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  • genetic
  • Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history. (skadi.net)
  • The gene contains the genetic sequence for the SHOX protein. (brighthub.com)
  • Leri-Weill dyschondrosteosis is a genetic disorder caused by an improperly functioning SHOX gene. (brighthub.com)
  • Taking mating patterns and effective population sizes of ape species into account, we conclude that genetic hitchhiking associated with positive selection due to sperm competition might explain the rapid decline in the Y chromosome gene number in chimpanzee. (springer.com)
  • Somatic recombination refers to the process involving the formation of immunoglobin genes through recombination of the germline genetic elements, or segmen. (reference.com)
  • Modern Biotechnology are interesting fields which are concerned expression of genes, taking advantage of natural genetic variation, modifying genes and transferring genes to new hosts, Environmental Biotechnology, Cell biology, Genetic Engineering and Molecular Biology, Tissue Engineering, Biosensor, Cancer Biology, Bioinformatics and Computational biology. (omicsonline.org)
  • A mutated "caretaker" gene, which usually stabilizes cellular DNA, plays a key role in the genetic instability that is the hallmark of many forms of cancer, researchers reported. (medpagetoday.com)
  • tumor suppr
  • It's not like most tumor suppressor genes, which when mutated lead to either enhanced cell proliferation or decreased cell death," he said. (medpagetoday.com)
  • metaphase
  • Metaphase chromosomes isolated from a cell line carrying the thymidine kinase (TK) gene of herpes simplex virus type I were used to transform the TK-deficient cell line LMTK- to the TK+ phenotype. (pnas.org)
  • amplification
  • The KIAA1096 gene is located at 1q23-24 with no overexpression or amplification in normal urothelium, but was significantly upregulated in 30% of tumors (P = 0.0001). (ebscohost.com)
  • The specimens were digested with proteinase-K and a part of them were digested with HpaII.The HpaII digested product and remaining undigested DNA were used as templates for PCR amplification for androgen receptor gene exonl including polymorphic trinucleotide repeat. (nii.ac.jp)
  • gorilla
  • To uncover the evolutionary forces governing ape Y chromosome degeneration, we determined the complete sequences of the coding exons and splice sites for 16 gorilla Y chromosome genes of the X-degenerate region. (springer.com)
  • We discovered that all studied reading frames and splice sites were intact, and thus, this genomic region experienced no gene loss in the gorilla lineage. (springer.com)
  • Surprisingly, our results indicate that the human and gorilla orthologues of the genes disrupted in chimpanzee evolve under relaxed functional constraints and might not be essential. (springer.com)
  • somatic
  • Haploid ( n ) number is the number of chromosomes in germ cells (23 in humans), diploid (2 n ) number is the number of chromosomes in somatic cells (46 in humans). (tripod.com)
  • Using a technique called human somatic cell gene targeting, they corrected the defective STAG2 gene in two aneuploid glioblastoma cell lines. (medpagetoday.com)
  • cell
  • The DNA packages of cell in every chromosomes are described. (ebscohost.com)
  • What Happens When the Cell Copies Its Chromosomes? (reference.com)
  • The chromosome replicates from the origin of replication during the S-phase of the cell cycle. (omicsonline.org)
  • Mitsuo Oshimura, Toward Gene and Cell Therapies Employing Human Artificial Chromosomes in Conjunction with Stem Cells" OMICS Group is among best open access publishers with expert reviewers and renowned scientists in its editorial board. (omicsonline.org)
  • Mitsuo Oshimura, Toward Gene and Cell Therapies Employing Human Artificial Chromosomes in Conjunction with Stem Cells" OMICS Group is one of the top open access publishers with 700+ peer-reviewed journals along with eminent scientists in its Editorial Board and expert reviewers to carry rigorous peer-review process. (omicsonline.org)
  • Similarly, knocking out STAG2 in cell lines where it is normally expressed led to cell division defects and the proliferation of cells with extra chromosomes, they reported. (medpagetoday.com)
  • disorder
  • A more severe disorder associated with the SHOX gene is Langer mesomelic dysplasia, which is characterized by even shorter bones in the arms and legs, as well as an underdeveloped jaw. (brighthub.com)
  • A similar disorder occurs when the SRY gene mistakenly translocates to the X chromosome. (brighthub.com)
  • ancestral
  • Compared with the X chromosome, the mammalian Y chromosome is considerably diminished in size and has lost most of its ancestral genes during evolution. (springer.com)
  • In more ancestral branches within the bear phylogeny, Y-linked genes evolved faster than autosome and X-linked genes, consistent with expectations based on male-driven evolution. (tcd.ie)
  • encodes
  • In our preliminary studies, we have observed that approximately two-thirds of patients with WAGR syndrome have deletion of the gene which encodes brain-derived neurotrophic factor (BDNF), and that BDNF haploinsufficiency is associated with obesity and with parent reports of hyperphagia and impaired nociception, suggesting that BDNF may play an important role in human energy balance as well as pain sensation. (clinicaltrials.gov)
  • study
  • Smoking can accelerate the loss of the Y chromosome in blood cells, a study claims. (bionews.org.uk)
  • Men may not be on the brink of extinction after all, according to a study on the evolution of the human Y chromosome. (bionews.org.uk)
  • The aim of the present paper is to study the potential involvement of thep15 gene in the evolution of TCCs. (ebscohost.com)
  • This study will examine how the genes on chromosome 11 affect people and whether the absence of specific genes is associated with specific symptoms. (clinicaltrials.gov)
  • The aim of this study is to evaluate the clonality in ameloblastomas by PCR assay of human androgen receptor gene polymorphism. (nii.ac.jp)
  • variation
  • In the process of bear evolution, we investigate the premise that such behavioral traits may be reflected in patterns of variation among genes with different modes of inheritance: matrilineal mitochondrial DNA (mtDNA), patrilineal Y chromosome, biparentally inherited autosomes, and the X chromosome. (tcd.ie)
  • humans
  • Sex chromosomes X and Y are the 23rd pair in humans. (tripod.com)
  • The syndrome is caused by heterozygous contiguous gene deletions of variable size on chromosome 11, involving a region that encompasses more than 100 genes, many of which have unknown function in humans. (clinicaltrials.gov)
  • Gnbll+/ - lacZ gene-trap mice demonstrate deficits in pre pulse inhibition of the startle response, a characteristic of psychosis in humans. (bl.uk)
  • Clinical
  • This gene may, therefore, be a putative marker for this cytogenetic phenomenon and provide an opportunity to evaluate the clinical significance of previous cytogenetic findings. (ebscohost.com)
  • Translation
  • Genes are expressed when their gene products are made, to do this transcription and translation must occur to synthesize the protein which is coded for by the DNA. (varsitytutors.com)
  • fewer
  • Stable TK+ derivatives of each line, isolated after prolonged cultivation, retained fewer copies of the TK gene than did their unstable parents. (pnas.org)