Gene regulates mef2 transcription factors. Medical search. Frequent questions

Analysis of the proteins that activate and repress different enhancers is combined with genetic studies to accurately position these factors within complex signalling networks. (ox.ac.uk)
The Arabidopsis genome contains an estimated 340,000 potential MADS binding sites ( de Folter and Angenent, 2006 ), leading to the intriguing question: What is the biological significance of the large number of potential MADS binding sites, and how many target genes do MADS proteins really regulate? (frontiersin.org)
Based on these studies, it appears that MADS proteins may directly regulate thousands of target genes (Figure 1 A), and may serve to integrate different biological processes. (frontiersin.org)
(A) Network representation (Cytoscape) of the reported target genes (represented by blue lines) of the four MADS proteins (yellow circles). (frontiersin.org)
The four MADS proteins share 70 target genes. (frontiersin.org)
It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)
We hypothesize that both the tissue-specific and the hormonal and/or metabolic regulation of the GLUT4 gene are carried out through these two regulatory domains and their cognate binding proteins. (ouhsc.edu)
To achieve these goals, we propose the following specific aims: 1) To understand the basis of cooperation between GEF and MEF2 proteins for DNA binding;2) To understand the mechanisms by which GEF and MEF2 proteins regulate the GLUT4 promoter;3) ) To determine the nature of the metabolic signal(s) that regulates GLUT4 gene transcription in vivo. (ouhsc.edu)
In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. (icr.ac.uk)
Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
The highly divergent C-terminal half of MEF2 proteins has been suggested to modulate their transcriptional activity17 18 The spectrum of targets activated by MEF2 transcription factors in different cell types is dependent on association with specific co-repressors and co-activators in response to multiple signaling pathways17. (researchassistantresume.com)
these multidomain guanine nucleotide exchange factors (GEFs) contain additional domains known to interact with phosphatidylinositides as well as with a number of different proteins. (biomedcentral.com)
CUX1 isoforms are transcription factors, whereas CASP are Golgi proteins that share with CUX1 the N-terminal region but not the DNA binding motifs [ 2 ]. (nature.com)
This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
Tamir, Y., and Bengal E . (2000) Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation . (technion.ac.il)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)

Additionally, we show that CHD7 reduces accessibility of enhancers with corresponding reduction in enhancer activity and proximal gene expression. (wustl.edu)
We show that myocyte enhancer factor 2 (MEF2) transcription factors suppressed excitatory synapse number in a neuronal activity- and calcineurin-dependent manner as hippocampal neurons formed synapses. (elsevierpure.com)
The MEF2 domain binds isoforms of the Myocyte Enhancer Factor 2 (MEF2) family of transcription factors, while Domain I binds GEF (GLUT4 Enhancer Factor), a transcriptional activator identified and cloned in our laboratory. (ouhsc.edu)
Analysis of this network identified serum response factor (SRF) and myocyte enhancer factor-2 (MEF2) as critical TFs in regulating longitudinal stretch-induced gene changes whose activity is modulated by protein kinase C (PKC). (escholarship.org)
Of particular importance has been the identification of two families of transcription factors: the myogenic regulatory factors (MRFs) and the myocyte enhancer factors (MEFs). (biologists.com)
MEF2B is a member of the myocyte enhancer-binding factor 2 (MEF2) family of transcription factors (including MEF2A -B -C -D) which are characterized by high homology in the MADS (MCM1 Agamous Deficiens SRF) box and an adjacent MEF2 domain17. (researchassistantresume.com)
Enhancer RNA facilitates NELF release from immediate early genes. (neurotree.org)

