• Glucose-6-phosphate dehydrogenase deficiency is a genetic disorder that affects red blood cells, which carry oxygen from the lungs to tissues throughout the body. (medlineplus.gov)
  • The most common medical problem associated with glucose-6-phosphate dehydrogenase deficiency is hemolytic anemia, which occurs when red blood cells are destroyed faster than the body can replace them. (medlineplus.gov)
  • In people with glucose-6-phosphate dehydrogenase deficiency, hemolytic anemia is most often triggered by bacterial or viral infections or by certain drugs (such as some antibiotics and medications used to treat malaria). (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase deficiency is also a significant cause of mild to severe jaundice in newborns. (medlineplus.gov)
  • An estimated 400 million people worldwide have glucose-6-phosphate dehydrogenase deficiency. (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase deficiency results from variants (also called mutations) in the G6PD gene. (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase deficiency occurs most frequently in areas of the world where malaria is common. (medlineplus.gov)
  • However, many females with one altered copy of this gene have glucose-6-phosphate dehydrogenase deficiency similar to affected males because the X chromosome with the normal copy of the G6PD gene is turned off through a process called X-inactivation . (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase deficiency causes haemolytic anaemia in the presence of simple infection, ingestion of fava beans or reaction with certain medicines, antibiotics, antipyrectics and anti- malarial. (scirp.org)
  • Haemoglobinophathies (including thalassaemia and sickle-cell disease) and glucose-6-phosphate dehydrogenase deficiency, which are not covered by the ICD-10 definition of congenital anomalies, account for 6% of all congenital disorders. (who.int)
  • Glucose-6-Phosphate dehydrogenase deficiency incidence in a Hispanic population. (cdc.gov)
  • BackgroundX-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. (tropmedres.ac)
  • The protective effect in heterozygous females is 0.78 (95% CI, 1.09-0.53) of that observed in hemizygous males and homozygous females.InterpretationThe G6PD Mediterranean genotype confers a very large and gene dose proportional protective effect against vivax malaria. (tropmedres.ac)
  • If variants in the G6PD gene reduce the amount of glucose-6-phosphate dehydrogenase or alter its structure, this enzyme can no longer play its protective role. (medlineplus.gov)
  • In females, who have two copies of the X chromosome, one altered copy of the G6PD gene in each cell can lead to less severe features of the condition or may cause no signs or symptoms at all. (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) (EC 1.1.1.49) is a cytosolic enzyme that catalyzes the chemical reaction D-glucose 6-phosphate + NADP+ + H2O ⇌ 6-phospho-D-glucono-1,5-lactone + NADPH + H+ This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). (wikipedia.org)
  • G6PD reduces NADP+ to NADPH while oxidizing glucose-6-phosphate. (wikipedia.org)
  • Humans also have two isoforms of a single gene coding for G6PD. (wikipedia.org)
  • Glucose-6-phosphate dehydrogenase in western Islamic Republic of Iran) to [G6PD] deficiency is a common X-linked find the prevalence of G6PD deficiency. (who.int)
  • 6-phosphate dehydrogenase (G6PD) of Physicians and Surgeons Pakistan , deficiency. (who.int)
  • The enzyme glucose-6-phosphate dehydrogenase (G6PD) catalyses the metabolite glucose-6-phosphate in producing NADPH throughout the first part of pentose-phosphate pathway thus gives decreasing energy to all cells for mobile development, antioxidant defence, and biosynthetic reactions in all dwelling organism. (redasoft.com)
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder that can result in destruction of red blood cells (hemolysis) after an acute illness or use of certain drugs. (msdmanuals.com)
  • People who have G6PD deficiency inherit a defect in the gene responsible for producing G6PD so they do not have enough of the enzyme in their blood cells. (msdmanuals.com)
  • However, activity of the G6PD gene is highly variable, so in some people G6PD does not work quite as well as it should and in others it does not work at all. (msdmanuals.com)
  • GAPDH catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). (avivasysbio.com)
  • Rankings provided from the three programs were similar between the two-row and the six-row and with exception of BestKeeper's ranking of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). (usda.gov)
  • Our results show that Actin (ACT) and Heat Shock Protein 70 (HSP70) were the most stable throughout micromalting, while Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Cyclophilin (CYP) were the least stable. (usda.gov)
