Gene precursor receptors laminin. Medical search. Frequent questions

These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. (wikipedia.org)
In addition, the precursor cells contained various proteins of the extracellular matrix. (innovationorigins.com)
Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. (embl.de)
Alzheimer's possesses complex pathologies of heterogeneous nature counting proteins as one major factor along with enzymes and mutated genes. (benthamscience.com)
Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)
5′-aza-dC and/or Trichostatin A resulted in transcriptional upregulation of the genes, suggesting that low expression of ECM components, proteoglycan core proteins and HS biosynthetic system is due to epigenetic suppression in type I cells. (oncotarget.com)
In this study, we are interested in investigating the expression of a variety of functional classes of proteins in ESCC and its precursor lesions and characterizing the correlation of these proteins with ESCC malignant progression. (biomedcentral.com)
To confirm the immunohistochemical results, three proteins, fascin, CK14 and laminin-5γ2, which were overexpressed in ESCC on tissue microarray, were detected in 12 ESCC cell lines by Western blot assay. (biomedcentral.com)
Among them, seven SNPs of moderate effect led to changes in the amino acid contents in the final proteins of the following genes: ANSa, GDH2, 4Cl, F3'5'Hb, UFGTa. (bvsalud.org)

Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)

RPSA was initially identified as a laminin binding protein. (wikipedia.org)
Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. (joplink.net)

Furthermore, the surface receptor of EGCG, 67LR, was localized on the neurons and glia in the retina. (nature.com)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. (wikipedia.org)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)
The two scientists found that the components of the extracellular matrix send a signal into the cell using an integrin receptor. (innovationorigins.com)
It is mediated by the contact of the precursor cell with the extracellular matrix and the mechanosensitive gene regulator YAP . (innovationorigins.com)

Procathepsin L and processed mature CatL can degrade laminin and fibronectin extracellular matrices (19) while CatL can also degrade collagen (20). (crispr-reagents.com)

We performed gain and loss of function studies for leukemia inhibitory factor (LIF) and showed a depletion of NSCs, a subset of multipotential neural precursors and immature oligodendrocytes in LIF null mice. (karger.com)
Virtually all of the neurons and glia that populate the mature brain arise from neural precursors (NPs) that reside immediately adjacent to the lateral ventricles. (karger.com)

Understanding these genes and their pathways can lead to the breakthrough of new medications target structured gene delivery and advancement of safer antidiabetic medications. (immune-source.com)
The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. (biomedcentral.com)
Genes and pathways associated with lactation number in cows were identified for the first time to date, and we found that many were comparable to those known to be associated with ageing in humans and model organisms. (biomedcentral.com)
Furthermore, the expression of the genes known to govern insulin expression including Pdx1 and Ngn3 was markedly induced by laminin 411, which suggests that Pdx 1 and Ngn 3 signaling pathways are involved in laminin 411 induced-insulin expression machinery. (biomedcentral.com)
Our results demonstrate that laminin 411 acts as a potent differentiation inducer of IPCs from UC-MSCs via the Pdx1 and Ngn3 signaling pathways. (biomedcentral.com)

Memantine non-competitively blocks the N-methyl-D-aspartate receptor in order to inhibit beta-amyloid (Aβ) secretion, and has been used to treat moderate-to-severe Alzheimer's disease (AD). (spandidos-publications.com)

The RPSA gene encodes a multifunctional protein, which is both a ribosomal protein and a high-affinity, non-integrin laminin receptor. (wikipedia.org)

It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)

We have shown previously that receptor activator of NF?B ligand (RANKL) a member of the paederosidic acid tumor necrosis factor family that is normally expressed around the cell surface of stromal cells and osteoblasts and mediates osteoclast differentiation and osteolysis or bone resorption can be upregulated by Snail overexpression in ARCaP and LNCaP prostate malignancy cells which was associated with increased osteoclastogenesis and (4). (crispr-reagents.com)

