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  • mutation
  • T is a deletion (see Table 1 for all genes mentioned) that includes a semidominant mutation that has been found in only non- t -carrying wild-type chromosomes. (genetics.org)
  • Differentiation
  • 1995 ) The expression pattern of the Distal-less homeobox-containing gene Dlx-5 in the developing chick limb bud suggests its involvement in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. (biologists.org)
  • Several studies have determined that Shh is indeed the notochord-derived signal that promotes patterns of cellular growth and differentiation within the ventral neural tube including the homeogenetic (like-by-like) induction of its own expression in the floor plate (see Jessell, 2000 ). (biologists.org)
  • Here, we demonstrate that one of the planarian LIM-homeobox genes, Djislet , is required for the differentiation of Djwnt1/P-1 -expressing cells from stem cells at the posterior end. (biologists.org)
  • Here, we describe a new insight into the relationship between Wnt signaling and a LIM homeobox transcription factor in the process of stem cell differentiation, and discuss how planarians coordinate the differentiated cells and stem cells to regulate regeneration. (biologists.org)
  • Further, we show that the floating head homeobox gene is required in axial mesoderm to repress the expression of both spadetail and papc, promoting notochord and blocking differentiation of paraxial mesoderm. (zfin.org)
  • As discussed below, the pancreas was among the first organs in which the importance of epithelial-mesenchymal interactions was recognized ( Golosow and Grobstein, 1962 ), and the development of enzymatic and radio-immunoassays for pancreatic gene products conferred remarkable quantitativeness to studies of the differentiation in this organ ( Pictet and Rutter, 1972 ). (biologists.org)
  • mesodermal
  • Genetic studies show that papc is a close downstream target of spadetail, gene encoding a transcription factor required for mesodermal morphogenetic movements. (zfin.org)
  • embryo
  • This suggests that the Brachyury gene product might interact with multiple factors during embryo development that can affect the variability at which the " T pathway" functions. (genetics.org)
  • Accordingly, the notochord serves as the axial skeleton of the embryo until other elements, such as the vertebrae, form. (biologists.org)
  • axial skeleton
  • Fate mapping studies demonstrated that, following elongation and formation of the primitive axial skeleton, the notochord gives rise to the nucleus pulposus in fully formed intervertebral discs. (biomedsearch.com)
  • somites
  • By blocking Nodal receptor activity at later stages, we demonstrate that Nodal signaling is required from the mid-to-late blastula period to specify sequentially, the somites, notochord, blood, Kupffer's vesicle, hatching gland, heart, and endoderm. (biomedcentral.com)
  • posterior
  • Recently, canonical Wnt/β-catenin signaling was shown to be required for posterior specification, and Hedgehog signaling was shown to control anterior-posterior polarity via activation of the Djwnt1/P-1 gene at the posterior end of planarians. (biologists.org)
  • mutants
  • In both ntl and flh mutants a notochord does not develop, and in cyc mutants the floor plate is nearly entirely missing. (zfin.org)
  • We made double mutants to learn how these genes might interact. (zfin.org)
  • tumor
  • Array-based molecular karyotyping and regional association studies have implicated micro-duplications on chromosome 22q11.21 and polymorphisms in the TP63 ( Tumor protein p63 ) gene [ 15 - 19 ]. (prolekare.cz)
  • Drosophila
  • Blair SS, Brower DL, Thomas JB, Zavortink M (1994) The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. (springer.com)
  • In this study, we isolated a homologue of the Drosophila sog gene in the spider Achaearanea tepidariorum , and characterized its expression and function. (biologists.org)
  • subsequently
  • By day 23, this notochordal process merges with the endodermal cells, forming the notochordal plate, which will subsequently form into the notochord by day 25 [3-(Figure 2 ). (cureus.com)
  • roles
  • These genes are expressed dynamically during the blastula stages and may have different roles at different times. (biomedcentral.com)
  • patterns
  • Several technological innovations have aided recent experimental advances, such as imaging multiple gene expression patterns and comparing genome sequences and homologous gene expression patterns in an ever increasing array of organisms from different branches of evolution. (pubmedcentralcanada.ca)
  • signals
  • There is an incomplete understanding of the genes and signals involved in HSC induction, migration, maintenance, and niche engraftment. (rupress.org)
  • cells
  • The first sign of a notochord in humans was discovered by Virchow and Luschka in 1857 when they found "vacuolated cells" during autopsies . (cureus.com)
  • Of the 20,000 to 30,000 genes now thought to be in the human genome, most cells express only a very small part - which makes sense, a liver cell has little need for the DNA code that makes neurons. (ds9a.nl)
  • Ptf1a
  • Interrogation of reads that had been discarded because only a single end mapped correctly to the Sd locus identified an early transposon (ETn) retroviral insertion at the Sd locus, located 12.5 kb upstream of the Ptf1a gene. (prolekare.cz)