Gene mediates. Medical search. Frequent questions

iii) modeled rates of pollen-mediated gene flow showed extensive mixing of germplasm between fields and farms and iv) as a result, segregation of GM and non-GM varieties is not likely to be an option in these systems. (nature.com)
Pollen-mediated gene flow at a distance could allow the spread of rare herbicide-resistant alleles and favor the evolution of multiple herbicide-resistant biotypes through the accumulation of different resistant genes in an individual weed or weed population. (unl.edu)
Pollen-mediated gene flow from glyphosate-resistant common waterhemp (Amaranthus rudis Sauer): consequences for dispersal of resistance genes. (unl.edu)

Thus, our work demonstrates that APA links genetic variation to variation in gene expression, protein expression, and disease risk, and reveals uncharted modes of genetic regulation. (elifesciences.org)
This thesis describes the regulation of CD25 gene expression by interleukin-4-activated signal transduction pathways in quiescent human B lymphocytes. (gla.ac.uk)
Although some of these genes are controlled by specific transcriptional programs, very little is known about their post-transcriptional regulation. (iric.ca)
Two copies of a motif (the retinoblastoma control element) similar to that found in the human c-fos, transforming growth factor β1, and c-myc promoters are responsible for conferring Rb regulation to the fourth promoter of the insulinlike growth factor II gene. (umn.edu)
To elucidate how silencing is accomplished, we screened an RNA interference library for suppressors of miRNA-mediated regulation in Drosophila melanogaster cells. (ox.ac.uk)
The lab investigates mechanisms of RNA mediated epigenetic gene regulation by employing a combination of biochemistry, cell and molecular biological methods, and genome wide approaches. (lncrnablog.com)
Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression. (bvsalud.org)
Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
Principles for regulation of gene expression through intercellular signalling. (lu.se)
Gene regulation in developmental biology and the cell cycle. (lu.se)

G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. (atsbio.com)
In addition, Akt activation leads to HIF-1alpha stabilization, whereas PTEN attenuates hypoxia-mediated HIF-1alpha stabilization. (ox.ac.uk)

This study demonstrates that mammalian condensin II functions to organize long-range chromosome contacts and regulate transcription at specific genes. (bepress.com)
Electric field-mediated gene transfer in mammalian cells (electrotransformation) depends on the pulsing conditions (field intensity, pulse duration, number of pulses). (uni-bielefeld.de)
Wolf H, Rols MP, Boldt E, Neumann E, Teissie J. Control by pulse parameters of electric field-mediated gene transfer in mammalian cells. (uni-bielefeld.de)
Control by pulse parameters of electric field-mediated gene transfer in mammalian cells", Biophysical Journal , vol. 66, 1994, pp. 524-531. (uni-bielefeld.de)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)

PIAS1, but not other PIAS proteins, blocked the DNA binding activity of Stat1 and inhibited Stat1-mediated gene activation in response to interferon. (nih.gov)
The ABC superfamily of genes encodes proteins that transport a number of substrates across cell membranes. (medscape.com)
DNA wraps around proteins called histones such that some genes can be accessed easily by cell proteins that "read" the gene, increasing gene expression, while others are less accessible, decreasing gene expression. (cdc.gov)

Because APOL1 mutations as a genetic marker for kidney disease risk remain a topic new to many health care professionals, AKF's campaign will also educate them about the role of variants in kidney genetics and the impact of APOL1-mediated kidney disease on people of color via a professional-facing webinar and educational materials. (kidneyfund.org)

Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation. (aspetjournals.org)
Our data suggests that antagomiR-mediated inhibition of miR-146a or other dystrophin targeting miRNAs could be a viable exon skipping DMD co-therapy and warrants further research. (gene-tools.com)

Conclusion: The high prevalence of mcr-1 in colistin-resistant E. coli isolates in our study is a cause of concern for the probable coming emergence of colistin resistance in human pathogens, due to horizontal transfer of resistant genes from poultry to human isolates. (tropmedres.ac)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)

