Gene mucins. Medical search. Frequent questions

Mucus comprises water, glycoproteins (mucins), and ions. (bmj.com)
The MUC7 gene belongs to a group of genes encoding soluble mucin glycoproteins. (benthamscience.com)
Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia. (nih.gov)
Mucins, the main constituents of the mucus layer, are glycoproteins synthesized by goblet cells. (scielo.br)
BACKGROUND AND AIMS: Trefoil factor family (TFF) peptides and the chromosome 11p15.5 mucin glycoproteins are expressed and secreted in a site specific fashion along the length of the gastrointestinal tract. (embl.de)

Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
The Mucin 1 (MUC1) gene encodes a membrane bound glycosylated phosphoprotein, belonging to the family of mucins which are heavily glycosylated proteins. (sigmaaldrich.com)
The MUC1 gene is mapped to human chromosome 1q22. (sigmaaldrich.com)
Mucin 1 (Muc1) exhibits protective action by binding to pathogens and is also associated with cell signaling capacity. (sigmaaldrich.com)
Upregulation of this gene, abnormal intracellular localization and varied glycosylation of Muc1 has been associated with carcinomas. (sigmaaldrich.com)
Mucin-1 kidney disease, previously described as medullary cystic kidney disease type 1 (MCKD1, OMIM 174000), is an autosomal dominant tubulointerstitial kidney disease recently shown to be caused by a single-base insertion within the variable number tandem repeat region of the MUC1 gene. (mit.edu)
This disease, previously referred to as MCKD type 1, is due to a mutation in the variable-number tandem repeat region of the MUC1 (Mucin 1) gene. (medscape.com)
Cancer antigen 15-3, or CA 15-3, is an epitope of a large transmembrane glycoprotein named MUC1 that is derived from the MUC1 gene. (medscape.com)
The MUC1 protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
The CA 15-3 antigen (also known as MUC1, from which it is derived) represents sequences of mucins that are often overexpressed in malignant glandular cells, such as breast cancer. (medscape.com)

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. (wikipedia.org)
New research from Stanford reveals how a class of particularly bushy proteins in this forest, called mucins, could hinder the flu's progression. (phys.org)
Studying it under the microscope, the UCSF team found that, in the presence of the oxidising conditions produced by inflammation of the sort encountered in an infected lung, adjacent strands of mucin proteins become chemically cross-linked together. (thenakedscientists.com)
Compared with individual exposures, co-exposure aerosols produced greater acellular and cellular oxidants detected by electron paramagnetic resonance (EPR) spectroscopy, and in vivo immune-spin trapping (IST), as well as synergistically increased lavage neutrophils, lavage proteins and inflammation related gene/protein expression. (cdc.gov)

1, 2 This review approaches the role of mucin degrading enzymes from the potential interaction of micro-organisms with the cervical mucus barrier, and discusses the contribution that mucin degrading enzymes may make to microbial colonisation of the reproductive tract. (bmj.com)
This gene belongs to the mucin family and is associated with the production of mucus, which lubricates and protects the airways. (indiatimes.com)
Mucus is rich in a gelatinous protein called mucin. (thenakedscientists.com)

