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  • progenitors
  • This process is generally referred to as the dedifferentiation step leading to the formation of blastema progenitors ( Iten and Bryant, 1973 ). (rupress.org)
  • The lack of molecular markers has also obstructed the prospective isolation of blastema progenitors. (rupress.org)
  • stump
  • The EryCs were transported from the stump region to the blastema through regenerating blood vessels/capillaries that extend from the stump to the blastema. (eurekalert.org)
  • distal
  • The homeodomain transcription factor encoded by Distal-less is required for the elaboration of proximodistal pattern elements in Drosophila limbs and can initiate proximodistal axis formation when expressed ectopically. (biologists.org)
  • Distal-less homologs, the Dlx genes, are expressed in developing appendages in at least six phyla, including chordates, consistent with requirements for Dlx function in normal appendage development across the animal kingdom. (biologists.org)
  • Distal-less ( Dll ), as its name suggests, is required for distal limb development. (biologists.org)
  • populations
  • Full limb regenerative capacity of failed stumps was restored by reamputation once endogenous macrophage populations had been replenished. (pnas.org)
  • This method opens up the possibility of marking and perturbing gene function inducibly in any definable cell populations in the axolotl, a key functionality required for the precise, rigorous understanding of processes such as regeneration. (pnas.org)
  • However, due to the lack of targeted gene knockin approaches, it has been difficult to label and manipulate some of the cell populations that are crucial for understanding the mechanisms underlying regeneration. (pnas.org)
  • Using viral vectors, we have found that progenitor populations for many different cell types within the blastema are present at all stages of limb regeneration, although their relative proportions change with time. (biologists.org)
  • stem
  • Studying the hydrozoan Hydractinia echinata we show that a burst of stem cell proliferation occurs following decapitation, forming a blastema at the oral pole within 24 hr. (elifesciences.org)
  • Reducing the activity of certain stem cell genes prevented the new head from growing, but the bud still formed. (elifesciences.org)
  • hindlimb
  • The results of a series of skin grafting experiments performed on the hindlimb of the newt Triturus cristatus are described. (cloudfront.net)
  • Transgenic
  • Transgenic mice were generated carrying the GFP gene driven by a 6.7-kb mouse c -kit promoter linked to fragments derived from the first intron including five chromatin DNase I hypersensitive sites ( 50 ). (pnas.org)
  • This discovery was made using transgenic newts, the use of which has only recently been made possible. (qubitsnews.com)
  • One of the researchers on the team, Martin Casco-Robles, from the Faculty of Life and Environmental Sciences, University of Tsukuba, is a pioneer in developing techniques for the creation of transgenic newts. (qubitsnews.com)
  • The gene was linked to a red fluorescent protein which could be switched on and off at precise times with the addition of a particular chemical to the rearing solution.Selected transgenic newts had a limb removed under anesthesia. (qubitsnews.com)
  • sponges
  • The short synopsis of my reading of this article is simply that by activating a gene that goes back to early evolution, we may be able to regrow limbs like Sponges, worms, or Starfish. (thinkatheist.com)
  • organs
  • It remains to be seen whether Dll and the Dlx genes have similar roles during the development of these organs. (biologists.org)