Gene transcription molecular mef2 transcription factors. Medical search. Frequent questions

MicroRNAs (miRs) are a novel family of highly conserved, short (~18-25 nucleotide), non-coding single-stranded RNA molecules that regulate transcriptional and post-transcriptional gene expression. (medscape.com)
16. Transcriptional activation of the intercellular adhesion molecule 1 (CD54) gene by human T lymphotropic virus types I and II Tax is mediated through a palindromic response element. (nih.gov)
Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear. (nih.gov)
Through breeding ADR myotonic mice with mice harboring a MEF2-dependent reporter gene, we found that the transcriptional activity of MEF2 was dramatically enhanced in myotonic muscles. (jci.org)
Post-translational induction of MEF2 transcriptional activity correlated with the activation of p38 MAPK and did not affect MEF2 DNA-binding affinity. (jci.org)
These findings suggest that the combined effects of class II HDAC deficiency and p38 MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles. (jci.org)
Thus, our results support the hypothesis that DNA sequences ultimately determine the unique epigenomes of different cell types through their interactions with transcriptional factors, epigenome remodeling system and extracellular cues during cell differentiation. (biomedcentral.com)
Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons. (broadinstitute.org)
We introduce Single-cell Nanopore Spatial Transcriptomics ( scNaST ), a software suite to facilitate the analysis of spatial gene expression from second- and third-generation sequencing, allowing to generate a full-length near-single-cell transcriptional landscape of the tissue microenvironment. (frontiersin.org)
2004). Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation. (geneticsmr.com)
The transcriptional factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis. (geneticsmr.com)

We found that a very stable G4 can form in the promoter of human myocyte enhancer factor 2D (MEF2D), the gene encodes a transcription factor belonging to the MEF2 (myocyte enhancer factor-2) family which regulates the response of heart to cardiac stress signals. (pku.edu.cn)
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. (wikidoc.org)

Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. (wikipedia.org)
microRNAs (miRs) have recently been evolved as key players in the various cardiovascular events through the regulation of cardiac gene expression. (medscape.com)
In this review, we will first summarize the recent advances made in the discovery of molecular regulations of mitobiogenesis and mitophagy and then focus on the mechanism and signaling pathways involved in the simultaneous regulation of mitobiogenesis and mitophagy in the response of tissue or cultured cells to energy needs, stress, or pathophysiological conditions. (biomedcentral.com)
We review the molecular regulation of both mitophagy and mitobiogenesis processes and give special attention to the crosstalk between them that fine tunes the balance of mitochondrial mass and quality. (biomedcentral.com)
10. Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells. (nih.gov)
11. Gene regulation mediated by interaction between HTLV-1 promoter elements and transcription factors Tax and CREB. (nih.gov)
DNA G-quadruplexes (G4s) are believed to be involved in many biological processes, including the gene expression regulation and the maintenance of telomere. (pku.edu.cn)
Arguments from paleontology, gene regulation molecular biology and phylogenetics intersect at this problem. (silverchair.com)
GO enrichment analysis for the host genes of DE circRNAs showed that biological process (BP) terms in the top 20 related to growth in F14vsF20 were found such as positive regulation of transcription involved in G1/S phase of mitotic cell cycle, multicellular organismal macromolecule metabolic process, and multicellular organismal metabolic process. (researchsquare.com)
We also ﬁnd that like growth factor-1 (IGF-1) has a key role in the regulation of MG53 protein level is not upregulated in the muscle samples skeletal muscle size. (marysfamilymedicine.org)
Interplay between histone acetylation and deacetylation is one of the key components in epigenetic regulation of transcription. (ppjonline.org)
Exercise metabolism and the molecular regulation of skeletal muscle adaptation. (academicinfluence.com)
PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. (anticorps-enligne.fr)

