AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
Arabidopsis ProteinsArabidopsisCyclin BCyclin D1Cyclin ACdh1 ProteinsCyclin B1Gene Expression Regulation, PlantCyclin ECyclinsMitosisPlants, Genetically ModifiedGenes, PlantCyclin D3Cyclin D2Cyclin A1SecurinUbiquitin-Protein Ligase ComplexesCell Cycle ProteinsAnaphase-Promoting Complex-CyclosomeCDC28 Protein Kinase, S cerevisiaeMutationMolecular Sequence DataCyclin A2CDC2 Protein KinaseCyclin DPlant RootsCdc20 ProteinsCell CyclePlant LeavesAnaphasePlant ProteinsFungal ProteinsAmino Acid SequenceG1 PhaseSaccharomyces cerevisiae ProteinsLigasesRNA, PlantSeedlingFlowersSeedsDNA, PlantCyclin G1Cyclin GSchizosaccharomyces pombe ProteinsSaccharomyces cerevisiaeIndoleacetic AcidsGenome, PlantPlant Growth RegulatorsCyclin CSchizosaccharomycesPlant ShootsCyclin-Dependent KinasesMeristemGerminationPhenotypeAbscisic AcidPlant EpidermisCyclin B2Ubiquitin-Protein LigasesEthylenesSequence Homology, Amino AcidPhosphorylationOxylipinsSalicylic AcidNuclear ProteinsPlant DiseasesSpindle ApparatusCyclin TCyclopentanesBase SequenceCyclin-Dependent Kinase 2Cyclin HCyclin G2Genetic Complementation TestTranscription FactorsCotyledonLightPhylogenyMADS Domain ProteinsMutagenesis, InsertionalCyclin-Dependent Kinase 4Sequence AlignmentCytokininsChloroplastsAGAMOUS Protein, ArabidopsisCDC2-CDC28 KinasesPseudomonas syringaePlant StomataSignal TransductionCloning, MolecularPlastidsPlant StructuresPlant StemsGibberellinsOryza sativaGlucosinolatesMultigene FamilyPollenRNA, Messenger
ProteinSpindleDifferentiallyPutativeKinasesProteinsChromosomeProgressionMitosisInhibitorsTransitionRegulatorsAnnotationTranscriptionCheckpointHighly conservedHomologsAnalyzed gene expressionOntologyMeiosisRegulationSubunitOverexpressionDistinctNucleotidePathwayInstabilityAuxinPrimordiaControlDroughtTranscriptTobaccoSequenceMolecular functionFamilyFunctionDevelopmentSignificantlyReproductiveIdentityPlantEssentialStudyInteractionTypeAnalysisDomain
Protein10
  • In this report, we describe a testis zinc finger protein (Tzfp) that binds to the upstream flanking sequence of the Aie1 gene. (lookformedical.com)
  • Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
  • 6.Soni R,Carmichael J P,Shah Z H,et al.A family of cyclin D homologs from plants differentially controlled by growth regulators and containing the conserved retinoblastoma protein interaction motif［J］.Plant Cell,1995,7(1):85-103. (nefu.edu.cn)
  • 9.Jacqmard A,De Veylder L,Segers G,et al.Expression of CKS1At in Arabidopsis thaliana indicates a role for the protein in both the mitotic and the endoreduplication cycle［J］.Planta,1999,207(4):496-504. (nefu.edu.cn)
  • Ameiotic1 ( Am1 ) encodes a plant-specific nuclear protein (AM1) required for meiotic entry and progression through early prophase I. Pollen mother cells (PMCs) remain mitotic in most am1 mutants including am1-489 , while am1-praI permits meiotic entry but PMCs arrest at the leptotene/zygotene (L/Z) transition, defining the roles of AM1 protein in two distinct steps of meiosis. (biomedcentral.com)
  • Here we address the posttranslational regulation of INHIBITOR/INTERACTOR OF CDK 1 (ICK1)/KIP RELATED PROTEIN 1 ( KRP1), an Arabidopsis ( Arabidopsis thaliana) CDK inhibitor. (uni-bielefeld.de)
  • Centromere-associated protein-E (CENP-E) is an essential mitotic kinesin that is required for efficient, stable microtubule capture at kinetochores. (rupress.org)
  • Interestingly, altered F-box protein gene expression was also observed in CSN2 and CSN5 knockdowns, suggesting a potential role of the CSN in regulating F-box protein transcription. (biomedcentral.com)
  • Homo sapiens BUB3 mitotic checkpoint protein (BUB3), transcript variant 2, mRNA. (dbcls.jp)
  • Geminiviral V2 Protein Suppresses Transcriptional Gene Silencing through Interaction with AGO4. (ncsu.edu)
Spindle5
  • It is initially barrel-shaped and forms from the mitotic spindle between the two daughter nuclei while nuclear envelopes reassemble around them. (wikipedia.org)
  • An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
  • A previous screen of a human kinase and phosphatase shRNA library to select genes that mediate arsenite induction of spindle abnormalities resulted in the identification of phosphatidylinositol-5-phosphate 4-kinase type-2 gamma (PIP4KIIγ), a phosphatidylinositol 4,5-bisphosphate (PIP2)-synthesizing enzyme. (biomedcentral.com)
  • Depletion of PIP4KIIγ enhanced the spindle pole accumulation of mitotic centromere-associated kinesin (MCAK), a microtubule (MT)-depolymerizing kinesin, and resulted in a less stable spindle pole-associated MT. Depletion of MCAK can ameliorate PIP4KIIγ depletion-induced spindle abnormalities. (biomedcentral.com)
