• Complement factor B is a protein that in humans is encoded by the CFB gene. (wikipedia.org)
  • Molecular cloning and characterization of the gene coding for human complement protein factor B". Proceedings of the National Academy of Sciences of the United States of America. (wikipedia.org)
  • CCAAT/enhancer-binding protein β (C/EBPβ), is a member of a family of transcription factors consisting of six structurally related basic leucine-zipper DNA-binding proteins. (biomedcentral.com)
  • Independent transcriptomic and proteomic datasets of ccRCC tumors were used for the analysis of gene and protein expression as well as the level of the immune infiltration. (bvsalud.org)
  • When administered systemically, however, their role in liver tropism is limited because CARpermissive and mutated viruses show similar biodistribution, a finding recently attributed to blood coagulation factor (F) IX or complement protein C4BP binding to the adenovirus fiber and "bridging" to either low-density lipoprotein receptorrelated protein or heparan sulfate proteoglycans. (gla.ac.uk)
  • Here, we show that hepatocyte transduction in vitro can be enhanced by the vitamin K-dependent factors FX, protein C, and FVII in addition to FIX but not by prothrombin (FII), FXI, and FXII. (gla.ac.uk)
  • What does this gene/protein do? (cancerindex.org)
  • Following this, the differentially expressed genes (DEGs) were included in Gene Ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, protein‑protein interaction network and survival analyses. (cancerindex.org)
  • HSPA1B, which encodes for heat-shock protein 70 kDa (Hsp70), was the most differentially expressed gene. (refine.bio)
  • Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. (nih.gov)
  • Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24. (nih.gov)
  • Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23. (nih.gov)
  • The CFHR5 gene provides instructions for making a protein called complement factor H-related 5. (medlineplus.gov)
  • However, its structure is similar to that of a protein called complement factor H (which is produced from the CFH gene). (medlineplus.gov)
  • Complemented ACVR2 protein complexed with ACVR1 with activin treatment, generating nuclear phosphoSMAD2 and activin-specific gene transcription. (nih.gov)
  • Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. (ouhsc.edu)
  • Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). (diabetesjournals.org)
  • The DEPs were mainly enriched in gene ontology (GO) items associated with immunity, complement activation, and protein activation cascade regulation corresponding to 24 pathways, of which complement and coagulation cascades as well as platelet activation pathways were the most significant. (izon.com)
  • Disease-associated mutations have been explained for the genes encoding the match regulators match element H (CFH), membrane cofactor protein, element I, and element B [1C4]. (bioinbrief.com)
  • The protein product of this cross gene is similar towards the aHUS-associated CFH mutant S1191L/V1197A, which develops through gene transformation [8]. (bioinbrief.com)
  • as well as the genes encoding the five supplement factor HCrelated protein have a home in a centromeric 355-kb portion on Chromosome 1. (bioinbrief.com)
  • NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
  • Is there any relationship between polymorphism of Heat Shock Protein 70 genes and Pemphigus foliaceus? (cdc.gov)
  • One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)
  • By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)
  • Blom, A. M. , Rytkönen, A., Vasquez, P., Dahlbäck, B. and Johnsson, A-B. (2001) A novel interaction between type IV pili of Neisseria gonorrhoeae and complement regulatory protein - C4b-binding protein. (lu.se)
  • Blom A. M. , Kask L. and B. Dahlbäck (2001) Structural requirements for the complement regulatory activities of C4b-binding protein. (lu.se)
  • Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)
  • Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)
  • Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)
  • Sjöberg A., Trouw L., McGrath F., Hack E. C. and Blom A. M. (2006) Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein. (lu.se)
  • The affected patients' genetic backgrounds revealed significant genetic heterogeneity in several genes involved in complement regulation, including the complement factor H, complement factor H-related proteins, complement factor I, complement factor B, complement component 3, and CD46 genes in the alternative complement pathway. (ekjt.org)