These results support that the newly identified apricot gene homologs have a crucial role in dormancy-associated physiological mechanisms. (frontiersin.org)
In this review, we discuss recent advances toward elucidating the molecular mechanisms underlying the coordination of mitobiogenesis and mitophagy. (biomedcentral.com)
In fact, the molecular mechanisms that protect the heart against stress are downregulated by aging, making the myocardium more susceptible to injury. (hindawi.com)
While cancer subtypes are often characterized by differences in gene expression, the mechanisms driving these differences are generally unknown. (bvsalud.org)
We set out to model the regulatory mechanisms driving sarcoma heterogeneity based on patient-specific, genome-wide gene regulatory networks. (bvsalud.org)
The learned motifs are interpretable and may provide insights into the underlying molecular mechanisms of establishing the unique epigenomes in different cell types. (biomedcentral.com)
Conversion of fibroblasts into functional cardiomyocytes represents a potential means of restoring cardiac function after myocardial infarction, but so far this process remains inefficient and little is known about its molecular mechanisms. (elsevierpure.com)
Applying a genetic model of impaired glutamate release, this study aims to further identify the molecular mechanisms that could modulate antide-pressant action and resistance to treatment.To that end, mice knocked-down for the vesicular glutamate transporter 1 (VGLUT1+/-) were used. (unav.edu)
They are both associated with systemic inflammation and they are both ameliorated by a healthy life style, suggesting that they may share cellular and molecular pathways and underlying mechanisms. (biomedcentral.com)

Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. (affbiotech.com)
Musculin (MSC) is a basic helix-loop-helix transcription factor that inhibits myogenesis during normal development and contributes to the differentiation defect in rhabdomyosarcoma. (biomedcentral.com)
As one of many transcription factors that impede myogenesis, its binding on a genome-wide scale relative to the widespread binding of the myogenic factor MyoD is unknown. (biomedcentral.com)
Molecular manipulations that disrupt the E3-ligase function of MG53 abolish IRS-1 ubiquitination and enhance skeletal myogenesis. (marysfamilymedicine.org)

Further studies of the crosstalk of these two opposing processes at the molecular level will provide a better understanding of how the cell maintains optimal cellular fitness and function under physiological and pathophysiological conditions, which holds promise for fighting aging and aging-related diseases. (biomedcentral.com)
5. Differential patterns of human cytomegalovirus gene expression in various T-cell lines carrying human T-cell leukemia-lymphoma virus type I: role of Tax-activated cellular transcription factors. (nih.gov)
At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. (hindawi.com)
Activation of the cellular senescence genetic program prompts a series of molecular changes, mostly affecting cell cycle, extracellular matrix (ECM), secretion of growth factors, and inflammatory mediators. (hindawi.com)
This complex is required by a variety of transcription factors and key cellular proteins. (cancer.gov)
The degree of AMPK activation during exercise can be influenced by many factors that impact on cellular energetics, including exercise intensity, exercise duration, muscle glycogen, fitness level, and nutrient availability. (springer.com)
However, disrupting cellular energy charge is the most influential factor for AMPK activation during endurance exercise. (springer.com)
Together these studies indicate that musculin might have either positive or negative activities in gene transcription depending on a variety of factors and cellular context. (biomedcentral.com)

Sridhar Hannenhalli is a professor in the Department of Cell Biology and Molecular Genetics and holds joint appointments in the Center for Bioinformatics and Computational Biology (CBCB) and UMIACS. (umd.edu)
He has served on program committee for numerous bioinformatics conferences and chaired Workshop on Algorithms in Bioinformatics (WABI) and Research in Computational Molecular Biology (RECOMB) conferences. (umd.edu)
Molecular Biology and EvolutionMol Biol Evol. (umd.edu)
Algorithms for Molecular Biology. (umd.edu)
Computational Biology of Transcription Factor BindingComputational Biology of Transcription Factor Binding. (umd.edu)
1. Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea. (ijbs.com)

7. STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. (nih.gov)
Recent progress in machine-learning has demonstrated that deep convolutional neural networks (CNNs) can achieve very high accuracy in predicting transcription factor (TF) binding affinity [ 10 ] and epigenetic marks in various cell types [ 11 , 12 , 13 ]. (biomedcentral.com)
Therefore, the investigators will follow these patients for a year to study how the heart, blood vessels, brain, and risk factors for cardiovascular disease affected by altered sex hormone patterns and studying what happens in the muscles and fat in both the short and long term with respect to particular gene expression and epigenetic changes and link it to metabolic changes and body composition. (stanford.edu)

To characterize the genomic landscape and leukemogenic pathways of older, newly diagnosed, non-intensively treated patients with AML and to study the clinical implications, comprehensive genetics analyses were performed including targeted DNA sequencing of 263 genes in 604 patients treated in a prospective Phase III clinical trial. (bvsalud.org)
Further analysis of those pathways found three crucial host genes MYH9, YBX3, IGF1R in both fast- and slow-growing groups, three important host genes CTNNA3, AFDN and CREBBP only in the fast-growing group, and six host genes FGFR2, ACTN2, COL1A2, CDC42, DOCK1 and MYL3 only in the slow-growing group. (researchsquare.com)

The present invention further provides libraries of mutant AAV comprising one or more mutations in a capsid gene. (justia.com)
Multivariable analysis identified FLT3 internal tandem duplications (ITD), SRSF2, and TP53 mutations as poor prognostic factors, while DDX41 mutations exerted an exceptionally favorable effect. (bvsalud.org)
Becker syndrome, a recessive nondystrophic myotonia caused by mutations in the chloride channel 1 gene (CLCN1), is characterized by delayed muscle relaxation after contraction. (jci.org)
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. (nature.com)
Mutations in the SLC13A5 gene, a sodium citrate cotransporter, cause a rare autosomal recessive epilepsy (EIEE25) that begins during the neonatal period and is associated with motor and cognitive impairment. (stanfordchildrens.org)
In the majority (80%) of cases, Dravet Syndrome is caused by mutations in the SCN1A gene, encoding the voltage-gated sodium channel NaV1.1, which is abundant in the central nervous system. (stanfordchildrens.org)
In 1997, missense mutations in the SNCA gene, which encodes synuclein, were found in patients with early-onset autosomal dominant familial parkinsonism [ 7 ]. (e-jmd.org)

This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. (wikipedia.org)
Mitochondria have circular DNA (mitochondrial DNA, mtDNA), and mitochondrial biogenesis (mitobiogenesis) involves the replication, transcription, and translation of mtDNA-encoded genes, the interorganelle transport of phospholipids, and the import of nuclear-encoded proteins into mitochondria through the protein translocation machinery of the outer and inner membranes [ 14 ]. (biomedcentral.com)
Given that the majority of mitochondrial proteins are nuclear-encoded, the transcription and translation of nuclear and mitochondrial genes must be tightly coordinated to ensure the creation of new mitochondria [ 17 ]. (biomedcentral.com)
Moreover, in cells lacking BRM expression, we have found that the BRM gene is epigenetically silenced and can be restored using small molecular inhibitors known to inhibit histone deacetylase proteins. (cancer.gov)
The first gene encodes four proteins necessary for genome replication (Rep78, Rep68, Rep52, and Rep40), and the second expresses three structural proteins (VP1-3) that assemble to form the viral capsid. (justia.com)
Additionally, genes involved in neuronal projection and dendrite development were also altered throughout the disease, culminating in a general decline of gene expression for synaptic proteins. (prolekarniky.cz)
Mortalin is an essential component of the molecular machinery that imports nuclear-encoded proteins into mitochondria, assists in their folding, and protects against damage upon accumulation of dysfunctional, unfolded proteins in aging mitochondria. (plos.org)
The ATPase domain-containing protein Mortalin is part of the molecular machinery that imports nuclear-encoded proteins into mitochondria, sorts them, and assists in their folding (for review, see [7] , [8] ). (plos.org)
Activates transcription as a heterodimer with E proteins. (affbiotech.com)
The Drosophila melanogaster gypsy transposable element encodes putative gene products homologous to retroviral proteins. (geneticsmr.com)
The structure of the MEF2S domain is entirely different from that of the equivalent SAM domain in SRF and MCM1, accounting for the absence of cross-reactivity with other proteins that interact with these transcription factors. (nih.gov)

