Gene infection streptococcus pneumoniae. Medical search. Frequent questions

Common infections include ones that are due to bacteria such as Haemophilus influenzae , pneumococci ( Streptococcus pneumoniae ), and staphylococci. (medlineplus.gov)
Tissue specimens also were evaluated by various immunohistochemical assays using antibodies that are specifically reactive with S. pneumoniae , Streptococcus pyogenes , Staphylococcus aureus, or Haemophilus influenzae . (cdc.gov)
Encapsulated bacteria, most commonly Streptococcus pneumoniae, followed by Haemophilus influenzae type b and staphylococcal species, are the typical pathogens. (medscape.com)
they have recurrent pyogenic lung, sinus, and skin infections with encapsulated bacteria (eg, Streptococcus pneumoniae , Haemophilus influenzae ). (msdmanuals.com)
Background: Bacterial respiratory tract infections, mainly caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are among the leading causes of global mortality and morbidity. (edu.au)
Including 26 infections with Pseudomonas aeruginosa , 26 infections with Staphylococcus aureus , 21 infections with Haemophilus influenzae , eight infections with Streptococcus pneumoniae and 33 infections with other bacteria. (bmj.com)

All bacteria were evaluated by a broad-range PCR assay that targets a segment of the 16S ribosomal DNA gene in DNA extracted from formalin-fixed, paraffin-embedded tissue ( 2 ). (cdc.gov)
Streptococcus pneumoniae is a bacteria that is also known as pneumococcus. (cdc.gov)
Clinical improvement has been reported independent of the presence or absence of chronic airway infection 11 and with antibiotic levels below the minimum inhibitory concentrations of several pathogenic bacteria 15 . (ersjournals.com)
Biofilm-related infections, particularly those caused by drug resistant bacteria, are difficult to handle with current antibiotic strategies. (era-learn.eu)
X-linked agammaglobulinemia is characterized by low levels or absence of immunoglobulins and absence of B cells, leading to recurrent infections with encapsulated bacteria. (msdmanuals.com)
Is this resistance the result of bacteria evolving new genes in response to the presence of antibiotics, or are antibiotic-resistant bacteria selected for in the environment by possessing antibiotic resistance genes beforehand? (icr.org)
To answer these questions a discussion of several factors involved in antibiotic resistance will show that resistance is a designed feature of pre-existing genes enabling bacteria to compete with the antibiotic producers in their environment. (icr.org)
Since World War II many more antibiotics isolated from fungi (molds) and bacteria have been used to treat a wide range of human and animal infections. (icr.org)
Gene expression profiles were obtained for 131 peripheral blood samples from pediatric patients with acute infections caused by influenza A virus, Gram-negative (Escherichia coli) or Gram-positive (Staphylococcus aureus and Streptococcus pneumoniae) bacteria. (gsea-msigdb.org)
Washington, D.C. - January 25, 2019 - Vaccinating laboratory mice with Streptococcus mitis bacteria prevents their virulent sibling, Streptococcus pneumoniae from infecting the mice. (asm.org)
Including 30 infections with P aeruginosa , 40 infections with S aureus , 32 infections with H influenzae , 11 infections with S pneumoniae and 39 infections with other bacteria. (bmj.com)
Data are scarce on the prevailing Streptococcus pneumoniae serotypes in the Philippines, including the relative antimicrobial resistance (AMR) of these bacteria. (who.int)
After infection, the bacteria multiply in tissues and cause a febrile illness until the onset of an immune response a week or so later. (nanomedicine.com)
Few studies have investigated occurrence of Antibiotic Resistance Genes (ARGs) among bacteria including Aminoglycoside Modifying Genes (AMGs) from Drinking Water Distribution Systems (DWDS) in Nigeria. (bvsalud.org)
Combination of aph(3")c and ant (3")b in a single bacteria was observed as the highest (14, 7.73%) among the detected gene combination. (bvsalud.org)
Overuse of these powerful drugs can lead to the development of drug-resistant bacteria, which renders certain antibiotics powerless to fight infection. (cdc.gov)
The Lancet paper estimated that almost a quarter-million neonatal deaths (214,000) each year across the globe occur due to untreatable sepsis from infections caused by drug-resistant bacteria. (cdc.gov)

