Gene liver regeneration. Medical search. Frequent questions

Comparative analysis of the transcriptomes from the 3 different conditions identifies 45 differentially expressed genes during oval cell regeneration, 27 up-regulated and 18 down-regulated. (uni-goettingen.de)
We obtained the rat liver tissue gene datasets (GSE63742) collected following partial hepatectomy (PH) from the Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information (NCBI), from which, this study screened the late stage LR samples (7 days post-PH) using the R/Bioconductor packages for the identiﬁcation of differentially expressed genes (DEGs). (jomh.org)
The key TF were identified by functional enrichment analysis from the list of differentially expressed genes identified in liver samples between 35 pigs fed with 1.5% or 3.0% soybean oil. (nature.com)
Hypergeometric analysis was used to identify canonical pathways and curated networks having statistically significant enrichment of differentially expressed genes. (urotoday.com)
Among the approximately 1000 differentially responsive genes expressed in both injured groups, there was an intense upregulation of genes related to the inflammatory response (i.e. (cdc.gov)

Hence, it was proposed that oval cells could represent a second compartment involved in the liver regeneration when the insult of the organ is too massive and proliferation of hepatocytes is suppressed.We performed the model of rat liver regeneration via oval cells using the protocol of 70% partial hepatectomy (PH) plus 2-Acetoamidofluorene (2-AAF) treatment. (uni-goettingen.de)
There are two types of damage from which the liver is able to regenerate, one being a partial hepatectomy and the other being damage to the liver by toxins or infection. (wikipedia.org)
The following describes regeneration following a partial hepatectomy. (wikipedia.org)
Following partial hepatectomy, regeneration occurs in three phases. (wikipedia.org)
Immediately after a hepatectomy, numerous signaling pathways activate to start the process of regeneration. (wikipedia.org)
To address this issue, we established a 70% hepatectomy model of liver fibrosis in mice, used high-throughput sequencing technology to obtain the expression profiles of lncRNAs, miRNAs, and mRNAs, and constructed a lncRNA-miRNA-mRNA regulatory network. (bvsalud.org)

The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
Liver transplants are often an important component to treatment, but unfortunately, there aren't enough donor livers to help every child. (childrenshospital.org)

Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. (nih.gov)
Mutations of PTCH1 gene in two pedigrees with bifid rib-basal cell nevus-jaw cyst syndrome. (nih.gov)
Diagnosis of Mutations in the dystrophin gene can cause Duchenne these disorders is based on clinical presentation, muscular dystrophy or Becker muscular dystrophy. (who.int)
90% of cases, mutations that from mutation in the dystrophin gene (located on short disrupt the reading frame (frame shift) lead to arm of X chromosome, Xp21). (who.int)
Better understanding of new mutations and the wide range of possible phenotypes led to the development of a new nomenclature proposal, based on the gene and inheritance pattern. (medscape.com)
[ 6 ] However, the gene mutations responsible for the different forms of CMT1 are clearly myelin genes. (medscape.com)
Antigenic drift involves small mutations in the genes of influenza viruses that lead to changes in HA and NA that accumulate over time, resulting in the emergence of novel strains that the human immune system may not recognize. (cdc.gov)
They are caused by mutations of the dystrophin gene, the largest known human gene, at the Xp21.2 locus. (msdmanuals.com)

This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. (nih.gov)
Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
In contrast, the thermally sensitive population exhibited higher basal levels of heat shock proteins and had three times fewer changes in gene expression overall. (frontiersin.org)

The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
Conclusions Human spindle-shaped AF-MSCs or HPL cells might be valuable tools to induce liver repair and support liver function by cell transplantation. (bmj.com)
His principal research interests are in the transplant-related immune tolerance and genes associated with progression and recurrence of hepatocellular carcinoma in patients undergoing liver transplantation. (wjgnet.com)
Dr. Wang holds memberships in the International Liver Transplantation Society (ILTS), European Association for the Study of the Liver (EASL), American Society of Transplantation (AST), and International Society for Infectious Diseases (ISID). (wjgnet.com)
His honors include the Young Investigator Awards in the 17th and 22nd Annual International Congress of ILTS, the Travel Award in the 12th Congress of the Asian Society of Transplantation, the Young Innovator Award in the 3rd Annual Scientific Exchange of the American Society of Transplantation, and the Young Innovator Award in the EASL Special Conference on Liver Transplantation 2011. (wjgnet.com)
Considering the advantage of exosomes as its non-living nature and dosing adjustability over MSC, exosome will be one alternative of MSC transplantation. (biomedcentral.com)
Many patients are not candidates given the advanced stage of their cancer at diagnosis or their degree of liver disease and, ideally, could be cured by liver transplantation. (medscape.com)

