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  • target genes
  • This view is suppored by the observation that ingibition of the AhR degradation by either MG132 or cycloheximide superinduces a number of other AhR target genes, including TiPARP, a novel TCDD-inducible poly(ADP-ribose) polymerase. (cdc.gov)
  • When ethylene is present, SRT1 and SRT2 interact with ENAP1 and deacetylate HISTONE3 at K9 (H3K9) of target genes, thereby repressing their expression. (plantcell.org)
  • laboratory
  • Dr. Jie Chen, who conducted this research while a graduate student in the Chemical Physics program, simulated the transcription bubble formation using a Brownian dynamics-based computer model developed by Dr. Thirumalai's laboratory. (phys.org)
  • liver
  • They also suggest that their findings might shed light on why some donated organ recipients, particularly those receiving livers, tend to be more likely to develop cancer-gene transcription in liver cells that occurred after the original owner died could have resulted in tumor growth. (phys.org)
  • cellular
  • This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. (wikiversity.org)
  • The assay was multiplexed with CellTiter-Blue® to determine cellular viability and demonstrated that changes in signal were due to effects on transcription only. (horizondiscovery.com)
  • Transcription - the transfer of DNA's genetic information through the synthesis of complementary molecules of messenger RNA - forms the basis of all cellular activities. (phys.org)
  • The most significant differences in gene transcription in HCV-specific CD8 T cells among the three groups were in genes related to cellular metabolism - the process of converting nutrients into energy - and to the regulation of gene transcription via the chromosomal structure called the nucleosome. (eurekalert.org)
  • ethylene
  • The known positive regulators of ethylene signaling include ETHYLENE INSENSITIVE2 (EIN2) and the transcription factor EIN3. (plantcell.org)
  • When the authors examined single mutants of srt1 and srt2 , they found evidence of a compensatory mechanism wherein the remaining gene was upregulated, and neither mutant showed clear ethylene-related phenotypes. (plantcell.org)
  • This conclusion was supported by the finding that the same genes were downregulated in an SRT2 overexpression line, even without ethylene treatment. (plantcell.org)
  • molecular
  • Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. (wikiversity.org)
  • Although the regulation of gene transcription is the most common form of gene control and understanding it is important for molecular biology and is of great interest in medicine, the correlation between TFs is so complex that the regulatory network is often unknown or not fully understood. (timeshighereducation.com)
  • signals
  • In contrast to conventional methods of controlling gene activity, the use of light allows cells to be controlled using complex, dynamic signals. (phys.org)
  • The engineered cell lines have a variety of baseline luciferase signals giving a true reflection of the different transcription levels of the genes of interest. (horizondiscovery.com)
  • Scientists
  • Scientists at Johns Hopkins say they are one step closer to understanding the genetic mechanism of a rare, complex, multiple-gene disorder called Hirschsprung's disease. (medicalxpress.com)
  • By understanding the functions of these regions, scientists expect to understand more about gene regulation ?how genes get turned on and off, the ignition system of our DNA, if you will. (bio-medicine.org)
  • researchers
  • Researchers led by Mustafa Khammash have developed a new method that uses blue light to control the transcription of DNA into RNA in single cells. (phys.org)
  • Genetics play a strong part in the development of attention-deficit/hyperactivity disorder (ADHD), but the path from a gene to risk for the disorder has remained a black box to researchers. (medicalxpress.com)
  • Phys.org)-An international team of researchers has found that gene transcription in an organism that has died continues for several days. (phys.org)
  • The researchers acknowledge that they did not find a reason for the continuation of gene transcription after death, but suggest it is likely due to the sudden stress placed upon the organism as a whole as they experienced the dying process. (phys.org)
  • The modification to the gene prediction software TWINSCAN is called N-...The addition of N-SCAN to TWINSCAN now provides genomics researchers t. (bio-medicine.org)
  • cell
  • A) P21 transcription was measured using Nano-Glo® luciferase and the assays were multiplexed with CellTiter-Blue® to give a measure of cell viability. (horizondiscovery.com)
  • By being able to switch genes on and off, TF ensure the right genes are expressed in the right cell at the right time and in the right amount in order to execute various functions. (timeshighereducation.com)
  • Results of preclinical studies by MUSC investigators reported in the July 2016 issue of PLOS One, demonstrate for the first time that the transcription factor KLF12 promotes CRC cell growth, in part, by activating EGR1. (medicalxpress.com)
  • These studies indicate that epinephrine and somatostatin lower HIT cell insulin mRNA levels in part by inhibiting insulin gene transcription. (diabetesjournals.org)
  • Dynamic microRNA gene transcription and processing during T cell development. (nih.gov)
  • Tetrahvmena histone acetyltransferase: A homology to yeast GCN5p linking histone acetylation to gene activation, Cell, 1996, 84: 845. (springer.com)
  • Therefore, the non-protein components of S. platensis are considered to stimulate BDNF gene transcription through the HO-1 induction in glial cells, thus proposing a potential ability of the algae to indirectly modulate the brain function through the glial cell activity. (nih.gov)
  • In addition, tumour size was associated with cell proliferation but not with the transcription of apoptotic genes. (biomedcentral.com)
  • significant differences
  • Statistical analysis using a priori groupings indicated significant differences among groups for several genes, while multidimensional scaling and cluster analyses of transcription C T values indicated strong differentiation of a large cluster and multiple outlying individual tortoises or small clusters in multidimensional space. (usgs.gov)
  • human
  • Dimeric structure of the MADS (red) and MEF2 (green) domains of the human MEF2B transcription factor complexed with DNA (orange) based on the PDB:1N6J crystallographic coordinates. (wikiversity.org)
  • This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. (wikiversity.org)
  • N-SCAN has proven to be the best program available at finding both the transcription start site (TSS) and the complete first exon in both the human and fruit fly genomes. (bio-medicine.org)
  • However, for nearly 40 percent of known human genes, transcription starts long before the beginning of the protein- coding region. (bio-medicine.org)
  • Running the modified TWINSCAN, on both the human and fruit fly genomes, Brent and colleagues predicted about 25,000 transcription-start sites, compared with a known 6,000. (bio-medicine.org)
  • To correlate the Ct values to copy number, a standard curve was generated using serial dilutions of a plasmid containing nucleotide (nt) −2606/+1308 from the human IL-12(p35) gene. (rupress.org)
  • functional
  • In this study, we analyzed the mechanism of agonist-induced degradation of the Ah receptor and its functional impact on AhR-mediated gene transcription to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). (cdc.gov)
  • Rev-erbα, a core repressive TF of the clock, opposes functional loop formation between Rev-erbα-regulated enhancers and circadian target gene promoters by recruitment of the NCoR-HDAC3 corepressor complex, histone deacetylation, and eviction of the elongation factor BRD4 and the looping factor MED1. (sciencemag.org)