  • In addition, coordination of MT polymerization/depolymerization at both ends to maintain the size and shape of mitotic spindles is also critical for the proper formation and function of the mitotic spindle. (biomedcentral.com)
Differentially2
  • This analysis revealed a developmental time point between 10 and 12 days after germination where FLC expression had decreased but LFY expression had not yet increased, which was characterized by a peak in the number of differentially expressed genes. (biomedcentral.com)
  • There are substantially more absolute On/Off and twice as many differentially expressed genes (sterile versus fertile) in am1-489 than in am1-praI . (biomedcentral.com)
Putative1
  • Many putative meiosis-related genes were found among them including a small subset of allele-specific, mis-regulated genes specific to the PMCs. (biomedcentral.com)
Kinases1
Proteins4
  • The anaphase promoter complex (APC) is a multiprotein complex - an ubiquitin E3 ubiquitin ligase - involved in ubiquitin-dependent proteolysis of cell cycle regulatory proteins, and in which we include the destruction of mitotic cyclins during the metaphase-anaphase transition. (fapesp.br)
  • In Arabidopsis thaliana, the SIAMESE-RELATED proteins (SIM/SMR1 to 13) are a plantspecific family of Cyclin-dependent Kinase Inhibitors (CKIs), homologous to the Kip-Related Proteins. (hal.science)
  • Chez Arabidopsis thaliana, les protéines SIAMESE-RELATED (SIM/SMR1 à 13) forment une famille plante-spécifique d'Inhibiteurs de Kinase Cycline-dépendante (CKI), homologue des Kip-Related Proteins. (hal.science)
  • Inhibition of Arabidopsis thaliana CIN-like TCP transcription factors by Agrobacterium T-DNA-encoded 6B proteins. (cnrs.fr)
Chromosome3
  • The mouse Tzfp gene, mapped to chromosome 7 B2-B3, encodes a 465-amino acid transcription factor containing a conserved N-terminal BTB/POZ domain and three C-terminal PLZF-like C(2)H(2) zinc fingers. (lookformedical.com)
  • FoxM1 is required for execution of the mitotic programme and chromosome stability. (knaw.nl)
  • Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. (tamu.edu)
Progression5
  • 1.Oakenfull E A,Riou-Khamlichi C,Murray J A.Plant D-type cyclins and the control of G1 progression［J］.Philos Trans R Soc Lond B Biol Sci,2002,357(1422):749-760. (nefu.edu.cn)
  • Our analysis of anther transcriptome modulations by two distinct am1 alleles, am1-489 and am1-praI , redefines the role of AM1 as a modulator of expression of a subset of meiotic genes, important for meiotic progression and provided stage-specific insights into the genetic networks associated with meiotic entry and early prophase I progression. (biomedcentral.com)
  • Recent studies have shown that cyclin-dependent kinase (CDK) inhibitors can have a tremendous impact on cell cycle progression in plants. (uni-bielefeld.de)
  • It has been demonstrated that members of the PIP5KI and PIP4KII families are specifically phosphorylated at the mitotic stage [ 9 ], suggesting that they may contribute to the control of mitotic progression. (biomedcentral.com)
  • Moreover, TSPAN12 accelerated mitotic progression by controlling cell cycle. (molcells.org)
Mitosis1
  • These mitotic kinesins are spatially and temporally regulated to stringently control their localized activity towards both ends of MTs at each stage of mitosis, thereby ensuring mitotic fidelity [ 3 ]. (biomedcentral.com)
Inhibitors3
  • We detected several other auxin related genes, including the pair of Gm09g38700 considering and Glyma18g47630 paralogs Inhibitors,Modulators,Libraries that are homologs of Arabidopsis PIN FORMED 5, which is required for auxin homoeostasis and gametophyte development. (plcsignaling.com)
  • In contrast, the 539 hypocotyl PEGs were enriched for an auxin mediated signaling pathway, and or Inhibitors,Modulators,Libraries photo morphogenesis, including homologs of the Arabidopsis NON PHOTOTROPIC HYPOCOTYL 3 gene. (plcsignaling.com)
  • As shown in Figure 4, AM was highly similar to both SAM38D and IBM, pairwise comparison would probably miss Inhibitors,Modulators,Libraries many genes active in meristems. (plcsignaling.com)
Transition2
  • We discovered an unprecedented burst of differential expression of cell cycle related genes at one particular point during transition to flowering. (biomedcentral.com)
  • Analysis of mutants with abnormal flowering time has allowed the identification of genes controlling floral transition [ 8 ]. (biomedcentral.com)
Regulators1
  • SIM and SMR1 are positive regulators of the switch from mitotic cycle to endoreplication. (hal.science)
Annotation2
  • Gene Ontology (GO) has been widely used in biological databases, annotation projects, and computational analyses. (biomedcentral.com)