These processes occur outside of the hepatocyte and prime the liver for regeneration. (wikipedia.org)
Using this approach, they identified genes that were only turned on by specific subsets of hepatocytes, and then used these genes as markers to distinguish the identities and functions of different hepatocyte subsets. (medicalxpress.com)

Kinetically down-regulated genes involved in the lipid metabolism are: hydroxyacid oxidase 3, fatty acid CoA ligase long chain 2, and steroyl CoA desaturase 1.The regulation of protein expression of the cell cycle genes CDC42 and cyclin D1 was studied by Western Blot technique, in the oval cell liver regeneration. (uni-goettingen.de)
The liver performs vital functions, including chemical detoxification, blood protein production, bile excretion, and regulation of energy metabolism. (medicalxpress.com)
In rats, hepatic ketogenic capacity increases rapidly during postnatal development ( 4 ) or fasting ( 5 ) when the mRNA, protein, and activity of HMGCS2 increase in liver ( 6 - 8 ). (aacrjournals.org)
Administration of dibutyryl-cyclic AMP to adult rats increases mRNA, protein levels, and enzymatic activity of HMGCS2 in the liver ( 6, 9 ). (aacrjournals.org)
Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients. (ucsf.edu)
Through the protein network analysis, a core protein interaction network composed of 20 hub genes was derived. (bvsalud.org)
Shukla V, Cuenin C, Dubey N, Herceg Z. (2011) Loss of histone acetyltransferase cofactor transformation/transcription domain-associated protein impairs liver regeneration after toxic injury. (who.int)
Diagnosis is suggested clinically and is confirmed by genetic testing or analysis of the protein product (dystrophin) of the mutated gene. (msdmanuals.com)

The Zhu lab also exposed mice to chemicals that mimicked common forms of liver damage, showing that cells in zone 2 were most able to evade death, regenerate hepatocytes, and sustain liver function. (medicalxpress.com)
Preclinical studies in mice have shown that gene therapy is a promising approach to treat individuals with Friedreich's ataxia. (curefa.org)
Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
In the present review, the phenotypes of Met gene‑modified mice are summarized. (spandidos-publications.com)
Using genetic engineering techniques, the team induced hepatoblastoma tumors in mice that either did or did not have Myc in their liver cells. (upmcphysicianresources.com)
They found that mice lacking Myc in their liver cells generated tumors more slowly and survived longer than expected. (upmcphysicianresources.com)
Mice lacking liver Myc still developed tumors, but the tumors grew more slowly, suggesting that tumor growth, but not initiation, is dependent on Myc," explained Dr. Prochownik. (upmcphysicianresources.com)
It reveals that all living things - from men to mice, from trees to seeds - are moulded and controlled by 'electrodynamic fields', which can be measured and mapped with standard modern volt-meters. (i-sis.org.uk)
The collected exosomes or MSCs were injected intravenously into liver injury mice that had been prepared by the intravenous con-A injection. (biomedcentral.com)
Chapter 3 outlines outcomes of liver-specific GR deficiency using mice with inducible liver-specific GR knockout, modeling sepsis with cecal ligation and puncture. (suny.edu)

Liver regeneration (LR) is a complex process inﬂuenced by various genes and pathways, the majority of the of research on LR focus on the initiation and proliferation phase while studies on termination phase is lacking. (jomh.org)
Taken together, the microarray analysis in this study suggests that DEGs such as Ste2 and Btg2 are the hub genes, which are associated with the regulation of termination stage LR, while the molecular mechanisms are possibly related to the MAPK and TGF-β signal transduction pathways. (jomh.org)
Transcriptomic analysis of liver biopsies in patients with NASH revealed that NASH progression is associated with rewiring of metabolic pathways, including upregulation of de novo lipid/cholesterol synthesis and fatty acid remodelling. (nih.gov)
Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. (urotoday.com)
Her research employs high throughput genomics, single cell sequencing, live imaging, cell biology, and functional approaches to unravel the pathways that balance stem cell self-renewal with tissue regeneration. (rockefeller.edu)