Biochemical and genetic analysis has demonstrated that Stat1 is essential for gene activation in response to interferon stimulation. (nih.gov)
We conclude that the overall genetic composition of maize, in this and similar agricultural contexts, will be strongly influenced both by self-organised ecological factors (pollen flow), and by socially mediated intervention (seed recycling and sharing). (nature.com)
One such genetic factor is mutations in the APOL1 gene, which makes a protein in the immune system. (kidneyfund.org)
Here, we tested whether DMN connectivity mediates an association between the 5-HTT genetic variants and impulsivity. (columbia.edu)
however, genetic analysis of GAD in affected families has not revealed any defects in this gene. (medscape.com)
In rare cases, a deletion of genetic material near the beginning of the LMNB1 gene leading to increased production of lamin B1 causes ADLD. (medlineplus.gov)
In at least one family with ADLD, the condition is instead caused by a loss (deletion) of genetic material near the beginning of the gene. (medlineplus.gov)
HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction. (cdc.gov)
Genetic susceptibility to CBD is associated with alleles of the major histocompatibility gene, human leukocyte antigen DP (HLA-DP) containing glutamic acid at the 69th position of the beta chain (HLA-DPbeta-E69). (cdc.gov)
The underlying genetic abnormality in harlequin ichthyosis is a mutation in the lipid-transporter gene ABCA12 on chromosome 2. (medscape.com)
Trained immunity is mediated through epigenetics , the modification of gene expression without changing the genetic code. (cdc.gov)
Gene technology: basic and applied molecular genetic methods. (lu.se)

In the PCR assay, 43.9% (18/41) of colistin-resistant isolates were screened positive for plasmid-mediated mcr-1. (tropmedres.ac)

To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous. (lu.se)
To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). (lu.se)
In July, the adeno-associated virus vector (AAV)-based SRP-9001 gene therapy was granted accelerated approval by the US Food and Drug Administration for the treatment of ambulatory pediatric patients aged 4-5 years with DMD with a confirmed mutation in the DMD gene. (medscape.com)

Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. (hindawi.com)
Our results indicate a common and pivotal role for distinct vitamin K- dependent coagulation factors in mediating hepatocyte transduction by adenoviruses in vitro and in vivo. (gla.ac.uk)

Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), also known as lysine (K)-specific demethylase 6A (KDM6A), functions as a tumor suppressor gene or oncogene depending on the tumor type and context. (bvsalud.org)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
The American Kidney Fund (AKF) today launched its new APOL1 campaign , which aims to educate and increase awareness about APOL1-mediated kidney disease, a spectrum of kidney diseases that is associated with mutations or variants in the apolipoprotein L1 (APOL1) gene and are linked to an increased risk for kidney disease in people of African and Caribbean descent. (kidneyfund.org)
Despite the clear link between APOL1 gene mutations and kidney disease, awareness of this association and the risks the mutations pose to people of African and Caribbean descent is relatively low," said LaVarne A. Burton, AKF President and CEO. (kidneyfund.org)
People who have kidney disease and APOL1 gene mutations may see their disease progress more quickly than other causes of kidney disease and turn into kidney failure. (kidneyfund.org)
Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by loss of function mutations in the Dystrophin gene resulting in loss of dystrophin protein. (gene-tools.com)
Subsequent studies showed elevated pipecolic acid levels in the plasma and cerebrospinal fluid of affected patients and this led to the recognition of a defect in aaminoadipic semialdehyde (a-AASA) dehydrogenase (antiquitin) in the cerebral lysine degradation pathway, and mutations in the antiquitin gene (ALDH7A1) on chromosome 5q31. (medscape.com)
At least 30 mutations in the LMNB1 gene have been found to cause autosomal dominant leukodystrophy with autonomic disease (ADLD). (medlineplus.gov)
Mutations in ABCA12 , a gene that encodes adenosine triphosphate (ATP)-binding cassette transporter (ABC), subfamily A, member 12, in chromosome region 2q35, underlie this disorder. (medscape.com)