  • Although the three root GO categories (MF, BP and CC) are structured as independent ontologies, their biological relationships (especially between BP and MF terms) may provide useful evidence for gene annotation [ 7 ]. (biomedcentral.com)
Transcription1
  • This phase separation might help P-TEFb to promote gene transcription. (natureasia.com)
Checkpoint2
  • It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset. (rupress.org)
  • Thus, CENP-E is required for enhancing recruitment of its binding partner BubR1 to each unattached kinetochore and for stimulating BubR1 kinase activity, implicating it as an essential amplifier of a basal mitotic checkpoint signal. (rupress.org)
Highly conserved1
  • Many genes essential for meiosis are highly conserved in fungi, invertebrates, mammals, and plants. (biomedcentral.com)
Homologs3
  • For instance, the PEGs included several homologs of SHORT VEGETATIVE PHASE that specify the reproductive organ identity and control flowering time in Arabidopsis and rice and genes involvement in WUSCHEL regulatory network essential for SAM maintenance. (plcsignaling.com)
  • We also found homologs of genes for auxin synthesis and response, such as YUCCA4, in accordance with the fact that the Arabidopsis YUCCA4 expression is restricted to the SAM and flower meristems or young floral primordia, as well so as 20 genes related to auxin responsive genes regulating SAM development. (plcsignaling.com)
  • Unlike the expression of Arabidopsis MS5 and MMD1 genes restricted in meiocytes, the soybean homologs showed high expression in AM, suggesting a possible unknown function in soybean. (plcsignaling.com)
Analyzed gene expression1
Ontology2
  • Gene Ontology (GO) enrichment analysis of these genes identified an overrepresentation of genes related to the cell cycle. (biomedcentral.com)
  • However, the existing cross-category ontology term similarity measures are either developed by utilizing the GO data only or based on manually curated term name similarities, ignoring the fact that GO is evolving quickly and the gene annotations are far from complete. (biomedcentral.com)
Meiosis1
  • For instance, in addition to the identification of several flower organ identity genes from ABC model, we also found genes specifically for meiosis, such as MS5 and MMD1. (plcsignaling.com)
Regulation4
  • Taken together, our results indicate that Tzfp recognizes a sequence-specific motif (tbs) and may play a role in the regulation of the genes carrying the tbs. (lookformedical.com)
  • At least 60 genes have been described as participants in flowering regulation [ 9 ]. (biomedcentral.com)
  • DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
  • Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. (molcells.org)
Subunit1
Overexpression1
Distinct2
  • The spaciotemporal pattern of those inductions revealed two groups of genes with distinct functions. (hal.science)
  • In the networks, the frequently occurred MF-centered hub indicates that a molecular function may be shared by different genes in multiple biological processes, or a set of genes with the same functions may participate in distinct biological processes. (biomedcentral.com)
Nucleotide1
  • In contrast, the same chimera did not activate the reporter gene when an essential nucleotide fifth C was mutated to A at the tbs. (lookformedical.com)
Pathway1
  • The photoperiod-dependent pathway of floral promotion converges on the gene CONSTANS ( CO ), which is known to be expressed in a circadian manner [ 10 ]. (biomedcentral.com)
Instability1
  • The instability of MT dynamics depends heavily on mitotic kinesins, a class of molecular motors, which use the energy from ATP hydrolysis to translocate along the MT or control MT dynamics by facilitating MT polymerization and depolymerization at both ends. (biomedcentral.com)
Auxin1
Primordia1
  • 4.De Veylder L,de Almeida Engler J,Burssens S,et al.A new D-type cyclin of Arabidopsis thaliana expressed during lateral root primordia formation［J］.Planta,1999,208(4):453-462. (nefu.edu.cn)
Control2
  • After flowering initiation, the action of LFY and AP1 , as well as CAULIFLOWER ( CAL ) results in the upregulation of genes that control floral organ identity [ 20 - 23 ]. (biomedcentral.com)
  • These elements are involved in control of gene expression which governs the phenotype and also plays role in disease biology. (researchgate.net)
Drought1
  • During drought stress, the expression of SIM, SMR1, SMR3 and SMR5 genes is induced. (hal.science)
Transcript1
  • Despite extensive studies of specific genes that regulate this process, the global changes in transcript expression profiles at the point when a vegetative meristem transitions into an inflorescence have not been reported. (biomedcentral.com)
Tobacco1
  • The transgenic plants were confirmed by PCR, and the result showed AtCYCD 2;1 gene was integrated into tobacco genome. (nefu.edu.cn)
