Gene mitochondrial ribosomal protein. Medical search. Frequent questions

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). (icr.ac.uk)

This gene encodes a 39S subunit protein. (nih.gov)
This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. (creativebiomart.net)
This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. (nih.gov)
This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. (utsouthwestern.edu)

Sequenced using PacBio technology and error-corrected using Illumina sequences, the complete mitochondrial genome was assembled into a circular molecule of 39,618 bp, with 22.03% GC content. (usda.gov)
The complete mitochondrial genome of the Senegal sole, Solea senegalensis Kaup. (unboundmedicine.com)
TY - JOUR T1 - The complete mitochondrial genome of the Senegal sole, Solea senegalensis Kaup. (unboundmedicine.com)
In this paper, we determined the complete mitochondrial genome of Octopus conispadiceus (Cephalopoda: Octopodidae). (tonmo.com)
In this study, we report the first complete mitochondrial genome sequence from a member of this family, Silene latifolia . (biomedcentral.com)

Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 50. (zfin.org)
Six genes involved in oxidative phosphorylation (OXPHOS) decreased. (diabetesjournals.org)
Two recent microarray studies have shown that genes involved in oxidative phosphorylation (OXPHOS) exhibit reduced expression levels in the skeletal muscle of type 2 diabetic subjects and prediabetic subjects. (diabetesjournals.org)
Thirteen of these genes provide instructions for making enzymes involved in oxidative phosphorylation. (medlineplus.gov)
The mitochondrial genome encodes the genetic information for the 13 polypeptide subunits essential for the process of oxidative phosphorylation. (medscape.com)

It encodes 39 protein coding genes, 25 tRNA genes, and two ribosomal RNA genes (rnl and rns). (usda.gov)
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. (nih.gov)
In addition, mitochondrial DNA (mtDNA) encodes 2 ribosomal RNA genes and 22 transfer RNA (tRNA) genes necessary for the intramitochondrial synthesis of these 13 polypeptides. (medscape.com)

They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. (nih.gov)
2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. (wikipedia.org)
The remaining genes provide instructions for making molecules called transfer RNA (tRNA) and ribosomal RNA (rRNA), which are chemical cousins of DNA. (medlineplus.gov)
The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. (icr.ac.uk)
The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379). (icr.ac.uk)
In addition, genes encoding 18S and, especially, 5S rRNA exhibit exceptional sequence divergence relative to other plants. (biomedcentral.com)
Divergence in one region of 18S rRNA appears to be the result of a gene conversion event, in which recombination with a homologous gene of chloroplast origin led to the complete replacement of a helix in this ribosomal RNA. (biomedcentral.com)
Plant mitochondrial genomes contain genes for their own rRNA subunits as well as for some of the ribosomal proteins and tRNAs required for translation (Figure 1 ), but many necessary ribosomal protein and tRNA genes are located in the nuclear genome, so their gene products must be imported into the mitochondrion [ 15 ]. (biomedcentral.com)
Internal transcribed spacer (ITS) regions between 18S and 28S rRNA genes have been used as molecular typing tools for other organisms. (cdc.gov)

In addition to the cellular energy sensor AMP kinase, the peroxisome proliferator-activated receptor cofactors PGC1α ( 5 , 6 , 7 ) and possibly PGC1β ( 8 ) activate mitochondrial biogenesis and increase OXPHOS gene expression by increasing the transcription, translation, and activation of the transcription factors necessary for mitochondrial DNA (mtDNA) replication. (diabetesjournals.org)
A rapid diagnostic 'mulitplex' one-step polymerase chain reaction protocol (RD-PCR) was developed using cytochrome oxidase subunit 1 (COX1) mitochondrial DNA (mtDNA) to discriminate between S. haematobium and S. bovis. (imperial.ac.uk)
This genetic material is known as mitochondrial DNA or mtDNA. (medlineplus.gov)
The mtDNA mutations that cause this condition alter the proteins that make up cytochrome c oxidase. (medlineplus.gov)
Alternatively, diagnosis may be established by muscle biopsy with histochemistry and mitochondrial DNA (mtDNA) analysis for major rearrangements. (medscape.com)
Located within the mitochondrial matrix, and lacking the efficient repair mechanisms available to nuclear DNA, mtDNA has a relatively high rate of mutation. (medscape.com)
Kearns Sayre Syndrome (OMIM #530000) occurs as a result of large-scale single deletions (or rearrangements) of mitochondrial DNA (mtDNA), which are usually not inherited but occur spontaneously, probably at the germ-cell level or very early in embryonic development. (medscape.com)
The proposed mechanism is based on the knowledge that transcription of mtDNA is polycistronic, which means that all genes encoded on the heavy and light strands are transcribed as 2 large precursor RNA strands. (medscape.com)