2011. Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and FailureClinical Perspective . (umd.edu)
Here we show that DAPT, a classical Notch inhibitor, enhances the conversion of mouse fibroblasts into induced cardiac-like myocytes by the transcription factors GATA4, HAND2, MEF2C, and TBX5. (elsevierpure.com)
Mechanistically, DAPT increases binding of the transcription factor MEF2C to the promoter regions of cardiac structural genes. (elsevierpure.com)
Our data revealed a clear regional isoform switching among differentially used transcripts for genes involved in cardiac muscle contraction and tissue morphogenesis. (frontiersin.org)
Molecular signatures involved in cardiac remodeling integrated with morphological context may support the development of new therapeutics towards the treatment of heart failure and the reduction of cardiac complications. (frontiersin.org)

Regulates gene expression differentially, depending on dimer composition. (affbiotech.com)

Recently, a mutation in the human myocyte enhancer factor-2A (MEF2A) gene was reported to be responsible for an autosomal dominant form of coronary artery disease (CAD). (nih.gov)
4. Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. (nih.gov)
Single Molecule Fluorescence Resonance Energy Transfer and Ensemble Biophysical Characterization of a G-quadruplex Formed in the Promoter of Human Myocyte Enhancer Factor 2D[J]. Acta Phys. (pku.edu.cn)

In the present study, we identified and characterized the apricot ( Prunus armeniaca L.) homologs of three dormancy-related genes, namely the ParCBF1 ( C-repeat binding factor ), ParDAM5 ( dormancy-associated MADS-BOX ) and ParDAM6 genes. (frontiersin.org)
Par DAM5 also contained all characteristic domains of the type II (MIKC C ) subfamily of MADS-box transcription factors. (frontiersin.org)

MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. (avivasysbio.com)
We showed that the heterogeneity identified with PORCUPINE is not associated with methylation profiles or clinical features, thereby suggesting an independent mechanism of patient heterogeneity driven by the complex landscape of gene regulatory interactions. (bvsalud.org)
Many regulatory genes appear to be utilized in at least superficially similar ways in the development of particular body parts in Drosophila and in chordates. (silverchair.com)
The apparently homologous expression of these genes in both insects and vertebrates has generated the view that the morphogenetic developmental programs generated by these regulatory molecules are conserved characters, and that the relevant body parts of insects and vertebrates may therefore be considered homologous. (silverchair.com)
We find that OSTN has been repurposed in primates through the evolutionary acquisition of DNA regulatory elements that bind the activity-regulated transcription factor MEF2. (broadinstitute.org)
Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. (academicinfluence.com)

Most of the miRs are located within introns of the host genes (protein-coding or non-protein-coding) or within the 3' untranslated region (UTR) of mRNA genes. (medscape.com)

2002). The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. (geneticsmr.com)

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. (nature.com)
SRY ( Sex-determining Region Y ) is a sex -determining gene on the Y chromosome in humans and other primates . (wikidoc.org)
translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome . (wikidoc.org)
These females have no SRY gene in their Y chromosome, or the SRY gene exists but is defective (mutated). (wikidoc.org)

Zinc finger protein 266 is a protein that in humans is encoded by the ZNF266 gene. (wikipedia.org)
This gene encodes a protein containing many tandem zinc-finger motifs. (wikipedia.org)
15. Human T-cell leukemia virus type I tax activates transcription of the human monocyte chemoattractant protein-1 gene through two nuclear factor-kappaB sites. (nih.gov)
Here, we identified the Drosophila transcription factor Motif 1 Binding Protein (M1BP) in physical association with the gypsy chromatin insulator core complex, including the universal insulator protein CP190. (nih.gov)
In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. (nature.com)
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. (nature.com)
The myogenic activity of MyoD can be inhibited by a variety of transcription factors, including other members of the bHLH protein family [ 4 ]. (biomedcentral.com)
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). (anticorps-enligne.fr)
The SRY gene encodes the testis determining factor , which is also referred to as the SRY protein . (wikidoc.org)
This protein is the testis-determining factor (TDF), which initiates male sex determination. (wikidoc.org)