Mediators of gene silencing pathways, microRNA (miRNA) populations have now been extensively characterised and implicated in numerous fundamental processes. (edu.au)
The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)

NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. (iric.ca)
Using proteomics, we identify protein clusters associated with the NF45-NF90 complex, including components of Staufen-mediated mRNA decay (SMD). (iric.ca)
microRNAs (miRNAs) silence gene expression by suppressing protein production and/or by promoting mRNA decay. (ox.ac.uk)

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. (cdc.gov)

Human immunodeficiency virus encodes a gene product termed tat that is able to activate viral gene expression when present in trans. (duke.edu)
[ 6 ] ABCA12 encodes a transmembrane protein that mediates lipid transport. (medscape.com)

Detection of Plasmid-Mediated Colistin Resistant mcr-1 Gene in Escherichia coli Isolated from Infected Chicken Livers in Nepal. (tropmedres.ac)

Tyrosine phosphorylated STATs dimerize and translocate into the nucleus to activate specific genes. (nih.gov)

In particular, the importance of a cAMP-dependent pathway, which down-regulates binding of a putative transcriptionally repressive protein factor from a negative regulatory element in the promoter region of the CD25 gene, is highlighted. (gla.ac.uk)
The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)
Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
We show that CCN1 (also known as CYR61), a matricellular protein that dampens and resolves liver fibrosis, also mediates cholangiocyte proliferation and ductular reaction, which are repair responses to cholestatic injury. (jci.org)
The LMNB1 gene provides instructions for making the lamin B1 protein. (medlineplus.gov)
The protein also plays a role in the copying (replication) of DNA in preparation for cell division and the activity (expression) of many genes by being involved in the organization of chromosomes within the nucleus. (medlineplus.gov)

TMP/SMX plus tobramycin exhibit a greater killing cate that class 1 integrons and IS CR elements linked to sul 2 genes can mediate TMP/SMX resistance in S. mal- capacity then TMP/SMX alone ( 7 , 8 ). (cdc.gov)
the most active were levofloxacin (6.5% resistance) and In addition to class 1 integrons, other mobile elements are associated with sul genes. (cdc.gov)
The resistance genes harbored by SXT are ment was conducted according to the standard 1-day pro- embedded in a composite transposon-like structure and tocol ( 16 ). (cdc.gov)
Background: Plasmid-mediated resistance to the colistin in poultry is considered as an emerging problem worldwide. (tropmedres.ac)
This study aimed to explore the prevalence of plasmid-mediated colistin resistance gene, mcr-1 in E. coli isolated from liver samples of dead poultry suspected of E. coli infections. (tropmedres.ac)
Colistin resistance was determined by agar dilution method and colistin-resistant strains were further screened for plasmid-mediated mcr-1 gene, using conventional polymerase chain reaction (PCR). (tropmedres.ac)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)

The transplantation of cultured myoblasts into mature skeletal muscle is the basis for a new therapeutic approach to muscle and non-muscle diseases: myoblast-mediated gene therapy. (rupress.org)
Directly targeting therapeutic suicide gene to a solid tumor is a hopeful approach for cancer gene therapy. (biomedcentral.com)
Cancer gene therapy approaches include the direct killing of tumor cells by injecting a therapeutic gene into the tumor cell or employing vaccine strategies to deliver an immunomodulatory gene that stimulates the immune system to recognize tumor antigens [ 1 ]. (biomedcentral.com)
Using a heat-inducible promoter to drive transgene expression enables us to control the activation of the therapeutic NIS gene locally as well as temporally. (lmu-klinikum.de)
In vivo administration of IL1RAP antibodies in mice transplanted with chronic and blast phase CML cells resulted in therapeutic effects mediated by murine effector cells. (lu.se)

