Gene influenza virus di particles defective viruses. Medical search. Frequent questions

Asymptomatic reactivation means that the virus causes atypical, subtle, or hard-to-notice symptoms that are not identified as an active herpes infection, so acquiring the virus is possible even if no active HSV blisters or sores are present. (wikipedia.org)
The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. (unt.edu)
Measles virus infection in rhesus macaques: altered immune responses and comparison of the virulence of six different strains. (unt.edu)
Vaccine-induced antibody and T cell responses correlated with protection against lethal influenza virus infection. (researchsquare.com)
Moreover, antibody responses induced by influenza virus vaccines are usually short-lived and less cross-reactive against antigenically drifted virus variants than those induced by a natural influenza virus infection 1 . (researchsquare.com)
Additionally, vaccine-induced neutralizing antibody titers diminish over time, thereby affecting the extent of protection against infection during an entire influenza season and the subsequent seasons. (researchsquare.com)
Our findings demonstrate AAV delivery of cross-subtype neutralizing nanobodies may be an effective strategy to prevent influenza infection and provide long-term protection independent of a host induced immune response. (frontiersin.org)
Experiments show that the vast majority of virions fail to express one or more gene segments and thus cannot cause a productive infection on their own. (bvsalud.org)
Previous within-host influenza models did not explicitly consider SIPs and largely ignore the potential effects of coinfection during virus infection. (bvsalud.org)
While the model without spatial structure fails to reproduce key aspects of within-host influenza virus dynamics, we found that the model implicitly considering the spatial structure of the infection process makes predictions that are consistent with biological observations, highlighting the crucial role that spatial structure plays during an influenza infection. (bvsalud.org)
This model predicts two phases of viral growth prior to the viral peak: a first phase driven by fully infectious particles at the initiation of infection followed by a second phase largely driven by coinfections of fully infectious particles and SIPs. (bvsalud.org)
Hepatitis E virus (HEV), an important agent of viral hepatitis worldwide, can cause severe courses of infection in pregnant women and immunosuppressed patients. (mdpi.com)
Several clinical observations point to an intricate crosstalk between iron (Fe) metabolism and chronic hepatitis C virus (HCV) infection. (microbiologyresearch.org)
A vaccine is available and effective in preventing or reducing the severity of infection with Influenza. (barthsyndrome.org)
We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design. (frontiersin.org)
Finally, based on these mechanisms, we discuss treatments that could increase the survival of older people, not simply by inhibiting the virus, but by restoring patients' ability to clear the infection and effectively regulate immune responses. (aging-us.com)
Importantly, these findings suggest oleandrin may have broad antiviral activity against enveloped viruses by reducing the incorporation of the envelope glycoprotein into mature particles, a stage of the infection cycle not targeted by modern HAART. (longdom.org)