Sequence motifs learned by both the cell or mark models are highly similar to known binding motifs of transcription factors known to play important roles in CD 4 + T cell differentiation. (biomedcentral.com)

Expression of class II histone deacetylases (HDACs), which repress MEF2-dependent gene expression, was significantly reduced in skeletal muscles from myotonic mice. (jci.org)
HDACs belong to either the HDAC family or the Sir2 family, and are traditionally divided into separate categories called classes (class I to class IV) according to sequence similarities and type of co-factors required for enzyme activity ( Seto and Yoshida, 2014 ). (ppjonline.org)
HDAC family consist of class I, II, and IV HDACs, which require zinc ions as co-factors, while Sir2 family contains class III HDACs, which require NAD+ as a co-factor for removal of acetyl group from lysine residues. (ppjonline.org)

To date, Drosophila melanogaster has been successfully used to investigate pathogenesis following the loss of several other PD-associated genes. (plos.org)
To gain further insights into homeotic gene action during CNS development, the role of the homeotic genes was characterized in embryonic brain development of Drosophila. (sdbonline.org)
Neuroanatomical techniques were used to map the entire anteroposterior order of homeotic gene expression in the Drosophila CNS. (sdbonline.org)

thus, the presence of these BRM-promoter polymorphic sites might not only correlate with the loss of BRM but also play a direct role in turning off the BRM gene during cancer development. (cancer.gov)

We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. (gsea-msigdb.org)

suggesting that MG53 upregulation is not a causative factor In vivo injection of IGF-1 in skeletal muscle or skeletal muscle- for the development of insulin resistance. (marysfamilymedicine.org)

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. (nature.com)

We found that a major cluster of genes is altered during pre-clinical disease after which expression either returns to basal levels, or alternatively undergoes a direct reversal during clinical disease. (prolekarniky.cz)

[ 7 ] miRs genes are transcribed by RNA polymerase II. (medscape.com)
Transcription of miR genes by RNA polymerase II form primary transcripts known as primary miR (pri-miR). (medscape.com)

Comparison of acetylation levels for H3K9 and H3K14 showed that lack of MoHDA1 gene led to significant increase in H3K9 and H3K14 acetylation level, compared to the wild-type and complementation strain, confirming that it is a bona fide histone deacetylase. (ppjonline.org)

Skeletal muscle differentiation, the MG53 gene in mice ameliorates high-fat/high-sucrose diet- hypertrophy and atrophy are tightly regulated by a variety of induced insulin resistance by increasing the IRS-1 expression hormones, growth factors and cytokines. (marysfamilymedicine.org)
Her other research areas look at exercise-mediated effects on skeletal muscle glucose metabolism and gene expression. (academicinfluence.com)
Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. (academicinfluence.com)
Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. (academicinfluence.com)

Human Molecular Genetics. (wikipedia.org)

The rs12526453 Polymorphism in an Intron of the PHACTR1 Gene and Its Association with 5-Year Mortality of Patients with Myocardial Infarction. (cdc.gov)
Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries. (cdc.gov)

Identification, Structural and Functional Characterization of Dormancy Regulator Genes in Apricot (Prunus armeniaca L. (frontiersin.org)

Gene symbols, accession ids and various other target identifiers. (nih.gov)

Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)
doi:10.1016/j.gene.2007.02.019 PMid:17459613 Kumar S, Nei M, Dudley J and Tamura K (2008). (geneticsmr.com)

Lysine 36 trimethylation marks primary coding and non-coding transcripts, facilitating gene annotation. (gsea-msigdb.org)

Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. (gsea-msigdb.org)