A pseudogene corresponding to this gene is found on chromosome 7p. (antibodies-online.cn)

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. (nih.gov)
Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. (icr.ac.uk)

Search on a gene symbol or gene name keyword(s). (jax.org)
Approved gene symbol with link to HUGO Gene Nomenclature Committee. (nih.gov)

Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

Quantitative PCR and high-throughput methods, such as expressed sequence tag analysis, have been used for measuring gene expression and identifying subsets of elm genes that are differentially expressed in the presence of O. novo-ulmi . (sisef.it)
These analyses have also helped identify genes that were differentially expressed in DED fungi grown under defined experimental conditions. (sisef.it)
To identify functional categories overrepresented in the differentially expressed genes, we used integrated gene-network analysis, gene ontology enrichment and mouse phenotype ontology analysis. (biomedcentral.com)
Furthermore, we performed direct enrichment analysis of ASD-associated genes from the SFARI repository in our differentially expressed genes. (biomedcentral.com)
Given the limited number of animals used in the study, we used permissive criteria and identified 842 differentially expressed genes in En2 -/- cerebellum and 862 in the En2 -/- hippocampus. (biomedcentral.com)
Furthermore, when directly compared to the repository of the SFARI database, our differentially expressed genes in the hippocampus showed enrichment of ASD-associated genes significantly higher than previously reported. (biomedcentral.com)
Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)

The variant isolates we ana- only source of available sequence for the cytochrome b lyzed were ST243 (Rakhine State) and MC53 (Tanintharyi ( cyt b ) gene (16). (cdc.gov)
Mutations in at least three mitochondrial genes can cause cytochrome c oxidase deficiency, which is a condition that can affect several parts of the body, including the muscles used for movement (skeletal muscles), the heart, the brain, or the liver. (medlineplus.gov)
The mitochondrial genes associated with cytochrome c oxidase deficiency provide instructions for making proteins that are part of a large enzyme group (complex) called cytochrome c oxidase (also known as complex IV). (medlineplus.gov)
A phylogenetic analysis of 19 sibling taxa in the Vertigo gouldii group was conducted on 73 individuals sampled across North America using DNA sequence data of the mitochondrial genes cytochrome oxidase subunit 1 (CO1) and 16S ribosomal RNA (16S), and the internal transcribed spacer-2 of the nuclear ribosomal RNA (ITS-2) gene. (researchgate.net)

Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. (nih.gov)
The complete nucleotide sequence of the mitochondrial genome for the Senegal sole Solea senegalensis Kaup was determined. (unboundmedicine.com)
Sequence features of the 13 protein-coding genes, two ribosomal RNAs and 22 transfer RNAs are described. (unboundmedicine.com)
Until recently, however, functional analysis of the DED fungi was hampered by the lack of protocols for efficient gene knockout and by the unavailability of a full genome sequence. (sisef.it)
A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. (ensembl.org)
Gene expression also relies on extensive C-to-U (and sometimes U-to-C) RNA editing, in which substitution of specific pyrimidines in the mRNA sequence restores phylogenetically conserved codons [ 8 ]. (biomedcentral.com)

Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)

The tRNA genes encode transfer RNAs for 19 essential amino acids except threonine. (usda.gov)

These similarites include introns, histones, several types of RNA polymerase, and methionine as the first amino acid in protein synthesis. (bartleby.com)
Conclusion: Molecular alterations in frontal cortex in DLB involve key biochemical pathways such as mitochondria and energy metabolism, protein synthesis, purine metabolism, among others and are accompanied by discrete innate inflammatory response. (ibecbarcelona.eu)

Caldovic L, Morizono H, Tuchman M. Mutations and polymorphisms in the human N-acetylglutamate synthase (NAGS) gene. (medscape.com)
Null mutations in the N-acetylglutamate synthase gene associated with acute neonatal disease and hyperammonemia. (medscape.com)

Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells. (nih.gov)
1) "native" tRNAs encoded in the mitochondrial genome and inherited from the α-proteobacterial progenitor of mitochondria, 2) chloroplast-like tRNAs, which are also encoded in the mitochondrial genome but which were acquired by functional gene transfer from the chloroplast genome during land plant evolution, and 3) nuclear-encoded tRNAs imported from the cytosol. (biomedcentral.com)