Moreover, expression of the gene among unaffected subjects carrying at least one copy of the variant allele was 37.4 times as high as it was among unaffected subjects who were homozygous for the wild-type allele. (genengnews.com)
It is believed that dysfunction in the expression of mucins and aberrant expression of some lncRNAs are associated with the occurrence and development of CRC. (sabanciuniv.edu)
Therefore, the aim of the present study was to investigate the expression of MUC15, MUC16, MUC20, PCAT1, CCAT1 and HOTAIR genes in colorectal cancer and its relationship with clinicopathological variables. (sabanciuniv.edu)
The gene primer was designed and RT-PCR was used to evaluate gene expression. (sabanciuniv.edu)
Results: The results of the present study showed that the expression of MUC15 (P = 0.0012), MUC20 (P = 0.009) and CCAT1 (P = 0.001) genes in patients with colorectal cancer were significantly different from tumor margin samples. (sabanciuniv.edu)
There were also associations between the expression of the studied genes and clinicopathological variables such as grade and stage of colorectal cancer tumor as well as the age of the patients. (sabanciuniv.edu)
Conclusion: The current experiment revealed changes in expression level of mucin genes and lncRNAs in CRC and its different stages, showing that they can be considered as biomarkers for diagnosis of this cancer. (sabanciuniv.edu)
16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
The MUC5AC and MUC2 gene expression was measured by real-time quantitative RT-PCR. (karger.com)
AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
B) Analysis of stem cell proliferation marker gene LGR5 expression by quantitative reverse transcription PCR in undifferentiated HIEs. (cdc.gov)
C) Heat map based on log (2 -∆∆Ct ) comparing gene expression levels for markers of differentiated small intestinal epithelial cells between undifferentiated and 4-day differentiated HIE monolayers. (cdc.gov)
IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone. (nih.gov)
Upon detection of environmental alterations, bacteria adjust their gene expression in order to obtain a phenotype that is suitable for the environment to which they are exposed ( Federle, 2012 ). (frontiersin.org)
Transcriptional regulators enable the microbes to sense and respond to environmental stimuli, by altering gene expression. (frontiersin.org)
Community level coordination of gene expression is known as quorum sensing (QS). (frontiersin.org)
Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
The 3' regulatory regions have a great diversity of cis -regulatory elements directly involved in polyadenylation, stability, transport and mRNA translation, essential to achieve the desired levels of gene expression. (frontiersin.org)
Although a small number of 3' regulatory regions have been identified and validated so far, many studies have shown that plant 3' regulatory regions have a higher potential to regulate gene expression in plants compared to widely used 3' regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. (frontiersin.org)
In this review, we discuss the role of 3' regulatory regions in gene expression, and the superior potential that plant 3' regulatory regions have compared to NOS, OCS and 35S 3' regulatory regions. (frontiersin.org)
Both PWN loading and hypoxia enhanced tracheal elasticity and thickened the apical extracellular matrix (aECM) of the tracheal tubes while a notable upregulated expression of a resilin-like mucin protein Muc91C was observed at the aECM layer of PWN-loaded and hypoxic tracheal tubes. (elifesciences.org)
In essence, OX40 activates the IL-9 gene in T helper cells, leading to the overproduction of IL-9 through a powerful molecular machinery of super-enhancers that regulate gene expression. (medindia.net)
METHODS: Expression of mucin genes in the UACL from small bowel tissue of patients with Crohn's disease was detected by in situ hybridisation, and localisation of the products by immunohistochemistry. (embl.de)
CONCLUSIONS: The UACL has a unique profile of mucin gene expression. (embl.de)
We identified a significant induction of epithelial alarmin (thymic stromal lymphopoietin-TSLP)-dependent interleukin-13 pathway after co-exposure, associated with increased mucin and interferon gene expression. (cdc.gov)
UMOD risk variants identified in the above-mentioned GWAS are located in the promoter region of the gene, leading to a theory that they altered UMOD expression. (medscape.com)

With the rationale that relevant tissue responses can be measured to evaluate the adverse health effects of tobacco products, we assessed changes in mucin secretion and the density and size of goblet cells in an in vitro human air-liquid-interface (ALI) airway tissue model after exposure to a tobacco smoke solution. (cdc.gov)
Mucin secretion returned to baseline levels following a 14-day recovery period. (cdc.gov)
Taken together, our results indicate that ALI cultures can be used to measure the modulation of mucin production, secretion, and clearance, disturbances that are manifested in tobacco smoke-related diseases, such as chronic obstructive pulmonary disease. (cdc.gov)

In particular, they analyzed a region of chromosome 6 known as the major histocompatibility complex (MHC), a polymorphic DNA segment with some 130 genes that encode many of the molecules involved in innate and acquired immune responses. (indiatimes.com)
The locus at chromosome 1q21 was identified by linkage mapping in 1998, but the gene has only recently been discovered due to difficulty with sequencing this highly repetitive region and was previously missed using next-generation sequencing. (medscape.com)

Mucin MUC7, Mucins - Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins (2013) 1: 398. (benthamscience.com)
Our research traced the evolution of an important mucin protein called MUC7 that is found in saliva. (disabled-world.com)
The finding comes from a University at Buffalo-led research project that examined the evolutionary history of MUC7, a gene that codes for an important salivary protein of the same name. (disabled-world.com)
As part of this investigation, the team examined the MUC7 gene in more than 2,500 modern human genomes. (disabled-world.com)
The Sub-Saharan variant was so distinctive that Neanderthal and Denisovan MUC7 genes matched more closely with those of other modern humans than the Sub-Saharan outlier did. (disabled-world.com)
Given the rate that genes mutate during evolution, the team calculated that the ancestors of people who carry the Sub-Saharan MUC7 variant interbred with another ancient human species as recently as 150,000 years ago, after the two species' evolutionary path diverged from each other some 1.5 to 2 million years ago. (disabled-world.com)
In some people, the gene that codes for MUC7 hold six copies of genetic instructions that direct the body to build parts of the corresponding protein. (disabled-world.com)
The evidence for this came from an analysis of biological samples from 130 people, which found different versions of the MUC7 gene were strongly associated with different oral microbiome compositions. (buffalo.edu)
From what we know of MUC7, it makes sense that people with different versions of the MUC7 gene could have different oral microbiomes," Ruhl says. (buffalo.edu)