RIViT-seq technology could speed up associating transcription factors with their target genes. (doe.gov)
We have demonstrated that the retinoblastoma gene product (Rb) can positively regulate transcription from the fourth promoter of the insulinlike growth factor II gene. (umn.edu)
Taken together, we suggest that the transcription of B/K gene in PC12 cells may be regulated by PKA-dependent mechanism. (kyobobook.co.kr)

These findings suggest that miRNAs mediate post-transcriptional gene silencing by more than one mechanism. (ox.ac.uk)

To examine the effect of catalase gene transfer on survival of corneal endothelial cells (EC) following challenge with hydrogen peroxide (H 2 O 2 ) in an ex vivo model of oxidative stress. (bmj.com)
To examine the morphological effects of catalase gene transfer in modulation of H 2 O 2 induced injury, transduced corneas were maintained in ex vivo culture and challenged with H 2 O 2 . (bmj.com)
Ex vivo catalase gene transfer can protect EC from death mediated by H 2 O 2 . (bmj.com)
This gene based approach to the protection of corneal endothelium from oxidative stress may have application in prevention of EC loss in pathological conditions in which H 2 O 2 is involved and in ex vivo donor corneal storage before transplantation. (bmj.com)
The present study uniquely combines olfactory ensheathing glia (OEG) implantation with ex vivo adenoviral (AdV) vector-based neurotrophin gene therapy in an attempt to enhance regeneration after cervical spinal cord injury. (edu.au)

Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. (org.in)
In this report, we used tripronuclear (3PN) zygotes to further investigate CRISPR/Cas9-mediated gene editing in human cells. (org.in)
Establishment of a CRISPR/Cas9-Mediated Efficient Knockout System of Trichoderma hamatum T21 and Pigment Synthesis PKS Gene Knockout. (qxmd.com)
CRISPR/Cas9 plasmid and donor DNA recombinant plasmid were constructed for disruption of the Thpyr4 and Thpks1 genes. (qxmd.com)

Methods for gene identification and analysis of gene structure: cloning, PCR, restriction mapping, in situ hybridisation, DNA sequencing. (lu.se)

Sperm-mediated gene transfer (SMGT) is a transgenic technique that transfers genes based on the ability of sperm cells to spontaneously bind to and internalize exogenous DNA and transport it into an oocyte during fertilization to produce genetically modified animals.1 Exogenous DNA refers to DNA that originates outside of the organism. (wikipedia.org)
These barriers allow for protection against the threat that every fertilization event could become a potentially mutagenic one.4 Transgenic animals have been produced successfully using gene transfer techniques such as sperm-mediated gene transfer. (wikipedia.org)
The development of commercially available transfection reagents for gene transfer applications has revolutionized the field of molecular biology and scientific research. (mdpi.com)
Maize gene flow occurs through cultivator determined seed selection and mixing as well as through pollen transfer between individual plants and fields. (nature.com)
The speaker will discuss examples of common waterhemp, Palmer amaranth, and giant ragweed to demonstrate the role of gene flow in transfer of herbicide-resistant alleles. (unl.edu)
The fate of the pure myoblast populations after transplantation was monitored by labeling the cells with the marker enzyme beta-galactosidase (beta-gal) using retroviral mediated gene transfer. (rupress.org)
Pulsing conditions inducing reversible permeabilization of the cell plasma membrane are not sufficient to induce gene transfer. (uni-bielefeld.de)
This ABCA12 -mediated lipid-transfer system is essential to the transfer of lipids from the cytosol of the corneocyte into lamellar granules. (medscape.com)
In harlequin ichthyosis, the ABCA12 -mediated transfer of lipid to lamellar granules is defective. (medscape.com)

Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy. (rupress.org)

In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

BF-rTK + GCV induced tumor apoptosis mediated by FasL and TNFR2 through the mitochondrial control of apoptosis via Bid and Bim without inducing necroptosis and autophagy. (biomedcentral.com)