Using primers to detect the mecA and nuc genes of Staphylococcus aureus and the cpn60 target on the chaperon gene of Kingella kingae , polymerase chain reaction (PCR) was performed using the purulent drainage obtained from the knee. (mlo-online.com)
These includes wound-infections (e.g. caused by Pseudomonas aeruginosa or Staphylococcus aureus), urinary tract infections (e.g. (era-learn.eu)
Staphylococcus aureus gene expression has been sparsely studied in deep-sited infections in humans. (biomedcentral.com)
Staphylococcus aureus is one of the leading causes of community- and hospital-acquired infections worldwide. (biomedcentral.com)
Cefoxitin (30g) was used as surrogate to determine phenotypic methicillin resistance in staphylococcus isolates, and the methicillin resistance ( mec A) gene was detected by conventional PCR assay. (who.int)

Pneumococcal infections are caused by Streptococcus pneumoniae, a lancet-shaped, gram-positive, catalase-negative facultative anaerobe commonly referred to as pneumococcus. (medscape.com)
Evidence of concurrent bacterial infection was found in specimens from 22 (29%) of the 77 patients, including 10 caused by Streptococcus pneumoniae (pneumococcus). (cdc.gov)
The main diseases pneumococcus causes are mild infections, like ear and sinus infections, but pneumococcus can also cause severe illnesses like pneumonia and meningitis. (cdc.gov)
Streptococcus pneumoniae ) OR ( S. pneumoniae ) OR pneumococcal OR pneumococcus) AND (polymorphisms OR polymorphism OR (genetic variant) OR (genetic variants) OR (genetic association study) OR (single nucleotide polymorphism) OR (single nucleotide polymorphisms) OR SNP OR SNPs OR genotype OR genotypes) without language restrictions and with search date cut offs between Jan 1, 1983 and Jul 4, 2018. (biomedcentral.com)

In previous influenza pandemics, studies of autopsy specimens have shown that most deaths attributed to influenza A virus infection occurred concurrently with bacterial pneumonia ( 1 ), but such evidence has been lacking for 2009 pandemic influenza A (H1N1). (cdc.gov)
These findings confirm that bacterial lung infections are occurring among patients with fatal cases of 2009 pandemic influenza A (H1N1) and underscore both the importance of pneumococcal vaccination for persons at increased risk for pneumococcal pneumonia and the need for early recognition of bacterial pneumonia in persons with influenza. (cdc.gov)
Confirmed fatal cases of 2009 pandemic influenza A (H1N1) were defined as influenza-like illness or postmortem findings suggestive of viral pneumonia and laboratory-confirmed 2009 pandemic influenza A (H1N1) virus infection by real time reverse transcriptase-- polymerase chain reaction (rRT-PCR). (cdc.gov)
The main cause of death is severe viral pneumonia complicating the infection. (springer.com)
Sarah Gregory] I'm talking today with Dr. Cynthia Whitney, a medical epidemiologist at CDC, about pneumonia vaccines and Streptococcus pneumoniae serotype 12F. (cdc.gov)
In 1952, Colonel Ogden Bruton noted the absence of immunoglobulins (Ig) in a boy with a history of pneumonia and other bacterial sinopulmonary infections. (medscape.com)
As Bruton originally described, XLA manifests as pneumonia and other bacterial sinopulmonary infections in 80% of cases. (medscape.com)
Macrolide antibiotics are used as first-line agents in the treatment of acute bacterial infections, such as community-acquired pneumonia 1 . (ersjournals.com)
Pneumonia, sepsis, meningitis, and empyema due to Streptococcus pneumoniae is a major cause of morbidity and mortality. (biomedcentral.com)
Invasive pneumococcal disease (IPD) is an infection confirmed by the isolation of Streptococcus pneumoniae from a normally sterile site, while non-invasive pneumococcal disease includes sinusitis, mastoiditis, acute otitis media, and community-acquired pneumonia (CAP). (biomedcentral.com)
There are other etiological tract infection and recently developed ra- agents of pneumonia such as viruses and diological signs [1,2]. (who.int)
6th among the causes of death in the world the mixed infection of pneumonia caused by today [3]. (who.int)
Streptococcus pneumoniae is one of A total of 485 patients with a clinical di- the major causes of bacterial pneumonia agnosis of pneumonia were included in the [6,7]. (who.int)
The remaining 29 patients were pneumonia in young adults and children, those admitted to the intensive care unit, the second only to S. pneumoniae [9]. (who.int)
S. pyo- dialysis unit and other surgical wards who genes may cause a variety of illnesses from developed pneumonia after 48 hours after very common ones such as pharyngitis admission (hospital-acquired pneumonia to less common severe infections includ- cases). (who.int)
At our center, 11 patients with COVID-19 pneumonia who had confirmed infection with SARS-CoV-2 were diagnosed with Streptococcus pneumoniae infection while in hospital. (medscimonit.com)
This pathogen is one of the most common causes of severe pneumonia, and can also cause meningitis, bloodstream and sinus infections, endocarditis, and middle ear infections in young children. (asm.org)
Streptococcus pneumoniae, an important pathogen causing sepsis, sinusitis, otitis media, bacterial meningitis and bacterial pneumonia, results in global morbidity and mortality each year. (tmu.edu.tw)
Streptococcus pneumoniae poses a serious public At present, more than 94 different pneumococcal health concern because it causes a wide range serotypes have been classified based on the unique poly- of diseases including otitis media, septicaemia, saccharide characteristics and composition expressed meningitis and pneumonia. (who.int)
But in many low- and middle-income countries, millions of people lack access to antibiotics and common infections like pneumonia pose a far greater threat than any superbug. (cdc.gov)