The activity-regulated cytoskeleton-associated protein (Arc) is induced by cocaine in the nucleus accumbens (NAc), an important brain reward region, but Arc's NAc function in SUD-related behaviour remains unclear. (bvsalud.org)
In most single gene autisms (Rett, Fragile-X, Pitt Hopkins etc) the underlying problem is that a faulty gene does not do its job of producing the expected protein. (epiphanyasd.com)
For example, in Timothy Syndrome the mutation in the gene produces too much of the protein, in this case the L-type calcium channel Cav1.2. (epiphanyasd.com)
MEF2 isoforms and GEF form a protein complex in vivo;however, the function of this complex in regulating gene transcription is not known. (ouhsc.edu)
In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. (icr.ac.uk)
whereas longitudinal but not transverse stretch induced expression of genes involved in sarcomere organization and cytoskeletal protein binding. (escholarship.org)
The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. (neurotree.org)
Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW , Kim TK , Greenberg ME , Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. (neurotree.org)
These mice express tamoxifen-induced Cre recombinase (Mer-cre-Mer) that enzymatically removes a stop codon flanked by lox sequences (floxed) on a reporter gene such as green fluorescent protein or yellow fluorescent protein, thus resulting in traceable fluorescence on the cells of interest. (musculoskeletalkey.com)
A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
The discovery that mutations in sarcomere protein genes cause HCM has enabled the development of mouse models that recapitulate clinical manifestations of disease. (rupress.org)
Alter J, Bengal E. (2011) Stress-Induced C/EBP Homology Protein (CHOP) Represses MyoD Transcription to Delay Myoblast Differentiation . (technion.ac.il)
Zetser, A., Gredinger, E., and Bengal, E. (1999) p38 mitogen-activated protein kinase promotes skeletal muscle differentiation: participation of the MEF2C transcription factor . (technion.ac.il)
Tamir, Y., and Bengal, E. (1998) p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene . (technion.ac.il)

Finally, analysis of the mice mPFC tissues revealed that NPAS4 regulates the expression of numerous genes linked to glutamatergic synapses and ribosomal function, the expression of upregulated genes in CSDS-susceptible animals, and differentially expressed genes in postmortem human brains of patients with common neuropsychiatric disorders, including depression. (bvsalud.org)
After 30 minutes of stretch, 53 and 168 genes were considered differentially expressed (DE) from transverse and longitudinal stretch, respectively. (escholarship.org)

Eileen Furlong obtained a Bachelor of Science degree at University College Dublin, and a PhD at the Conway institute at UCD, studying transcriptional regulation of immediate early response genes in the lab of Finian Martin. (wikipedia.org)
Her research integrates genomics, genetics and computational biology approaches to functionally dissect the role of non-coding cis-regulatory elements in the regulation of gene expression. (wikipedia.org)
Tissue-specific regulation of gene expression by the transcription factors Ying-Yang 1 and nuclear factor 1 (PhD thesis). (wikipedia.org)
To better understand these mechanisms involved in gene regulation, we pursue two questions: 1) what are the roles of the chromatin remodeler CHD7 in cerebellar development and 2) what are the roles of the MEF2 TF family in cerebellar function. (wustl.edu)
Thus, TFs also play a vital role in proper gene regulation. (wustl.edu)
Finally, motor activity induces a switch from non-compensatory to compensatory MEF2-dependent gene regulation. (wustl.edu)
The goal of my laboratory is to understand how blood vessels grow, differentiate and regress through studying the transcriptional regulation of vascular genes. (ox.ac.uk)
To study vessel regulation, my laboratory primarily focuses on the identification, characterisation and delineation of enhancers ( cis -regulatory elements) directing gene expression within the vasculature. (ox.ac.uk)
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. (ox.ac.uk)
In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
To reach this goal, we must first understand the molecular basis for transcriptional regulation of the GLUT4 gene. (ouhsc.edu)
The primary goal of this proposal is to understand the molecular mechanisms of the tissue-specific and hormonal/metabolic regulation of GLUT4 gene transcription. (ouhsc.edu)
the presence of HDAC7 blocked the induction of key genes for macrophage function, such as immune, inflammatory, and defense response, cellular response to infections, positive regulation of cytokines production, and phagocytosis. (eur.nl)
We have previously shown that MSY3/Csda binds a highly conserved cis-acting element located upstream of the myogenin promoter (myogHCE) and regulates the postnatal down-regulation of myogenin [ 16 ]. (biomedcentral.com)
Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. (neurotree.org)
Kolpakova A*, Katz S*, Keren A, Rojtblat A, Bengal E . (2013) Transcriptional Regulation of Mesoderm Genes by MEF2D during Early Xenopus Development . (technion.ac.il)
Regulation of gene expression plays a central role in embryonic development. (biomedcentral.com)