An Rb-condensin II complex mediates long-range chromosome interactions and influences expression at divergently paired genes" Molecular and Cellular Biology Vol. 40 Iss. (bepress.com)
Drug-Drug-Gene Interactions in Cardiovascular Medicine. (cdc.gov)

As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. (hindawi.com)

However, in these cell lines PTEN regulates hypoxia- and IGF-1-induced angiogenic gene expression by regulating Akt activation of HIF-1 activity. (ox.ac.uk)

PHOENIX - Children with Duchenne muscular dystrophy (DMD) treated with the only gene therapy to date to be approved for treatment of disease in the United States show sustained maintenance of motor function after 4 years, compared with untreated patients who showed significant decline over the same time period, new research shows. (medscape.com)

The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation. (yeastrc.org)

Meanwhile, three human digestive system xenograft tumor models (colorectal cancer colo320, gastric cancer MKN-45 and liver cancer SSMC-7721) and a breast cancer (MDA-MB-231) model were employed to validate the universality of BF-rTK + GCV in solid tumor gene therapy. (biomedcentral.com)
The most commonly reported adverse reactions of the gene therapy include vomiting, nausea, increases in liver enzymes, pyrexia (fever), and thrombocytopenia, all of which occurred within 90 days of infusion and been manageable. (medscape.com)
Other reported adverse events include acute serious liver injury, immune-mediated myositis, and myocarditis. (medscape.com)

SMGT could also be useful in generating animals as models for human diseases or lead to future discoveries relating to human gene therapy. (wikipedia.org)
These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
According to Kolon, Invossa is the world's first cell-mediated gene therapy for osteoarthritis, a degenerative joint disease affecting more than 150 million people. (prnewswire.com)
Kolon Life Science has been developing innovative cell and gene therapies including Invossa, the world's first cell-mediated gene therapy for osteoarthritis, since its founding in 2000. (prnewswire.com)
The properties of these cells after transplantation--the stability of resulting hybrid myofibers without immune suppression, the persistence of transgene expression, and the lack of tumorigenicity--suggest that studies of cell-mediated gene therapy using primary myoblasts can now be broadly applied to mouse models of human muscle and non-muscle diseases. (rupress.org)
Survival analysis results of multiple cancer models confirmed that BF-rTK + GCV system has a wide field of application in solid tumor gene therapy. (biomedcentral.com)
The Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-TK + GCV) system is currently one of the best-studied tumor suicide gene therapy systems [ 9 - 11 ]. (biomedcentral.com)
To improve the effectiveness and tumor selectivity of MSC-mediated gene therapy, we are investigating the combination of regional hyperthermia with NIS gene therapy. (lmu-klinikum.de)
The benefits of pharmacogenomic testing before starting drug therapy has been well documented for several single gene-drug combinations. (cdc.gov)
SRP-9001, a single-dose recombinant gene therapy administered as an intravenous infusion, was designed to deliver a trimmed down form of dystrophin to compensate for the deficit. (medscape.com)
Due to the latter risk, the therapy is contraindicated in patients with any deletion in exon 8 and/or exon 9 in the DMD gene. (medscape.com)
Strategies for gene therapy and production of medicines via genetically-modified organisms (expression vectors and viral vectors). (lu.se)

The mechanism of action of the tat gene product appears to be bimodal, resulting in both an increase in the steady-state level of viral mRNA and the enhanced translation of that RNA. (duke.edu)
However, the lack of adequate knockout technologies has hindered gene function and biocontrol mechanism research of this species. (qxmd.com)
To delineate the precise mechanism by which indisulam mediates the DCAF15-RBM39 interaction, we solved the DCAF15-DDB1-DDA1-indisulam-RBM39(RRM2) complex structure to a resolution of 2.3 Å. (nature.com)

Long-range chromosome contacts are disrupted by loss of condensin II loading, which leads to altered expression at bidirectional gene pairs. (bepress.com)