To investigate whether the absence of Muc2 results in a compensatory up-regulation of other intestinal mucins after ethanol administration, intestinal gene and protein expression of several mucins was assessed. (rafsignaling.com)
Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin. (tamu.edu)
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. (tamu.edu)
The top three clusters from modules more highly expressed in the PP cows all involved regulation of gene transcription, particularly zinc fingers. (biomedcentral.com)
however, little is known about a role of laminin 411 in the regulation of IPC differentiation from human MSCs. (biomedcentral.com)

Surprisingly, the related cytokine, CNTF, was less potent than LIF in increasing the NSCs and more potent than LIF in increasing the PDGF responsive multipotential precursors. (karger.com)

A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains. (lookformedical.com)

The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. (neurotree.org)
Estrone is only a weak agonist of estrogen receptor but it serves as a precursor for biosynthesis of 17β-estradiol, 16α-hydroxyestrone and catechol estrogens. (helsinki.fi)

Additionally Snail overexpression promoted osteoclastogenesis which was significantly inhibited by the MSKE as effectively as Z-FY-CHO a CatL-specific inhibitor or osteoprotegerin a receptor activator of nuclear factor kappa B ligand (RANKL) antagonist. (crispr-reagents.com)
Receptor Activator of NF-κB (RANK) expressed on osteoclasts and their precursors is a receptor for RANK ligand (RANKL). (korilog.com)

While all Reg family members mRNAs could be discovered from total pancreas and genes have already been discovered in pancreatic islet cells as verified by immunofluorescence23 and appearance was remarkably elevated during being pregnant in rats24. (immune-source.com)
These data claim that there's a solid hyperlink between gene rejuvenation and category of pancreatic islets. (immune-source.com)
are laminin-like diffusible chemotactic protein involved with pancreatic morphogenesis and are likely involved in the legislation of duct-cell and foetal GSK1838705A islet cell migration. (immune-source.com)
Laminin 411 markedly induced the expression of the genes Foxa2 and Sox17 , markers for pancreatic precursor cells, efficiently induced IPC differentiation from MSCs, and up-regulated insulin expression at both mRNA and protein levels. (biomedcentral.com)

Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)

Secondly, the green tea extract directly and selectively binds with laminin67R receptors that are overexpressed in prostate tumor cells. (genengnews.com)

They were "early" corresponding to mild and moderate DYS with overexpression of fascin, FADD and CDC25B and underexpression of Fas, caspase 8, CK4 and annexin I, "intermediate" to severe DYS and CIS with overexpression of FADD and CK14, and "late" to invasive lesions (ESCC) and to advanced pTNM stage ESCC lesions with overexpression of CK14, laminin-5γ2 and SPARC. (biomedcentral.com)

Another cluster included genes encoding enzymes in the mitochondrial beta-oxidation pathway. (biomedcentral.com)

Consistently, chronic MS lesions were found to have not only a decreased OL density but also a decreased proportion of OLs that expressed myelin gene regulatory factor (MYRF) compared to NAWM [ 16 ]. (encyclopedia.pub)
The development of esophageal squamous cell carcinoma (ESCC) progresses a multistage process, collectively known as precursor lesions, also called dysplasia (DYS) and carcinoma in situ (CIS), subsequent invasive lesions and final metastasis. (biomedcentral.com)
Fas, FADD, caspase 8, CDC25B, fascin, CK14, CK4, annexin I, laminin-5γ2 and SPARC were analyzed using immunohistochemistry on tissue microarray containing 205 ESCC and 173 adjacent precursor lesions as well as corresponding normal mucosa. (biomedcentral.com)
Analyzing the protein expression patterns of Fas, FADD, caspase 8, CDC25B, fascin, CK14, CK4, annexin I, laminin-5γ2 and SPARC would be valuable to develop rational strategies for early detection of lesions at risk in advance as well as for prevention and treatment of ESCC. (biomedcentral.com)
A multistage process has been proposed for the evolution of esophageal squamous cell carcinoma (ESCC), in which normal squamous epithelia undergo a series of histological and genetic progression towards noninvasive precursor lesions, i.e., dysplasia (DYS) and carcinoma in situ (CIS), then towards invasive cancer, and, finally towards deep invasion and metastasis to lymph nodes and other organs. (biomedcentral.com)
Although cDNA microarray has been successfully used to explore the gene expression in ESCC, it is difficult to be used in the precursor lesions due to the difficulty to obtain the dysplastic cells accurately. (biomedcentral.com)
The method of tissue microarray (TMA), which could confirm the results of cDNA microarray on protein level, has been popularly used for gene expression profiling in many types of cancer including ESCC, but rarely in the consecutive stages of carcinogenesis, especially in the precursor lesions. (biomedcentral.com)

