• The use of other conserved but distinguishing traits in phylogenetic inference and retroviral classification discussed here are: nucleotide bias, number of zinc fingers, translational strategy, C-terminal Pro and Pol motifs, presence of dUTPase and accessory genes and LTR length. (biomedcentral.com)
  • Con- trol of vertebrate left-right asymmetry by a snail-related zinc finger gene. (imbc-med.ru)
  • Katoh O, Oguri T, Takahashi T, Takai S, Fujiwara Y, Watanabe H. ZK1, a novel Krüppel-type zinc finger gene, is induced following exposure to ionizing radiation and enhances apoptotic cell death on hematopoietic cells. (labome.org)
  • The isolation and expression of cDNA for human trehalase should facilitate studies of the structure of the gene, as well as a basis for a better understanding of the catalytic mechanism. (labome.org)
  • The temporal patterns of gene expression that underlie these processes in lymphocytes collectively span a time frame that extends from minutes to days, with the induction of immediate early and early response genes coinciding with that period of mitogenic stimulation required to commit a cell to a program of activation ( 1 ). (rupress.org)
  • While IFN-gamma must be present for IL-12 p40 gene induction, the p35 gene is strongly induced by LPS, even in the absence of IFN-gamma, and therefore the induction of the p35 gene is IRF-1 independent. (labome.org)
  • Interestingly, peptides spanning CCR2 and/or LZ disrupt IKKγ-Tax and IKKγ-PP2A interactions and potently inhibit NF-κB activation by Tax and tumor necrosis factor-α. (elsevier.com)
  • He made a seminal discovery that mutations of the tumor suppressor gene p53 lead to the activation of its oncogenic activity. (nhri.org.tw)
  • The global H3K27me3 alterations involved ATL-specific gene expression changes that included several tumor suppressors, transcription factors, epigenetic modifiers, miRNAs, and developmental genes, suggesting diverse outcomes by the PRC2-dependent hierarchical regulation. (nih.gov)
  • Recently, we reported that tumor suppressor in lung cancer 1 (TSLC1/IgSF4/CADM1) is usually overexpressed in acute-type ATLL cells in a DNA microarray-based survey of gene manifestation (24). (health-e-nc.org)
  • Tax also causes aneuploidy (abnormal chromosome numbers), which is a possible cause of transformation (normal cells becoming cancer cells). (wikipedia.org)
  • Although Tax from HTLV-1 and HTLV-2 can cause cells to become cancerous experimentally, Tax produced by HTLV-2 is less oncogenic than that from HTLV-1 and therefore is thought to be the reason that HTLV-2 is not associated with ATL. (wikipedia.org)
  • Consistent with IRF-4 functioning as a repressor of IFN-induced gene expression, the absence of IRF-4 expression in c-rel −/− B cells coincided with a greater sensitivity of these cells to the antiproliferative activity of IFNs. (rupress.org)
  • As part of a strategy aimed at identifying genes regulated by Rel, the expression of genes normally induced early in lymphocyte activation were examined in c-rel −/− B and T cells. (rupress.org)
  • Like Rel, it also appears to be critical in lymphocyte proliferation, as IRF-4 −/− B and T cells respond poorly to mitogens ( 14 ) and deregulated overexpression of IRF-4 due to the translocation of the gene into the Ig CH locus occurs in a subset of human multiple myelomas ( 15 ). (rupress.org)
  • Several systems have facilitated the study of gene activation in eukaryotic cells. (springer.com)
  • 3) How can these be used to understand gene activation in eukaryotic cells? (springer.com)
  • We found that polycomb-repressive complex 2 (PRC2)-mediated trimethylation at histone H3Lys27 (H3K27me3) was significantly and frequently reprogrammed at half of genes in ATL cells. (nih.gov)
  • The Tax-dependent immortalized cells showed H3K27me3 reprogramming that was significantly similar to that of ATL cells. (nih.gov)
  • With genetic engineering, in order for a gene to be inserted into a cell, you need something good at invading cells, which is why bacteria and viruses are typically used to "smuggle" desirable DNA from one organism into another. (mercola.com)
  • These data suggest that the ZK1 gene is one of early response genes by exposure to ionizing radiation, and may have some functions on radiation-induced apoptotic cell death on hematopoietic cells. (labome.org)
  • These data provide new insight into the direct regulation of OX40 by Tax and add to our understanding of the possible role of the OX40/OX40 ligand system in the proliferation of HTLV-I + T cells. (jimmunol.org)
  • In this report, we examined the manifestation profile of ATLL cells, focusing on genes regulated by HTLV-1 contamination. (health-e-nc.org)
  • Within the Tax-regulated genes, we found that was specifically downregulated in ATLL cells compared with CD4+ T lymphocytes, while was upregulated in the HTLV-1-infected cell lines. (health-e-nc.org)
  • These results demonstrate that multiple factors are responsible for transcriptional control of the substance P precursor gene through the CRE region. (labome.org)
