• C57BL/6 mouse splenocytes were stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and 0.25 µg of Rat IgG2b kappa Isotype Control, Super Bright 600 (Product # 63-4031-82) (left) or 0.25 µg of CD3 Monoclonal Antibody, Super Bright 600 (right). (thermofisher.com)
  • Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)
  • Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Below are the most recent publications written about "Mice, Inbred C57BL" by people in Profiles. (uchicago.edu)
  • Cftr-/- mice showed a higher expression of Muc6 at both protein and RNA levels compared with their control Cftr+/+ littermates suggesting that as in the human disease, Muc6 may contribute to the formation of materials that block pancreatic acini and ducts in mouse models of cystic fibrosis. (ox.ac.uk)
  • The rabbit anti-mouse Muc6 polyclonal antibody seems highly specific to the mouse mucin and will be useful to study pancreatic pathology in cystic fibrosis. (ox.ac.uk)
  • One of the first INBRED MOUSE STRAINS to be sequenced. (uchicago.edu)
  • such as for example and continues to be examined using several pets contaminated or normally experimentally, and Helicobacter an infection continues to be discovered to induce chronic energetic hepatitis, biliary and hepatocellular tract carcinomas, typhlocolitis, and decrease colon cancer in susceptible strains of inbred and Fluopyram engineered mice[29-39] genetically. (baxkyardgardener.com)
  • Probably the most extremely resistant (R) & most extremely vulnerable (S) lines had been further analyzed for haemocyte amounts and for manifestation of a -panel of genes regarded as involved with oxidative stress or elsewhere implicated in the R/S phenotype. (immune-source.com)
  • Here, the great strengths are derived from the very refined use of inbred and genetically manipulated mice under controlled conditions that negate environmental variation. (clinical-research-informatics.com)
  • The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice. (ox.ac.uk)
  • In order to further study Muc6 in mice, our aims were to obtain a specific Muc6 antibody, to validate it and to test it in Cftr deficient mice. (ox.ac.uk)
  • Description: The 17A2 monoclonal antibody reacts with the mouse CD3 complex. (thermofisher.com)
  • Applications Tested: This 17A2 antibody has been tested by flow cytometric analysis of mouse splenocytes. (thermofisher.com)
  • Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. (ouhsc.edu)
  • Large antibody titers correlate with low colony forming devices (CFUs) of UPEC following transurethral challenge of vaccinated mice. (morainetownshipdems.org)
  • sequencing and analysis of nucleic acids are revolutionizing the measurement of gene expression in nonmodel organisms, with promising applications in the study of the immune system 1. (clinical-research-informatics.com)
  • Animal models (e.g., mice, rats, zebrafish and others) are sufficiently like humans in their anatomy, physiology or response to a pathogen that researchers can extrapolate the results of animal model studies to better understand human physiology and disease. (genome.gov)
  • When snail size pass on haemocyte quantity and constitutive OSI-420 haemocyte mRNA degrees of chosen genes were regarded as alongside the R/S phenotypes complicated relationships emerged. (immune-source.com)
  • Food-associated estrogenic compounds induce estrogen receptor-mediated luciferase gene expression in transgenic male mice. (knaw.nl)
  • This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)
  • In these mice, N-cad was efficiently expressed in the E-cad expression domains. (biomedcentral.com)
  • gene expression profiles with analytical tools derived from ecology and systems biology to reverse engineer interaction networks between immune responses, other organismal characteristics and the environment (including symbiont exposures), revealing regulatory architecture. (clinical-research-informatics.com)
  • An inbred strain of mouse. (jefferson.edu)
  • Of the 5379 expected proteins in prototype UPEC strain CFT073, only six proteins met all of our founded criteria: (1) surface exposure (expected and shown), (2) induction during growth in human being urine, (3) high manifestation in experimentally infected mice Minocycline hydrochloride and (4) high manifestation in ladies with UTI, (5) immunogenicity, and (6) pathogen-specificity. (morainetownshipdems.org)
  • If weakness were the only effect of the mutant allele, so it conveyed only disadvantages, natural selection would weed out this version of the gene until it became extinct from the population. (wikipedia.org)
  • To block apoptosis, we conditionally deleted one allele of p53 in Ncadk.i. mice and observed a temporal rescue of alveolar morphology and function. (biomedcentral.com)
  • The CF allele cannot produce CFTR! (proprofs.com)
  • The CF allele overproduces CFTR! (proprofs.com)
  • On the other hand, gene knockdown experiments demonstrated that the function of O. dancena FXYD12 allowed maintenance of a high level of NKA activity. (ijbs.com)
  • This mutation, which at first glance appeared to be harmful, conferred enough of an advantage to heterozygotes to make it beneficial, so that it remained at dynamic equilibrium in the gene pool. (wikipedia.org)
  • Huntington's Disease is a hereditary condition that is caused by a mutation in a person's genes. (proprofs.com)
  • It is a genetic disorder that results from a mutation in the hemoglobin gene, causing red blood cells to become sickle-shaped. (proprofs.com)
  • Baran AA, Silverman KA, Zeskand J, Koratkar R, Palmer A, McCullen K, Curran WJ, Edmonston TB, Siracusa LD, Buchberg AM. The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression. (jefferson.edu)