  • Long-Range Chromatin Contacts in Embryonic Stem Cells Reveal a Role for Pluripotency Factors and Polycomb Proteins in Genome Organization. (ca.gov)
  • Additionally, we identified two further levels of genome organization in ESCs characterized by colocalization of regions with high pluripotency factor occupancy and strong enrichment for Polycomb proteins/H3K27me3, respectively. (ca.gov)
  • It is a main inductor of genes of antioxidant proteins and phase II detoxifying enzymes [ 1 ]. (hindawi.com)
  • The complement system is a group of proteins that work together to destroy foreign invaders (such as bacteria and viruses), trigger inflammation, and remove debris from cells and tissues. (medlineplus.gov)
  • The Txn Factor ChIP tracks show DNA regions where transcription factors, proteins responsible for modulating gene transcription, bind as assayed by chromatin immunoprecipitation with antibodies specific to the transcription factor followed by sequencing of the precipitated DNA (ChIP-seq). (ucsc.edu)
  • ACVR2 transmits the growth effects of activin via phosphorylation of SMAD proteins to affect gene transcription. (nih.gov)
  • This deletion is a result of nonallelic homologous recombination and prospects to the loss of two genes, and which encode element HCrelated proteins 1 and 3, respectively. (bioinbrief.com)
  • Series analysis of the region provides proof for multiple unbiased huge genomic duplications, referred to as low-copy repeats also, producing a high amount of series identification between and [9, 10]The secreted proteins products of the genes are related in framework, because they are composed of recurring units (60 proteins) named brief Limonin ic50 consensus repeats (SCRs) [11]. (bioinbrief.com)
  • Comprehensive lack of both CFHR3 and CFHR1 but existence of aspect H, factor HClike proteins 1, CFHR2, and CFHR4A was discovered in 19 aHUS sufferers (16%) in comparison to two out of 100 control individuals (2 = 10.4, = 0.0012, odds proportion = 8.5). (bioinbrief.com)
  • How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? (nih.gov)
  • We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)
  • Attack by phagocytic cells can be facilitated when antigens are coated with antibody (Ab), which is produced as part of acquired immunity, or when complement proteins opsonize antigens. (msdmanuals.com)
  • This gene localizes to the major histocompatibility complex (MHC class III) region on chromosome 6. (wikipedia.org)
  • Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. (sdbonline.org)
  • Recent studies have revealed that variants of histone H2A and histone H3 play important roles not only in gene expression but also in the repair of DNA breaks and the assembly of chromosome centromeres. (sdbonline.org)
  • This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. (cancerindex.org)
  • The identified DEGs included 20 downregulated genes and 51 upregulated genes, which were highly associated with the cell cycle, organelle fission, chromosome segregation, cell division and spindle stability. (cancerindex.org)
  • We statement a novel susceptibility element for aHUS in the form Rog of a chromosomal deletion of a large (84 kb) genomic fragment in the regulators of match activation gene cluster at Chromosome 1q32. (bioinbrief.com)
  • Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)
  • This gene encodes complement factor B, a component of the alternative pathway of complement activation. (wikipedia.org)
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. (cancerindex.org)
  • The imprinted gene PLA2G7 , which encodes lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ), was one of the top hypomethylated genes with an increased expression upon inflammation. (biomedcentral.com)
  • In particular, miR-23B, miR-93, miR-144, and miR-212 were found to play a role as NRF2 inhibitors, while miR-340 appears to have a role as an NRF1 and MAPK inhibitor with miR-383 and miR-510 having a less clear role in the regulation of NRF1 and NRF2 levels [ 7 ]. (hindawi.com)
  • The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. (cansar.ai)
  • Using genome-wide microarray screening we established a specific fingerprint of freshly isolated arterial (HUAEC) and venous EC (HUVEC) from human umbilical cord comprising 64 arterial and 12 venous genes, representing distinct functions and pathways. (refine.bio)
