Gene sodium dependent amino acid transporter amino acids neutral. Medical search. Frequent questions

ATB 0+ (SLC6A14) is a transporter for numerous dipolar and cationic amino acids and thus has a much broader substrate specificity than the glycine transporters alongside which it is grouped on the basis of structural similarity [ 10 ]. (guidetopharmacology.org)
Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y + ), apparently as an exchange mechanism. (guidetopharmacology.org)

Subsequent to our kinetic identification of the transport process, significant advances have been achieved in the genetic and protein identification and characterization of the X AG - transporter class as EAATs (excitatory amino acid transporters). (biomedcentral.com)

This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. (nih.gov)
Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. (life-science-alliance.org)

We identified differentially expressed genes in the Olig2- and GFAP-astrocytes. (biomedcentral.com)

Moreover, we identified metabolic compensation mediated by the glutamate/aspartate transporters SLC1A2 and SLC1A3 under glutamine-limiting conditions. (life-science-alliance.org)
In this review, I describe the molecular mechanism underlying the extreme stability of unboiled NAD-dependent glutamate dehydrogenase from the hyperthermophile Pyrobaculum islandicum . (go.jp)
In other cells (predominantly excitable tissue cells), EAAC1 has been reported to function as a glutamate transporter rather than as an aspartate transporter. (biomedcentral.com)
The identification of EAAC1 as the high-affinity L-aspartate transporter now permits studies to elucidate the mechanism of hormonal regulation of EAAC1 gene expression, and to investigate the mechanism by which the cellular environment effects the functioning of EAAC1 as an aspartate transporter or as a glutamate transporter. (biomedcentral.com)
The kinetic properties are representative of the Na+- dependent high-affinity glutamate-aspartate transporters referred to as the X AG - class of amino acid transporters. (biomedcentral.com)

SLC6A19 is a system B(0) transporter that mediates epithelial resorption of neutral amino acids across the apical membrane in the kidney and intestine. (wikipedia.org)
[ 10 , 11 ] In an animal model of Hartnup disorder, mice lacking SLC6A19 (B 0 AT1) transporter general neutral aminoaciduria were observed, as well as the decreased body weight, demonstrating the essential role of epithelial amino acid uptake in optimal growth and bodyweight regulation. (medscape.com)
In earlier kinetic studies we identified the existence of a unique Na+-dependent high-affinity L-aspartate transport process in rat prostate secretory epithelial cells. (biomedcentral.com)

Sodium-dependent neutral amino acid transporter B(0)AT1 is a protein that in humans is encoded by the SLC6A19 gene. (wikipedia.org)
The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. (aspetjournals.org)
The hOAT3 protein was shown to be localized in the basolateral membrane of renal proximal tubules and the hOAT3 gene was determined to be located on the human chromosome 11q12-q13.3 by fluorescent in situ hybridization analysis. (aspetjournals.org)
Glycine is an amino acid, or a building block for protein. (supplemented.co.uk)
This amino acid is found in high-protein foods including meat, fish, eggs, dairy and legumes. (supplemented.co.uk)
Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)
The active full-length CRYAA protein corresponding to amino acids 1-173 of CRYAA was recombined. (molvis.org)
In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)

Mutations in the SLC6A19 gene cause Hartnup disease. (wikipedia.org)
Mutations in the SLC6A19 gene, which encodes the SLC6A19 (B 0 AT1) neutral amino acid transporter, causes a failure of the transport of neutral (ie, monoaminomonocarboxylic) amino acids in the small intestine and the renal tubules. (medscape.com)
This explanation is also supported by experimental assays showing nearly neutral mutations in temperate conditions become strongly deleterious at high temperature [ 5 ]. (nature.com)

In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. (nih.gov)

Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. (nih.gov)
The env gene maintained an ORF coding for a 538-amino acid polypeptide that has all the characteristic features of env proteins and mediates intercellular fusion in vitro [ 11 - 13 ]. (ecancer.org)
OAT1 is a PAH/dicarboxylate exchanger and mediates the high-affinity transport of PAH in a sodium-independent manner. (aspetjournals.org)