Killed and live influenza virus vaccines are effective in preventing and curbing the spread of disease, but new technologies such as reverse genetics could be used to improve them and to shorten the lengthy process of preparing vaccine seed viruses. (cdc.gov)
Specifically, the 2005-2006 vaccine formulation is made up of the A/New Caledonia/20/99 (H1N1), A/California/7/2004 (H3N2), and B/Shanghai/361/2002 viruses. (cdc.gov)
Changes in the HA of circulating viruses (antigenic drift) require periodic replacement of the vaccine strains during interpandemic periods. (cdc.gov)
Because of this bureaucratic roadblock, the H3N2 component of the 2003-2004 influenza virus vaccine was antigenically "off" and showed suboptimal efficacy. (cdc.gov)
Also, because the cumbersome classical reassortment technique used for preparing the appropriate seed strains makes the yearly process of manufacturing influenza virus vaccines unnecessarily lengthy, new variants first appearing early in the season are rarely considered for the vaccine formulation of the following winter. (cdc.gov)
Measles inclusion body encephalitis caused by the vaccine strain of measles virus. (unt.edu)
A final vaccine analysis using a lethal influenza virus challenge showed that despite the differences in the immune responses observed in the mice, the mice had very similar patterns of protection. (mdpi.com)
Influenza vaccine effectiveness could be improved by combination with an adjuvant with the potential to enhance the host-vaccine response both quantitatively and qualitatively. (researchsquare.com)
The goal of this study was to explore a RIG-I agonist (SDI-nanogel) and a TLR7/8 agonist (Imidazoquinoline (IMDQ)‐PEG‐Chol) as adjuvants, when co-administered with a licensed quadrivalent inactivated influenza vaccine (QIV), and to determine the role of these adjuvants in directing helper T (Th) cell responses for their role in the immunoglobulin (Ig) class switching. (researchsquare.com)
Despite several vaccine candidates available on the market, influenza virus is responsible for severe illness in humans, with a substantial global death toll every year (https://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html). (researchsquare.com)
Therefore, there is an urgent need for a better cost-effective influenza vaccine which can induce antigenically broader and long-lasting immune response. (researchsquare.com)
ABSTRACTDespite the human immunodeficiency virus (HIV) pandemic continuing worldwide for 40 years, no vaccine to combat the disease has been licensed for use in at risk populations. (cdc.gov)
Overall, our findings advance the understanding of NA antibody response and provide important insights into the development of a broadly protective influenza vaccine. (bvsalud.org)
Ask specifically about getting the pneumococcal vaccine and influenza vaccines. (barthsyndrome.org)
ZMapp), anti-sense phosphorodiamidate morpholino oligomers (PMO AVI-6002), lipid nanoparticle small interfering RNA (LNP-siRNA: TKM-Ebola), and an EBOV glycoprotein-based vaccine using live-attenuated recombinant vesicular stomatitis virus (rVSV-EBOGP) or a chimpanzee adenovirus (rChAd-EBOGP)-based vector. (biomedcentral.com)

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomic names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. (wikipedia.org)
The risk is considerable when the mother is infected with the virus for the first time during late pregnancy, reflecting high viral load. (wikipedia.org)
While most viral STDs can not be transmitted through objects as the virus dies quickly outside of the body, HSV can survive for up to 4.5 hours on surfaces and can be transmitted through use of towels, toothbrushes, cups, cutlery, etc. (wikipedia.org)
Different immunoglobulin G (IgG) subclasses produced by class-switched B cells help in opsonization and virus neutralization and hence, facilitate viral clearance from the host. (researchsquare.com)
Influenza A virus (IAV) populations harbor large subpopulations of defective-interfering particles characterized by internally deleted viral genomes. (bvsalud.org)
The A56 protein is capable of binding two viral proteins, a serine protease inhibitor (K2) and the vaccinia virus complement control protein (VCP), and anchoring them to the surface of infected cells. (microbiologyresearch.org)
I suspect that the reason that we haven't seen novel viruses evolve lately may be related to A) there are a limited number of core viral types (the equivalent to the theoretical minimal genome for microbial life) and B) the niches that they could fill are already occupied. (microbe.tv)
Besides their function in the virus replication cycle, the viral glycoprotein, nucleoprotein, minor matrix protein and polymerase cofactor are viral determinants of pathogenicity, with evasion of the host innate and adaptive immune responses as the main mechanism. (biomedcentral.com)
The late transcribed genes are L1-L5, encoding viral capsid components (Fig. 7B). (genemedi.com)
The treatment of HTLV-1+ lymphoma T-cells with either oleandrin or a N. oleander extract did not significantly inhibit viral replication or the release of p19Gag-containing particles into the culture supernatants. (longdom.org)
Unlike HIV-1, extracellular HTLV-1 particles are poorly infectious and viral transmission typically occurs via direct intercellular interactions across a virological synapse. (longdom.org)
The botanical glycoside, oleandrin, and an extract of Nerium oleander have been shown to prevent the incorporation of the gp120 envelope glycoprotein of HIV-1 into mature virus particles and inhibit viral infectivity in vitro [ 1 ]. (longdom.org)
Besides the virus inhibiting effect, the increased synthesis of mutant virions under the action of FPV possess a threat of the emergence of novel threatening viral strains with high pathogenicity for humans and animals and acquired resistance to chemotherapeutic compound. (crie.ru)
This problem is theoretically prevented by intracellular expression of lhRNAs generating multiple siRNAs that target the virus simultaneously, thus reducing the chance of viral escape. (biomedcentral.com)