Kattesh V. Katti, M.D., Ravi Shukla, M.D., and colleagues detail their studies in a paper titled "Laminin receptor specific therapeutic gold nanoparticles ( 198 AuNP-EGCg) show efficacy in treating prostate cancer. (genengnews.com)
Interaction of biocompatible EGCg with 198 Au precursor affords the production of inherently therapeutic gold nanoparticles through a novel synthetic route, effectively eliminating toxic chemicals that are routinely utilized in pharmaceutical formulations," the authors conclude. (genengnews.com)

This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)

There was no significant difference in the gene expression of secreted mucin Muc6 or of membrane-bound mucins (such as Muc1 and Muc4) in Muc2−/− mice relative to wild-type mice after 1 week of intragastric feeding of ethanol (Fig. 4B). (rafsignaling.com)
Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. (nih.gov)
Piglets (14 from each genetic type) were slaughtered at weaning (28 days) and longissimus dorsi was sampled for composition and gene expression studies. (biomedcentral.com)
Correlation among the expression of these RF and DE genes show relevant differences between genetic types. (biomedcentral.com)
3 cows with MP 2-3 as background using DESeq2 followed by weighted gene co-expression network analysis (WGCNA). (biomedcentral.com)
He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)

Alerts transduced by RANKL-RANK interplay induce genes important for the differentiation and performance of osteoclasts, partly via the direct binding of NFATc1, to focus on gene promoters. (korilog.com)
UC-MSCs were then cultured in the IPC induction and differentiation medium in the presence of laminin 411. (biomedcentral.com)

Transcript differences were validated for a subset of DE genes by qPCR. (biomedcentral.com)

Desk I Genes involved with beta cell proliferation Up to now five REG protein have already been reported in human beings that participate in gene family. (immune-source.com)

Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. (thermofisher.com)

These findings demonstrate that GTE is an effective agent in suppressing LPS-induced retinal inflammation, probably through its potent anti-oxidative property and a receptor-mediated action on transcription factors that regulate production of pro-inflammatory cytokines. (nature.com)

The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST and Klein WL: Abeta oligomers induce neuronal oxidative stress through an N- methyl- d - aspartate receptor- dependent mechanism that is blocked by the Alzheimer drug memantine. (spandidos-publications.com)

It is particularly exciting for us that our data answer a question that has been driving our field of research for decades," says Henrik Semb, explaining how some precursors mature into scaffold cells, while others become endocrine cells through activation of the so-called Notch signaling pathway. (innovationorigins.com)

It also acts as a cell surface receptor, in particular for laminin, and is involved in several pathogenic processes. (wikipedia.org)

Mutations in GPR56 , an orphan G-protein-coupled receptor (GPCR), cause bilateral frontoparietal polymicrogyria (BFPP), a disorder characterized by mental retardation, seizures, motor developmental delay, and ataxia. (jneurosci.org)

The present study aimed to establish an AD cell model overexpressing the 695‑amino‑acid Swedish mutant of Aβ precursor protein (APP695swe) in order to observe the effects of memantine on the cell viability, autophagy and apoptosis of SH‑SY5Y cells in the AD model, and to investigate the associated underlying mechanisms. (spandidos-publications.com)

The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. (nih.gov)