Collectively, our studies on CHD7 and MEF2 provide further understanding of the roles of two critical classes of gene regulators in cerebellar development and function. (wustl.edu)
Enhancers are densely clustered groups of transcription factor binding motifs and are the principal regulators of spatio-temporal patterns of gene transcription. (ox.ac.uk)
MEF2 transcription factors are key regulators of sprouting angiogenesis. (ox.ac.uk)
MADS domain transcription factors are key regulators in yeast, animals, and plants. (frontiersin.org)
By altering the major axis of biaxial, mechanical stretch, I hypothesized that different signaling pathways and transcription regulators would be activated and lead to divergent gene expression profiles in cardiac myocytes. (escholarship.org)
Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)

The latter part of this dissertation will address the roles of paralogous transcription factors, MEF2A and MEF2D, and their roles in cerebellar function. (wustl.edu)
Using single and double conditional knockout of MEF2 family TFs, we find that MEF2A and MEF2D play functionally redundant roles in cerebellar-dependent motor learning. (wustl.edu)
Although both TFs are highly expressed in granule neurons, transcriptomic analyses show MEF2D is the predominant genomic regulator of gene expression in vivo. (wustl.edu)
A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w. (neurotree.org)

However, our ability to manipulate vessel growth for therapeutic aims is hampered by a poor understanding of the mechanisms regulating vessel growth in both physiological and pathological contexts. (ox.ac.uk)
In individuals with a substance use disorder (SUD) and attempting to remain abstinent, these powerful drug-cue associations can trigger a return to active drug use, but the molecular mechanisms regulating drug-cue associations remain poorly understood. (bvsalud.org)
This network model was used in conjunction with the RNA-Seq data to identify the mechanisms regulating gene expression changes due to longitudinal and transverse stretch. (escholarship.org)
Abstract Objective To investigate the incidence, mechanisms, types of injury, most affected anatomical regions, and factors leading to injuries in trail bikers. (bvsalud.org)
In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)

(B) Venn diagram depicting the numbers of shared target genes. (frontiersin.org)
ChIP-seq was performed using antibodies against SEP3 in wild type and agamous ( ag-1 ) inflorescence tissues, resulting in 4282 and 2828 peaks (binding events) respectively, corresponding to 3475 and 2424 putative target genes. (frontiersin.org)
In this study the authors were also interested in identifying target genes associated with perianth development. (frontiersin.org)
MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. (archivesofmedicalscience.com)

Importantly, sites experiencing compensatory MEF2A occupancy are concentrated within open chromatin and undergo functional compensation for genomic activation and gene expression. (wustl.edu)

Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. (thermofisher.com)
Despite the expression of multiple Rho GDP/GTP exchange factors (GEFs) in the nervous system, the Kalrn gene, which encodes multiple isoforms of Kalirin, plays an essential, non-redundant role. (biomedcentral.com)
p200 CUX1 acts as a transcriptional repressor, whereas short CUX1 isoforms can activate or suppress transcription [ 1 , 3 ]. (nature.com)

May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. (icr.ac.uk)
Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)

We show here that the neuronal activity-regulated transcription factor, NPAS4, in the mPFC is regulated by chronic social defeat stress (CSDS), and it is required in this brain region for CSDS-induced changes in sucrose preference and natural reward motivation in the mice. (bvsalud.org)
In the mammalian nervous system, neuronal activity regulates the strength and number of synapses formed. (elsevierpure.com)
In response to increased neuronal activity, calcium influx into neurons induced the activation of the calcium/calmodulin-regulated phosphatase calcineurin, which dephosphorylated and activated MEF2. (elsevierpure.com)
Thus, our results demonstrate that changes in neuronal activity initiate competing signaling pathways that positively and negatively regulate the growth of the dendritic arbor. (jneurosci.org)
Emerging themes in neuronal activity-dependent gene expression. (neurotree.org)
Widespread transcription at neuronal activity-regulated enhancers. (neurotree.org)
Proteasome activity is also affected by neuronal activity, via increased expression of UBE3A through transcription factor MEF2, which leads to the internalization of AMPA-R. Variations in the Calcium-channel CACNA1C are also associated with ASD and [https://en.wikipedia.org/wiki/Timothy_syndrome Timothy Syndrome]. (wikipathways.org)

Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. (eur.nl)

mTOR is regulated by the TCS1/2 complex, and several signaling pathways upstream of TSC1/2 positively or negatively regulate this complex, including PI3K-AKT, Ras-ERK, LKB1-AMPK and Wnt-GSK3β pathways. (wikipathways.org)