It makes a sticky protein called mucin that coats urinary tubes inside the kidney. (sciencedaily.com)
Central to their findings was the identification of T helper cells that communicate with mucin-producing cells in the lungs through a small protein called interleukin 9 (IL-9). (medindia.net)

Mucinases are enzymes capable of degrading mucins (the complex high molecular weight molecules that are the major non-aqueous components of mucous gels). (bmj.com)
One of the key features of asthma is an overproduction of a highly sticky protein secreted by the mucous membranes of airways in the lungs, called mucin, which leads to plugging up the small airways and stopping air from traveling in and out of them. (medindia.net)
The researchers hope that their method and findings will help in tackling other viruses that infect individuals through places like the lungs and respiratory tracts, which have mucin-rich mucous coatings. (phys.org)

The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
Embedded in these epithelial cells are a very important cell type called mucin-producing cells that are vital for keeping the epithelial surface moisturized and healthy, and they secrete mucin to protect the surface of the airways. (medindia.net)

1000 mucin-like genes in the parasite genome. (silverchair.com)
Sub-objective 1C: Reduce the incidence of Campylobacter in pre and postharvest poultry using mucin-adapted bacteriophage and genome targeting CRISPR-Cas system. (usda.gov)
Sub-objective 1D: Evaluate the genome wide effect of natural plant compounds and probiotics on Campylobacter especially genes critical for colonization in chicken using high-throughput deep sequencing of mRNA transcripts using RNA-seq. (usda.gov)

In the present study we demonstrate that one such group of genes, termed TcSMUG L , codes for previously unrecognized mucin-type glycoconjugates anchored to and secreted from the surface of insect-dwelling epimastigotes. (silverchair.com)

This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. (wikipedia.org)
MUC-4 belongs to the human mucin family that is membrane-anchored and can range in molecular weight from 550 to 930 kDa for the actual protein, and up to 4,650 kDa with glycosylation. (wikipedia.org)
MUC4 mucin consists of a large extracellular alpha subunit that is heavily glycosylated and a beta subunit that is anchored in the cell membrane and extends into the cytosol. (wikipedia.org)
Epithelial mucins can be classified into two distinct families: secretory (gel forming) and membrane bound. (bmj.com)
Once a virus is successfully bound, the cell membrane folds back on itself to swallow the virus, along with the mucins and other cell surface sugars in the vicinity, to make a small bubble inside the cell, called an endosome. (phys.org)
The researchers wanted to deconvolute the ways that the length of mucins, their density on the surface, and the amount of sialic acid could each help or inhibit membrane binding and fusion. (phys.org)
Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus, Proceedings of the National Academy of Sciences (2020). (phys.org)

The TIM-1 gene is highly polymorphic and undergoes alternate splicing (1). (rndsystems.com)

This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. (nih.gov)

The surface of the protozoan Trypanosoma cruzi is covered by a dense coat of mucin-type glycoconjugates, which make a pivotal contribution to parasite protection and host immune evasion. (silverchair.com)
They found that a dense coat of mucins hindered binding and slowed down fusion. (phys.org)

Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. (embl.de)
Evidence for coexpression of mucins and trefoil peptides has been suggested in numerous gastrointestinal mucosal pathologies. (embl.de)
We tested the hypothesis that individual trefoil peptides are uniquely localised with specific mucins in the UACL and normal gastrointestinal epithelia. (embl.de)
Colocalisation of mucins and trefoil peptides was demonstrated by immunofluorescent colabelling in UACL and normal gastrointestinal epithelia. (embl.de)
Coordinated localisation of trefoil peptides and mucins in UACL and normal gastrointestinal epithelia suggests they may assist each others' functions in protection and repair of gastrointestinal mucosa. (embl.de)

The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. (nih.gov)
The mucin region undergoes extensive O-linked glycosylation. (rndsystems.com)

Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. (wikipedia.org)
The two subunits of MUC4 are transcribed from a single gene made of 25 exons and with its exon/intron structure identical to that of the mouse gene. (wikipedia.org)
namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)