  • Predicted to be part of glycerol-3-phosphate dehydrogenase complex. (nih.gov)
  • Pentose phosphate pathway. (lu.se)
  • In affected individuals, a defect in an enzyme called glucose-6-phosphate dehydrogenase causes red blood cells to break down prematurely. (medlineplus.gov)
  • This gene provides instructions for making an enzyme called glucose-6-phosphate dehydrogenase. (medlineplus.gov)
  • Glucose-6-phosphate dehydrogenase is also an enzyme in the Entner-Doudoroff pathway, a type of glycolysis. (wikipedia.org)
  • This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. (nih.gov)
  • The enzyme shows more affinity towards NADP + than glucose-6-phosphate. (scirp.org)
  • Keeping in view the clinical significance of the enzyme and less studied from plant sources the present study has been aimed with purification and characterization of glucose-6-phosphate dehydrogenase from pigeon pea seeds. (scirp.org)
  • Specifically, few Gene Ontology biological processes (BPs) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were modulated after a short (24H) compared to a long (48H) treatment. (nature.com)
  • DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that the candidate reference genes were significantly enriched in cellular metabolic process, protein metabolic process and ribosome in early development and normal adult tissues as well as in cellular localization and endocytosis in the hindgut under sulfide stress. (biomedcentral.com)
  • GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
  • Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes. (yeastgenome.org)
  • Predicted to be involved in glycerol catabolic process and glycerol-3-phosphate metabolic process. (nih.gov)
  • It catalyzes the transformation of glucose-6-phosphate to 6-phosphogluconolactone concomitant with conversion of NADP to NADPH. (scirp.org)
  • D-glucose 6-phosphate + NADPH(+) = d-glucono-1,5-lactone 6-phosphate + NADPH. (lu.se)
  • The scripts used for RNA-seq data analysis including differential gene expression and gene set enrichment analysis can be found in https://github.com/akaraw/Yanshan_Zhu_et_al . (plos.org)
  • The expression level of target genes was examined by PCR, western blot, and immunohistochemistry (IHC). (hindawi.com)
  • In order to enhance berry coloration of bright-red grape cultivars, the effects of abscisic acid (ABA) treatment on the quantity and composition of anthocyanins as well as the expression of genes related to flavonoid biosynthesis in the berry were examined. (scirp.org)
  • Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)
  • Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)
  • We hypothesized a HFD may affect expression of genes involved in mitochondrial function and biogenesis. (diabetesjournals.org)
  • Two recent microarray studies have shown that genes involved in oxidative phosphorylation (OXPHOS) exhibit reduced expression levels in the skeletal muscle of type 2 diabetic subjects and prediabetic subjects. (diabetesjournals.org)
  • PGC1α- and PGC1β-responsive OXPHOS genes show reduced expression in the muscle of patients with type 2 diabetes ( 3 , 4 ). (diabetesjournals.org)
  • In addition to the cellular energy sensor AMP kinase, the peroxisome proliferator-activated receptor cofactors PGC1α ( 5 , 6 , 7 ) and possibly PGC1β ( 8 ) activate mitochondrial biogenesis and increase OXPHOS gene expression by increasing the transcription, translation, and activation of the transcription factors necessary for mitochondrial DNA (mtDNA) replication. (diabetesjournals.org)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • RNA extracted from mock-infected and WNV-infected cells was assessed for differential expression of genes using Affymetrix microarray. (molvis.org)
  • Low-level WNV infection of hRPE cells induced expression of genes that are typically associated with the host cell response to virus infection. (molvis.org)
  • Changes in morphology were imaged, and changes in gene expression of CEC typical genes such as zonula occludens (ZO-1), sodium/potassium (Na/K)-ATPase, paired-like homeodomain 2 (PITX2), and collagen 8 (COL-8) were measured with real-time polymerase chain reaction. (lww.com)
  • Adhesion of MSCs to DLT molded in silicone and particularly in collagen initiates polygonal morphology and monolayer formation and enhances not only transcription of CEC typical genes such as ZO-1, Na/K-ATPase, PITX2, and COL-8 but also expression of the corresponding proteins. (lww.com)
  • This study provides a differential gene expression profile between TMJ fibrous and bony ankylosis. (medscimonit.com)
  • Despite this, there is still a lack of information regarding the expression of key genes related to phosphate-solubilization (PS) and efficient formulation strategies. (ufz.de)
  • SSR (DSM 109610) by relating it to bacterial gene expression and searching for an efficient formulation. (ufz.de)