The solution structure of the 33 kDa complex between the dimeric DNA-binding core domain of the transcription factor MEF2A (residues 1-85) and a 20mer DNA oligonucleotide comprising the consensus sequence CTA(A/T)(4)TAG has been solved by NMR. (nih.gov)

The concomitant decrease of gene expression with endodormancy release is consistent with a role of ParDAM5 and ParDAM6 genes in dormancy induction and maintenance. (frontiersin.org)
The induction of lineage-specific gene programs are strongly influenced by alterations in local chromatin architecture. (mdpi.com)

17. HTLV-1 tax activation of the GM-CSF and G-CSF promoters requires the interaction of NF-kB with other transcription factor families. (nih.gov)
Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. (nih.gov)

Targets also transcription factors and signaling molecules to regulate heart function. (nih.gov)
Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity. (broadinstitute.org)

Genes with low-CpG-density promoters (LCP) bearing histone H3 trimethylation mark at K4 (H3K4me3) in embryonic stem cells (ES). (gsea-msigdb.org)

We constructed a de novo transcriptome using long-read data, and successfully assigned 19,794 transcript isoforms in total, including clinically-relevant, but yet uncharacterized modes of transcription, such as intron retention or antisense overlapping transcription. (frontiersin.org)

PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population. (cdc.gov)
PHACTR1 and SLC22A3 gene polymorphisms are associated with reduced coronary artery disease risk in the male Chinese Han population. (cdc.gov)

Retroviral expression of MNX1 was able to induce AML in mice, with similar gene expression and pathway enrichment to t(7;12) AML patient data. (bvsalud.org)
These networks have primarily been studied in mice, and it is not known whether there are species- or clade-specific activity-regulated genes that control features of brain development and function. (broadinstitute.org)
Muscle samples derived from human diabetic patients and mice with insulin resistance show normal expression of MG53, indicating that altered MG53 expression does not serve as a causative factor for the development of metabolic disorders. (marysfamilymedicine.org)

It has also been reported that inhibition from the NF B signaling pathway suppresses tumor necrosis factor induced EMT and Twist expression. (liverxreceptor.com)

We found that gene expression within these neurons is dynamic and characterized by distinct phases of activity. (prolekarniky.cz)

These findings provide new molecular targets for potential treatment of congenital myotonia. (jci.org)

This view reflects the amazing conservation of genetic apparatus that has been discovered across the Bilateria, particularly of genes encoding transcription factors and signaling molecules. (silverchair.com)

Furthermore, familial parkinsonian patients harboring duplication/triplication of the SNCA gene were reported, and the fact that patients with triplications showed much more severe symptoms suggested that the burden of α-synuclein might be related to the disease [ 8 , 9 ]. (e-jmd.org)

Approved gene symbol with link to HUGO Gene Nomenclature Committee. (nih.gov)

Characterizing inter-tumor heterogeneity is crucial for selecting suitable cancer therapy, as the presence of diverse molecular subgroups of patients can be associated with disease outcome or response to treatment. (bvsalud.org)

Anatomy16

Organisms9

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes79

Disciplines and Occupations1

Information Science3

Transcriptional11

Encodes a transcription factor2

Regulation13

Mechanisms9

Myogenesis4

Cellular8

Biology6

Epigenetic3

Pathways2

Mutations7

Proteins11

Cardiac5

Differentially1

Enhancer3

MADS-BOX2

Regulatory6

Host genes1

20021

Chromosome4

Protein12

Motifs1

HDACs3

Drosophila3

Promoter1

Enrichment analysis1

Upregulation1

Downstream1

Cluster1

Polymerase2

Histone deacetylase1

Skeletal4

Genetics1

Myocardial infarction2

Structural1

Identifiers1

PMid2

Transcripts1

Oxidative1

MEF2A1

Induction2

Interaction2

Regulate2

Embryonic1

Antisense1

Coronary artery2

Mice3

Signaling pathway1

Neurons1

Findings provide1

Molecules1

Familial1

Symbol1

Tumor1