Streptococcus pneumoniae is the most common Gram-positive bacterial pathogen causing OM. (ewha.ac.kr)
Four hundred and seventy-one Dutch Caucasian childhood BM were genotyped for 11 single nucleotide polymorphisms (SNPs) in seven different genes involved in pathogen recognition. (biomedcentral.com)
Besides clinical, environmental and pathogen-related factors, the ability of the host's innate immune system to clear bacterial infections also influences the course of BM. (biomedcentral.com)
The major focus of this research is the molecular pathogenesis of invasion and inflammation induced by Streptococcus pneumoniae, the leading invasive bacterial pathogen of children. (stjude.org)

Phylogenetic analysis of emergent Streptococcus pneumoniae serotype 22F causing invasive pneumococcal disease using whole genome sequencing. (cdc.gov)
Sarah Gregory] After the PCV vaccine was introduced in Israel in 2009, there was apparently an increase in Streptococcus pneumoniae serotype 12F. (cdc.gov)
The manuscript we are discussing here talks about how surveillance for pneumococcal infections in Israel found that the new vaccine program was preventing a lot of disease, but they also detected an increase in one of the strains that the vaccine doesn't cover-- serotype 12F. (cdc.gov)
The engineered vaccine worked as expected, boosting protection against S. pneumoniae serotype 4, but not against S. pneumoniae serotype 2, as compared to the wild type vaccine. (asm.org)
This study is designed to fill that gap by describing the serotype distribution and AMR of S. pneumoniae in the Philippines from 2012 to 2018. (who.int)

All S pneumoniae isolates, regardless of the isolation site, should be tested for susceptibility to penicillin and cefotaxime or ceftriaxone. (medscape.com)
The overall AMR of invasive S. pneumoniae isolates was low. (who.int)
With the inclusion of PCV13 in the National Immunization Program, continued monitoring of the prevailing serotypes of S. pneumoniae isolates in the Philippines is needed to guide disease and AMR control measures. (who.int)
Four of the 9 (44.4%) CoNS isolates were cefoxitin resistant and all the 4 (100%) carried mec A gene. (who.int)

Antibiotics are often needed to treat bacterial infections. (medlineplus.gov)
Many possess genes that encode proteins to neutralize the affects of antibiotics and prevent attacks on their cell machinery. (icr.org)
In recent decades, the increase of S. pneumoniae strains' resistance to β-lactam antibiotics and other classes of antimicrobials has made treatment even more complicated. (tmu.edu.tw)
Antibiotics like amoxicillin are medicines that treat bacterial infections. (healthline.com)
Severe infections may require injected or intravenous antibiotics. (healthline.com)
Healthcare professionals prescribe different antibiotics to treat conditions such as strep throat , bronchitis , and inner ear infections . (healthline.com)
Read on to learn more about the most common types of antibiotics and which infections they treat. (healthline.com)
Penicillin antibiotics are effective at killing Staphylococci and Streptococci infections. (healthline.com)
Tetracyclines are a group of antibiotics with anti-inflammatory properties that can treat several bacterial infections. (healthline.com)
the Lancet study also shows that giving the pneumococcal conjugate vaccine (PCV) to all children under age five would bring about a 47 percent reduction in the number of days kids need to take antibiotics for infections caused by Streptococcus pneumoniae . (cdc.gov)

