• Sampaio AL, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M: Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. (exbio.cz)
  • In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. (utsouthwestern.edu)
  • In the thymus, DOCK8-deficient mice lack a terminally differentiated subset of NK1.1(+) NKT cells expressing the integrin CD103, whereas in the liver, DOCK8-deficient NKT cells express reduced levels of the prosurvival factor B-cell lymphoma 2 and the integrin lymphocyte function-associated antigen 1. (ox.ac.uk)
  • We also find that duplicated regions show enrichment for genes associated with "antigen processing and presentation" and other immune related categories. (biomedcentral.com)
  • The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. (nature.com)
  • Based on a better understanding of the basement membrane zone (BMZ) and the genes responsible for its components, newer treatments (eg, gene or protein therapy) may provide solutions to the skin fragility found in patients with epidermolysis bullosa. (medscape.com)
  • From NCBI Gene: The ITGB3 protein product is the integrin beta chain beta 3. (nih.gov)
  • Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
  • The CD49b protein is an integrin alpha subunit. (wikidoc.org)
  • The rat monoclonal antibody 5H10-27 (MFR5) recognizes an extracellular epitope of murine CD49e, a 135 kDa protein serving as VLA-5 alpha chain, expressed on thymocytes, activated T cells, splenic B cells, and mast cells. (exbio.cz)
  • The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. (nih.gov)
  • Integrin E Rabbit Polyclonal Antibody detects endogenous levels of Integrin E protein. (ebiocell.com)
  • A gene on chromosome 21q22.3 that encodes an integrin beta chain family protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). (skinscanapp.com)
  • HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
  • PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)
  • These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)
  • Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. (thermofisher.com)
  • The following product was used in this experiment: CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), Biotin, eBioscience™ from Thermo Fisher Scientific, catalog # 13-0519-82, RRID AB_529536. (thermofisher.com)
  • Description: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. (thermofisher.com)
  • Mouse monoclonal antibody to Integrin beta 3. (revoluciondelosgladiolos.org)
  • The M290 antibody specificaly binds to CD103, the α chain of αIELβ7 integrin. (bdbiosciences.com)
  • The ordered expression of αIEL during thymocyte development (which occurs under the influence of the thymic epithelium), high level of αIEL expression on peripheral T cells in epithelial tissues (IEL and DEC), and expression of CD103 on a subset of CD8+ lymphocytes responding to allogeneic epithelial cells, suggest that αIELβ7 integrin may have a common role in the interactions of T lymphocytes with epithelia during T-cell maturation and effector functions. (bdbiosciences.com)
  • CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)
  • They constitute subunits of the integrin alpha-M/beta-2 receptor. (proconsortium.org)
  • The product of this gene belongs to the integrin alpha chain family of proteins. (wikipedia.org)
  • Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (nih.gov)
  • ST3GAL5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 359 amino acids (83-418a.a) and having a molecular mass of 41kDa. (prospecbio.com)
  • other specificity is tiny gene activity and distribution browser through the kinase of the R-RasGAP complex ileal to suitable or through the functionality of RhoA. (evakoch.com)
  • An integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. (lookformedical.com)
  • Integrin alpha II combines with Integrin beta 1 to form the alpha2/beta1 integrin duplex. (ximbio.com)
  • Integrin beta 3 is found along with the alpha IIb chain in platelets. (nih.gov)
  • Compression force sensing regulates integrin aIIbß3adhesive function on diabetic platelets. (lsbio.com)
  • This gene encodes an alpha 4 chain. (wikipedia.org)
  • This gene encodes the integrin alpha M chain. (dimabio.cn)
  • This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. (utsouthwestern.edu)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? (nature.com)
  • In May 2023, the US Food and Drug Administration approved Vyjuvek (beremagene geperpavec), a topical gene therapy drug, for wound treatment in dystrophic epidermolysis bullosa with COL7A1 mutations. (medscape.com)
  • Epidermolysis bullosa is a family of bullous disorders caused by an absence of basement membrane components due to underlying gene mutations. (medscape.com)
  • E-cadherin is the epithelial cell ligand for αIELβ7 integrin. (bdbiosciences.com)
  • Expression of the AMP gene drosomycin (a Toll target) was blocked when expression of the Toll ligand Spätzle was knocked down in haemocytes. (cnrs.fr)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Integrin Alpha 4 (ITGa4) in samples from tissue homogenates, cell lysates or other biological fluids. (ibiomagazine.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Integrin Alpha 4 (ITGa4) in Tissue homogenates, cell lysates and other biological fluids. (ibiomagazine.org)
  • CD49e, the alpha 5 integrin, noncovalently associates with the beta 1integrin (CD29) to form VLA-5 integrin complex. (exbio.cz)
  • The RPA gene is the structural excretion loss-of-function, However Binding it from the corresponding growth( De Laat et al. (evakoch.com)
  • Subsequent screening for structural variants in candidate genes located in the same regions identified a homozygous deletion that includes exons 17 to 23 of the integrin beta 4 ( ITGB4 ), a gene that was previously associated with the same defect in humans. (biomedcentral.com)
  • The structural basis for the divalent cation-dependent binding of heterodimeric alphabeta integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. (rcsb.org)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (dimabio.cn)
  • Transcript variants encoding various isoforms have been found for this gene. (prospecbio.com)
  • Next Generation Sequencing was conducted to find out the potential causative gene variants in all patients. (biomedcentral.com)
  • Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. (wikipedia.org)
  • CD49e itself is composed of two disulfide-linked chains of 135 kDa and 25 kDa. (exbio.cz)
  • Term] id: PR:000001012 name: integrin alpha-M def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. (proconsortium.org)
  • Detects human Integrin beta 1/CD29 in direct ELISAs and Western blots. (rndsystems.com)
  • The Integrin beta 1 subunit, also known as VLA-beta chain or CD29, associates with at least ten different Integrin alpha subunits. (rndsystems.com)
  • Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C. (lookformedical.com)
  • The adhesion of T cells to the endothelium of blood vessels through the molecule alpha-4 integrin is an important process at the beginning of transmigration. (news-medical.net)
  • It makes up half of the α2β1 integrin duplex. (wikidoc.org)
  • Staining of M21 cells with 0.5 µg of Mouse IgG1 kappa Isotype Control Biotin (Product # 13-4714-85) (open histogram) or 0.5 µg of Anti-Human CD51/CD61 (Integrin alpha/beta 3) Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). (thermofisher.com)
  • CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. (thermofisher.com)
  • Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. (rcsb.org)
  • Free GAGs chains are secreted to the extracellular space and distributed both in the pericellular matrix and extracellular matrix proper. (hindawi.com)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
  • DAVID was used to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). (medscimonit.com)
  • Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)
  • Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. (nih.gov)
  • The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. (embl.de)
  • The study highlighted several mechanisms underlying species diversification, including selection acting on existing standing variation, high rates of gene duplication, novel microRNAs and rapid sequence divergence in otherwise conserved non-coding elements. (biomedcentral.com)