EnzymeGlycosideEnzymesEpoxide hydrolaseProteinsGlycosyl hydrolasesCandidate genesBiosynthesisMetabolismFAAHAntibodyFattyLysosomalRRNA geneMutationsFolateSpeciesSymbolMembraneBacillusSNPsConvertsRecombinantDegradePolymorphismsDiseasesActivityFamilyGenomesKnockoutVariantsChromosomeHepaticSequenceExpressionBacterialMutationCOMPLEXGenotypeSucrose
Enzyme13
- US2003124697A1 ] A novel enzyme which is useful in the optical resolution of D,L-pantolactone via D-selective asymmetric hydrolysis and a gene encoding the the same are provided. (epo.org)
- FAAH belongs to the serine hydrolase enzyme family. (tocris.com)
- The AHCY gene provides instructions for producing the enzyme S-adenosylhomocysteine hydrolase. (medlineplus.gov)
- Most of these variants substitute one amino acid for another amino acid in the S-adenosylhomocysteine hydrolase enzyme, causing it to process methionine less efficiently. (medlineplus.gov)
- Other variants introduce a premature stop signal in the instructions for making the S-adenosylhomocysteine hydrolase enzyme. (medlineplus.gov)
- These changes reduce the activity of the S-adenosylhomocysteine hydrolase enzyme, impairing the breakdown of methionine. (medlineplus.gov)
- The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. (novusbio.com)
- A potential immunotherapy, a new gene therapy, an enzyme inhibitor, and a compound originally isolated from a Chinese herb are among the latest approaches scientists are proposing to treat addiction. (nih.gov)
- Their strategy is to use gene transfer to produce high and sustained levels of a modified version of the enzyme butyrylcholinesterase (BChE), which efficiently degrades cocaine in the bloodstream before it reaches the brain. (nih.gov)
- They will identify and optimize compounds that inhibit an enzyme called fatty acid amide hydrolase (FAAH), which degrades the endocannabinoid anandamide. (nih.gov)
- Neutral cholesterol ester hydrolase 1 (NCEH) also known as arylacetamide deacetylase-like 1 (AADACL1) or KIAA1363 is an enzyme that in humans is encoded by the NCEH1 gene. (thermofisher.com)
- Alpha-Mannosidosis is caused by an enzyme defect due to mutations in the gene for lysosomal alpha-Mannosidase (LAMAN) affecting the lysosomal and cellular glycoprotein catabolism with severe consequences for the organism. (europa.eu)
- This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). (ucsc.edu)
Glycoside6
- In molecular biology, Glycoside hydrolase family 10 is a family of glycoside hydrolases. (wikipedia.org)
- Glycoside hydrolases EC 3.2.1. (wikipedia.org)
- A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. (wikipedia.org)
- Functional Characterization of the Glycoside Hydrolase Encoding Gene OsBE1 during Chloroplast Development in Oryza sativa [J].Acta Agron Sin, 2014, 40(12): 2090-2097. (chinacrops.org)
- 2]Wang X C, Xue L, Sun J Q, Zuo J R. The Arabidopsis BE1 gene, encoding a putative glycoside hydrolase localized in plastids, plays crucial roles during embryogenesis and carbohydrate metabolism. (chinacrops.org)
- 3]Wang X C, Yang Z R, Wang M, Meng L Z, Jiang Y W, Han Y H. The BRANCHING ENZYME1 gene, encoding a glycoside hydrolase family 13 protein, is required for in vitro plant regeneration in Arabidopsis. (chinacrops.org)
Enzymes8
- Photosynthate within plants is transported from source to sink tissues as sucrose, which is hydrolyzed by plant glycosyl hydrolase family 32 enzymes (GH32) into its constituent monosaccharides to meet plant cellular demands. (elsevierpure.com)
- The other 2 genes encoded phase 2 enzymes [NAD(P)H-quinone oxidoreductase1and aldehyde dehydrogenase family 3, subfamily A1]. (thieme-connect.com)
- biodegradable enzymes present in the genes of some bacteria degrade HCH in soil. (ispub.com)
- Mainly, two genes linA and linB encode dehydrochlorinase and dehalogenase enzymes involved in degradation of HCH. (ispub.com)
- In fact, special enzymes called hydrolases are required in order to get hydrolysis to occur at all in a cell. (wordnik.com)
- These genes encode enzymes that generate the mannose-6-phosphate signal, which directs a diverse group of hydrolases to the lysosome. (wordnik.com)
- Acid hydrolases are enzymes which, in the acidic medium of the lysosomes, are activated and digest other proteins. (wordnik.com)
- Coccidioides immitis dimorphism involves the construction and rupture of the spherule, or tissue form, for which chitin and glucan synthetases and hydrolases are key enzymes. (cdc.gov)
Epoxide hydrolase12
- epoxide hydrolase (EPHX Exon3, EPHX Exon4). (cdc.gov)
- These compounds are degraded by the soluble epoxide hydrolase. (usda.gov)
- When the soluble epoxide hydrolase gene, Ephx2, was deleted in mice, blood pressure was initially reduced in males, but not females. (usda.gov)
- What we observed was that the soluble epoxide hydrolase null mice showed increased plasma epoxy fatty acids, decreases in their soluble epoxide hydrolase-dependent metabolites, while measured levels of lipoxygenase- and cyclooxygenase-dependent oxylipins were unchanged. (usda.gov)