Clinical signs and symptoms and physical examination findings alone cannot distinguish S pneumoniae disease from infections caused by other pathogens. (medscape.com)
14 Because the focus of our institution is children, we pre-determined our critical clinical need to be the rapid identification of pediatric pathogens in osteoarthritis: MSSA, MRSA, K kingae , and Streptococcus pneumoniae . (mlo-online.com)
In this project, we aim to provide new tools, targets and agents for understanding and treating biofilm-associated infections in four major AMR pathogens (P. aeruginosa, UPEC, S. aureus and S. pneumoniae). (era-learn.eu)
However, pathogens are likely to make host-specific adaptions by altering gene expression, which necessitates studies in humans. (biomedcentral.com)
By comparing these essential genes to the human genome, and a database of genes from commensal human gut microbiota, we identified and excluded potential drug targets in respiratory tract pathogens that will have off-target effects in the host, or disrupt the natural host microbiota. (edu.au)

Besides acute infections, S. aureus can adapt to a biofilm mode of growth in response to certain environmental cues and thereby infections become persistent and recurrent, particularly in association with prosthetic implants [ 1 ]. (biomedcentral.com)
However, few studies have investigated nutrient acquisition and metabolism of S. aureus in vivo during infection, which is an important aspect of S. aureus pathophysiology. (biomedcentral.com)
It is recognized that the success of S. aureus depends not only on its virulence genes and development of antibiotic resistance, but also on a coordinated and timely expression of genes upon infection of its host. (biomedcentral.com)
6 ] is the only published investigation of the transcriptome of S. aureus in humans with cutaneous infections caused by the methicillin-resistant USA300 strain. (biomedcentral.com)
The aim of this study was to compare the in vivo expression of virulence and metabolic genes of S. aureus in a prosthetic joint infection in a human subject with growth in vitro as reference using RNA sequencing (RNA-seq). (biomedcentral.com)
A different signature discriminated patients with E coli versus S aureus infections with 85% accuracy (34 of 40). (gsea-msigdb.org)

Streptococcus pneumoniae strains lacking the enzyme dihydrolipoamide dehydrogenase (DLDH) show markedly reduced ability to grow on raffinose and stachyose as sole carbon sources. (lu.se)
We showed that strains of Pseudomonas aeruginosa with increased mutation rates (caused by deletion of genes involved in DNA mismatch repair) produced more biofilm biomass in laboratory experiments. (southampton.ac.uk)

If a pneumococcal infection is suspected or considered, Gram stain and culture of appropriate specimens should be obtained, when possible. (medscape.com)
Circulating Pneumolysin, another common PAMP produced by Streptococcus pneumoniae , induced cardiomyocyte injury through triggering profound calcium influx during pneumococcal infection ( 11 ). (frontiersin.org)
Treatment of pneumococcal infection has been hampered by the complexity of the host immune response. (tmu.edu.tw)

Genetic transformation in Streptococcus pneumoniae, Streptococcus mitis and Streptococcus oralis is regulated by secreted peptide pheromones named the competence-stimulating peptide (CSP). (anaspec.com)
The research suggests that vaccination of humans with live S. mitis might offer protection from some of the many serotypes of S. pneumoniae that vaccines currently do not exist for. (asm.org)
S. mitis , which lacks many of the virulence genes present in S. pneumoniae , but is otherwise quite similar, commonly inhabits the oral cavity and the upper respiratory tract, living in peaceful coexistence with the host. (asm.org)
The investigators intranasally vaccinated mice with two different versions of S. mitis , to compare their efficacy: wild type S. mitis , and S. mitis which they had genetically engineered to express a sugar coat that is found on the exterior of the cell wall of S. pneumoniae . (asm.org)
Our study reveals that S. mitis a natural human colonizer that resembles S. pneumoniae but seldom causes diseases, can be the answer offered by nature for a safe vaccine against S. pneumoniae . (asm.org)

RafK carries a C-terminal regulatory domain present in a subset of ATP-binding proteins that has been involved in both direct regulation of transporter activity (inducer exclusion) and transcription of transporter genes. (lu.se)

