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  • Adult T-Cell L
  • Other less common clinical variants are the mycosis fungoides d'emblee variant, Woringer-Kolopp disease, Szary syndrome, alopecia mucinosa, poikiloderma vasculare atrophicans, lymphomatoid papulosis, CD30+ large cell lymphoma, and human T-lymphocyte virus type 1 (HTLV-1)-associated adult T-cell leukemia/lymphoma. (cancernetwork.com)
  • Immunoglobulin
  • In mice deficient for Aiolos and OBF-1, the numbers of immature B cells are reduced, small pre-BII cells are increased and a significant impairment in immunoglobulin light chain DNA rearrangement is observed. (nih.gov)
  • Furthermore, HPS1A augments recombination frequency of extrachromosomal substrates in an in vitro recombination assay.DNA binding proteins recognizing HPS1A have been identified and are restricted to early B and T cells, during the time of active rearrangement of endogenous TCR and immunoglobulin loci.These data are consistent with delta deletion playing an important role in maintaining separate TCR alpha and delta loci. (nih.gov)
  • DNA binding proteins recognizing HPS1A have been identified and are restricted to early B and T cells, during the time of active rearrangement of endogenous TCR and immunoglobulin loci. (nih.gov)
  • Chronic
  • It is also known by the following terms: proliferation of large granular lymphocytes (LGLs), LGL leukemia, Tγ-lymphoproliferative disorder, and, in common with other T cell leukemias such as T-cell prolymphocytic leukemia, T-cell chronic lymphocytic leukemia. (wikipedia.org)
  • The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. (merckmillipore.com)
  • cutaneous
  • ABSTRACT: Cutaneous lymphomas comprise a spectrum of diseases characterized by infiltration of the skin by malignant lymphocytes. (cancernetwork.com)
  • Many factors have been implicated in the etiology of cutaneous lymphomas, including chemical and drug exposures, as well as microbial agents, such as the Epstein-Barr virus (EBV), human T-lymphocyte virus-1 (HTLV-1), and Borrelia burgdorferi. (cancernetwork.com)
  • Evidence implicating viral infections as possible etiologic or contributing factors has been sought since the isolation of HTLV-1, a type-C retrovirus, from the lymphocytes of a patient with cutaneous T-cell lymphoma. (cancernetwork.com)
  • Discovery of molecular determinants of lymphocyte trafficking to mucosal and cutaneous sites has provided a paradigm for understanding clinical patterns of lymphoproliferative diseases. (vin.com)
  • Leukemia
  • Gene therapy may be particularly useful for treating enzyme deficiency diseases, hemoglobinopathies, and leukemias and may also prove useful in restoring drug sensitivity, particularly for leukemia. (healthmatics.info)
  • somatic
  • Gene therapies are designed to deliver genetic material into somatic cells and not germ cells, so that only cells of patients and not those of their offspring contain and express the genetic material delivered. (healthmatics.info)
  • Protein
  • Gene therapy techniques attempt to replace a faulty/missing gene associated with a particular disease, mediate localized delivery of a protein producing specified therapeutic effects, or introduce new cellular functions. (healthmatics.info)
  • dysfunction
  • thus, many researchers have tried to elucidate the relationship between age and immune system dysfunction by examining losses and changes in circulating T-lymphocytes ( 1 , 2 ). (frontiersin.org)
  • liver
  • To observe anti-cancer effects of Jianpi Jiedu Recipe (JJR) on liver cancer (LC) rats with Pi deficiency syndrome (PDS) and its relation with the third complementary-determining region gene spectratyping of TCRVβ-chain (TCRVβCDR3). (cancerindex.org)
  • development
  • We are looking at how the levels of expression of these genes are changed in cancer in order to find out how important they are in cancer development and in the development of drug-resistance. (keele.ac.uk)
  • TCRγδ + lymphocytes are DN in stages of full maturity, while TCRαβ + lymphocytes are DN only in earliest stages of intrathymic development. (biology-online.org)
  • Cancer
  • Mutations in apoptosis-controlling genes underlie many forms of cancer as well as autoimmune and degenerative diseases. (keele.ac.uk)
  • transcription
  • These studies uncover a novel role for OBF-1 and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR function. (nih.gov)
  • found
  • The gene for the β chain of the TCR is found to be rearranged more often than the γ chain. (wikipedia.org)
  • human
  • Ultimately, disease association with genetic factors has often been defined in terms of human leukocyte antigens (HLA), particularly those for the highly polymorphic class I and class II genes. (springer.com)