Factors that increase the probability liver diseases are developed include but are not limited to obesity, type 2 diabetes, tattoos or body piercings, the injection of drugs using shared needles, exposure to other people's blood and body fluids, unprotected sex, and exposure to chemicals and toxins. (wikipedia.org)
In the early 1970s, researchers discovered that most severe liver diseases caused such findings regardless of etiology, and, in the late 1970s, the biochemical and enzymatic causes of the disease were reported. (medscape.com)
To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
Diseases, such as hepatitis and liver cancer, can put a child's life at risk. (childrenshospital.org)
When functioning normally, the Hippo pathway is important to cell growth, but when malfunctioning, the Hippo pathway can also play a role in diseases such as liver cancer and liver fibrosis. (childrenshospital.org)
The Camargo lab has recently identified chemicals that control Hippo signaling, which could be turned into novel treatments for liver cancer and other liver diseases. (childrenshospital.org)
More importantly, the factors they release may also play an important role in cell treatment in diseases of the liver. (bmj.com)

She combines mRNA injections, whole-embryo live-imaging, single cell sequencing and in situ whole mount hybridization to capture the dynamics and molecular players of development. (uni-goettingen.de)
His efforts are focused on the identification of the complete set of biomineralizing effector genes in the pulmonate gastropod Lymnaea stagnalis , and on identifying the gene regulatory and cellular communication events that coordinate the initiation of shell formation in the early snail embryo. (uni-goettingen.de)

Her lab has recently worked with gene expression patterns during sexual reproduction and regeneration of syllids. (uni-goettingen.de)
Scoccianti C, Ricceri F, Ferrari P, Cuenin C, Sacerdote C, Polidoro S, Jenab M, Hainaut P, Vineis P, Herceg Z. (2011) Methylation patterns in sentinel genes in peripheral blood cells of heavy smokers: Influence of cruciferous vegetables in an intervention study. (who.int)

2012) Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers. (who.int)

We aimed to identify potential genes and reveal the underlying the molecular mechanisms involved in the precise regulation of liver size during the termination phase of LR. (jomh.org)
Liver regeneration-mechanisms and models to clinical application. (jomh.org)
Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
To learn more about mechanisms that hepatocytes in zone 2 use to regenerate liver function, members of the Zhu lab performed genetic screens to look for genes important for growth and regeneration. (medicalxpress.com)
Zebrafish Fin: Complex Molecular Interactions and Cellular Mechanisms Guiding Regeneration. (uni-ulm.de)
Studies in several vertebrate models and Drosophila have uncovered a surprising degree of evolutionary conservation of regulatory mechanisms and genes that control early cardiogenesis. (biologists.com)

Oval cells proliferate and differentiate in hepatocytes expressing albumin, and they differentiate in biliary cells expressing cytokeratin 7 (CK 7).Serial Analysis of Gene Expression (SAGE) was applied to the hepatic stem cell model of rat liver regeneration for studying gene expression pattern of liver regeneration during early stage of oval cell proliferation and differentiation. (uni-goettingen.de)
Since the metabolism of galactose is dependent on liver blood flow and hepatic functional mass, further studies are needed. (hindawi.com)
The hepatic artery supplies 30% of the blood flow to the normal liver parenchyma but greater than 90% to hepatic tumors, including both HCC and metastatic lesions. (medscape.com)
The primary venous drainage of the liver is through three large hepatic veins that enter the inferior vena cava adjacent to the diaphragm. (medscape.com)
The biliary anatomy of the liver generally follows hepatic arterial divisions. (medscape.com)
The hepatic duct then divides into two or three additional ducts draining the liver. (medscape.com)

Liver and serum samples were collected 24 h later to evaluate the macro- and microscopic images, the alanine aminotransferase (ALT), and cytokine messenger RNA (mRNA) expression levels. (biomedcentral.com)
The suppressive effects of MSC-derived exosomes and the MSCs in this injury model were evaluated by the level of plasma alanine aminotransferase (ALT), histopathological examinations, the messenger RNA (mRNA) expression of pro- and anti-inflammatory cytokines, and the population alteration of regulatory T cells (Treg) among non-parenchymal liver cells (NPCs). (biomedcentral.com)