The prevalence of colonization is not surprising, the most useful and the most widely available tests for considering that numerous S. Recurrent gas gangrene has been described as long as 20 to 30 years after an initial episode until local trauma or hematoma provides a stimulus for germination of the spore and initiation of infection. (seagullindia.com)
Mathematical Modeling of Streptococcus pneumoniae Colonization, Invasive Infection and Treatment. (wiko-berlin.de)

Pneumococci lacking RafK showed a 50- to 80-fold reduction in expression of the raf operon genes aga (alpha-galactosidase) and rafEFG (raffinose substrate binding and permease genes), and both glucose and sucrose inhibited raffinose uptake through inducer exclusion. (lu.se)
Like RafK, the presence of DLDH also activated the expression of raf operon genes, as DLDH-negative pneumococci showed a significantly decreased expression of aga and rafEFG, but DLDH did not regulate rafK or the putative regulatory genes rafR and rafS. (lu.se)
The authors did this by analyzing information from case reports over time and by doing tests on the particular pneumococci causing these infections to see what serotypes they were. (cdc.gov)
However, naturally transformable pneumococci may escape vaccine-induced immunity by switching their capsular genes to non-vaccine serotypes. (tmu.edu.tw)

Analysis of Antibiotic Resistance Genes in Multidrug-Resistant Acinetobacter sp. (google.sk)
1] In 1980 it was estimated that 3-5% of S. pneumoniae were penicillin-resistant and by 1998, 34% of the S. pneumoniae sampled were resistant to penicillin.1 Antibiotic resistance by other organisms reflects the same trend observed between S. pneumoniae and penicillin. (icr.org)
The increase in resistance among these organisms clearly indicates a change in the frequency of antibiotic resistance genes. (icr.org)
Antibiotic resistance has been making headlines lately, and for good reason: the identification of new resistance genes , rising resistance rates and widespread public misunderstanding of the problem are all causes for concern about the growing proliferation of drug-resistant "superbugs. (cdc.gov)

Early in the 2009 influenza A (H1N1) virus pandemic, CDC provided guidelines for submission of tissue specimens for evaluation of influenza virus infections. (cdc.gov)
Specimens were received from 77 patients who had 2009 pandemic influenza A (H1N1) virus infection confirmed before death (N = 41) or after death (N = 36). (cdc.gov)

From the transcriptome analysis we found increased expression of siderophore synthesis genes and multiple known virulence genes. (biomedcentral.com)
Virulence genes are identified by genetic screens as well as by analysis of the completed genome. (stjude.org)

It plays a role in innate immunity as an early defense system against infections. (wikipedia.org)
Humoral immunity deficiencies Immunodeficiency disorders are associated with or predispose patients to various complications, including infections, autoimmune disorders, and lymphomas and other cancers. (msdmanuals.com)

In 1967 the first penicillin-resistant Streptococcus pneumoniae was observed in Australia, and seven years later in the U.S. another case of penicillin-resistant S. pneumoniae was observed in a patient with pneumococcal meningitis. (icr.org)

Sepsis is a lethal syndrome induced by infection, which has a reported annual death of 200,000 in the United States ( 1 ). (frontiersin.org)
Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)

Antimicrobial resistance (AMR) occurs when changes in microorganisms render the drugs used to treat infections ineffective. (biomedcentral.com)
Antimicrobial who were seen and 85 923 who were given medication susceptibility profiling of S. pneumoniae has played from January to December 2012. (who.int)
Conclusion: The overall prevalence of bacterial infections was high with many being resistant to commonly pre-scribed antimicrobial agents. (bvsalud.org)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)

Empyema caused by Streptococcus pneumoniae. (medscape.com)

Designed reduction of Streptococcus pneumoniae pathogenicity via synthetic changes in virulence factor codon-pair bias. (anaspec.com)

ABSTRACT Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. (harvard.edu)

2 Invasive pneumococcal in the Africa-Eastern Mediterranean region, whereas disease (IPD), defined as infection of normally sterile serotypes 1 and 14 were prevalent in Europe and Latin sites of the body with S. pneumoniae , most frequently America. (who.int)