R1a-B6-Fc fusions of both isotypes gave complete protection against lethal challenge with both pandemic A/California/07/2009 (H1N1)pdm09 and avian influenza A/Vietnam/1194/2004 (H5N1). (frontiersin.org)
In this study, we aimed to investigate the diversity and complexity of the internally deleted IAV genomes within a panel of plaque-purified avian influenza viruses selected for their enhanced interferon-inducing phenotypes. (bvsalud.org)
Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells. (probiogen.de)
New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation. (probiogen.de)
Here, using crystallography and cryo-electron microscopy, we determine the structures of FluPol A from human influenza A/NT/60/1968 (H3N2) and avian influenza A/duck/Fujian/01/2002 (H5N1) viruses at a resolution of 3.0-4.3 Å, in the presence or absence of a cRNA or vRNA template. (nature.com)

In an outbreak, the virus in a nerve cell becomes active and is transported via the neuron's axon to the skin, where virus replication and shedding occur and may cause new sores. (wikipedia.org)
HIV persistence may arise from ongoing residual virus replication and/or from latently-infected cells defined as the cellular reservoir in which long-lived resting memory CD4+ T cells harbouring an integrated but transcriptionally silent provirus represent the largest pool in the blood (Chomont et al. (europa.eu)
The rule of six, a basic feature for efficient replication of Sendai virus defective interfering RNA. (microbiologyresearch.org)
Finally, 16 compounds targeting our identified host factors suppress IAV replication, with two targeting CDK2 and FLT3 showing pan-antiviral activity across influenza and coronavirus families. (cdc.gov)
Impaired antiviral response of adenovirus-transformed cell lines supports virus replication. (probiogen.de)
We also show that a nanobody (a single-domain antibody) that interferes with FluPol A dimerization inhibits the synthesis of vRNA and, consequently, inhibits virus replication in infected cells. (nature.com)
Fig. 4: Nb8205, which binds FluPol A at the dimer interface, inhibits cRNA to vRNA replication and virus growth. (nature.com)
Virus Oncolitici 0 domande Tumor-selective, replication competent VIRUSES that have antineoplastic effects. (lookformedical.com)
To prevent infected cell lysis, recombinant replication deficiency virus has been developed as a gene delivery tool to replace wild-type adenovirus (recombinant AdV in "application" part). (genemedi.com)
However, HIV-lhNef demonstrated a severe production and replication defect, which we were able to solve by selecting spontaneous virus variants with truncated hairpin structures. (biomedcentral.com)
Like all viruses, the EBOV largely relies on host cell factors and physiological processes for its entry, replication, and egress. (biomedcentral.com)

Clinically, nasal or respiratory airway care with saline reduces symptoms of seasonal coronaviruses and other common cold viruses. (springer.com)
Even prior to SARS-CoV-2, human coronaviruses and influenza viruses have been known to impact older people disproportionately [ 6 ], yet therapeutic strategies to protect this fraction of the population, with the exception of vaccines, have largely failed. (aging-us.com)

Influenza is an ribonucleic acid virus with a genome that comprises eight segments. (bvsalud.org)
Regarding the family, it is grouped within the Retroviridae family, viruses that have the enzyme Reverse Transcriptase (TR) - responsible for transcribing the RNA genome into complementary DNA (cDNA), being the subfamily Orthoretrovirinae ( 2 ). (scielo.sa.cr)
Virus Incompleti 0 domande Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. (lookformedical.com)
Provirus 0 domande Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. (lookformedical.com)
Virus Riassortanti 0 domande Viruses containing two or more pieces of nucleic acid (segmented genome) from different parents. (lookformedical.com)
It is a medium sized (90-100nm) and non-enveloped virus with an icosahedral nucleocapsid containing a 36kb double stranded DNA genome (Fig. 7A). (genemedi.com)
Top panel: a simplified map of the adenovirus serotype 5 genome showing the early genes (E1-E4) and the region from which the major late transcript is produced. (genemedi.com)
In order to solve this problem, we constructed an HIV-1 variant with a 300 bp long hairpin structure in the 3' part of the genome corresponding to the Nef gene (HIV-lhNef). (biomedcentral.com)