  • SSR inoculated soil supplemented with rock phosphate (RP) showed a 6-fold higher expression of pqqC and pho compared to inoculated soil without RP. (ufz.de)
  • The present study reports for the first time marker gene expression of an inoculated PSB strain and provides a valuable groundwork to design field scale formulations that can maintain inoculum dynamics and increase its shelf life. (ufz.de)
  • IPO13 was colocalized with K17 in the epithelium of the pterygium, and overexpression or knockdown of the IPO13 gene induced upregulation or downregulation of K17 expression in PECs, respectively. (molvis.org)
  • Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. (jneurosci.org)
  • These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)
  • Real-time quantitative PCR (RT-qPCR) is a crucial and widely used method for gene expression analysis. (biomedcentral.com)
  • The expression stability of the ten genes was analyzed using four methods (geNorm, NormFinder, BestKeeper, and ∆Ct). (biomedcentral.com)
  • Our study is the first to select reference genes for RT-qPCR from transcriptome data in Echiura and provides important information for future gene expression studies in U. unicinctus . (biomedcentral.com)
  • Reference genes are used for the normalization of gene expression because of the stability of expression levels among different tissues, different developmental stages, or under various treatments [ 5 ]. (biomedcentral.com)
  • Data on PCR primer design for glucose 6-phosphate dehydrogenase gene and the effects of dietary carbohydrate levels on its expression in the liver of Malaysian mahseer. (redasoft.com)
  • Beyond this time, no differences in global gene expression in infected and control animals were detectable by microarray analysis. (biomedcentral.com)
  • Whereas in the acute phase of the disease immunoregulatory processes prevail in the hippocampus and the cortex, we observed a strong activation of neurogenic processes in the hippocampal dentate gyrus, both by gene expression and immunohistology starting as early as 3 days after infection. (biomedcentral.com)
  • For this purpose we evaluated the gene expression profile of the two brain structures predominantly affected by brain damage, i.e. the cortex and the hippocampus, at four different stages of the disease in an infant rat model. (biomedcentral.com)
  • We identified the most stable genes to study gene expression in micromalting as Actin and Heat Shock Protein 70. (usda.gov)
  • The aim of this study was to assess the mRNA expression of MIF gene and its serum levels in the clinical manifestations of ACS and unrelated individuals age- and sex-matched with patients as the control group (CG). (hindawi.com)
  • All samples were run using the conditions indicated in TaqMan Gene Expression Assay protocol. (hindawi.com)
  • We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
  • METHODS: We obtained gene expression profiles of patients with HCC from 20 independent cohorts available in public databases. (bvsalud.org)
  • Compared to controls, treatment with PMA, arsenic, and phenol resulted in increases in IL1alpha gene expression by six fold, three fold, and two fold, respectively. (cdc.gov)
  • Treatment with dermatotoxic chemicals did not alter G3PDH gene expression. (cdc.gov)
  • Academy of Sciences of the United States phosphate dehydrogenase phenotypes of America , 1988, 85:5171-5. (who.int)
  • Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
  • Primer sequences for interleukin-1alpha (IL1alpha), c-jun, c-fos, and glyceraldehyde-3-phosphate- dehydrogenase (G3PDH) were used. (cdc.gov)
  • In the inherited hemolytic anemias, one or more of the genes that control the production of red blood cells are defective, causing the bone marrow to make abnormal cells. (daviddarling.info)
  • Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
  • Genetic of glucose-6-phosphate dehydrogenase blood disorders survey in the Sultanate deficiency in the Fars province of Iran. (who.int)
  • Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia. (nih.gov)
  • Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
  • The location of exon 4 mutations in RP1 raises challenges for genetic counselling and gene therapy. (cdc.gov)
  • Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. (nih.gov)
  • Combined, these results suggest a mechanism whereby HFD downregulates genes necessary for OXPHOS and mitochondrial biogenesis. (diabetesjournals.org)
  • Moreover, at least 168 disease-causing mutations in this gene have been discovered. (wikipedia.org)
  • The high HCC4 score group shows a higher frequency of mutations in genes TP53, RB1 and TSC1/2, as well as increased activity of cell-cycle, glycolysis and hypoxia signaling pathways, higher cancer stemness score, and lower lipid metabolism activity. (bvsalud.org)