Sequence1
  • The zinc finger domain of Tzfp binds to the TGTACAGTGT motif (Tzfp binding site, termed tbs) located at the upstream flanking sequence of the Aie1 gene by gel mobility shift, DNase I footprinting, and competition analyses. (lookformedical.com)
Molecular function1
  • For example, if a set of gene products that have the same molecular function often participate in multiple biological processes, then these biological processes may be tightly associated with each other at metabolic level via this molecular function. (biomedcentral.com)
Family1
  • A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)
Function1
  • In this paper we introduce a new cross-category similarity measurement called CroGO by incorporating genome-specific gene co-function network data. (biomedcentral.com)
Development1
  • For annual plants, such as Arabidopsis thaliana , proper determination of the flowering time is critical for plant reproductive success because a switch from vegetative to reproductive development is irreversible. (biomedcentral.com)
Significantly3
  • A cooperative module pair is defined as two modules that significantly cooperate with certain functional genes in a cellular process. (biomedcentral.com)
  • This method identifies cooperative module pairs that significantly influence a cellular process and the correlated genes and interactions that are essential to that process. (biomedcentral.com)
  • In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation of TSPAN12 gene expression was significantly correlated with patient survival, suggesting that TSPAN12 might be a potential prognostic marker for OC. (molcells.org)
Reproductive1
  • However, both genes were found with highest expression in cotyledon, but nearly undetectable in reproductive tissues, suggesting PIN5 may have a divergent role in soybean. (plcsignaling.com)
Identity1
  • It is presently unclear how L2-d cells are programmed to be pre-meiotic within anthers or how this identity is retained during the mitotic divisions prior to PMC maturation. (biomedcentral.com)
Plant2
  • In this project, our aim is to use the TAP (Tandem Affinity Purification) and two hybrid technique to identify new genes in the Arabidopsis model plant, with biotechnological potential for increasing biomass, once its potential is confirmed, we will transfer the knowledge obtained in our study with Arabidopsis to a crop of economic interest in Brazil, tomato, in order to produce plants with greater biomass production. (fapesp.br)
  • 5.Dahl M,Meskiene I,Bögre L,et al.The D-Type alfalfa cyclin gene cycMs4 complements G1 cyclin deficient yeast and is induced in the G1 phase of the cell cycle［J］.Plant Cell,1995,7(11):1847-1857. (nefu.edu.cn)
Essential2
  • The essential mechanism of MAPK cascade for phragmoplast expansion is suppressed by cyclin dependent kinase (CDK) activity before telophase. (wikipedia.org)
  • Although a number of approaches have been used to predict gene functions and interactions, tools that analyze the essential coordination of functional components in cellular processes still need to be developed. (biomedcentral.com)
Study4
  • In our study, CYCD 2;1 was amplified from Arabidopsis inflorescences cDNA by PCR. (nefu.edu.cn)
  • In this work, we present a new approach to study the cooperation of functional modules (sets of functionally related genes) in a specific cellular process. (biomedcentral.com)
  • In this study, we explored how PIP4KIIγ regulates the assembly of mitotic spindles. (biomedcentral.com)
  • In this study, we investigated how TSPAN12 regulates OC cell proliferation both in vitro and in vivo and found that it contributed to tumor proliferation and poor prognosis in this disease through cyclin and cyclin-dependent kinase (CDK) pathways. (molcells.org)
Interaction1
Type1
  • 12.RiouKhamlichi C,Huntley R,Jacqmard A,et al.Cytokinin activation of Arabidopsis cell division through a Dtype cyclin［J］.Science,1999,283(5407):1541-1544. (nefu.edu.cn)
Analysis2
  • 11.You X L,Xing X,Wei Z,et al.Analysis of the expression of a CycB gene isolated from Nicotiana tabacum ［J］.Biotechnology & Biotechnological Equipment,2009,23(2):1194-1198. (nefu.edu.cn)
  • To gain more insights into the roles of AM1 in the transcriptional pre-meiotic and meiotic programs, we report here an in depth analysis of gene expression alterations in carefully staged anthers at 1 mm (meiotic entry) and 1.5 mm (L/Z) caused by each of these am1 alleles. (biomedcentral.com)
Domain2
  • The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)
  • Localization to the chromocenters is mediated by an N-terminal domain, in addition we find that this domain may be involved in cyclin binding. (uni-bielefeld.de)