  • We are now focused on delineating the transcription factors and signaling pathways that are responsible for generating photoreceptors from retinal progenitor cells. (nih.gov)
  • Two of these genes, arginase 1 and eotaxin 1 are the focus of continuing investigations in mouse models of asthma regarding differences in mechanistic pathways depending on the allergen. (cdc.gov)
  • Array studies provide candidate genes to identify common mechanistic pathways in the effector phase, as well as mechanistic pathways unique to individual allergens. (cdc.gov)
  • We divide the field of genomics into genotyping (focused on the genome sequence), transcriptomics (focused on genomic expression) and epigenomics (focused on epigenetic regulation of genome expression). (bmj.com)
  • This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. (nih.gov)
  • My lab studies how the genomic sequences that control gene expression function and evolve. (berkeley.edu)
  • For each of the approximately 40 transcription factors critical in shaping anterior-posterior and dorsal-ventral patterns, our goals are to: 1) measure the factor s in vitro affinity to each of its potential target sequences, 2) identify the genomic regions bound by each factor in living embryos, 3) determine the expression pattern of the factor and its targets in three-dimensions at cellular resolution. (berkeley.edu)
  • Epigenetic alteration results in phenotypic change without affecting the genomic DNA sequence, which is a regulation layer sensitive to environmental change and may provide a link between environment and gene expression [ 4 ]. (biomedcentral.com)
  • Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation. (cdc.gov)
  • To identify key genes differentially expressed in the human retinal pigment epithelium (hRPE) following low-level West Nile virus (WNV) infection. (molvis.org)
  • We conducted a genome-wide analysis to identify differentially methylated genes in vulnerable and non-vulnerable atherosclerotic lesions to understand more about pathogenesis. (biomedcentral.com)
  • Moreover, 67% displayed hypomethylation in symptomatic plaques, and the differentially hypomethylated genes were found to be involved in various aspects of inflammation. (biomedcentral.com)
  • The expression of genes encoding cytokines was evaluated in 100 matched-paired control-RCC tumor samples. (bvsalud.org)
  • We highlighted that while IL32β-stimulated macrophages secreted several protumoral factors, they supported tumor survival through a soluble dialog, mostly driven by BAFF. (haematologica.org)
  • Kim H, Lee E, Lim T, Jung J and Lyu Y: Inhibitory effect of Asparagus cochinchinensis on tumor necrosis factor-alpha secretion from astrocytes. (spandidos-publications.com)
  • Transient transfection experiments were made to analyze transcriptional regulation of C3 by C/EBPβ . (biomedcentral.com)
  • The major events in the regulation of the host response on a transcriptional level occur within the first 3 days after infection. (biomedcentral.com)
  • Using the bioinformatics tool MAGICTRICKS and reversible pharmacological inhibition, we found that primed genes required the transcriptional activities of NF-κB. (frontiersin.org)
  • Blood induced widespread microglial transcriptional changes, including changes involving oxidative stress and neurodegenerative genes. (nature.com)
  • 2 3 The HGP demonstrated that a relatively limited number of genes could be identified in the human genome, which substantiated the theory that complex biological processes were regulated on other levels than DNA sequence alone. (bmj.com)
  • 11 , 12 Thirty-one susceptibility loci for SLE have been identified by genome-wide association studies and other gene mapping studies. (bmj.com)
  • The analyzed gene datasets were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) database. (cancerindex.org)
  • We are a hybrid computational and experimental lab who couple genome-scale computational and experimental analysis of gene regulation in Drosophila melanogaster and Saccharomyces cerevisiae with extensive analysis of comparative sequence data and experimental analysis of species closely related to these model systems. (berkeley.edu)
  • We focus on short evolutionary timescales where it is possible to couple specific changes in genome sequences with alterations in gene regulation and expression. (berkeley.edu)
  • The detailed experimental data we are generating for D. melanogaster , and the genome sequences of 12 Drosophila species are a tremendous resource for studying the evolution of gene regulation. (berkeley.edu)