The ongoing annotation of these genomes should spark a new wave of interest in the DED pathosystem, as it should lead to the formal identification of genes modulating parasitic fitness. (sisef.it)
The mitochondrial genomes of flowering plants exhibit a number of characteristics that distinguish them from the mitochondrial genomes of other eukaryotes [ 1 ]. (biomedcentral.com)
Angiosperm mitochondrial genomes also contain numerous introns, some of which have been split such that the resulting gene fragments must be transcribed separately and then trans- spliced together [ 7 ]. (biomedcentral.com)
The size and complexity of plant mitochondrial genomes, especially when compared with animals and fungi, make them powerful models for exploring the forces affecting eukaryotic genome structure and evolution. (biomedcentral.com)

Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. (nih.gov)

Comparison of nuclear-encoded cytoplasmic ribosomal proteins and mitochondrial ribosomal proteins showed that intron positions were conserved (Yoshihama et al. (bartleby.com)
Cloning and characterization of the gene coding for cytoplasmic seryl-tRNA synthetase from Saccharomyces cerevisiae. (ymdb.ca)

Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q. (wikipedia.org)
Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. (thermofisher.com)
There are multiple pseudogenes of this gene dispersed throughout the genome. (nih.gov)

Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)

The 534 amino acid residues contained in the ribosomal protein are reduced to 486 by cleavage at the N -terminus upon import to the mitochondrion. (medscape.com)

As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die. (medlineplus.gov)
Methods: Real-time quantitative PCR, mitochondrial enzymatic assays, and analysis of β-amyloid, tau, and synuclein species were used. (ibecbarcelona.eu)
Mitochondrial gene loss and functional transfer to the nucleus is an ongoing process in many lineages of plants, resulting in substantial variation across species in mitochondrial gene content. (biomedcentral.com)

However, increased soluble β-amyloid 1-40 and β-amyloid 1-42, and increased TNFα mRNA and protein expression, distinguish rpDLB. (ibecbarcelona.eu)

Other frequently associated clinical features include cerebellar ataxia, cardiac conduction block, raised cerebrospinal fluid (CSF) protein content, and proximal myopathy. (medscape.com)

These types of RNA help assemble protein building blocks (amino acids) into functioning proteins. (medlineplus.gov)
Even assuming expanded wobble-pairing rules, the mitochondrial genome can support translation of only 17 of the 61 sense codons, which code for only 9 of the 20 amino acids. (biomedcentral.com)

These changes mimic those observed in diabetes and insulin resistance and, if sustained, may result in mitochondrial dysfunction in the prediabetic/insulin-resistant state. (diabetesjournals.org)
Importantly, it has been suggested that mitochondrial dysfunction might precede the metabolic change. (intechopen.com)
Severe mitochondrial dysfunction involving activity of four complexes, minimal inflammatory responses, and dramatic altered expression of ORs and TASRs discriminate DLB from Alzheimer's disease. (ibecbarcelona.eu)

Two transcript variants encoding different protein isoforms have been identified. (creativebiomart.net)
Alternatively spliced transcript variants have been observed for this gene. (utsouthwestern.edu)
This gene has 1 transcript ( splice variant ), 68 orthologues and 1 paralogue . (ensembl.org)
This gene has 1 transcript ( splice variant ) and 43 orthologues . (ensembl.org)
qPCR was performed for representative genes to confirm relative transcript levels compared to those detected in microarrays. (biomedcentral.com)

The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (nih.gov)

Genetic and molecular analyses have led to the identification, cloning and characterization of a few genes that contribute to parasitic fitness in the pathogens. (sisef.it)

The three-domain tree, containing Eukarya, Archea, and Bacteria, soon became too simplistic due to the realization that some bacteria possessed the ability to exchange genetic information by horizontal gene transfer (Koonin and Wolf, 2012). (bartleby.com)
Changes in mitochondrial DNA are among the best-studied genetic factors associated with age-related hearing loss. (medlineplus.gov)
Some of the genetic changes alter single DNA building blocks (nucleotides), whereas others rearrange larger segments of mitochondrial DNA. (medlineplus.gov)
Here, we analyzed three mitochondrial ( mt-atp8&6 and mt-nd2 ) and one nuclear ( nuc-s7 ) marker in order to assess the genetic diversity and population structure of T. hildebrandi . (peerj.com)

We hypothesized a HFD may affect expression of genes involved in mitochondrial function and biogenesis. (diabetesjournals.org)
Combined, these results suggest a mechanism whereby HFD downregulates genes necessary for OXPHOS and mitochondrial biogenesis. (diabetesjournals.org)
At the molecular and structural level, mitochondrial biogenesis and mitochondrial function are altered in diabetes, as well as in insulin-resistant relatives of type 2 diabetic subjects ( 1 , 2 ). (diabetesjournals.org)
The developmental gradient in monocot leaves has been exploited to uncover leaf developmental gene expression programs and chloroplast biogenesis processes. (biomedcentral.com)

a mechanism consistent with the high levels of GpII in some α-proteobacteria (Robart & Zimmerly, 2005) and the ability of yeast mitochondrial GpII to insert themselves into double stranded genomic DNA (Zimmerly et al. (bartleby.com)