Like other mucins, MUC-4 is a high-molecular weight glycoprotein. (wikipedia.org)

Influence of the application of enemas with oily extract of curcumin ( Curcuma longa ) on the tissue content of neutral and acidic mucins in the colonic mucosa without fecal stream ☆ ☆ Study conducted at Universidade São Francisco (USF), Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Investigação Médica (LIM), Bragança Paulista, SP, Brazil. (scielo.br)
To verify if the application of enemas containing oily extracts of curcumin preserves the tissue content of mucins in the glands of the colonic mucosa without fecal stream. (scielo.br)
Tissue quantification of neutral and acid mucins in the mucosa of the colon with and without fecal stream in rats. (scielo.br)

Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)

Partial or complete degradation of mucin molecules by microbial enzymes is often a fundamental step in disruption of defensive mucosal barriers, as these constitute direct interfaces between internal and external environments. (bmj.com)
Mucin and cadherin-like protein (MUCDHL), also known as μ-protocadherin, is a 100 kDa type I transmembrane protein belonging to the protocadherin family of cell adhesion molecules. (rndsystems.com)

Scientists have discovered the identity of genes that predispose people to chronic kidney disease. (sciencedaily.com)
An international study lead by University of Manchester scientists has discovered the identity of genes that predispose people to chronic kidney disease. (sciencedaily.com)
We hope that some of the kidney genes we discovered may become attractive targets for the development of future diagnostics and treatment for patients with chronic kidney disease. (sciencedaily.com)
Because of variable age of disease onset and often subtle signs and symptoms, clinical diagnosis of mucin-1 kidney disease and differentiation from other forms of hereditary kidney disease have been difficult. (mit.edu)
We therefore developed and validated a mass spectrometry-based probe extension assay with a series of internal controls to detect the insertion event using 24 previously characterized positive samples from patients with mucin-1 kidney disease and 24 control samples known to be wild type for the variant. (mit.edu)
Validation results indicate an accurate and reliable test for clinically establishing the molecular diagnosis of mucin-1 kidney disease with 100% sensitivity and specificity across 275 tests called. (mit.edu)

Mucin-secreting goblet cells exhibited increased cell density and decreased size after 5 daily treatments then recovered to their normal size, but with decreased cell density, 14 days after the last treatment. (cdc.gov)

Sub-objective 1A: Reduce the incidence of Campylobacter in preharvest poultry by selecting probiotics that utilize mucin for growth and competitively inhibit Campylobacter colonization in broiler chickens. (usda.gov)

Immunostaining for components of those pathways and mucins were performed on lung tissue obtained from patients with IPF (n=20), chronic obstructive pulmonary disease (n=13), idiopathic pulmonary artery hypertension (n=5) and from organ donors (n=6). (bmj.com)
There was an increase in the tissue content of neutral mucins in animals treated with curcumin at a concentration of 50 mg/kg/day for four weeks, whereas in the group treated with 200 mg/kg/day there was an increase independent of the time of intervention. (scielo.br)

ADTKD is caused by mutations in certain genes. (limamemorial.org)

Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)

Barrier agains t pathogen s gut bacterial genes in the MetaHIT ation when attempting to extrapolate [10], although Proteobacteria, Ver- catalogue were also well represent- results obtained in mouse models to rucomicrobia, and Fusobacteria are ed in the other metagenomes that the situation in humans. (who.int)
In 2014, the MetaHIT consortium by bacteria of the genera Lacto- alytical method used: 66 from 16S published an integrated catalogue bacillus , Prevotella , and Sneathia , rDNA sequencing [11] or 57 from of 10 million bacterial genes de- whereas for infants delivered by whole-metagenome sequencing [5]. (who.int)

A complex interaction between the cleavage and polyadenylation molecular complex and cis -elements determine the polyadenylation site, which may result in the choice of non-canonical sites, resulting in alternative polyadenylation events, involved in the regulation of more than 80% of the genes expressed in plants. (frontiersin.org)

When overexpressed, the disorganization of mucins may reduce adhesion to other cells as well as the extracellular matrix, promoting cancer cell migration and metastasis. (wikipedia.org)
To help immune cells survive, OX40 organizes super-enhancers, which are regions of DNA that control what genes become active, causing T helper cells to produce an abundance of IL-9. (medindia.net)
First, when cells are infected with viruses, they often begin making a lot more mucins. (phys.org)
Though the genes involved in the process have mostly been identified, why cells do this is unknown. (phys.org)
Combined with previous research, this finding supports a theory that cells make more mucins in response to infection to make a thicker barrier that impedes the flu virus during binding and fusion. (phys.org)