  • 100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions of ~81% of human genes, as calculated following gene enrichment analysis. (mdpi.com)
  • Additionally, we find that the ESC genome is organized in such a way as to juxtapose regions of DNA that show similar regulation by demonstrating that spatially associated regions in the genome are associated with the same gene regulatory factors. (ca.gov)
  • This finding adds a new dimension to our understanding of how ESC-specific gene regulation is maintained and how the genome is organized. (ca.gov)
  • The relationship between 3D organization of the genome and gene-regulatory networks is poorly understood. (ca.gov)
  • Together, our data highlight a pluripotency-specific genome organization in which pluripotency factors such as Nanog and H3K27me3 occupy distinct nuclear spaces and reveal a role for cell-type-specific gene-regulatory networks in genome organization. (ca.gov)
  • studies on cell cycle regulation and genome instability. (ncl.ac.uk)
  • How do numerous non-coding variations in the human genome affect gene expression in the retina? (nih.gov)
  • We now have extensive comparative sequence data for fruitflies (12 Drosophila genomes) and yeasts (many fungal genomes), and are using these data to characterize how the individual building blocks of regulatory sequences (transcription factor binding sites) and higher order structures (e.g. developmental enhancers) evolve. (berkeley.edu)
  • My lab is applying the high-resolution fluorescent imaging methods developed for D. melanogaster to systematically analyze gene expression, and dissect regulatory networks, in other Drosophila species and in several inbred lines of D. melanogaster . (berkeley.edu)
  • In the current report, a systematic approach is implemented to catalogue regulatory elements within HERVs, as a roadmap to potential functions of HERV sequences in gene networks. (mdpi.com)
  • Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). (medlineplus.gov)
  • These tracks complement each other and together can shed much light on regulatory DNA. (ucsc.edu)
  • Genomewide association studies (GWAS) are increasingly used to detect novel genes and genetic elements associated with bacterial phenotypes, which may provide insight for future preventive strategies and control measures ( 9 - 12 ). (cdc.gov)
  • Our results suggest that primary cells relevant to disease phenotypes complement traditional approaches for prioritization and validation of GWAS hits for follow-up studies. (nih.gov)
  • This study aimed to demonstrate the phenotypic and genotypic factors associated with photodynamic therapy (PDT) for age-related macular degeneration (AMD). (dovepress.com)
  • Many recent studies on atypical hemolytic uremic syndrome have described genetic abnormalities related to excessive activation of the alternative complement pathway. (ekjt.org)
  • Atypical hemolytic uremic syndrome (aHUS) is normally connected with faulty complement regulation. (bioinbrief.com)
  • Altogether, these results indicate that C3 is a downstream target of C/EBPβ, and it could be a mediator of the pro-inflammatory effects of this transcription factor in neural cells. (biomedcentral.com)
  • Each transcription factor had a different impact on gene regulation, with some stimulating only few and others boosting a large proportion of arterial genes. (refine.bio)
  • Unraveling a novel transcription factor code determining the human arterial-specific endothelial cell signature. (refine.bio)
  • We are particularly interested in understanding how selection to maintain transcription factor binding sites affects the evolution of target sequences, and how the extensive plasticity seen in the organization of developmental enhancers is related to their function. (berkeley.edu)
  • The transcription factor ChIP assay has a high resolution at the DNA level and, due to the very specific nature of the transcription factors, is often informative with respect to functional detail. (ucsc.edu)
  • However, since each transcription factor must be assayed separately, the information is only available for a limited number of transcription factors on a limited number of cell lines. (ucsc.edu)
  • We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)
  • approximately 10(-3)) were tested for cis-association of gene expression in HObs and in lymphoblastoid cell lines (LCLs) using publicly available data and showed that HObs have a significantly greater enrichment (threefold) of converging cis-eQTLs as compared to LCLs. (nih.gov)
  • Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma. (cancerindex.org)
  • Therefore, this variant may be used as a prognostic factor to estimate the PDT response with significant predictive power. (dovepress.com)
  • The prognostic significance of the major redox regulator nuclear factor erythroid-2-related factor (NRF2) is recognized in many cancers, but the role of NRF1 is not generally well understood in cancer. (hindawi.com)
  • Deletion of the blood coagulation factor fibrinogen largely reversed blood-induced microglia neurodegenerative signatures. (nature.com)
  • Various genetic, epigenetic, immunoregulatory, environmental and infectious factors contribute to the susceptibility, onset, progression and prognosis of the clinical disease in a given patient. (bmj.com)
  • 2015 ) Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1. (neurotree.org)
  • We recommend diagnostic screening of aHUS individuals for these susceptibility factors. (bioinbrief.com)
  • Role of FOXP3 gene polymorphism in the susceptibility to Tunisian endemic Pemphigus Foliaceus. (cdc.gov)
  • The molecular genetics and polymorphism of C2 and factor B". British Medical Bulletin. (wikipedia.org)
  • We have identified the molecular defect in factor V Leiden and we have delineated specific amino acid regions on the factor V/Va molecule that are crucial for their functions. (csuohio.edu)
  • Previous studies have been limited to exploring virulence factors and molecular characterization of invasive S. pneumoniae isolates ( 7 , 8 ). (cdc.gov)
  • To identify novel molecular regulations, we performed a transcriptomic analysis based on the comparison of circulating MCL cells (n=77) versus MCL lymph nodes (n=107) together with RNA sequencing of malignant (n=8) versus normal B-cell (n=6) samples. (haematologica.org)
  • We are driven by a desire to understand the molecular basis of organismal diversity, and the belief that many differences in physiology, morphology and behavior arise from changes in gene regulation. (berkeley.edu)
  • Both host factors (genetics) and low molecular weight allergens. (cdc.gov)
  • Examples of high molecular environmental factors are known to influence the development weight occupational allergens include proteases used in the and expression of asthma, and a vast array of triggers of asthma detergent industry, laboratory animal allergens, and ovalbumin have been identified. (cdc.gov)
  • This synthetic genetic interaction is seen at the level of single genes and acts downstream of promoter nucleosome reorganization. (sdbonline.org)
  • CREB siRNA inhibited upregulation of both cytoprotective genes by MTX, while chromatin immunoprecipitation demonstrated CREB binding to the MnSOD promoter in MTX-treated EC. (bmj.com)
  • Analysis of the mouse C3 promoter showed that it is directly regulated by C/EBPβ through a C/EBPβ consensus site located at position −616/-599 of the gene. (biomedcentral.com)
  • 0.1) located at the promoter regions of 7048 genes. (biomedcentral.com)
  • These differences are achieved through the regulation of individual genes such that they are only on in particular cell types. (ca.gov)
  • Among the epigenetic modifications, DNA methylation has been demonstrated to alter the expression of several individual genes involved in plaque progression and vulnerability (e.g. (biomedcentral.com)
  • By acquisition of the complete part or a large part of a novel ospC gene, an otherwise adapted strain would assume a new serotypic identity, thereby being comparatively fitter in an area with a high prevalence of immunity to existing OspC types. (cdc.gov)
  • Acquisitions of OspC genes that are novel for the region confer to recipients unique identities to host immune systems and, presumably, selective advantage when immunity to existing types is widespread among hosts. (cdc.gov)
  • The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics. (ncl.ac.uk)
  • Both genetics and environmental factors influence the expression of asthma, and not all asthma is the result of a specific immune response to allergen. (cdc.gov)
  • Our results indicate a common and pivotal role for distinct vitamin K- dependent coagulation factors in mediating hepatocyte transduction by adenoviruses in vitro and in vivo. (gla.ac.uk)
  • As a consequence, both factors are transported to the nucleus to induce the expression of their target genes. (hindawi.com)
  • Innate immune cells integrate environmental signals to rapidly activate target genes and perform specialized cellular functions 5 . (nature.com)