40S ribosomal protein SA is a ribosomal protein that in humans is encoded by the RPSA gene. (wikipedia.org)
The complementary DNA (cDNA) of the RPSA gene is formed by the assembly of seven exons, six of which correspond to the coding sequence. (wikipedia.org)
RPSA can be sub-divided in two main domains: an N-domain (residues 1-209), which corresponds to exons 2-5 of the gene, and a C-domain (residues 210-295), which corresponds to exons 6-7. (wikipedia.org)
RPSA is a ribosomal protein which has acquired the function of laminin receptor during evolution. (wikipedia.org)
Both recombinant N-domain and C-domain of RPSA bind laminin in vitro, and they bind with similar dissociation constants (300 nM). (wikipedia.org)
Both RPSA and laminin belong to the heparin/heparan sulfate interactome. (wikipedia.org)
Moreover, the C-domain of RPSA and heparin compete for binding to laminin, which shows that the highly acidic C-domain of RPSA mimicks heparin (and potentially heparan sulfates) for the binding to laminin. (wikipedia.org)
RPSA is a potential cellular receptor for several pathogenic Flaviviruses, including the dengue virus (DENV), and Alphaviruses, including the Sindbis virus (SINV). (wikipedia.org)
RPSA is also a receptor for small molecules. (wikipedia.org)

Many of the effects of laminin are mediated through interactions with cell surface receptors. (wikipedia.org)
Also functions as a cell surface receptor for laminin. (joplink.net)
M2-polarization-related CNTNAP1 gene might be a novel immunotherapeutic target and biomarker for clear cell renal cell carcinoma. (nih.gov)
We have now succeeded in working out the basic signals that decide whether a precursor cell develops into an endocrine - i.e. hormone-producing - or a scaffold cell," said Prof. Dr. Henrik Semb. (innovationorigins.com)
This signal influences the development of the precursor cell. (innovationorigins.com)
events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)

Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (joplink.net)

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (nih.gov)
3 cows were pooled, and the gene lists subjected to David functional annotation cluster analysis. (biomedcentral.com)

To do this, they applied precursor cells to glass plates. (innovationorigins.com)
These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
Despite factors in codon, all apoptotic dwarfism genes person three employed cells( CRs) and each is with RAS and MEK synapses, although with pulmonary cyclins. (evakoch.com)
Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)
The excessive affinity immunoglobulin E (IgE) receptor-FcεR1 is principally expressed on the floor of effector cells. (korilog.com)

The purpose of this study was to analyze the leaf quality and SNPs in quality-related genes in the tea plant collection of 20 mutant genotypes growing without nitrogen fertilizers. (bvsalud.org)

More importantly, administration of laminin 411-induced IPCs rapidly and significantly down-regulated fasting blood glucose levels, significantly reduced the HbA1c concentration and markedly improved the symptoms and survival of T1DM rats. (biomedcentral.com)

Candidate genes with known effects on muscle growth were found among the DE genes upregulated in DU×IB. (biomedcentral.com)

Gain of function studies showed that LIF increased the abundance of these precursors. (karger.com)
These novel finding highlights a potential clinical application of laminin 411 induced-IPCs in the treatment of T1DM, which calls for further studies. (biomedcentral.com)

Accordingly, it switches specific genes on or off. (innovationorigins.com)
and (Desk I). Besides these genes specific peptides or their analogues such as for example glucagon like peptide-1/exendin-4 may also be involved with islet regeneration. (immune-source.com)

Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. (tamu.edu)

Anatomy14

Organisms4

Diseases2

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes25

Disciplines and Occupations1

Information Science3

Proteins9

Amyloid precurs2

Binding protein2

67LR1

Extracellular matrix5

Fibronectin1

Neural precursors2

Pathways5

Beta-amyloid1

Integrin1

Signal transduction1

Mediates1

Regulation6

PDGF1

Biosynthetic1

Agonist2

Activator2

Pancreatic4

Synthesis1

Binds1

Overexpression1

Enzymes1

Lesions7

EGCG2

Biosynthesis1

Expression6

Differentiation2

Subset1

Proliferation1

Isoforms1

Potent1

Mechanism2

Endocrine cells1

Processes1

Mutations1

Amino1

Initially identified1

RPSA9

Cell6

Ribosomal1

Functional2

Cells7

Mutant1

Significantly1

Candidate1

Studies2

Specific2

Chromosome1