  • Neither the HTLV-I enhancer nor basal promoter elements of the HSV-1 gD gene were essential for activation and no increase in accumulated HTLV-I mRNA was observed due to HHV-6 infection. (microbiologyresearch.org)
  • By reporter gene analysis with progressive 5′ deletions from nucleotides −1259 to −64, we have defined a 157-bp DNA fragment as a minimal promoter for constitutive expression. (jimmunol.org)
  • The site-directed mutagenesis of each NF-κB site demonstrates that cooperative NF-κB binding is a prerequisite for Tax-directed activity as neither site alone is sufficient for a full Tax responsiveness of the OX40 promoter. (jimmunol.org)
  • Bock R (2010) The give-and-take of DNA: horizontal gene transfer in plants. (springer.com)
  • Sawada H, Suzuki F, Matsuda I, Saitou N. Phylogenetic analysis of Pseudomonas syringae pathovars suggests the horizontal gene transfer of argK and the evolutionary stability of hrp gene cluster. (labome.org)
  • Arvidsson U, Schalling M, Cullheim S, Ulfhake B, Terenius L, Verhofstad A, Hökfelt T (1990) Evidence for coexistence between calcitonin gene-related peptide and serotonin in the bulbospinal pathway in the monkey. (springer.com)
  • CAMBRIDGE, Mass.--( BUSINESS WIRE )--Obsidian Therapeutics, Inc., a biotechnology company dedicated to the development of next-generation cell and gene therapies with pharmacologic operating systems, today announced the completion of a $49.5 million Series A financing to further build its technology platform and advance its lead programs toward clinical development. (businesswire.com)
  • A large proportion of the abnormal gene downregulation was detected at the early stage of disease progression and was explained by H3K27me3 accumulation. (nih.gov)
  • Obsidian has licensed technology relating to DDs from Stanford University and has recently launched a research collaboration with Crystal Mackall, M.D., of the Stanford School of Medicine, focusing on the use of DDs to regulate CAR activity in CAR-T products. (businesswire.com)
  • Thus, Tax-mediated increases in NF-kappaB nuclear translocation result from direct interactions of Tax and MEKK1 leading to enhanced IKKbeta phosphorylation of IkappaB alpha. (nih.gov)
  • What Role can chemistry play in cationic liposome-based gene therapy research today? (elsevier.com)
  • Alevizaki M, Shiraishi A, Rassool FV, Ferrier GJM, MacIntyre I, Legon S (1986) The calcitonin-like sequence of the ß CGRP gene. (springer.com)
  • HTLV-1 causes an aggressive form of leukaemia: adult T cell leukaemia (ATL), and Tax has largely been implicated in the oncogenic potential of this virus. (wikipedia.org)
  • Arias J, Scopsi L, Fischer JA, Larsson LI (1989) Light- and electron-microscopic localization of calcitonin, calcitonin gene-related peptide, somatostatin and C- terminal gastrin/cholecystokinin immunoreactivities in rat thyroid. (springer.com)
  • In the present study, we evaluated the activity of HTLV-2 Tax in promoting aberrant proliferation of human CD4 T lymphocytes. (elsevier.com)
  • (nih.gov)
  • RNase P control reagent (Applied Biosystems, Foster City, CA) was used for the primers and the probe for the human RNase P DNA gene as an internal control. (health-e-nc.org)
  • The cell cycle has four stages (G1, S, G2 and M) and Tax is known to accelerate the transition between G1 and S phase. (wikipedia.org)
  • Tax fingerprint in adult T-cell leukemia. (nih.gov)
  • Graduate students, scientists, and clinicians interested in molecular and cell biology interested in gene therapy. (elsevier.com)
  • Dominant negative mutants of both IKKbeta and MEKK1 prevent Tax activation of the NF-kappaB pathway. (nih.gov)
  • In situ chromosomal hybridization demonstrated that the Lhx8 gene was localized in the distal region of mouse chromosome 3. (labome.org)
  • The chromosomal location determined by FISH revealed that NFATz and NFATx genes are in the same region. (labome.org)
  • The system is composed of two parts - a synthetic biological cassette that is installed in the gene vector and a small-molecule drug that controls the activity of the cassette. (businesswire.com)
  • Tax is produced by members of the retroviral family primate T-lymphotropic virus, which are classified as Deltaretroviruses. (wikipedia.org)
  • Biotechnological applications toward Cannabis research and product development are still in their early stages. (springer.com)
  • An important feature of biotechnology is the collection of gene transfer technologies that are used to introduce genetic material into host organisms. (springer.com)
  • The Future of Food is not a new film, but still does an excellent job of covering contemporary issues that continue to threaten your health, including genetic engineering, gene patenting, and the corporatization of the food supply. (mercola.com)
  • The HLX2-CCR2-LZ bundle becomes unfolded by signal-induced modifications of IKKγ or after Tax binding. (elsevier.com)