S pneumoniae can cause a wide variety of clinical symptoms owing to its ability to cause disease by either direct extension from the nasopharynx into surrounding anatomic structures or vascular invasion with hematogenous spread. (medscape.com)
Murine gene mutations in human counterparts may be associated with a clinical illness different from the illness seen in mice. (medscape.com)
In the context of the BioVacSafe project, UNISI is involved in Work Package 2 " Establishment of reliable in vivo animal models and in vitro models predicting early inflammation and autoimmune diseases ", where is responsible for studying the biomarker expression in the context of acute bacterial infections in pre-clinical models and in humans. (biovacsafe.eu)
This single case study highlights the capacity of combined transcriptome and metabolome analyses for elucidating the pathogenesis of prosthetic infections of major clinical importance. (biomedcentral.com)
The clinical spectrum ranges from superficial skin lesions to deep-sited or generalized infections. (biomedcentral.com)
We retrospectively analyzed the clinical characteristics and outcomes of patients subsequently admitted to AMITA Health Saint Francis Hospital between March 1 and June 30, 2020, with documented SARS-CoV-2 and S. pneumoniae coinfection. (medscimonit.com)
The aim of this thesis was to evaluate the prognostic relevance of recurrent gene mutations and to assess the clinicobiological associations and clinical impact of BcR IG stereotypy in CLL. (ndltd.org)
In a series of 8593 CLL patients, stereotyped subsets showed marked differences in demographics, clinical presentation, cytogenetic aberrations and gene mutational spectrum. (ndltd.org)
NLRP3 gene expressions were found to be higher with specific clinical phenotypes such as cataract in galactosemia patients, lung involvement in LPI group or hepatic fibrosis in tyrosinemi patients. (hacettepe.edu.tr)

Toll-like receptors are transmembrane glycoproteins, which recognize many PAMPs with extracellular domains and aggravate the exaggerated inflammatory response to bacterial infection through activating nuclear factor (NF)-κB ( 12 ). (frontiersin.org)

The selection and diagnostic upper respiratory tract, particularly among criteria for primary and secondary pneumo- patients with chronic obstructive pulmonary nia were a positive chest X-ray and clini- disease, whereas Klebsiella pneumoniae, cal features. (who.int)
25%), Coagulase negative staphylococci (2/8;25%), Klebsiella pneumoniae (2/8;25%) and Streptococcus pyogenes 2/8(25%) were isolated. (bvsalud.org)

Escherichia coli), chronic airway infections (e.g. (era-learn.eu)

Since then, penicillin has been commonly used to treat a wide range of infections. (icr.org)
They commonly treat chest, urethral, and pelvic infections. (healthline.com)

These infections also result in more outpatient visits, excess length of stay in hospitals, and increased utilization of intensive care and isolation units [ 2 ]. (biomedcentral.com)

Cephalexin is the gold standard in upper and lower respiratory tract infections and here also shall play a vital role besides other conventional therapies. (seagullindia.com)
The COVID-19 pandemic has changed the epidemiology of upper respiratory tract infections (URTI) and the disease profile of patients attending the emergency department (ED). Hence, we sought to explore the changes in ED physicians' attitudes and behaviours in four EDs in Singapore. (biomedcentral.com)

Overview of Immunodeficiency Disorders Immunodeficiency disorders are associated with or predispose patients to various complications, including infections, autoimmune disorders, and lymphomas and other cancers. (msdmanuals.com)
However, bacterial coinfection is considered relatively infrequent in hospitalized patients with COVID-19, and the co-prevalence of Streptococcus pneumoniae is low. (medscimonit.com)
We identified 11 patients with S. pneumoniae coinfection. (medscimonit.com)
This study highlights the importance of monitoring bacterial coinfection in patients with viral lung infection due to SARS-CoV-2. (medscimonit.com)
In a cohort of 3490 patients, NOTCH1, SF3B1 and TP53 mutations were enriched within clinically aggressive cases carrying unmutated IGHV genes (U-CLL), frequently co-occurring with trisomy 12, del(11q) and del(17p), respectively. (ndltd.org)
Among many mucin genes, MUC5AC has been found to be greatly up-regulated in the middle ear mucosa of human patients with OM. (ewha.ac.kr)
Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute E. coli infection. (gsea-msigdb.org)
Thirty-five genes were identified that best discriminate patients with influenza A virus infection from patients with either E coli or S pneumoniae infection. (gsea-msigdb.org)
These genes classified with 95% accuracy (35 of 37 samples) an independent set of patients with either influenza A, E coli, or S pneumoniae infection. (gsea-msigdb.org)
Furthermore, distinctive gene expression patterns were observed in patients presenting with respiratory infections of different etiologies. (gsea-msigdb.org)