A total of 153,057 tags were analysed from normal liver (52,343 tags), from sham control treated with 2-AAF (50,502 tags), and from an early stage of the oval cell proliferation (50,212 tags). (uni-goettingen.de)
His team previously showed that although Myc plays a variety of roles in healthy dividing cells, it is not important for normal liver cell growth and regeneration. (upmcphysicianresources.com)
In fact, the Myc gene can be completely deleted from normal liver cells without affecting their long-term regenerative potential, as Dr. Prochownik and his colleagues reported in other work earlier this year. (upmcphysicianresources.com)
The more controlled conditions that exist with normal liver regeneration are therefore much less Myc-dependent. (upmcphysicianresources.com)

With the hypothesis that liver-specific glucocorticoid therapy will be more clinically beneficial than systemic therapy, we studied liver-specific GR effects in infection, inflammation, or sepsis. (suny.edu)

Temporal regulation of these genes in the context of the oval cell regeneration was studied by Real Time PCR. (uni-goettingen.de)
From the data of the present study we conclude that the cell cycle genes CDC42 and cyclin D1 could be involved in the mechanism of proliferation of the oval cell in the liver regeneration process. (uni-goettingen.de)
Individual lobules are organized in concentric zones in which hepatocytes, the primary liver cell type, carry out diverse functions. (medicalxpress.com)
However, more investigation is needed to understand the different cell types in the human liver," says Hao Zhu, M.D., an associate professor at CRI and lead author of the study. (medicalxpress.com)
Researchers at the University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh of UPMC have uncovered how a key cancer gene works to accelerate cell growth in a mouse model of pediatric liver tumors. (upmcphysicianresources.com)
A research team led by Jared Churko, PhD, director of the University of Arizona iPSC Core in the UA Sarver Heart Center, used a transcriptomic approach - studying what genes are expressed - to identify gene signatures of cell subpopulations identified as atrial-like or ventricular-like. (azbio.org)
In a study published this month in Nature Communications, Jared Churko, PhD, assistant professor of Cellular and Molecular Medicine at the UA College of Medicine - Tucson, used a systems-based approach encompassing single-cell transcriptomics, single-cell proteomics and CRISPR gene-editing to identify different subpopulations of cardiomyocytes. (azbio.org)
CRISPR gene editing is a technology for modifying an organism's DNA code at the single-cell level. (azbio.org)
In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)
Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. (uni-ulm.de)
Gene networks reveal stem-cell state convergence during preneoplasia and progression to malignancy in multistage skin carcinogenesis. (ucsf.edu)
Hair cell regeneration was not a major topic of research in hearing science until 1986-87. (hearingreview.com)
Hair cell regeneration occurring after hair cells were destroyed. (hearingreview.com)
We and others are working hard to understand the molecular chain of events responsible for hair cell regeneration in species where it occurs. (hearingreview.com)
The work on mammals now is at a point where we can induce a small amount of cell division in the inner ear in a dish (that is, in a culture), as well as in vivo (occurring within a living organism). (hearingreview.com)
In fact, a team of researchers has recently used new findings from research on development of the inner ear to induce a few new cells in the guinea pig cochlea to become hair cells again proving that hair cell regeneration will be possible. (hearingreview.com)
The good news is that, for the first time in history, there are teams of investigators worldwide exploring the possibility that hair cell regeneration can be induced in the mammal and human cochlea. (hearingreview.com)
From discovery of molecules that could induce regeneration in laboratory animals, it could be as little as another 10 years until we achieve hair cell regeneration in humans. (hearingreview.com)
Ralf Heinrich is interested in apoptosis and pharmacological intervention with apoptotic processes to support cell survival, functionality and regeneration. (uni-goettingen.de)
This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. (biomedcentral.com)
Comparisons were made in primary human hepatocytes, the human hepatoma cell line HEPG2, and the non-liver cell line HEK293t. (suny.edu)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
and stem cell regeneration. (lu.se)

Experimental pathology of liver: restora-tion of liver of white rat following partial surgical removal. (jomh.org)
The liver can regenerate after partial surgical removal or chemical injury. (wikipedia.org)

Dr. Miller received a PhD in molecular biology from Princeton University, where he developed functional genomic approaches to study tumor virus control of cellular gene expression. (nih.gov)
We used a high density SNP array (600 K, Affymetrix) to estimate genomic heritability, perform genome-wide association analysis, and identify genomic regions and positional candidate genes (PCGs) associated with internal organ traits in an F2 chicken population. (biomedcentral.com)
Thus, the discovery of genomic regions and positional candidate genes (PCGs) for intestine length or weights and percentages of heart, liver, gizzard or lungs, is a first step for understanding their genetic architecture. (biomedcentral.com)