Making Better Influenza Virus Vaccines? (cdc.gov)
By taking advantage of these new technologies, we could develop live vaccines that would be safe, cross-protective against variant strains, and require less virus per dose than conventional vaccines. (cdc.gov)
Furthermore, pandemic vaccines against highly virulent strains such as the H5N1 virus can only be generated by reverse genetics techniques. (cdc.gov)
Finally, universal influenza virus vaccines seem to be within reach. (cdc.gov)
These new strategies will be successful if they are supported by regulatory agencies and if a robust market for influenza virus vaccines against interpandemic and pandemic threats is made and sustained. (cdc.gov)
Influenza virus vaccines were first developed in the 1940s and consisted of partially purified preparations of influenza viruses grown in embryonated eggs. (cdc.gov)
This technology, which originated from uses for military purposes, revolutionized the purification process and industrial production of many viruses for vaccines. (cdc.gov)
To this day, it remains the basis for the manufacturing process of our influenza virus vaccines. (cdc.gov)
Most influenza virus vaccines used in the United States and Europe consist of embryonated egg-grown and formaldehyde-inactivated preparations, which, after purification, are chemically disrupted with a nonionic detergent (for example, Triton X-100). (cdc.gov)
The split virus preparations show lower pyrogenicity than whole virus vaccines. (cdc.gov)
However, due to antigenic drift in influenza viruses, vaccines need to be updated every year to protect against the circulating strains of the virus. (researchsquare.com)
This may have implications for the development of virus strains to be used as live-attenuated virus vaccines. (biomedcentral.com)

Bender C, Hall H, Huang J, Klimov A, Subbarao K. Characterization of the surface proteins of influenza A (H5N1) viruses isolated from humans in 1997-1998. (unt.edu)
We have previously described R1a-B6, an alpaca-derived single domain antibody (nanobody), that is capable of potent cross-subtype neutralization in vitro of H1N1, H5N1, H2N2, and H9N2 influenza viruses, through binding to a highly conserved epitope in the influenza hemagglutinin stem region. (frontiersin.org)

Hands on experience in techniques involving recombinant DNA technology such as preparation of plasmid DNA, transformation of bacteria by plasmid DNA, characterization of plasmids, cloning of DNA fragments into vectors, vaccinia virus, hybridization and electrophoretic procedures. (sprayprotectgo.com)
A much more promising strategy is to use recombinant monoclonal antibodies (mAbs) against influenza and several are currently in clinical development ( 9 - 13 ). (frontiersin.org)

Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. (frontiersin.org)
In a pandemic, a new influenza virus emerges and infects the human population which has little or no pre-existing immunity ( 2 , 3 ). (frontiersin.org)
For enhanced surveillance capacity during the 2009 influenza pandemic, new sites were added to this platform. (cdc.gov)
FluSurv-NET has helped to determine the risk for influenza-associated illness in various segments of the US population, define the severity of influenza seasons and the 2009 pandemic, and guide recommendations for treatment and vaccination programs. (cdc.gov)

Protective anti-influenza immunity often correlates with antibody responses to influenza surface glycoproteins, particularly hemagglutinin (HA), the main antigenic determinant on the surface of both influenza virus and infected cells. (researchsquare.com)

Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. (cdc.gov)
Although antiviral drugs such as Oseltamivir are available to control the spread of the virus their effectiveness is limited in treating patients with influenza ( 5 , 6 ). (frontiersin.org)
Antiviral medications can treat Influenza and can sometimes shorten the duration of the illness. (barthsyndrome.org)
We showed previously that cytoplasmic release of mtDNA activates the cGAS STING TBK1 pathway resulting in interferon-stimulated gene (ISG) expression that promotes antiviral immunity4. (regenerativemedicine.net)
Here, we find that persistent mtDNA stress is not associated with basally activated NF-κB signalling or interferon gene expression typical of an acute antiviral response. (regenerativemedicine.net)

A more practical and cost-effective strategy would be to use antibody gene therapy which would provide long term sustainable protection through antibody production within the patient. (frontiersin.org)
The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators. (frontiersin.org)
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles ' by Syed, A., et al. (asm.org)

Infectious transcripts and cDNA clones of RNA viruses. (microbiologyresearch.org)
These particles, called semi-infectious particles (SIPs), can induce virion production through complementation when multiple SIPs are present in an infected cell. (bvsalud.org)
Virus 1 quesito Minute infectious agents whose genomes are composed of DNA or RNA, but not both. (lookformedical.com)
We therefore tested whether oleandrin or an extract from N. oleander could also inhibit the infectivity of the human T-cell leukemia virus type-1 (HTLV-1) -a related enveloped retrovirus and emerging tropical infectious agent. (longdom.org)
3) Permanent application of high therapeutic doses of FPV under the strict medical control to enhance the lethal mutagenic effect on an infectious virus in the recipient organism to prevent the multiplication of its mutant forms. (crie.ru)