  • To identify key genes differentially expressed in the human retinal pigment epithelium (hRPE) following low-level West Nile virus (WNV) infection. (molvis.org)
  • Functional annotation clustering of the microarray data showed that gene clusters involved in immune and antiviral responses ranked highly, involving genes such as chemokine (C-C motif) ligand 2 ( CCL2 ), chemokine (C-C motif) ligand 5 ( CCL5 ), chemokine (C-X-C motif) ligand 10 ( CXCL10 ), and toll like receptor 3 ( TLR3 ). (molvis.org)
  • Birth defects are a diverse group of disorders of prenatal origin which can be caused by single gene defects, chromosomal disorders, multifactorial inheritance, environmental teratogens and micronutrient deficiencies. (who.int)
  • X-Linked Inheritance Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body or code for functional RNA molecules. (msdmanuals.com)
  • A reduction in the amount of functional glucose-6-phosphate dehydrogenase appears to make it more difficult for this parasite to invade red blood cells. (medlineplus.gov)
  • The aim of the study was to screen the downstream functional genes of THSD7A and explore their functions in ESCC, based on the reported research into THSD7A function and on gene microarrays. (hindawi.com)
  • However, whether there are functional target genes downstream of THSD7A in ESCC has not been reported. (hindawi.com)
  • The candidate reference genes STX12 , EHMT1 , and LYAG were the most stable genes in early development, normal adult tissues, and hindgut under sulfide stress, respectively. (biomedcentral.com)
  • Our previous study found that the thrombospondin type 1 domain-containing 7A ( THSD7A ) gene plays a procancer role in ESCC and participates in important signaling pathways, including mammalian target of rapamycin (mTOR). (hindawi.com)
  • Gene enrichment analysis revealed that these lncRNA-related mRNAs are associated with cell adhesion, collagen adhesion, cell differentiation, and mainly enriched in ECM-receptor interaction and PI3K-Akt signaling pathways. (biomedcentral.com)
  • The effects of these target genes on ESCC malignant biological behavior were performed in vivo and in vitro . (hindawi.com)
  • The Kaplan-Meier (K-M) survival analysis and Cox regression were used to analyze the prognostic significance of target genes in ESCC patients. (hindawi.com)
  • We further explored the cancer-promoting mechanism of target genes in ESCC by sequencing of the genes' exons. (hindawi.com)
  • Selecting suitable reference genes is extremely important for the accuracy of RT-qPCR results. (biomedcentral.com)
  • Commonly used reference genes are not always stable in various organisms or under different environmental conditions. (biomedcentral.com)
  • With the increasing application of high-throughput sequencing, transcriptome analysis has become an effective method for identifying novel stable reference genes. (biomedcentral.com)
  • In this study, we identified candidate reference genes based on transcriptome data covering embryos and larvae of early development, normal adult tissues, and the hindgut under sulfide stress using the coefficient of variation (CV) method in the echiuran Urechis unicinctus , resulting in 6834 (15.82%), 7110 (16.85%) and 13880 (35.87%) candidate reference genes, respectively. (biomedcentral.com)
  • Subsequently, ten genes including five new candidate reference genes and five commonly used reference genes, were validated by RT-qPCR. (biomedcentral.com)
  • The comprehensive results indicated that the new candidate reference genes were more stable than most commonly used reference genes. (biomedcentral.com)
  • Therefore, two or more reference genes are desirable to improve the reliability and accuracy of the RT-qPCR results. (biomedcentral.com)
  • With the increasing application of high-throughput sequencing, RNA-seq has provided a new strategy for identifying new highly stable reference genes from transcriptome data. (biomedcentral.com)
  • The most commonly used method of interpretation is relative quantification and thus necessitates the use of normalization controls (i.e. reference genes) to standardize transcript abundance. (usda.gov)
  • This is the first study to examine the potential of several reference genes for using in qPCR normalization during barley malting. (usda.gov)
  • We compared the stability of 13 reference genes across both two-and six-row malting barleys (Conrad and Legacy, respectfully) throughout the entirety of the malting process. (usda.gov)
  • Two reference genes are necessary for stable transcript normalization according to geNorm and the best two reference genes (ACT and HSP70) provided a sufficient level of stability. (usda.gov)
  • one includes structural genes encoding enzymes that directly participate in the formation of anthocyanins and other flavonoids, and the other comprises regulatory genes controlling the transcription of structural genes. (scirp.org)
  • DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
  • these often differ significantly from the 'housekeeping' genes commonly used for normalisation in transcriptomics and qPCR studies. (biorxiv.org)
  • qPCR primers were designed for PS marker genes glucose dehydrogenase (gcd), pyrroloquinoline quinone biosynthesis protein C (pqqC) and phosphatase (pho). (ufz.de)
  • RT-qPCR is a relatively modern technique that is commonly employed to measure gene transcript abundance. (usda.gov)
  • In order to use RT-qPCR effectively, researchers must first run preliminary experiments that identify genes that are stably expressed to use as a normalizer. (usda.gov)
  • The most popular gene targets for RT-qPCR are housekeeping genes because they are thought to maintain a static transcript level among a variety of samples. (usda.gov)
  • We adopted quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and Celigo high-content screening (HCS) technology to screen the downstream genes of THSD7A . (hindawi.com)
  • encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
  • Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. (thermofisher.com)
  • Quantitative real-time PCR analysis revealed that ABA treatment around véraison resulted in the upregulation of genes encoding enzymes responsible for both general flavonoid and anthocyanin biosynthesis. (scirp.org)
  • Ten DEGs, including 7 hub genes from PPI analysis, were confirmed by real-time PCR. (medscimonit.com)
  • Incidence and molecular polymerase-chain-reaction amplification analysis of glucose-6-phosphate dehyd- of the entire coding region from genomic rogenase deficiency in the province of DNA. (who.int)
  • dehydrogenase deficiency in some ethnic recommended screening test for glucose- groups of Pakistan. (who.int)
  • Proposal for an individualized dietary strategy in patients with very long-chain acyl-CoA dehydrogenase deficiency. (cdc.gov)
  • Affinity chromatography (2', 5'-ADP Sepharose 4B) first used by De Flora [20] is a common tech- nique for purification of glucose-6-phosphate dehydrogenase. (scirp.org)
  • The reports on purification of glucose-6-phos- phate dehydrogenase from plant sources are very less. (scirp.org)
  • Additionally, we have determined that only two genes are required for sufficient normalization under micromalting conditions. (usda.gov)
  • In addition, silencing of the IPO13 gene blocked nuclear translocation of c-Jun. (molvis.org)
  • In addition, STARD12/14 could regulate the ferroptosis related genes. (medsci.org)
  • Applying phosphate solubilizing bacteria (PSB) as bio-fertilizers has enormous potential for sustainable agriculture. (ufz.de)
  • Therefore, it is important to explore candidate genes that could have significance to the clinical diagnosis, as well as the treatment of esophageal squamous cell carcinoma (ESCC) at the molecular level [ 4 ]. (hindawi.com)
  • Tumor-related studies have shown the clinical application and research prospects of this gene, suggesting that it might play the important role in the treatment of tumors. (hindawi.com)
  • At present, there is a paucity of robust gene signatures that could assist clinicians in making clinical decisions for patients with HCC. (bvsalud.org)
  • Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital-based study. (cdc.gov)
  • Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds. (medscape.com)
  • meaning that mainly males are affected and females are carriers of the defective gene. (msdmanuals.com)
  • Chemical reactions involving glucose-6-phosphate dehydrogenase produce compounds that prevent reactive oxygen species from building up to toxic levels within red blood cells. (medlineplus.gov)
  • The authors conclude that dermatotoxic chemical exposure increases the AP1 DNA binding activity and the stimulation of early/immediate genes. (cdc.gov)
  • Quantitative real-time PCR analysis of 23 genes was used to validate the microarray results. (molvis.org)
  • Polymerase chain reaction (PCR) assays and sequencing was used to determine the presence of β-lactamase encoding genes (bla) including bla NDM-1 and plasmid-mediated quinolone and aminoglycoside resistance determinants. (who.int)
  • Analysis of ribosomal RNA genes suggests that trypanosomes are monophyletic. (wikimedia.org)
  • At least immunofluorescence analysis has been conducted to confirm gene data on the protein level. (lww.com)
  • The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
  • We found that scavenger receptor class A member 5( SCARA5 ), located on chromosome 8p21.1, is the downstream driving gene of THSD7A in ESCC [ 5 ]. (hindawi.com)
  • On the other hand, the gene expressions of enzymes involved in proanthocyanidin synthesis were drastically decreased at véraison and remained extremely low even with ABA treatment. (scirp.org)