Among the transporters identified, we characterized the cationic amino acid transporter SLC7A3 as a gene that, when up-regulated, overcame low availability of arginine and lysine by increasing their uptake, whereas SLC7A5 was able to sustain cellular fitness upon deprivation of several neutral amino acids. (life-science-alliance.org)

Alanine and derivatives are compounds containing alanine or a derivative thereof resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. (cannabisdatabase.ca)

This study shows that EAAC1 functions as the high-affinity L-aspartate transporter that is responsible for the uptake and accumulation of aspartate in prostate cells. (biomedcentral.com)

The maintenance of the intracellular level of amino acids is crucial for cellular homeostasis. (spandidos-publications.com)
Therefore, the shortage of the intracellular amino acid pool appears to determine the sensitivity to GEF. (spandidos-publications.com)
Intracellular levels of amino acids are maintained by the balance between their influx, utilization and recycling ( 1 ). (spandidos-publications.com)
In contrast to the influx of amino acids, the degradation of proteins is also the important intracellular mechanism for releasing free amino acids both under steady-state conditions and during cellular stresses. (spandidos-publications.com)
A download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa to of residues are experienced regulated for the high 3-phosphate by which SP1 assemblies present to connected formation phagosome by UCP1 in transmembrane C1q-mediated fusion momenta, and preferentially by the intracellular genes as Once. (evakoch.com)

In the past decades, great efforts were made to understand the metabolic strategies deep-sea hyperthermophiles use to conserve energy and cope with physicochemical stresses, and to appreciate the molecular mechanisms leading to the stabilization of nucleic acids and proteins at exceedingly high temperatures [ 2 , 3 ]. (nature.com)

Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)

Given its particular distribution in normal human tissues and its potential roll as an immune modulator and in amino acid transport, tissue tolerance and protection against retroviral infection, syncytin could be a potential target for immune therapy using specific inhibitors. (ecancer.org)
One of the potential effects of TEs is the generation of new gene sequences [ 3 , 6 , 7 ] such as the envelope (env) genes of retroviral origin found in several mammals. (ecancer.org)

One-by-one depletion of 13 amino acids required for cell proliferation enabled gain-of-function genetic screens using a SLC-focused CRISPR/Cas9-based transcriptional activation approach to uncover transporters relieving cells from growth-limiting metabolic bottlenecks. (life-science-alliance.org)

Among them, mRNA for SLC7A10, a neutral amino acid transporter, was preferentially expressed in the Olig2-astrocytes. (biomedcentral.com)

Hartnup disease is an autosomal recessive disorder caused by impaired neutral (ie, monoaminomonocarboxylic) amino acid transport in the apical brush border membrane of the small intestine and the proximal tubule of the kidney. (medscape.com)

Multiple transcript variants encoding different isoforms have been found for this gene. (nih.gov)

Functions as a sodium-dependent neutral amino acid transporter. (nih.gov)
L-Arginine is an amino acid that has numerous functions in the body. (cannabisdatabase.ca)
The Olig2 gene thus seems to play a role in generating astrocytic heterogeneity, and the regional heterogeneity of Olig2-astrocyte distribution implies that each subpopulation has specific and different functions. (biomedcentral.com)

In 2004, a causative gene, SLC6A19 (MIM#608893, Genbank accession NM 001003841) , was located on band 5p15.33. (medscape.com)
SLC6A19 is a sodium-dependent and chloride-independent neutral amino acid transporter, expressed predominately in the kidneys and intestine. (medscape.com)
Cloning and expression of the mouse SLC6A19 gene demonstrated that this transporter has all the properties of the amino acid transport system B 0 AT1. (medscape.com)
The human SLC6A19 gene was cloned independently by 2 groups of researchers in 2004. (medscape.com)
A novel mutation, c.850G→A, in exon 6 of the SLC6A19 gene was described in a Chinese family with typical clinical characteristics of Hartnup disorder. (medscape.com)
[ 15 ] Also, a mutation in the SLC6A19 gene was described in a 6-year-old patient with late-onset seizures in whom pellagralike skin lesions developed after the diagnosis of Hartnup disease at age 9 years, confirming the allelic, as well as phenotypic, heterogeneity of the disease. (medscape.com)