Sendai virus M protein is found in two distinct isoforms defined by monoclonal antibodies. (microbiologyresearch.org)

Such viruses are produced in cells coinfected with different strains of a given virus. (lookformedical.com)

As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by hiding from the immune system in the cell bodies of neurons, particularly in sensory ganglia. (wikipedia.org)
The SARS-CoV-2 virus binds to ACE2 enzymes on airway epithelial cells in the upper respiratory tract where they are endocytosed and replicated (top left), alerting the immune system. (aging-us.com)
Viruses then travel to the alveoli and infect type 2 pneumocytes which, in the youthful system (lower left), are recognized by alveolar macrophages (AMs) or dendritic cells (not pictured) that release cytokines and present antigens to T cells and other adaptive immune cells. (aging-us.com)

The vaccinia virus A56 protein was one of the earliest-described poxvirus proteins with an identifiable activity. (microbiologyresearch.org)

Emerg Infect Dis 1999;5:102-12. (unt.edu)
Emerg Infect Dis. (cdc.gov)

2002. Genetic organization of Iris yellow spot virus M RNA: indications for functional homology between the Gc. (esciencepress.net)

Blydt-Hansen T, Subbarao K, Quennec P, McDonald J. Recovery of respiratory syncytial virus from stethoscopes by conventional culture and polymerase chain reaction. (unt.edu)
Hepatitis E virus (HEV) ORF1 protein (pORF1) contains methyltransferase (MetT), papain-like cysteine protease (PCP), RNA helicase (Hel) and RNA-dependent RNA polymerase (RdRp) domains. (microbiologyresearch.org)
Defective forms of L-RNA containing core polymerase regions were observed. (esciencepress.net)
1995. An RNA-dependent RNA polymerase activity associated virions of tomato spotted wilt virus, a plant and insect-infecting Bunyavirus. (esciencepress.net)

Whole exome sequencing of patients who experienced severe influenza reveals several genes, including scaffold protein AHNAK, with predicted loss-of-function variants that are also identified in our proteomic analyses. (cdc.gov)
The virus that causes COVID-19 and the one that causes Severe Acute Respiratory Syndrome (SARS) are different from one another. (barthsyndrome.org)
IMPORTANCE: Racial and ethnic minority groups, such as Black, Hispanic, American Indian or Alaska Native, and Asian or Pacific Islander persons, often experience higher rates of severe influenza disease. (cdc.gov)

Purification of modified vaccinia virus Ankara from suspension cell culture. (probiogen.de)
Boosting Upstream, Downstream Processing: To Expedite Biomanufacturing, Deploy a New Genotype of Modified Vaccinia Virus Ankara. (probiogen.de)
Deletion of the A56R gene results in varying effects on vaccinia virus virulence. (microbiologyresearch.org)

They include both DNA and RNA viruses as well viruses from humans and animals. (lookformedical.com)

At present, there are no antiretroviral drugs that inhibit incorporation of the envelope glycoprotein into newlysynthesized virus particles. (longdom.org)
The botanical glycoside, oleandrin, derived from extracts of Nerium oleander , has previously been shown to reduce the levels of the gp120 envelope glycoprotein on human immunodeficiency virus type-1 (HIV-1) particles and inhibit HIV-1 infectivity in vitro . (longdom.org)

Molecular cloning and characterization of a Sendai virus internal deletion defective RNA. (microbiologyresearch.org)
1992. Characterization of distinct isolate of tomato spotted wilt virus TSWV. (esciencepress.net)

Does prior exposure to larvicides influence dengue virus susceptibility in Aedes aegypti (Diptera: Culicidae)? (cdc.gov)
We compared vector susceptibility of Aedes aegypti (L.) for dengue virus, serotype 1 (DENV-1) previously exposed as larvae to an LC50 of different classes of insecticides as formulated larvicides. (cdc.gov)

neuraminidase [NA] subtype 1), an H3N2 influenza A virus, and an influenza B virus. (cdc.gov)