Eileen E. M. Furlong FRS MAE is an Irish molecular biologist working in the fields of transcription, chromatin biology, developmental biology and genomics. (wikipedia.org)
She is known for her work in understanding how the genome is regulated, in particular to how developmental enhancers function, how they interact within three dimensional chromatin topologies and how they drive cell fate decisions during embryogenesis. (wikipedia.org)
Furlong serves on the editorial boards of the scientific journals Developmental Cell, Development, Molecular Systems Biology, Current Opinion in Genetics Development, Current Opinion in Cell Biology, a European Research Council (ERC) panel member and an organiser of the international Conferences From Functional Genomics to Systems Biology, EMBL Transcription and Chromatin meeting, and a keynote speaker at national and international conferences including Intelligent Systems for Molecular Biology (ISMB). (wikipedia.org)
This control is regulated by the interplay of chromatin remodelers and transcription factors (TFs). (wustl.edu)
The recruitment of chromatin remodelers to specific regions is accomplished by multiple factors including transcription factors. (wustl.edu)
These studies have set the basis for understanding how TFs and chromatin remodelers control gene expression. (wustl.edu)
Chromatin assembly factor 1. (lookformedical.com)
The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure preceding massive gene expression changes. (biomedcentral.com)

The primary microRNA (Pri-miRNA) is produced in the cell nucleus through the transcription of a DNA strand mediated by RNA polymerase II [ 2 ]. (archivesofmedicalscience.com)
NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior. (neurotree.org)
HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. (neurotree.org)
Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus. (uiowa.edu)

We found that HDAC7 specifically interacted with the transcription factor MEF2C in pre-B cells and was recruited to MEF2 binding sites located at the promoters of genes critical for macrophage function. (eur.nl)
The use of alternate promoters and 3'-terminal exons of the mouse Kalrn gene were investigated using real-time quantitative polymerase chain reaction. (biomedcentral.com)

Many cellular processes, including ribosome biogenesis, are regulated through post-transcriptional RNA modifications. (nature.com)

Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. (uiowa.edu)

To date, the central role of specific transcription factors in positively regulating these distinct differentiation processes to acquire a B cell-specific genetic program is well established. (eur.nl)

Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. (omicsdi.org)
New disease genes and pathogenic mutations often seem far afield from the overt manifestations of human pathology, in particular when the gene is expressed life long, but the disease emerges only after years or decades. (rupress.org)
Multiple mutations affecting embryonic development have been induced by chemical and insertional mutagenesis resulting in the identification of genes with important roles in development in Drosophila [ 23 - 25 ]. (biomedcentral.com)

MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. (univ-paris5.fr)

Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. (uiowa.edu)
Most known CUX1 functions derive from studies on cancer cells, where the gene can act as an oncogene or a haploinsufficient tumor suppressor gene [ 12 ]. (nature.com)
Alter, J., Rozentzweig, D., and Bengal, E. (2008) Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor . (technion.ac.il)

Using transgenic mice, we have shown that cis-elements regulating the human Glut4 promoter are located within 895 bp immediately 5'of the transcription initiation site. (ouhsc.edu)

To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)

The whole adipogenic process was driven by a coordinated activation of transcription factors and epigenetic modulators. (biomedcentral.com)

Here, we sought to determine whether the epigenetic enzyme, histone deacetylase 5 (HDAC5), regulates relapse-associated behavior in an animal model of OUD. (bvsalud.org)
These changes are regulated primarily at the epigenetic and transcriptional levels. (musculoskeletalkey.com)

CnB, the regulatory subunit, contains 4 Ca 2+ -binding EF hand motifs that regulate (through a conformational change) the catalytic function of Cn. (pancreapedia.org)

MADS genes are MADS targets and autoregulatory feedback loops are present. (frontiersin.org)
The putative targets are enriched for transcription factors of different families and, interestingly, for hormonal signaling pathways (auxin, brassinosteroids, and gibberellins). (frontiersin.org)
Targets also transcription factors and signaling molecules to regulate heart function. (icr.ac.uk)
CN has a number of targets but its most prominent are the NFAT (nuclear factor of activated T cells) transcription factors. (pancreapedia.org)

Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)

The gene encodes a transcriptional activator and is found mutated in ～11% of diffuse large B cell lymphomas (DLBCLs) and ～12% of follicular lymphomas. (researchassistantresume.com)