- These metabolites can oppose the blood pressure reductions in the soluble epoxide hydrolase null mouse by constricting blood vessels and reducing sodium, and thus water, excretion. (usda.gov)
- This shift in renal metabolism is likely a metabolic compensation for the loss of the soluble epoxide hydrolase gene. (usda.gov)
- Therefore, if the therapeutic use of soluble epoxide hydrolase inhibitors reaches the clinic, combinations with arachidonic acid omega-hydroxylase inhibitors and or diuretics may be help them retain their efficacy. (usda.gov)
- Soluble epoxide hydrolase converts epoxyeicosatrienoic acids to their corresponding diols, dihydroxyeicosatrienoic acids, modifying or eliminating the function of these oxylipins. (usda.gov)
- To better understand the phenotypic impact of Ephx2 disruption, two independently derived colonies of soluble epoxide hydrolase-null mice were compared. (usda.gov)
- Ephx2gene disruption eliminated soluble epoxide hydrolase protein expression and activity in liver, kidney and heart from each colony. (usda.gov)
- Finally, the soluble epoxide hydrolase-null mice show a survival advantage following acute systemic inflammation. (usda.gov)
- Certain genetic variations in the GPX1 (Glutathione peroxidase) and EPHX1 (Epoxide hydrolase) genes are among the few that have been studied by researchers. (livemint.com)
Proteins2
- Bioinformatics strategies were used to find other homologous genes and proteins, which can also degrade HCH present in various bacteria for controlling of pollution and offer clue to prevent its entry in the food chain. (ispub.com)
- This study shows that variants of proteins that guide hydrolases to the lysosome are associated with stuttering. (wordnik.com)
Glycosyl hydrolases2
- One of these families is known as the cellulase family F or as the glycosyl hydrolases family 10. (wikipedia.org)
- Chitinases are glycosyl hydrolases that catalyze the hydrolysis of the β-1,4 linkages in complex carbohydrates and those that contain GlcNAc. (researchgate.net)
Candidate genes4
- Thus, the first step in identifying the disease-susceptibility genes should involve identification of candidate genes. (livemint.com)
- Candidate genes for T2DM include genes responsible for pancreatic cell (Beta cell), insulin action/glucose metabolism, or other metabolic conditions that increase T2DM risk (eg, energy intake/expenditure, lipid metabolism). (livemint.com)
- More than 50 candidate genes for T2DM have been studied worldwide. (livemint.com)
- Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)
Biosynthesis3
- Virulence genotype analysis revealed that strain CR1 lacked hemolytic phospholipase C and D, three genes for LPS biosynthesis and had reduced antibiotic resistance genes when compared with clinical strains. (frontiersin.org)
- The present case-control study aimed to investigate the main effect of polymorphisms in genes involved in xenobiotic metabolism and estrogen biosynthesis, CYP1A1, CYP1B1, COMT and CYP17, CYP19 and the BRCA1 founder mutation in relation to BC risk and to explore possible interactions between the gene polymorphisms and serum POP levels on BC risk in Greenlandic Inuit women. (biomedcentral.com)
- Polymorphisms including single nucleotide polymorphisms (SNPs) in genes involved in xenobiotic metabolism and in genes involved in oestrogen biosynthesis and metabolism might affect circulating estrogen levels and modulate the individual susceptibility to environmental carcinogens in relation to developing BC [ 5 ]. (biomedcentral.com)
Metabolism2
- S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. (medlineplus.gov)
- Yeast-form-specific genes identified in Histoplasma capsulatum function in calcium/calmodulin signaling pathways and sulphur metabolism. (cdc.gov)
FAAH1
- Fatty acid amide hydrolase , (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide , to free fatty acid and ethanolamine. (tocris.com)
Antibody1
- There are currently no images for ADP-ribosylarginine hydrolase Antibody (NBP3-20168AF532). (novusbio.com)
Fatty1
- Tocris offers the following scientific literature for Fatty Acid Amide Hydrolase to showcase our products. (tocris.com)
Lysosomal2
- Sphingomyelinase is an acidic lysosomal hydrolase that catalyses the cleavage of sphingomyelin to phosphoryl choline and ceramide. (medscape.com)
- Sphingomyelinase follows the same intracellular targeting and posttranslational processes as most of the lysosomal hydrolases. (medscape.com)
RRNA gene2
- Three strains of Elizabethkingia -like, gram-negative bacilli sharing similar phenotypic characteristics were isolated from the 3 patients, but confident identification results were not obtained by matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry and 16S rRNA gene sequencing. (cdc.gov)
- Analysis by 16S rRNA gene sequencing grouped the strains into 11 LAB species, which belonged to six genera: Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Pediococcus and Weissella. (who.int)
Mutations4
- More than 10 variants (also known as mutations) in the AHCY gene have been described in people with hypermethioninemia. (medlineplus.gov)
- Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
- Mutations in the beta subunit of the cGMP phosphodiesterase gene (beta PDE) can cause a recessively inherited retinal degeneration in several species, including mice, dogs and humans. (nih.gov)
- Novel mutations in CYBB Gene Cause X-linked chronic Granulomatous Disease in Pakistani patients. (cdc.gov)
Folate2
- The MTHFR gene provides instructions for your body to make the MTHFR protein , which helps your body process folate. (cdc.gov)
- Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. (gentaur.com)
Species5
- Using bioinformatic and PCR-based analyses, we tested for GH32 gene presence in all available fungal genomes and an additional 149 species representing a broad phylogenetic and ecological range of biotrophic fungi. (elsevierpure.com)
- Ancestral state reconstruction of GH32 gene abundance showed a strong correlation with nutritional mode, and gene family expansion was observed in several clades of pathogenic filamentous Ascomycota species. (elsevierpure.com)
- Few mycorrhizal species were found to have GH32 genes as compared to other guilds of plant-associated fungi, such as pathogens, endophytes and lichen-forming fungi. (elsevierpure.com)
- Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene. (ucsc.edu)
- Some species have more than one papain-like protease gene. (bvsalud.org)
Symbol1
- Search on a gene symbol or gene name keyword(s). (jax.org)
Membrane1
- May be a single membrane channel protein acting both as a hydrolase and a translocase. (lu.se)
Bacillus1
- Comparative Genome Analysis of Two Bacillus pumilus Strains Producing High Level of Extracellular Hydrolases. (uibk.ac.at)
SNPs1
- DNA microarray was used to assess associations with 52 candidate asthma genes (772 SNPs) using a gene centric analytic approach. (cdc.gov)
Converts1
- Specifically, S-adenosylhomocysteine hydrolase controls the step that converts the compound S-adenosylhomocysteine to the compounds adenosine and homocysteine. (medlineplus.gov)
Recombinant1
- To reduce potentially toxic effect on the host cell, the growth and production phases were separated by using the inducible promoter GAL1p to control recombinant gene expression. (lu.se)
Degrade1
- and hydrolases to degrade the chlorophyll content of the fruit resulting in color change. (scientificamerican.com)
Polymorphisms1
- Genetic polymorphisms in the C19orf66 gene influenced HIV-1 infection in a Yunnan population. (cdc.gov)
Diseases2
- Most diseases involve complex interactions of the involved genes, in addition to environmental stimuli. (livemint.com)
- Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population. (cdc.gov)
Activity1
- Although we inherit genetic material from our parents, it is at times reshaped by certain epigenetic alterations-influencing (silencing or over-expressing) the activity of certain genes. (livemint.com)
Family1
- Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. (nature.com)
Genomes2
- GH32 gene number in fungal genomes ranged from 0-12. (elsevierpure.com)
- Endophytic fungi are more similar to plant pathogens in their possession of GH32 genes, whereas most genomes of mycorrhizal taxa lack GH32 genes. (elsevierpure.com)
Knockout1
Variants3
- It is important to know that there are other extremely rare MTHFR gene variants not discussed here. (cdc.gov)
- These gene variants may have significant effects on your health. (cdc.gov)
- Talk to your doctor or a genetic counselor if you have concerns about what having one of these extremely rare MTHFR gene variants means for your health care. (cdc.gov)
Chromosome1
- The AHCY gene is found on chromosome 20 . (medlineplus.gov)
Hepatic1
- Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. (lu.se)
Sequence1
- A gene variant is a change in a DNA sequence that is different from the expected DNA sequence. (cdc.gov)
Expression2
- GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
- The fungal cell cyle is considered with respect to the mechanism of sequential gene expression in Candida albicans, since little is known about the cell cycle in pathogenic molds. (cdc.gov)
Bacterial2
- Genes belonging to proteases, bacterial exporters and DNA stabilization were found to be under strong positive selection, thus facilitating pathogenicity and survival of the outliers. (frontiersin.org)
- Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal consortium. (nature.com)
Mutation1
- The genetic composition of a population's gene pool changes over time owing to mutation and other factors. (livemint.com)
COMPLEX1
- The GARP complex is the transport network that recycles receptors of acid hydrolases from the lysosomes (the stomach of the cell) to the Golgi apparatus. (wordnik.com)
Genotype1
- A genotype is the combination of the set of genes responsible for a particular trait. (cdc.gov)
Sucrose1
- The aim of this study was to explore the distribution and abundance of GH32 genes in fungi to understand how sucrose utilization is structured within and among major ecological guilds and evolutionary lineages. (elsevierpure.com)