T . equi has lost the putative genes for host cell transformation, or the genes were acquired by T . parva and T . annulata after divergence from T . equi . (biomedcentral.com)

Absolute Quantification of Matrix Metabolites Reveals the Dynamic of Mitochondrial Metabolism. (ucsf.edu)

A deletion anywhere in the mitochondrial genome may affect transcription or translation of genes that were not affected by the deletion. (medscape.com)

Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)

In this study, we systematically analyzed CD19 CAR-T cells of 10 children with R/R B-ALL enrolled in the CARPALL trial via high-throughput single-cell gene expression and T cell receptor sequencing of infusion products and serial blood and bone marrow samples up to 5 years after infusion. (nature.com)
PGC1α- and PGC1β-responsive OXPHOS genes show reduced expression in the muscle of patients with type 2 diabetes ( 3 , 4 ). (diabetesjournals.org)
While the selective inactivation of Ophiostoma genes by insertional mutagenesis remains a challenge, an alternative approach based on RNA interference is now available for down-regulating the expression of targeted genes. (sisef.it)
This allows us to generate the first biologically-informed gene expression map of this leaf, with the entire developmental gradient from meristematic to fully differentiated cells captured. (biomedcentral.com)
Using a network reconstruction algorithm, we predict that known chloroplast gene expression regulators are differentially involved across those developmental stages. (biomedcentral.com)
An increase in LUM gene expression was observed in OA cartilage from the medial part of the humeral condyle. (biomedcentral.com)
The molecular changes characterising OA include the differential expression of matrix proteins, proteoglycans, collagens, metalloproteinases and their inhibitors in both cartilage and bone. (biomedcentral.com)
Cerebellar and hippocampal tissue samples from three En2 -/- and wild type (WT) littermate mice were assessed for differential gene expression using microarray hybridization followed by RankProd analysis. (biomedcentral.com)
Several studies have analyzed genome-wide expression profiles of ASD patients using lymphoblastoid cell lines and blood samples, supporting upregulation of immune genes and downregulation of neurodevelopmental genes as key players in the pathogenesis of ASD (see [ 8 ] for a review). (biomedcentral.com)

As people age, mitochondrial DNA accumulates damaging mutations, including deletions and other changes. (medlineplus.gov)
[ 5 ] The deletions vary in size and location on the mitochondrial genome in different individuals, although a common deletion of 4.9kB is present in at least a third of patients with Kearns-Sayre syndrome. (medscape.com)
How can a heterogeneous group of mitochondrial deletions lead to a similar phenotype? (medscape.com)

These findings suggest a markedly expanded role for nuclear gene products in the translation of mitochondrial genes in S. latifolia and raise the possibility of altered selective constraints operating on the mitochondrial translational apparatus in this lineage. (biomedcentral.com)

Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)

AGA and AGG were thought to have become mitochondrial stop codons early in vertebrate evolution ( Osawa, Ohama, Jukes & Watanabe 1989 ). (nih.gov)

Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes. (nih.gov)

p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (nih.gov)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

Orthologous to human MRPS25 (mitochondrial ribosomal protein S25). (zfin.org)
In areas where human and cattle schistosomiasis overlap and are transmitted in close proximity, this mitochondrial assay will be a valuable identification tool for epidemiological studies, especially when used in conjunction with other nuclear diagnostic markers. (imperial.ac.uk)
Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)

Hierarchical classifications for this protein from different ontologies. (nih.gov)

Anatomy6

Organisms6

Diseases1

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes12

Information Science3

Large ribosomal subunit1

Subunit protein4

Complete mitochondrial genome5

Oxidative phosphorylation5

Encodes3

RRNA9

MtDNA8

Chromosome1

Mammalian2

Symbol2

Kinase1

Differentially expressed7

Cytochrome4

Sequence6

Sequences1

TRNA genes1

Synthesis2

Synthase2

Mitochondria2

Genomes4

Consist of a small1

Cytoplasmic2

Pseudogenes3

PMID1

Mitochondrion1

Species3

MRNA1

Proximal myopathy1

Amino acids2

Dysfunction3

Transcript5

Chromosomes1

Characterization1

Genetic4

Biogenesis4

Yeast1

Putative1

Metabolism1

Transcription1

Genomic1

Expression9

Deletions3

Nuclear gene1

NCBI1

Codons1

Ontology1

Fetal2

Human3

Ontologies1