Once these processes are complete, hepatocytes are able to enter the liver to start the process of proliferation. (wikipedia.org)
At Boston Children's Hospital, researcher Fernando Camargo, PhD , is investigating the different processes that promote liver regeneration and healing. (childrenshospital.org)

Fulminant onset of liver failure occurs in the first few months of life. (medscape.com)
In the current study, researchers studied the gene's role in a mouse model of hepatoblastoma, a form of liver cancer that occurs in children, typically under the age of 3. (upmcphysicianresources.com)
c-Myc transrepression is mediated by blockade of the transactivating activity of Miz-1, which occurs mainly through a Sp1-binding site in the proximal promoter of the gene. (aacrjournals.org)
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)

Her team investigates how stem cells establish unique chromatin landscapes and programs of gene expression, and how this shifts in response to changes in their local environment. (rockefeller.edu)

The rat HMGCS2 gene contains elements that control its multihormonal regulation and tissue specificity ( 11 - 14 ). (aacrjournals.org)

These two types of cells can repair liver tissue even when the normal mechanism of liver regeneration fails. (wikipedia.org)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
The liver is one of the few organs in the body where differentiated adult stem cells can divide to regenerate after an injury. (childrenshospital.org)
Studying the Hippo pathway can help scientists develop treatments which encourage a liver to heal itself, allow scientists to grow liver cells in the lab (a therapeutic approach not yet available) or study the development of liver cancer. (childrenshospital.org)
Conditioned medium (CM) derived from AF-MSCs or HPL cells was then delivered intrahepatically in order to determine whether the engraftment of the cells or their secreted molecules are the most important agents for liver repair. (bmj.com)
While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. (medicalxpress.com)
Now, research from the Children's Medical Center Research Institute at UT Southwestern (CRI) has identified the cells responsible for liver maintenance and regeneration while also pinpointing where they reside in the liver. (medicalxpress.com)
Previous efforts to identify the cells most responsible for liver regeneration were hindered by a lack of markers to distinguish and compare the functions of distinct types of hepatocytes in different regions of the liver. (medicalxpress.com)
Along with three previously established mouse strains, researchers observed how the labeled cells multiplied or disappeared over time, and which were responsible for liver regeneration after damage. (medicalxpress.com)
Members of the Zhu lab discovered that cells in zone 2 gave rise to new hepatocytes that populated all three zones of liver lobules while cells from zones 1 and 3 disappeared. (medicalxpress.com)
These unexpected observations suggested that there is not a rare population of stem cells responsible for liver maintenance, but instead, a common set of mature hepatocytes within a specific region of the liver that regularly divide to make new hepatocytes throughout the liver. (medicalxpress.com)
So it makes sense that cells in zone 2, which are sheltered from toxic injuries affecting either end of the lobule, would be in a prime position to regenerate the liver. (medicalxpress.com)
In addition, the tools we created to study different types of hepatocytes can be used to examine how different cells respond to liver damage or to genetic changes that cause liver cancer ," says Zhu. (medicalxpress.com)
Certain measurements are used to determine the amount of liver cells indirectly by measuring metabolic function or drug clearance as a substitute for quantitative liver function. (hindawi.com)
HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
However, because Myc is expressed in normal cells as well as cancerous ones, there have been concerns in the field that inhibiting the gene would produce too many detrimental side effects. (upmcphysicianresources.com)
Understanding the gene signatures of different populations of hiPSC-CMs will impact our understanding of how to use such cells to discover drugs, model heart disease and repair a damaged heart," Dr. Churko explained. (azbio.org)
We have also discovered one gene (and there will be others) that is responsible for turning off the production of hair cells during development and may be involved in preventing regeneration. (hearingreview.com)
Phenotypical change of non-parenchymal liver cells was also evaluated by flow cytometry. (biomedcentral.com)
This type of liver injury is mediated through activation of the adaptive immune system including natural killer and Kupffer cells, which is employed as a method to evaluate the induction liver tolerance [ 19 - 21 ]. (biomedcentral.com)

Animal experimentation (Rat PH model) was performed to acquire liver tissues which were then used for western blot analysis to verify our results. (jomh.org)