We therefore investigated whether oleandrin or a N. oleander extract could inhibit virus transmission from a GFP-expressing HTLV-1+ lymphoma T-cell-line to huPBMCs in co-culture assays. (longdom.org)
Such dependence poses a serious challenge to drug developers in their attempts to create medications that are able to inhibit the target virus without having an adverse effect on biochemical processes of the host macroorganism. (crie.ru)
Although these escape variants lost the ability to trans-inhibit HIV-1, they effectively outgrew the wild-type virus in competition experiments in SupT1 cells. (biomedcentral.com)
An alternative method to inhibit HIV-1 is the use of gene constructs encoding HIV-1-specific long hairpin RNAs (lhRNAs, transcripts folding an extended hairpin structure) or long double-stranded RNAs (dsRNAs, two complementary transcripts that form an extended duplex). (biomedcentral.com)

This is a new virus in the coronavirus family. (barthsyndrome.org)

Genetic variability of hepatitis E virus within and between three epidemics in India. (unt.edu)
Genetic manipulation of non- segmented negative-strand RNA viruses. (microbiologyresearch.org)
Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. (lookformedical.com)
Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus. (lookformedical.com)
Virus A Rna 0 domande Viruses whose genetic material is RNA. (lookformedical.com)

Our earlier study has demonstrated that hepatitis C virus (HCV)-associated cholesterol plays a key role in virus infectivity. (microbiologyresearch.org)
We also provide evidence that virion-associated cholesterol contributes to the interaction between HCV particles and apolipoprotein E. The molecular basis for the effects of different sterols on HCV infectivity is discussed. (microbiologyresearch.org)
However, the collected virus particles from treated cells exhibited reduced infectivity on primary human peripheral blood mononuclear cells (huPBMCs). (longdom.org)

The combined surveillance platform is called the Influenza Hospitalization Surveillance Network (FluSurv-NET). (cdc.gov)
OBJECTIVE: To describe rates of influenza-associated hospitalization, intensive care unit (ICU) admission, and in-hospital death by race and ethnicity over 10 influenza seasons. (cdc.gov)
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from the Influenza-Associated Hospitalization Surveillance Network (FluSurv-NET), which conducts population-based surveillance for laboratory-confirmed influenza-associated hospitalizations in selected counties, representing approximately 9% of the US population. (cdc.gov)
MAIN OUTCOMES AND MEASURES: The main outcomes were age-adjusted and age-stratified rates of influenza-associated hospitalization, ICU admission, and in-hospital death by race and ethnicity overall and by influenza season. (cdc.gov)

so far, however, the only viruses that have been etiologically connected with the disease are the human retroviruses human immunodeficiency virus (HIV) and human T-cell lymphotrophic virus type I (HTLV-I), the simian retroviruses, and coxsackievirus B. Those viruses may directly invade the muscle tissue, damaging the vascular endothelium and releasing cytokines, which then induce abnormal expression of the major histocompatibility complex (MHC) and render the muscle susceptible to destruction. (medscape.com)

Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles. (probiogen.de)

This surveillance enabled monitoring of the severity of influenza seasons and provided a platform for addressing priority questions associated with influenza. (cdc.gov)

Substitution of Val 113 in Sendai virus (SeV) M protein generates non-functional polypeptides, characterized by their exclusion from virus particles and by their ability to interfere with virus particle production. (microbiologyresearch.org)
Analysis of the Sendai virus M gene and protein. (microbiologyresearch.org)
Virus Helper 0 domande Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. (lookformedical.com)
In addition, since the gene encoding the A56 protein is non-essential, it can be used as an insertion point for foreign genes and has been deleted in some viruses that are in clinical development as oncolytic agents. (microbiologyresearch.org)
The protein encompassing the predicted MetT-PCP domains of HEV ORF1 was tested for deubiquitinating activity using fluorogenic substrates - ubiquitin-7-amino-4-methylcoumarin (AMC), IFN-stimulated gene 15 (ISG15)-AMC, Nedd8-AMC and SUMO-AMC. (microbiologyresearch.org)
Analyzing the human transcriptome in this way, we identified more than 12,000 methylated sites in mRNA molecules derived from approximately 7,000 protein-coding genes. (pharmaceuticalintelligence.com)

