AnatomyChemicals and DrugsPhenomena and Processes
Integrin alphaVIntegrin beta3Integrin alphaVbeta3CerebrosidesSulfoglycosphingolipidsIntegrinsLewis Blood-Group SystemIntegrin beta ChainsIntegrin alpha5Integrin alpha5beta1Receptors, VitronectinIntegrin alpha6Antigens, CD29Integrin alpha ChainsCell Line, TumorIntegrin alpha3beta1Integrin beta4Integrin alpha4Integrin alpha2Cell AdhesionIntegrin alpha2beta1Integrin alpha6beta4
Beta3ITGAVProteinSubunitsSeveral integrinsHeterodimeric integralExtracellular matrixVitronectin receptorSignal transductionCD51PlateletsLigandCombine with multipleInhibitionDifferentiationIntegralAngiogenesisPhenotypesBetaPathwayStructuralComplexPMIDAlphaTherapeuticCompoundsInflammationTriglycerideFocalMoleculeRegulateTumorHumanMutationsExpression patternsChromosomeAccessionCellular
Beta34
  • Description: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. (thermofisher.com)
  • Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C. (lookformedical.com)
  • The ligand binds at the major interface between the alphaV and beta3 subunits and makes extensive contacts with both. (rcsb.org)
  • Ligand binding induces small changes in the orientation of alphaV relative to beta3. (rcsb.org)
ITGAV4
  • Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. (wikipedia.org)
  • ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (wikipedia.org)
  • In mammals the integrins that include alpha-V are : Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer, and prostate cancer. (wikipedia.org)
  • Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. (scbdd.com)
Protein7
  • This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. (nih.gov)
  • The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. (nih.gov)
  • The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. (nih.gov)
  • Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
  • Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
  • The CD49b protein is an integrin alpha subunit. (wikidoc.org)
  • The ITGB3 protein product is the integrin beta chain beta 3. (modellab.cn)
Subunits4
  • CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)
  • Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. (assaygenie.com)
  • Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
  • In mammals, 24 different integrins are generated through different combinations of 18 α and 8 β subunits. (transcriptionfactor.org)
Several integrins1
  • “This is the first foray into targeting not just a single integrin, but rather several integrins that appear to be working in concert to promote fibrosis,†said David Griggs, Ph.D., Director of Biology at Saint Louis University’s Center for World Health and Medicine and an author of the paper. (healthmedicinet.com)
Heterodimeric integral2
  • Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. (assaygenie.com)
  • Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)
Extracellular matrix2
  • Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
  • Integrins are a family of cell surface transmembrane receptors, each consisting of an α and a β subunit that bind to extracellular matrix (ECM) proteins and cellular counter receptors and associate with the cytoskeleton. (transcriptionfactor.org)
Vitronectin receptor1
  • the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). (wikipedia.org)
Signal transduction2
  • In addition to adhesion, many integrins are known to facilitate signal transduction. (wikipedia.org)
  • Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
CD513
  • The following product was used in this experiment: CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), Biotin, eBioscience™ from Thermo Fisher Scientific, catalog # 13-0519-82, RRID AB_529536. (thermofisher.com)
  • Staining of M21 cells with 0.5 µg of Mouse IgG1 kappa Isotype Control Biotin (Product # 13-4714-85) (open histogram) or 0.5 µg of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). (thermofisher.com)
  • CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. (thermofisher.com)
Platelets1
  • Integrin beta 3 is found along with the alpha IIb chain in platelets. (modellab.cn)
Ligand3
  • Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
  • Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)
  • Integrin alpha-V/beta-5 is a receptor for fibronectin and it recognizes the sequence R-G-D in its ligand. (transcriptionfactor.org)
Combine with multiple2
Inhibition2
  • Therefore, pharmacological inhibition of integrins is of great interest for the treatment and prevention of disease. (thno.org)
  • In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)
Differentiation1
  • DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
Integral1
  • Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (modellab.cn)
Angiogenesis3
  • This integrin may regulate angiogenesis and cancer progression. (assaygenie.com)
  • Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. (nih.gov)
  • Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
Phenotypes1
  • A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. (edu.sa)
Beta7