Genes associated with the classical complement pathway were downregulated in non-muscle invasive cancer. (urotoday.com)

Scarring in the liver is very dangerous and can lead to further complications and liver disease. (wikipedia.org)
Complications increase when the initial cause of the damage to the liver is still present. (wikipedia.org)
Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)

In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)

Proteome profile analysis of HPL-CM indicated the presence of anti-inflammatory factors such as interleukins IL-10, IL-1ra, IL-13 and IL-27 which may induce liver recovery. (bmj.com)

The liver is an organ essential to digestion, energy metabolism and filtration of poisons from the body. (childrenshospital.org)
Galactose is a C-4 epimer of glucose and is catalyzed to glucose-1-phosphate by galactokinase, the rate-limiting step of metabolism for galactose exclusively in the liver [ 5 , 6 ]. (hindawi.com)

Induction of stathmin expression during liver regeneration. (wikidata.org)

Our present study identifies the Dorsocross T-box genes as key mediators of combined Dpp and Wg signals during this process. (biologists.com)

The new research focuses on one of cancer's key genetic players, a gene called Myc. (upmcphysicianresources.com)
Although the weights of internal organs have not been direct targets for selection in poultry breeding programs, feed intake (commonly targetted for selection) has exhibited positive genetic correlations with heart weight (0.77), liver weight (0.73) and intestine weight (0.92) in a meat-type chicken population [ 8 ]. (biomedcentral.com)
Our loss- and gain-of-function studies, as well as the observed genetic interactions among Dorsocross, tinman and pannier , suggest that co-expression of these three genes in the cardiac mesoderm, which also involves cross-regulation, plays a major role in the specification of cardiac progenitors. (biologists.com)
Antigenic shifts are probably due to genetic recombination (an exchange of a gene segment) between influenza A viruses that affect humans and/or animals. (cdc.gov)
Х-зчеплений рецесивний Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)

Pentoxifylline improves liver regeneration through down-regulation of TNF-α synthesis and TGF-β1 gene expression. (wjgnet.com)
Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1) and male-specific lethal 3 (Msl3). (nih.gov)
The limited changes in gene regulation suggest that individuals have reduced genome plasticity to tolerate thermal fluctuations and consequently may not have enough energy to repair damage and resume cellular homeostasis at extreme temperatures. (frontiersin.org)

The meaning of genes and genomes begins to emerge in this wider context. (cam.ac.uk)

To these ends his team is also developing methods to characterize gene function in this nontraditional model organism. (uni-goettingen.de)

Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. (nih.gov)
Postmortem examination revealed that both the liver and the kidney had a highly unusual pattern of nodular cirrhosis, the histopathologic hallmark of the disease. (medscape.com)
These findings, reported today in Science , could help scientists answer important questions about liver maintenance, liver damage (such as from fatty liver or alcoholic liver disease), and liver cancer. (medicalxpress.com)
The identification of zone 2 hepatocytes as a regenerative population answers some fundamental questions about liver biology and could have important implications for liver disease. (medicalxpress.com)
In a mouse model of cardiac disease, these doses only corrected cardiac dysfunction partially and transiently and led to adverse findings associated with iron-sulfur cluster deficiency in liver. (curefa.org)
Liver disease is a substantial contributor to the development of end-stage renal disease (ESRD). (hindawi.com)
The results provide a better understanding of how inhibition of this gene can be used to combat the disease, and also suggest that doing so may be associated with fewer side effects than originally assumed. (upmcphysicianresources.com)
The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. (medscape.com)
Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis, using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements. (medscape.com)
There is also a growing problem with cirrhosis, which develops in the setting of nonalcoholic fatty liver disease (NAFLD), or nonalcoholic steatohepatitis (NASH). (medscape.com)
3] Thus, developing effective and efficient care for patients with end-stage liver disease and HCC must become a significant focus. (medscape.com)
People with liver disease may need to use lower doses of CBD. (medlineplus.gov)

Analyses based on STRING database and Cytoscape software identiﬁed genes like Ste2 and Btg2 as the hub genes in the termination stage LR. (jomh.org)
In this respect, he is using a broad range of methods including immunohistochemical analyses, histological staining procedures and ultrastructural investigations as well as gene expression analyses and phylogenomic approaches. (uni-goettingen.de)
cRNA samples were prepared and loaded onto Sentrix Rat-Ref12 Beadchips for gene array analyses. (cdc.gov)