Two gene products, GlyT1 and GlyT2, are known that give rise to transporters that are predominantly located on glia and neurones, respectively. (guidetopharmacology.org)

It has been suggested that TEs are a source of variation as a result of the insertion of fragments of their sequence into functioning genes elsewhere in the genome. (ecancer.org)
These are the ' zinc-binding cellular acid ' sugar and the ' genome resulting ' history. (evakoch.com)

This is achieved by the existence of a Na+-dependent high-affinity L-aspartate transport process with kinetic properties that result in cellular accumulation of aspartate from circulation [ 5 - 7 ]. (biomedcentral.com)
An important unresolved issue was the identification of the putative prostate high-affinity L-aspartate transporter. (biomedcentral.com)

Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)

In contrast, in citrate-producing prostate cells, aspartate is an essential amino acid that must be derived from circulation. (biomedcentral.com)
The reason we focused on the LGP is that Olig2- and GFAP-astrocytes intermingled and occupied mutually exclusive territories in this nucleus, with possible contrast in function and gene expression. (biomedcentral.com)

Belongs to the class of organic compounds known as l-alpha-amino acids. (cannabisdatabase.ca)
A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. (aspetjournals.org)
first, organic anions are transported from the peritubular plasma by basolateral organic anion transporter(s) and subsequently effluxed into the tubular lumen by luminal transporter(s). (aspetjournals.org)

The present report is concerned with the identification of this putative L-aspartate transporter in rat and human prostate cells. (biomedcentral.com)

The size of the central cavity of CadB and PotE is dependent on the angle of transmembrane helix 6 (TM6) against the periplasm. (tcdb.org)

SLC7A10 (also known as ASC-1) was one of the representative neutral amino acid transporter genes in the cluster. (biomedcentral.com)

Normal alanine metabolism, like that of other amino acids, is highly dependent upon enzymes that contain vitamin B6. (cannabisdatabase.ca)

Unbiased classification of gene expression profiles and subsequent gene ontology analyses revealed that the majority of Olig2-astrocytes belonged to an astrocytic cluster that is enriched for transporter-related genes. (biomedcentral.com)

The deduced amino acid sequence of hOAT3 showed 36 to 51% identity to those of other members of the OAT family. (aspetjournals.org)

80%) and biological pathways (such as adipocytokine, Notch, Hedgehog and NOD-like receptor signaling) were not identified by previous gene array studies. (mdpi.com)
Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)

Overall, this gain-of-function approach using human cells uncovered functional transporter-nutrient relationships and revealed that transport activity up-regulation may be sufficient to overcome environmental metabolic restrictions. (life-science-alliance.org)
Understanding the regulation of acid-base balance requires appreciation of the fundamental definitions and principles underlying this complex physiologic process. (medscape.com)

Sodium-iodide symporters (NIS) actively transport iodide ions from the bloodstream into thyroid follicular cells against a sodium electrochemical gradient, which is maintained by the sodium-potassium pump (Na+/K+-ATPase). (myendoconsult.com)

However, an analysis of the synonymous and non-synonymous substitutions indicated a relatively high degree of amino acid change in hominoids [ 15 ], which could be consistent with a low degree of selective pressure. (ecancer.org)

L-Alanine or Alanine, abbreviated Ala or A, is a non-essential amino acid made in the body from either the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. (cannabisdatabase.ca)
Arginine or l-arginine, abbreviated Arg or R, is an essential amino acid that is physiologically active in the L-form. (cannabisdatabase.ca)
In mammals, arginine is formally classified as a semi-essential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. (cannabisdatabase.ca)
The addition of essential amino acids, but not non-essential amino acids to the cell culture medium resulted in the cancellation of this pronounced cytotoxicity. (spandidos-publications.com)
Amino acids are essential for cellular homeostasis, growth and proliferation via their contribution to a diverse range of cellular processes. (spandidos-publications.com)
and, therefore is a non-essential amino acid. (biomedcentral.com)
In these specialized prostate cells, aspartate is an essential amino acid that is derived from circulation. (biomedcentral.com)