Collectively, this series of experiments indicates that NF-kappa B/Rel is positively regulated by the cAMP cascade to help initiate iNOS gene expression in response to LPS stimulation of macrophages. (aspetjournals.org)
Insulin stimulation of gene expression mediated by p21ras activation. (wikidata.org)

Scholars@Duke publication: Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events. (duke.edu)
These results suggest that tat could play a role in human immunodeficiency virus replication essentially similar to that proposed for the trans-acting nuclear gene products described for several other virus species. (duke.edu)

In human cells, the expression of ∼1,000 genes is modulated throughout the cell cycle. (iric.ca)
This phenomenon was not dependent on proteolytic activation or cell signaling activity and for FX was mediated by direct virus-factor binding. (gla.ac.uk)
The colo320 cell was analyzed by the gene silencing method. (biomedcentral.com)
Restoration of wild-type PTEN to glioblastoma cell lines lacking functional PTEN ablates hypoxia and IGF-1 induction of HIF-1-regulated genes. (ox.ac.uk)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

Some researchers have proposed that TS may have an immune-mediated pathogenesis similar to pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). (medscape.com)

Moreover, sequencing revealed fragment deletions between dual sgRNA target sites or GFP gene insertions presented in knockout strains. (qxmd.com)

We propose that loss of PTEN during malignant progression contributes to tumor expansion through the deregulation of Akt activity and HIF-1-regulated gene expression. (ox.ac.uk)
GATA6-mediated PDA progression could be blocked, at least partially, by silencing UTX expression. (bvsalud.org)

Linkage of IS CR3 , IS CR9, and IS CR10 to sul 2 and dhfr tion therapies of TMP/SMX plus ciprofloxacin and genes was not demonstrated. (cdc.gov)

Taken together, this study suggests a gene-brain-behavior pathway that perhaps underlies the role of the serotonergic neuromodulation in impulse control. (columbia.edu)

Reproductive biology differs markedly among weed species, as does the potential for gene flow. (unl.edu)

Agrobacterium tumefacien strain LBA4404 harboring a pB1333-EN4-RCG3 plasmid having chitinase gene and selectable marker hygromycin gene under the control of the CaMV 35S promoter was used. (ajol.info)

These results identify PIAS1 as a specific inhibitor of Stat1-mediated gene activation and suggest that there may exist a specific PIAS inhibitor in every STAT signaling pathway. (nih.gov)

In conclusion, loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and metastasis . (bvsalud.org)

All OEG grafts were filled with neurofilament-positive axons, and AdV vector-mediated expression of BDNF by implanted cells significantly enhanced regenerative sprouting of the rubrospinal tract. (edu.au)

Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling. (bakerco.com)
A comparison of gene expression profiles in cells depleted of AGO1 or of individual decapping activators shows that approximately 15% of AGO1-targets are also regulated by Ge-1, DCP1, and HPat, whereas 5% are dependent on EDC3 and LSm1-7. (ox.ac.uk)

AMR, through acquired genes located on transposons or conjugative plasmids, is the horizontal transmission of genes required for a given bacteria to withstand antibiotics. (mdpi.com)

Pollen-mediated gene flow3

Regulation10

Hypoxia-mediated2

Mammalian5

Proteins3

Genetics1

Inhibition2

Resistant genes2

Genetic12

Isolates1

Adeno-assoc3

Vitro and in vivo2

Tumor Supp1

Mutations8

Pathways2

MRNA decay3

Adverse Drug Reac1

Encodes2

Escherichia1

Specific genes1

Protein6

Resistance7

Therapeutic5

Transcription3

MiRNAs1

Vivo5

CRISPR4

Situ1

Transfer9

Characterization1

Somatic1

Autophagy1

Interactions2

Molecular1

Regulates1

Duchenne1

Chromosomes1

Liver3

Therapy12

Mechanism3

Chromosome1

Stimulation2

Nuclear2

Cell6

Immune1

Strains1

Progression2

Therapies1

Suggests1

Biology1

Plasmid1

Activation1

Conclusion1

Regenerative1

Cells3

Bacteria1