Sometimes, hepatocytes do not have the ability to proliferate and an alternative form of regeneration may take place to rebuild the liver. (wikipedia.org)

Bei Schädigung des Lebergewebes können sie durch ihre Fähigkeit zur Proliferation eine Regeneration der Leber herbeiführenUnter bestimmten Umständen wie z.B. Hepatokarzinogenese oder einer durch Drogen, Viren oder Toxine induzierten chronischen Leberschädigung, wenn die proliferative Fähigkeit der Hepatozyten beeinträchtigt ist, kommt es zur Rekrutierung fakultativer hepatischer Stammzellen den so genannten Ovalzellen die in der Lage sind Hepatozyten und Gallengangszellen zu generieren. (uni-goettingen.de)
Es kann daher angenommen werden, dass die Ovalzellen ein zweites Kompartiment sind, dass an der Regeneration der Leber beteiligt ist, wenn diese massiv geschädigt und die Proliferation der Hepatozyten suprimiert ist.Um die Rattenleberregeneration durch Ovalzellen zu untersuchen wurde das Protokoll der 70% igen partiellen Hepatektomie (PH) und einer zusätzlichen Behandlung mit 2-Acetoamidofluoren (2-AAF) verwendet. (uni-goettingen.de)
After the regeneration process has completed, TGF-β puts an end to the proliferation by inducing apoptosis. (wikipedia.org)

The liver has the unique capability to regenerate by itself after an injury. (uni-goettingen.de)
The liver is the only visceral organ with the capacity to regenerate. (wikipedia.org)
As little as 51% of the original liver mass is required for the organ to regenerate back to full size. (wikipedia.org)

While evaluating an AAV9-based frataxin gene therapy using a chicken β-actin promoter, the authors showed that toxic overexpression of frataxin could be reached in mouse liver and heart with doses between 1 × 1013 and 1 × 1014 vg/kg. (curefa.org)
Together, these data provide insights into the toxicity of frataxin overexpression that should be considered in the development of a gene therapy approach for Friedreich's ataxia. (curefa.org)
This understanding could lead to regenerative therapy discoveries for the millions of people living with damaged heart muscle caused by heart attacks or other chronic heart conditions. (azbio.org)
Human Gene Therapy. (elsevierpure.com)

The factors responsible for the postnatal and starvation-associated induction of HMGCS2 gene expression have been identified and shown to involve changes in circulating hormone and fatty acid levels. (aacrjournals.org)

Liver homeostasis is maintained by midlobular zone 2 hepatocytes" Science (2021). (medicalxpress.com)

Thus, the effect of HD on actual residual liver function remains unclear. (hindawi.com)
The role of lncRNAs in the regeneration of fibrotic liver is unclear. (bvsalud.org)

1974. Pesticidal chemicals affecting some energy-linked functions of rat liver mitochondria in vitro . (cdc.gov)

HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)

Recent advancements in understanding fin regeneration in zebrafish. (uni-ulm.de)

We found that the more thermally tolerant population had greater plasticity of gene expression and had significantly more downregulated genes, which may provide more energy to repair damage associated with thermal stress and to maintain basic functions at these extreme temperatures. (frontiersin.org)
However, a single HD session does not affect liver function significantly as assessed by the GSP test. (hindawi.com)

Anatomy14

Organisms13

Diseases16

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes20

Disciplines and Occupations1

Technology, Industry, Agriculture1

Humanities1

Information Science2

Named Groups1

Differentially5

Hepatectomy6

Donor livers2

Mutations8

Proteins3

Transplantation9

Hepatocyte2

Protein8

Mice10

Pathways5

Diseases7

Embryo2

Patterns2

Cancers1

Mechanisms6

Hepatic6

MRNA2

Normal liver4

Inflammation1

Cell24

Partial2

Genomic3

Processes2

Occurs4

Chromatin1

Tissue-specificity1

Cells20

Western Blot1

Pathway1

Complications3

Transcription factors1

Induce liver1

Metabolism2

Stathmin1

Identifies1

Genetic5

Regulation3

Context1

Organism1

Disease12

Analyses3

Proliferate1

Proliferation3

Regenerate3

Therapy4

Induction1

20211

Unclear2

Chemicals1

Tissues1

Advancements1

Significantly2