  • Quantum dots with cyclo(RGDfC) covalently immobilized to their surface effectively targeted cultured TM cells and were rapidly and efficiently endocytosed by binding to alpha(v)beta(3) and alpha(v)beta(5) integrins. (uni-regensburg.de)
  • Due to their antagonism for alpha(v)beta(3) and alpha(v)beta(5) integrins, these cyclic RGD pentapeptides effectively ameliorated the CTGF-induced effects and strongly promoted specific nanoparticle association. (uni-regensburg.de)
  • Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. (nih.gov)
  • It is expressed on erythrocytes and erythroblasts, and serves as a receptor for LFA-1, Mac-1, and CD11c/CD18, plus alpha 4 beta 1 and alpha-V containing integrins. (rndsystems.com)
  • Capillary Electrophoresis Frontal Analysis for Characterization of Alpha-V Beta-3 Integrin Binding Interactions. (ubc.ca)
  • An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)
  • The researchers showed that removing a gene in the myofibroblasts that makes a specific subset of proteins called alpha v integrins blocks the ability of these cells to trigger activation of TGF beta. (healthmedicinet.com)
Pathway1
  • Our data suggest that genes involved in the TGFbeta pathway, coagulation, cell adhesion and cell hydration pathways may be important in risk for priapism. (duke.edu)
Structural1
  • The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. (rcsb.org)
Complex1
  • Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. (rcsb.org)
PMID1
  • Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)
Alpha2
  • The product of this gene belongs to the integrin alpha chain family. (assaygenie.com)
  • Lineage-Specific Induced Pluripotent Stem Cell-Derived Smooth Muscle Cell Modeling Predicts Integrin Alpha-V Antagonism Reduces Aortic Root Aneurysm Formation in Marfan Syndrome Mice. (stanford.edu)
Therapeutic1
  • Specific targeting of TM cells could play a critical clinical role by increasing the therapeutic efficacy of nanoparticles, e.g. for nonviral gene delivery. (uni-regensburg.de)
Compounds1
  • Herein, this review examines and evaluates the various drugs and compounds targeting integrins and the disease states in which they are implicated. (thno.org)
Inflammation1
  • Candidate genes for association with priapism were identified based on their involvement in adhesion, coagulation, inflammation and cell signalling. (duke.edu)
Triglyceride1
  • Serum lipid is modulated by many factors, including some genes, such as leptin, adipose triglyceride lipase and so on. (biomedcentral.com)
Focal1
  • The integrin tails have no intrinsic kinase activity but rather serve as a site for the docking of various kinases and related adaptor proteins that comprise focal adhesions. (thno.org)
Molecule1
  • Furthermore, they were able to replicate the effect of the gene deletion by treatment with a small molecule compound, thus opening the door to a potential new therapy for patients. (healthmedicinet.com)
Regulate1
  • The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
Tumor3
  • The focus of this article is Tumor Suppressor Genes. (assaygenie.com)
  • Indeed, while it is clear that cancer metastasis must involve detachment of cancer cells from the primary tumor, such a phenomenon could well be attributed to mutation(s) and/or aberrant gene expression patterns in one or a few genes and not necessarily reflect involvement of a more coordinated process such as EMT [ 9 ]. (biomedcentral.com)
  • 2005). Stabilized plasmid-lipid particles containing PEG-diacyglyceriols exhibit extended circulation lifetimes and tumor selective gene expression. (ubc.ca)
Human2
  • A number of human congenital disorders have been associated with defective integrin-mediated adhesion, including the blistering disorder junctional epidermolysis bullosa, the bleeding disorder Glanzmann's thrombastenia , leukocyte adhesion deficiency-I (β2 integrins in leukocytes) and leukocyte adhesion deficiency-III, nephrotic syndrome and interstitial lung disease and muscular dystrophy. (transcriptionfactor.org)
  • Human ITGA2 genome location and ITGA2 gene details page in the UCSC Genome Browser . (wikidoc.org)
Mutations4
  • Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. (nih.gov)
  • PLP1 gene mutations cause spastic paraplegia type 2 in three families. (nih.gov)
  • The Angiosarcoma Project performed whole-exome sequencing of 47 tumors and found recurrent mutations of genes including KDR , TP53 , and PIK3CA . (medscape.com)
  • Lafora disease is a rare disorder caused by loss of function mutations in either the EPM2A or NHLRC1 gene. (ibecbarcelona.eu)
Expression patterns1
  • Together, these findings suggest that Rps27 and Rps27l are evolutionarily retained because their subfunctionalized expression patterns render both genes necessary to achieve the requisite total expression of two equivalent proteins across cell types. (stanford.edu)
Chromosome1
  • Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. (tamu.edu)
Accession1
  • Gene symbols, accession ids and various other target identifiers. (nih.gov)
Cellular2
  • J.de Jonge, J. Leenhouts, M. Holtrop, P. Schoen, P. Scherrer, P.R. Cullis, J. Wilschut and A. Huckriede, "Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA. (ubc.ca)
  • Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)