Mice, KnockoutPhenotypeGene Knockout TechniquesMice, Inbred C57BLGene TargetingGene DeletionDisease Models, AnimalMetabolic EngineeringMice, TransgenicSignal TransductionIntegrasesGenetic EngineeringMolecular Sequence DataRNA, MessengerMutationGenes, EssentialCells, CulturedGene Expression RegulationHaloferax volcaniiBase SequenceReverse Transcriptase Polymerase Chain ReactionEmbryo, MammalianLiverMetabolic Networks and PathwaysApolipoproteins ECrosses, GeneticMutagenesis, InsertionalGene ExpressionGene Expression Regulation, DevelopmentalModels, BiologicalInterferon-gammaHeterozygoteBrainImmunohistochemistryBlotting, WesternGene SilencingHomozygoteRecombination, Genetic