  • Accumulating evidence suggests that a large percentage of the patients diagnosed with secondary TMA exhibit genetic abnormalities associated with complement dysregulation. (ekjt.org)
  • Similar to NRF2, it is responsive to oxidative stress and activates antioxidant responsive element- (ARE-) driven genes [ 4 ]. (hindawi.com)
  • Functional annotation clustering of the microarray data showed that gene clusters involved in immune and antiviral responses ranked highly, involving genes such as chemokine (C-C motif) ligand 2 ( CCL2 ), chemokine (C-C motif) ligand 5 ( CCL5 ), chemokine (C-X-C motif) ligand 10 ( CXCL10 ), and toll like receptor 3 ( TLR3 ). (molvis.org)
  • Spiller B. O., Blackbourne, D., Mark L, Proctor D. and * Blom A. M. , (2003) Functional activity of the complement regulator encoded by Kaposi's sarcoma associated herpesvirus. (lu.se)
  • The recognition of deficiency in aHUS individuals may lead to the design of fresh diagnostic methods, such as enhanced screening for these genes. (bioinbrief.com)
  • Several studies have shown that aHUS is definitely associated with mutations in genes Limonin ic50 coding for match regulators, which leads to defective regulation of match Limonin ic50 activation, particularly at cell surfaces. (bioinbrief.com)
  • Recently, we showed in a family with aHUS that nonallelic homologous recombination [6] results in the formation of a cross gene derived from exons 1C21 of and exons 5C6 of match element HCrelated 1 [7]. (bioinbrief.com)
  • Regulation of Suv39H1-H3K9 trimethylation could prevent further epigenetic modifications, and prevent diabetic retinopathy. (nature.com)
  • Micro- array data from the ovalbumin and TMA model of asthma were also compared to previous data using Aspergillus as allergen to identify putative asthma `signature genes', i.e. genes up-regulated with all 3 allergens. (cdc.gov)
  • We used RNA sequencing coupled with chromatin immunoprecipitation sequencing to analyze primed microglial inflammatory gene expression and modifications to histone H3 lysine 4 trimethylation (H3K4me3) at the promoters of primed genes. (frontiersin.org)
  • Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)
  • The reduced expression of most of these genes in htz1Delta cells was reversed by the deletion of SIR2 (sir2Delta) suggesting that H2A.Z antagonizes telomeric silencing. (sdbonline.org)
  • Studies of human umbilical vein endothelial cells (HUVEC) and arterial endothelial cells (HAEC) showed that therapeutically relevant concentrations of MTX phosphorylate AMPKα Thr172 , and induce cytoprotective genes including manganese superoxide dismutase (MnSOD) and haem oxygenase-1 (HO-1). (bmj.com)
  • 15 The key role of aberrant B cell autoreactivity in SLE was revealed in a landmark murine study using a knockout gene mutation to prevent lupus mice from developing B cells, which resulted in a lack of autoantibody formation and clinical manifestations (nephritis or vasculitis). (bmj.com)
  • Here, microarray analysis in peripheral blood cells in eight patients with AF and stroke and eight AF subjects without stroke identified a stroke related gene expression pattern. (refine.bio)
  • For instance, the regulation of specific genes allows skin cells to serve their specialized epidermal function. (ca.gov)
  • RNA extracted from mock-infected and WNV-infected cells was assessed for differential expression of genes using Affymetrix microarray. (molvis.org)
  • Low-level WNV infection of hRPE cells induced expression of genes that are typically associated with the host cell response to virus infection. (molvis.org)
  • Complement factor H helps to protect healthy cells by preventing the complement system from being turned on (activated) when it is not needed. (medlineplus.gov)
  • Both HCT116+chr2 and parental HCT116 cells (as well as HEC59 and ACVR2 and hMSH2 complemented HEC59+chr2 cells) were assessed for genetic complementation and biologic function. (nih.gov)
  • ACVR2 small interfering RNA reversed these effects in complemented cells. (nih.gov)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Analysis from the Gene Expression Omnibus datasets supported the mRNA findings. (hindawi.com)
  • RCC CM and the selected recombinant cytokines were used to analyze their influence on MSCs migration and microarray-targeted gene expression. (bvsalud.org)
  • Targeted analysis of 274 cytokines and global proteomics of RCC CM revealed decreased DPP4 and EGF, as well as increased AREG, FN1 and MMP1, with consistently altered gene expression in RCC cell lines and tumors. (bvsalud.org)
  • MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by imperfect matching of mRNA [ 6 ]. (hindawi.com)
  • Other Htz1-activated genes flank the silent HMR mating-type locus. (sdbonline.org)
  • Intragenic recombination among ospC genes is known, but the extent to which recombination extended beyond the ospC locus itself is undefined. (cdc.gov)
  • Given the poor prognosis of posttransplant thrombotic microangiopathy, further research is necessary to improve the diagnosis and treatment protocols based on risk factors or genetic predisposition, and to develop new therapeutic agents. (ekjt.org)
  • 13 Aberrant epigenetic regulation including DNA methylation, histone modifications and microRNA-mediated regulation may contribute to the complex array of immune abnormalities and disease manifestations in SLE. (bmj.com)
  • 2019 ) KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits. (neurotree.org)
  • The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)
  • The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. (sdbonline.org)
  • More recently we have demonstrated that C/EBPβ regulates the expression of several genes involved in inflammatory processes and brain injury [ 14 ] and mice lacking C/EBPβ showed a reduced inflammatory response after kainic acid injection and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus [ 15 ]. (biomedcentral.com)
  • Complement factor H regulates a part of the body's immune response known as the complement system. (medlineplus.gov)
  • Among the genes displaying significant changes in expression was complement component 3 ( C3 ), which showed a dramatic decrease in mRNA content in the hippocampus of C/EBPβ −/− mice. (biomedcentral.com)
  • This cluster includes several genes involved in regulation of the immune reaction. (wikipedia.org)
  • Inflammation in lupus is caused by the formation of autoantibodies and immune complexes and can cause inflammatory responses and activate the complement system. (bmj.com)
  • Sjöberg A., Önnerfjord, P., Mörgelin, M., Heinegård, D. and Blom A. M. (2005) Extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. (lu.se)
  • Microarray analysis revealed that HTZ1-activated genes cluster near telomeres. (sdbonline.org)
  • Blom A. M. , Webb J., Villoutreix B. and *Dahlbäck B. (1999) A cluster of positively charged amino acids in the N-terminal modules of C4BP a-chain is crucial for the C4b binding and factor I cofactor function. (lu.se)
  • To provide a solid experimental foundation for our evolutionary studies, we are working with several other labs in Berkeley to systematically dissect gene expression and regulation in the early D. melanogaster embryo. (berkeley.edu)
  • Extensive DNA methylation modifications serve as a new and critical layer of biological regulation that contributes to atheroprogression and destabilization via inflammatory processes. (biomedcentral.com)
  • Different statistical methods with varying selection criteria resulted in identification of similar candidate genes. (cdc.gov)
  • The principal site of glycation of human complement factor B". The Biochemical Journal. (wikipedia.org)
  • Orthologous to human CFH (complement factor H). (jax.org)
  • 3. Kalafatis, M., Takahashi, Y., Girma, J.P., and Meyer, D. Localization of a collagen interactive domain of human von Willebrand Factor between amino acid residues Gly 911 and Glu 1365. (csuohio.edu)
  • Agency is provided by the study of of carcinogenesis associated with the treatment of invasive cervical cancer the role of cutaneous HPV types in important risk factors for two common by decreasing recurrences of cancerous skin carcinogenesis, carried out by the human cancers. (who.int)
  • Among the arterial genes were 8 transcription factors, including HEY2, a downstream target of Notch signaling and the current golden standard pathway for arterial EC specification. (refine.bio)
  • Nuclear factor erythroid-2-related factor 2 (NRF2) is the most studied member of the Cap 'n' collar basic leucine zipper (CNC-bZIP) family of transcription factors. (hindawi.com)
  • genes are flanked by lengthy homologous repeats with lengthy interspersed nuclear components (retrotransposons) and we claim that non-allelic homologous recombination between these repeats leads to the increased loss of both genes. (bioinbrief.com)
  • We research gene expression control during development and misregulated in diseases. (ncl.ac.uk)