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  • Transcription
  • 10,11 NF-κB, an oxidant-sensitive transcription factor, plays a critical role in late PC 12 and in the activation of a multitude of genes in response to various stimuli and therefore serves as a general mediator of cellular responses to stress. (ahajournals.org)
  • May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. (genecards.org)
  • GO annotations related to this gene include poly(A) RNA binding and transcription regulatory region DNA binding . (genecards.org)
  • GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding . (genecards.org)
  • Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. (genecards.org)
  • The protein encoded by this gene is a member of the E2F family of transcription factors. (nih.gov)
  • The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. (nih.gov)
  • After translocation into nucleus, Nrf2 forms a heterodimer with other transcription factors, such as small Maf, which in turn binds to the 5'-upstream CIS-acting regulatory sequence, termed antioxidant response elements (ARE) or electrophile response elements (EpRE), located in the promoter region of genes encoding various antioxidant and phase 2 detoxifying enzymes. (nih.gov)
  • Plant development requires a precise and dynamic regulatory network, in which transcription factors play major roles by temporally and spatially regulating gene expression. (uni-koeln.de)
  • The SBP-box genes encode a group of plant-specific transcription factors, highly conserved in their DNA-binding domain, but quite heterogeneous outside. (uni-koeln.de)
  • DNA topoisomerase I is required for the normal development of multicellular organisms, probably because it plays a role in controlling gene activity, in addition to its function in relieving tortional stress during DNA replication and transcription. (springer.com)
  • The budding yeast protein Asr1 is the prototypical member of the RPC (RING, PHD, CBD) family of ubiquitin-ligases, characterized by the presence of amino-terminal RING (really interesting new gene) and PHD (plant homeo domain) fingers and a carboxyl-terminal domain that directly binds the largest subunit of RNA polymerase II (pol II), Rpb1, in response to phosphorylation events tied to the initiation of transcription. (pnas.org)
  • Here, we present evidence that Asr1-mediated ubiquitylation of pol II is required for silencing of subtelomeric gene transcription. (pnas.org)
  • We show that Asr1 associates with telomere-proximal chromatin and that disruption of the ubiquitin-ligase activity of Asr1-or mutation of ubiquitylation sites within Rpb1-induces transcription of silenced gene sequences. (pnas.org)
  • In addition, we report that Asr1 associates with the Ubp3 deubiquitylase and that Asr1 and Ubp3 play antagonistic roles in setting transcription levels from silenced genes. (pnas.org)
  • cAMP can stimulate the transcription of many activity-dependent genes via activation of the transcription factor, cAMP response element-binding protein (CREB). (jneurosci.org)
  • However, in mouse cortical neuron cultures, prior to synaptogenesis, neither cAMP nor dopamine, which acts via cAMP, stimulated CREB-dependent gene transcription when NR2B-containing NMDA receptors (NMDARs) were blocked. (jneurosci.org)
  • Although CREB phosphorylation is necessary, it may not be sufficient to initiate gene transcription. (jneurosci.org)
  • Here, we report that, in immature neurons from embryonic mouse cortex, prior to synaptogenesis, DA and cAMP do not stimulate CREB-dependent gene transcription when NMDA receptors (NMDARs) are blocked. (jneurosci.org)
  • Our results suggest that cAMP stimulates CREB-dependent gene transcription via a two-step process by inducing release of an excitatory amino acid, identified here as l -aspartate, which then activates NMDARs, leading to Ca 2+ entry and gene transcription. (jneurosci.org)
  • histone
  • Over the past two decades, it has become clear that Ub-dependent processes impact multiple steps in gene expression, ranging from signaling histone modifications ( 2 ) to coordinating events of mRNA export from the nucleus ( 3 ). (pnas.org)
  • biosynthesis
  • In addition, the proline biosynthesis genes, Δ 1 -Pyrroline-5-Carboxylate Synthase 1 and 2 ( P5CS1 and P5CS2 ) were up-regulated in HvPIP2;5 overexpressing plants under salt and osmotic stresses, which coincided with increased levels of the osmoprotectant proline. (frontiersin.org)
  • Molecular data indicated that genes involved in GA biosynthesis/response are affected in SPL8 overexpressing lines, suggesting altered endogenous GA levels. (uni-koeln.de)
  • transcript
  • Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. (genecards.org)
  • Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (genecards.org)
  • DDIT3 (DNA Damage Inducible Transcript 3) is a Protein Coding gene. (genecards.org)
  • Multiple alternatively spliced transcript variants of this gene have been described. (nih.gov)
  • Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. (nih.gov)
  • This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. (nih.gov)
  • Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (nih.gov)
  • Mutations
  • Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. (genecards.org)
  • Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). (genecards.org)
  • Mutations in this gene are associated with acute myeloid leukemia. (nih.gov)
  • Mutations in this gene are associated with pituitary tumors. (genecards.org)
  • thereby
  • Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. (genecards.org)
  • A local treatment can thereby be beneficial to the patients, and gene therapy with an intrapleural administration of vectors is one of the potential therapeutics. (hindawi.com)
  • subsequent
  • Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. (genecards.org)
  • genetic
  • How are genetic conditions and genes named? (nih.gov)
  • Further studies, aiming at the identification of target genes and genetic interactions with other GA-signaling components, are needed to deepen our understanding of the role SPL8 plays in these more defined aspects of plant development. (uni-koeln.de)
  • enzyme
  • The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. (genecards.org)
  • We also show that Asr1 interacts with Ubp3, an enzyme that reverses ubiquitylation, and that the two play antagonistic roles in silencing subtelomeric genes. (pnas.org)
  • roles
  • Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. (nih.gov)
  • Relaxed selection may play important roles in the process of functional differentiation evolved through gene duplications as well. (biomedcentral.com)
  • polymerase
  • We present evidence that the ubiquitin ligase Asr1 associates with subtelomeric DNA and ubiquitylates RNA polymerase II to prevent it from transcribing genes at these locations. (pnas.org)
  • tumor
  • Promyelocytic leukemia tumor suppressor gene concentrates in distinct subnuclear structures known as PML-Nuclear Bodies (PML-NB), also called PML Oncogenic Domains (POD), Nuclear Domain 10 (ND10), or Kremer bodies ( Bernardi and Pandolfi, 2007 ). (frontiersin.org)