

The amnionless protein is primarily found embedded in the outer membrane of kidney cells and cells that line the small intestine. (medlineplus.gov)
At least 30 mutations in the AMN gene have been found to cause Imerslund-Gräsbeck syndrome. (medlineplus.gov)
63 genes found. (jax.org)
MPL has found that PRR has a profound effect on systemic blood pressure, baroreflex sensitivity, and brain inflammatory mediators, using gene transfer and genetic knockdown technologies. (mtu.edu)

Anatomy33

Organisms16

Diseases1

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes66

Disciplines and Occupations2

Technology, Industry, Agriculture4

Information Science7

CFTR12

Genomic4

Encodes10

Ontology1

Glycoprotein2

Cystic1

Chromosome6

Mutation3

Signaling pathway2

Helices4

Pathways2

Regulator1

Mutations in the gene4

Isoform1

Type14

Sequences4

Extracellular3

Expression25

Kinase2

Localization1

Symbol1

Putative2

Nucleotide2

Stargazin1

Orthologs1

Humans2

Binds3

Functional2

Sequence5

Neuronal1

Membrane Proteins3

Polypeptide1

TMEM531

Modulate1

MRNA2

Regulatory2

Intracellular2

Membranes2

Functionally1

Receptor1

Regulate2

Linkage Disequilibrium1

MiRNAs2

Integral3

Extracytoplasmic1

Isoforms1

Glycosylation2

Uptake3

Loci1

Transcript1

Digestion3

20231

Cadherin2

Family7

Strains1

Promoter2

Homologues1

Homologous1

Monoclonal2

Found4