The recent success gut microbial genes, obtained after has fantastic potential, it has only of faecal microbiota transplantation, sequencing whole faecal microbiota been about 10 years since the sci- especially in the context of Clostridi- metagenomes from 124 European indi- entific community first realized its im- um difficile infection, argues for such viduals [4]. (who.int)

When the mucins are planted close together, however, they extend straighter from the surface and create a thicker barrier that the incoming virus must navigate. (phys.org)
2 2 Gaudier E, Hoebler C. Physiological role of mucins in the colonic barrier integrity. (scielo.br)

This gene family is involved in the regulation of Th1 and Th2-cell-mediated immunity. (rndsystems.com)
Both WSSs induced concentration- and time-related hypersecretion of mucins 5AC and 5B, accompanied by up-regulation of the respective mucin genes. (cdc.gov)

In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)

Since 2020, researchers in several countries, including Brazil, have been looking for genes that confer protection against the novel coronavirus, either preventing infection or avoiding progression to severe disease, in the hope that this knowledge will make a vital contribution to the development of vaccines and treatments for viral diseases. (indiatimes.com)
The pair recognized their shared interest in how mucins on cell membranes affect viral infection. (phys.org)

Many cigarette smoke-associated airway diseases involve alterations in mucin homeostasis. (cdc.gov)

As a mucin, MUC-4 also alters adhesive properties of the cell. (wikipedia.org)
Second, mucins often contain a specific sugar, called sialic acid, that could tether the virus to a cell and help position it to bind to receptors on the cell surface . (phys.org)
Further experiments showed that when there is ample space between them, mucins of various lengths can relax on themselves and settle atop the cell surface resulting in a thin mucin coat. (phys.org)

This means the abnormal gene is needed from only one parent in order to inherit the disease. (limamemorial.org)

Moreover, they demonstrated that phosphorylated NKCC2 levels rose in tandem with UMOD gene dosage. (medscape.com)

Total mucin in culture supernatants was measured using enzyme-linked lectin assay. (karger.com)

One of the hypotheses entertained by the authors is therefore that the resilient subjects may have optimal control of mucin production. (indiatimes.com)
Chemical inhibitors were used to stop this assembly of IL-9 gene super-enhancers to prevent the production of IL-9, which in turn reduces mucin production in asthma patients. (medindia.net)
Production of mucin is normally tightly controlled, but too much of it can be damaging," he said. (medindia.net)
This, in turn, leads to massive production of mucin in the airways, eventually clogging them up. (medindia.net)
Using chemical inhibitors, Li and his colleagues found a new way to stop this assembly of IL-9 gene super-enhancers to prevent the production of IL-9. (medindia.net)

The possible contribution of mucin degrading enzymes to the pathogenesis of infection is, therefore, not to be underestimated. (bmj.com)
They found that increasing the density of mucins on the surface inhibited two major steps of influenza A infection. (phys.org)

Through APA, a single gene containing multiple PAS can generate a considerable number of transcript isoforms, thereby producing a highly diversified transcriptome ( Tian and Manley, 2013 ). (frontiersin.org)

While the exact density needed to cause these changes varied based on the length of individual mucins, they observed these virus-impeding shifts in both short and long mucins. (phys.org)

Prior studies by other researchers found that the five-copy version of the gene protected against asthma, but Gokcumen and Ruhl did not see this association when they ran a more detailed analysis. (disabled-world.com)

The analysis yielded a surprise: A group of genomes from Sub-Saharan Africa had a version of the gene that was wildly different from versions found in other modern humans. (disabled-world.com)

Anatomy7

Diseases4

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Information Science1

Glycoproteins5

MUC112

Proteins4

Mucus3

Expression28

Secretion3

Chromosome2

MUC79

Protein called2

Mucous3

Epithelial cells2

Genome3

Group of genes1

Membrane7

Polymorphic1

Encodes1

Dense coat2

Peptides5

Glycosylation2

MUC43

High-molecular weight1

Mucosa3

Human1

Molecules2

Kidney disease6

Goblet cells1

Inhibit1

Tissue2

Mutations1

Apical1

Bacterial2

Molecular1

Cells5

Microbial1

Barrier2

Regulation2

Differentiation1

Viral2

Alterations1

Cell3

Abnormal1

UMOD1

Assay1

Production5

Infection2

Single gene1

Density1

Asthma1

Humans1