Gene symbols, accession ids and various other target identifiers. (nih.gov)

The best known of the human env-derived genes is syncytin-1, or ERVWE1, which originated from a human endogenous retrovirus (HERV) of the HERV-W family inserted on chromosome 7q21 in human-pre-hominoids 40-45 million years ago [ 11 , 10 ]. (ecancer.org)
The members of the L-type amino acid transporter (LAT) family are Na + -independent transporters that deliver neutral amino acids into cells ( 2 ). (spandidos-publications.com)
SLC7 family members may be divided into two major groups: cationic amino acid transporters (CATs) and glycoprotein-associated amino acid transporters (gpaATs). (guidetopharmacology.org)

Gene information is provided for human (Hs), mouse (Mm) and rat (Rn). (guidetopharmacology.org)

We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
The transport of serum amino acids into cells is an active process that is facilitated by plasma membrane-localized amino acid transporters. (spandidos-publications.com)
Various anionic drugs have been indicated to be taken up into the proximal tubular cells by the classic p -aminohippurate (PAH) transporter. (aspetjournals.org)

[ 14 ] The most common mutation in Hartnup disorder is c.517G→A, resulting in the amino acid substitution p.D173N, and it can be found in 43% of patients. (medscape.com)

They proposed that Lys158 is central to proton-coupled transport and that the amine group serves the same functional role as the Na2 ion in LeuT, thus demonstrating common principles among proton- and sodium-coupled transporters. (tcdb.org)

Plasma alanine is often decreased when the BCAA (branched-chain amino acids) are deficient. (cannabisdatabase.ca)

Arginine is a basic amino acid as its side chain contains a positively charged guanidinium group, which is highly polar, at the end of a hydrophobic¬†aliphatic¬†hydrocarbon chain. (cannabisdatabase.ca)
With a pKa of 12.48, the guanidinium group is positively charged in neutral, acidic, and even most basic environments. (cannabisdatabase.ca)

To complement the in silico data analyses, we differentially isolated Olig2- and GFAP-astrocytes from the same frozen section of the lateral globus pallidus using laser microdissection and compared their gene expression by quantitative reverse transcription PCR. (biomedcentral.com)

May have a role as transporter for neurotransmitter precursors into neurons. (nih.gov)
Here we described the role of Si and its transporters in mitigating abiotic stress condition in horticultural plants. (researchsquare.com)

It is highly concentrated in muscle and is one of the most important amino acids released by muscle, functioning as a major energy source. (cannabisdatabase.ca)

Thus, buffers work as a first-line of defense to blunt the changes in pH that would otherwise result from the constant daily addition of acids and bases to body fluids. (medscape.com)

Anatomy16

Organisms14

Diseases5

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes57

Disciplines and Occupations1

Information Science4

Health Care1

Cationic amino acids2

Identification and characterization1

Solute2

Differentially expressed genes1

Glutamate5

Epithelial3

Protein10

Mutations3

Neurotransmitter transporter1

Mediates3

SLC7A31

Glycine1

Uptake1

Intracellular5

Proteins1

PMID1

Retroviral2

Cell proliferation1

Preferentially1

Apical1

Isoforms1

Functions3

SLC6A196

Predominantly1

Genome2

Affinity2

Transcriptional1

Contrast2

Organic3

Putative1

Transmembrane1

Representative1

Enzymes1

Subsequent1

Sequence1

Receptor2

Regulation2

Thyroid1

High1

Essential7

Accession1

Family3

Human1

Cells3

Hartnup1

Common1

Plasma1

Basic2

Expression1

Role2

Major1

Addition1