Streptococcus was the most common genus in the oral, bronchial, and lung tissue samples, and multiple other taxa were present in both the upper and lower airways. (biomedcentral.com)
and a previously unknown hantavirus, producing an often fatal lung infection, was linked to exposure to infected rodents. (cdc.gov)

Otitis media (OM) is the most common childhood bacterial infection and the major cause of conductive hearing loss in children. (ewha.ac.kr)

We identified five studies with a hypothesis free approach of which one resulted in one genome wide significant association in a gene coding for lincRNA with pneumococcal disease susceptibility. (biomedcentral.com)
Identification of Streptococcus pneumoniae genes associated with hypothiocyanous acid tolerance through genome-wide screening. (otago.ac.nz)
Using combination of chromatin immunoprecipitation and genome sequence analysis, we detected 55 CcpA binding sites corresponding to 140 genes directly controlled by CcpA. (studyres.com)

In acute inflammation, CRP can increase as much as 50 to 100 mg/L within 4 to 6 hours in mild to moderate inflammation or an insult such as skin infection, cystitis, or bronchitis[clarification needed]. (wikipedia.org)
CRP between 100 and 500 mg/L is considered highly predictive of inflammation due to bacterial infection. (wikipedia.org)
We now define a regulatory mechanism that links the circadian clock and glucocorticoid hormones to control both time-of-day variation and the magnitude of pulmonary inflammation and responses to bacterial infection. (ox.ac.uk)
This is the first study which investigates the inflammasome and autophagy gene and protein expressions, the relationship between oxidative stress, autophagy and inflammation, immun functions and metabolomic profiling simultaneously in intoxication type inherited metabolic diseases. (hacettepe.edu.tr)

Without treatment, most severe infections are deadly. (medlineplus.gov)
Thus, XLA is most likely to be diagnosed when unusually severe or recurrent sinopulmonary infections occur in a male infant younger than 1 year. (medscape.com)
Upregulation of fermentation genes and the presence of ethanol in joint fluid indicated severe oxygen limitation in vivo. (biomedcentral.com)
In this case, these infections are moderate to severe and have not improved with other treatments. (healthline.com)

Systems biology analysis, including co-expression analysis of differently expressed genes induced by Varilrix revealed biological pathways and biofunctions exclusive to Varilrix. (biovacsafe.eu)

Background: Bacterial infections are an important cause of maternal morbidity and mortality especially in re-source limited countries such as Ethiopia. (bvsalud.org)

However, recurrent infections are more likely to have causes other than immunodeficiency (eg, inadequate treatment, resistant organisms. (msdmanuals.com)
Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
Delayed case detection is associated with reduced cure rates and provides opportunity for continued transmission, which became even more a serious problem with the co-infections of HIV and the emergence of highly drug-resistant TB. (cdc.gov)

Most of the identified genetic variation was found in genes controlling the host response to microbes [ 14 ]. (biomedcentral.com)

Approximately 20% of all genes in these three species were essential for growth and viability, including 128 essential and conserved genes, part of 47 metabolic pathways. (edu.au)
Including 19 infections with Aspergillus species, seven infections with Candida and seven infections with other fungi. (bmj.com)

They also treat urinary tract infections (UTIs), epididymo-orchitis, and cellulitis. (healthline.com)
The major bacterial infections include urinary tract infections, septice-mia and endometritis. (bvsalud.org)
Urinary tract infection (UTI) in pregnancy is associated with significant morbidity for both mother and baby. (who.int)

Approach to the Patient With Suspected Immunodeficiency Immunodeficiency typically manifests as recurrent infections. (msdmanuals.com)

Genetic ablation of the clock gene Bmal1 (also called Arntl or MOP3) in bronchiolar cells disrupts rhythmic Cxcl5 expression, resulting in exaggerated inflammatory responses to lipopolysaccharide and an impaired host response to Streptococcus pneumoniae infection. (ox.ac.uk)

The CcpA regulon comprises genes involved in sugar uptake, fermentation and amino acids metabolism, confirming the role of CcpA as a link between carbon and nitrogen pathways. (studyres.com)

About 18% of all C. difficile genes are regulated by glucose, for which 50% depend on CcpA for regulation. (studyres.com)

P. aeruginosa) and preinfection colonisation by Streptococcus pneumoniae. (era-learn.eu)

Anatomy16

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