To address some of the limitations of these models, here we used two complementary ex vivo models based on Xenopus embryos: pluripotent animal cap explants expressing Gata4 transcription factor and conjugates of gastrula -stage AE with animal caps (AC). (xenbase.org)
2009. Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo . (umd.edu)

We report that the histone deacetylase HDAC7 was highly expressed in pre-B cells but dramatically down-regulated during cellular lineage conversion to macrophages. (eur.nl)

Here we addressed the molecular mechanism behind repression of non-lymphoid genes in B cells. (eur.nl)
New Molecular Insights into the Excitation-Transcription Coupling. (neurotree.org)

Early ontogeny is associated with dramatic gene expression changes that underlie and determine the developmental processes. (biomedcentral.com)
Expression of this genome entails several, highly regulated processes, with newly synthesised transcripts being cleaved, chemically modified, polyadenylated and further matured in neighbouring structures known as mitochondrial RNA granules (MRGs). (nature.com)

This is in contrast to (B), where injection of cer1 or hhex MOs in AE leads to downregulation of both cardiac and liver marker gene mRNA levels in conjugates. (xenbase.org)
In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. (icr.ac.uk)
2011. Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and FailureClinical Perspective . (umd.edu)
In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. (spandidos-publications.com)

We demonstrate that the GTPase Rem2 is regulated at the transcriptional level by calcium influx through L-VGCCs and inhibits dendritic arborization in cultured rat cortical neurons and in the Xenopus laevis tadpole visual system. (jneurosci.org)
However, negative mediators of experience-dependent dendritic outgrowth that are activity regulated at the transcriptional level are less well understood. (jneurosci.org)

Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. (univ-paris5.fr)

When activated, MEF2 promoted the transcription of a set of genes, including ore and synGAP, that restrict synapse number. (elsevierpure.com)

The number of MADS genes varies greatly among taxa, with yeast (4) and animals (5) having modest numbers. (frontiersin.org)
MADS genes have undergone significant duplication in plant lineages, ranging from 1 gene in green algae, to over 20 in mosses, to more than 100 in angiosperms ( Gramzow and Theissen, 2010 ). (frontiersin.org)

Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. (icr.ac.uk)

Since phosphorylation of FLNC by PKC diminishes the calpain sensitivity, assembly, and disassembly of the Z-disc may be regulated by phosphorylation of FLNC. (omicsdi.org)

Depending on the organism and availability, mt-tRNA Val or mt-tRNA Phe are incorporated, most likely due to their genomic proximity to mt-rRNA genes and consequent near stoichiometric presence of their transcripts 4 , 8 . (nature.com)

Precise control of gene expression is essential for neural development and function. (wustl.edu)
Despite of the relevance of this issue, very little is known about the factors regulating the development of adipose tissue in fish, and the possible health alterations associated to an increased fat deposition. (biomedcentral.com)
Page-McCaw A Genes & development 20.14 (2006 Jul 15): 1899-910. (uiowa.edu)
The mTOR pathway is also regulated by the brain‐derived neurotrophic factor (BDNF), which plays a key role in the development and the plasticity of the central nervous system and is considered a risk factor for ASD. (wikipathways.org)
Enthesis development has historically been studied with lineage tracing of individual genes selected a priori, which does not allow for the determination of single-cell landscapes yielding mature cell types and tissues. (elifesciences.org)

The RNA polymerase II subunit RPB-9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription. (ericmiskalab.org)
The FLNC subunit is dimerized through R24 and calpain cleaves off the dimerization domain to regulate mobility of the FLNC subunit. (omicsdi.org)

Anatomy15

Organisms9

Chemicals and Drugs138

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes67

Disciplines and Occupations1

Information Science4

Proteins17

Enhancer7

Protein17

Differentially expressed2

Regulation17

Regulators6

MEF2D4

Mechanisms5

Target genes4

MEF2A1

Isoforms3

Skeletal muscle2

Neuronal7

Repressor1

Negatively regulate1

Chromatin8

Nucleus4

Promoters2

Ribosome biogenesis1

Proliferation3

Positively1

Mutations3

Induces2

Tumor3

Promoter1

Differentiation2

Modulators1

Epigenetic2

Motifs1

Targets4

Pathways1

Transcriptional activator1

Vivo2

Histone1

Molecular2

Processes2

Cardiac4

Dendritic2

Nuclear receptor1

Synapse1

MADS2

Influx1

Phosphorylation1

Genomic1

Development5

Subunit2