  • Additionally, it will consider how immunological measurement, interpreted in the light of paradigms from laboratory mouse immunology, can define individual variation relevant to ecological and epidemiological studies of infectious disease in the natural environment LY2090314 1, 6. (clinical-research-informatics.com)
  • Each of these themes will be considered in turn and then the reasons why nonmodel rodents (species excluding M.?domesticusand studies in natural populations tracking the effects of environmental variables using manipulative experimental or observational approaches (see for example, the solid wood mouse case study below), or through transplantation of naturally occurring lineages to (and monitoring of the changes occurring in) experimentally manipulated anthropogenic environments. (clinical-research-informatics.com)
  • We recently addressed the question of interchangeability of the two cadherins by generating a mouse model in which N-cad cDNA was introduced into the E-cad locus. (biomedcentral.com)
  • Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)
  • Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)
  • A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. (uchicago.edu)
  • Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. (jefferson.edu)
  • HKPP is a genetic disease and causal variants have been found in three different ion channel genes. (blogspot.com)
  • Concordantly, 55% of Ncadk.i. mice harboring a heterozygous p53 deletion developed malignant and invasive tumors. (biomedcentral.com)
  • Thus, we provide a new mouse model to investigate the molecular mechanisms of fibrocystic mastopathy and the transition from benign to malignant tumors. (biomedcentral.com)
  • Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism. (uchicago.edu)
  • Innate level of resistance of mosquitos to Dengue pathogen can be similarly considered to depend on 'basal-level immune system activation' of immune-related genes (Sim et al. (immune-source.com)
  • A protein consists of one or more chains of amino acids (called polypeptides) whose sequence is encoded in a gene. (genome.gov)
  • Protein levels of sAPPα and sAPPβ are measured by western blot assay in cerebral cortex of 12-month-old AD mice with different treatments (RSG and GW9662). (medchemexpress.com)
  • Major genes almost always have multiple effects (pleiotropism), which can simultaneously convey separate advantageous traits and disadvantageous traits upon the same organism. (wikipedia.org)
  • This graph shows the total number of publications written about "Mice, Inbred DBA" by people in this website by year, and whether "Mice, Inbred DBA" was a major or minor topic of these publications. (jefferson.edu)
  • We hypothesised that higher amounts of haemocytes or haemocytes which constitutively communicate relevant defence genes at higher amounts would effectively thwart trematode disease. (immune-source.com)
  • We shown for all four vaccine antigens that antigen-specific serum IgG represents a strong correlate of safety in vaccinated mice. (morainetownshipdems.org)
  • Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. (uchicago.edu)
  • may set up a chronic an infection in A/JCr mice by colonizing the low colon and, sporadically, the liver organ, in the bile canaliculi[40] particularly. (baxkyardgardener.com)
  • Dominant" means that a single copy of the mutated gene (from one parent) is enough to cause the disorder. (genome.gov)
  • By contrast, an autosomal recessive disorder requires two copies of the mutated gene (one from each parent) to cause the disorder. (genome.gov)
  • Recessive" means that two copies of the mutated gene (one from each parent) are required to cause the disorder. (genome.gov)
  • By contrast, an autosomal dominant disorder requires only a single copy of the mutated gene from one parent to cause the disorder. (genome.gov)
  • Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. (ouhsc.edu)
  • Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. (uchicago.edu)
  • Themis, M. (2012) ' Monitoring for potential adverse effects of prenatal gene therapy: Genotoxicity analysis in vitro and on small animal models ex vivo and in vivo '.Methods in Molecular Biology, 891. (testavec.com)
  • Effects of Depilatory Cream Formulation and Contact Time on Mouse Skin. (uchicago.edu)
  • Five orthologous gel-forming mucins have been cloned in human and mouse. (ox.ac.uk)
  • Human Gene Therapy, 17 (7). (testavec.com)
  • Systems genetics analysis of mouse chondrocyte differentiation. (jefferson.edu)
  • In combination with a conditional gene inactivation approach, we expressed N-cad in the absence of E-cad (referred to as Ncadk.i.) in alveolar epithelial cells of the mammary gland starting in late pregnancy. (biomedcentral.com)
  • PPARγ level is determined by IF assay in 3×Tg-AD mice, 3×Tg-AD mice with RSG treatment, 3×Tg-AD-KO mice, 3×Tg-AD-KO mice with GW9662 stimulation. (medchemexpress.com)
  • A well-established case of heterozygote advantage is that of the gene involved in sickle cell anaemia. (wikipedia.org)
  • In this instance, the state of the organism's environment will provide selection, with a net effect either favoring or working in opposition to the gene, until an environmentally determined equilibrium is reached. (wikipedia.org)
  • Anti-inflammatory effect of pigment epithelium-derived factor in DBA/2J mice. (ouhsc.edu)
  • The first epithelial cell layer in the development of mouse embryos, the trophectoderm of blastocysts, requires E-cad for proper function. (biomedcentral.com)