Seasonal Influenza A virus (IAV) and influenza B virus (IBV) co-circulate in the human population and keep evolving with time. (researchsquare.com)

2) Viruses would come back fairly quickly (at least some of them) unless the switch also eliminates retroviruses hidden away in various genomes around the world. (microbe.tv)

Herpes simplex viruses can affect areas of skin exposed to contact with an infected person. (wikipedia.org)
The cover image depicts herpes-simplex and N1H1 viruses translocating through a nanopore. (acs.org)

Influenza virus continues to be a major public health concern, causing both annual epidemics and occasional pandemics ( 1 ). (frontiersin.org)

J Infect Dis 1999;180:950-8. (unt.edu)
Pediatr Infect Dis J 1999;18:552-5. (unt.edu)
Clin Infect Dis 1999;29:855-61. (unt.edu)
Scand J Infect Dis 1999;31:51-5. (unt.edu)

Forensic microbiology is a scientific area that has emerged with the need to investigate biocrimes, as in the case of intentional transmission of the Human Immunodeficiency Virus (HIV). (scielo.sa.cr)
The need for the study of microbiological expertise can be applied in biocrimes linked to the transmission of microorganisms intentionally, such as the intentional transmission of Human Immunodeficiency Virus (HIV), a pathogen that causes Acquired Immunodeficiency Syndrome (AIDS). (scielo.sa.cr)
Human immunodeficiency virus type 1 (HIV-1) can be inhibited by means of RNA silencing or interference (RNAi) using synthetic short interfering RNAs (siRNAs) or gene constructs encoding short hairpin RNAs (shRNAs) or long hairpin RNAs (lhRNAs). (biomedcentral.com)
AN - check the tag INFANT HN - 2008 FX - Child Nutrition FX - Infant Nutrition Physiology FX - Milk FX - Milk, Human DH - Adolescent Nutrition DI - 052508 MN - SP6.021.067 MS - Nutrition of persons 10 through 19 years of age. (bvsalud.org)

The transcripts of most expressed genes, in a variety of cell types, were shown to be methylated, indicating that m6A modifications are widespread. (pharmaceuticalintelligence.com)

Upon attachment, interaction between the penton-base Arg-Gly-Asp (RGD) and cellular αv integrins, which can stimulate actin polymerization, leads to internalisation of the virus into the endosome. (genemedi.com)

One hundred fifty-three pediatric deaths were associated with influenza infections during the 2003-2004 season in 40 states, whereas only 9 such deaths had been reported in the following season ( 3 ). (cdc.gov)
2003. Ultrastructural differences in mixed infections of six Turnip mosaic virus and one Ribgrass mosic virus isolates in Crucifers. (esciencepress.net)
In 2003, surveillance for influenza in hospitalized persons was added to the Centers for Disease Control and Prevention Emerging Infections Program network. (cdc.gov)

The first clue to the emergence of HIV-2 came in 1986 when a morphologically similar but previously distinct virus was found to cause AIDS in patients in West Africa ( 4 ). (scielo.sa.cr)

Intramembrane structural differentiation in Sendai virus maturation. (microbiologyresearch.org)
The RPA gene is the structural excretion loss-of-function, However Binding it from the corresponding growth( De Laat et al. (evakoch.com)

Batteriofagi 0 domande Viruses whose hosts are bacterial cells. (lookformedical.com)

Anatomy12

Organisms85

Diseases17

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes42

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care6

Infection17

Vaccine15

Viral14

Avian5

Replication11

Coronaviruses2

Genome8

Vaccines12

H5N12

Recombinant2

Pandemic4

Hemagglutinin1

Antiviral5

Antibody3

Infectious5

Monoclonal antibodies1

Strains1

Immune3

Proteins1

Emerg Infect Dis2

20021

Polymerase4

Severe3

Vaccinia virus3

Humans1

Glycoprotein2

Characterization2

Dengue2

H3N21

Inhibit4

Coronavirus1

Genetic5

Infectivity3

Hospitalization4

Induce1

Periodic1

Severity1

Protein6

Seasonal1

Genomes1

Herpes simplex2

Epidemics1

19994

Human4

Transcripts1

Cellular1

Infections3

West Africa1

Structural2

Bacterial1