Gene human nuclear protein. Medical search. Frequent questions

Mitochondria harbor multiple copies of a maternally inherited, non-nuclear genome (mtDNA) that encodes for 13 subunit proteins of the respiratory chain. (ca.gov)
From a cost-efficiency perspective, the human genome is an engineering nightmare. (mpg.de)
Since the completion of the human genome project in 2001, it has become clear that huge swaths of our genome are made of self-replicating genetic elements with the so-called "functional genome" haphazardly distributed in between them (Lander et al. (mpg.de)
2001). Every single transposable element (TE) insertion to our genome is a massive burden: each element is copied trillions of times in a single organism (there are ~37 trillion cells in a human body). (mpg.de)
However, in practical terms, these elements become nucleation points for a plethora of nuclear RNA-binding proteins as soon as they are transcribed by RNAPII, which then affect the content and the fate of the resulting mRNA, even though these sequences themselves do not necessarily contribute to the translated part of our genome. (mpg.de)
While each DNA blueprint, or gene, encodes for a different machine or structure, the genome, the collection of DNA wrapped up inside the nucleus, is much more active than a quiet library of neatly stacked blue-prints. (birmingham.ac.uk)
We are investigating the impact of specific classes of gene mutations, such as ATM, BRCA1, and MYBL2 on genome integrity. (birmingham.ac.uk)
The aim of this study is to identify susceptibility gene variants that could contribute to the pathogenesis of diisocyanate asthma (DA) using a Genome-Wide Association Study (GWAS) approach. (cdc.gov)

BRD4 protein recognizes acetylated lysine residues on proteins and by doing so participates in the regulation of DNA replication, DNA transcription, and thereby key cellular processes involved in the development of neoplasms (i.e. malignant or benign tissue growths). (wikipedia.org)
Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator proteins. (aspetjournals.org)
This study was designed to examine the influence of zinc status of HepG2 cells on the expression of Egr-1, a transcription factor that has been shown to be involved in the regulation of apoA-I gene expression. (usda.gov)
The existence of mRNAs retaining both nuclear cap binding protein and EJC in the distal sites of neuronal processes suggests that some localized mRNAs have not yet undergone the "very first translation," which contribute to the spatio-temporal regulation of gene expression. (frontiersin.org)
ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. (embl.de)
Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure ( PUBMED:10838570 ). (embl.de)
Overlap of 2 suggestive SNPs with likely TF binding sites suggests possible roles in disruption of gene regulation. (cdc.gov)
Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)

The NUTM1 gene is located in band 14 on the long (or "q") arm of chromosome 15. (wikipedia.org)
The BRD4-NUTM1 fusion gene is a translocation that encodes a fusion protein that has merged most of the protein coding region of the NUTM1 gene with a large part of the BRD4 gene located in band 13 on the short (i.e. "q") arm of chromosome 19. (wikipedia.org)
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
A pseudogene for this gene has been located on chromosome 17. (origene.com)
Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. (origene.com)
MicroRNA-34a gene (MIR-34A) that is located on chromosome 1p36 belongs to one of evolutionary-conserved miRNA families (MIR-34 family) that consists of three members: MIR-34A, MIR-34B, and MIR-34C [ 10 ]. (hindawi.com)
3411. P.C. Park, U. De Boni, 'A specific conformation of the territory of chromosome 17 locates ERBB-2 sequences to a DNase-hypersensitive domain at the nuclear periphery,' Chromosoma 107(May 1998):87-95. (nanomedicine.com)
Conformation of replicated segments of chromosome fibres in human S-phase nucleus,' Chromosome Res. (nanomedicine.com)
Here, using double-label fluorescence in situ hybridization for the autosome chromosome 21 (chromosome 21 point probes combined with chromosome 21 "paint" probes), along with immunocytochemistry and cell sorting, we present evidence for chromosome gain and loss in the human brain. (jneurosci.org)
Chromosome 21 aneuploid cells constitute ∼4% of the estimated one trillion cells in the human brain and include non-neuronal cells and postmitotic neurons identified by the neuronspecific nuclear protein marker. (jneurosci.org)
Toward determining the presence of constitutional aneuploidy in the human brain, we report here an analysis of the frequency of chromosome 21 gain and loss among neurons and non-neuronal cells isolated from the cerebral cortex and hippocampus of normal individuals ranging from 2 to 86 years of age. (jneurosci.org)
13 Our study substantially expands this work by not only analysing imputed classical human leukocyte antigen (HLA) alleles, but also examining variant HLA amino-acid positions in conjunction with single-nucleotide polymorphism (SNP) genotypes across the extended MHC region (chromosome 6: 26-34 Mb). (cdc.gov)
Mitochondria contain DNA in a single circular chromosome that codes for 13 proteins, various RNAs, and several regulating enzymes. (msdmanuals.com)

On average, we identify 43 mutations per tumour, excluding four cases with a mutator phenotype that harboured inactivating mutations in mismatch repair genes. (nih.gov)

Homo sapiens uracil-DNA glycosylase (UNG), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. (lu.se)

Proliferating cell nuclear antigen (PCNA) was originally identified by immunofluorescence as a nuclear protein whose appearance correlated with the proliferative state of the cell. (ihcworld.com)
Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization. (ihcworld.com)
Pathway analysis indicated that these genes are associated with antigen processing and presentation, and other immune pathways. (cdc.gov)
We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. (cdc.gov)

This gene encodes a protein that binds to matrix attachment regions. (thermofisher.com)
This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. (antikoerper-online.de)

Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. (lu.se)
Most of the target genes were involved in the MAPK signaling pathway and innate immune response. (hindawi.com)

NUT protein facilitates the acetylation of chromatin (i.e. (wikipedia.org)
In addition to mutations in TP53 and KRAS, we identify genetic alterations in chromatin remodelling genes, ARID1A and ARID1B, in histone methyltransferase MLL3, in histone deacetylase modifier SPOP and in chromatin assembly factor BAZ1A, in nearly two thirds of cases. (nih.gov)
The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. (fishersci.com)
PRC1 regulates chromatin organization and gene transcription. (rndsystems.com)
3420. J.R. Davie, 'Nuclear matrix, dynamic histone acetylation and transcriptionally active chromatin,' Mol. (nanomedicine.com)
It is a nuclear protein that is largely chromatin-bound and has a strong preference for binding to methylated DNA sequences in vivo . (portlandpress.com)

The protein produced from the RPS17 gene is among those found in the small subunit. (medlineplus.gov)
This protein is the full-length p52 subunit and partial p100 subunit. (abcam.com)
NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. (gentaur.com)

The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (abcam.com)
Potential host target genes were predicated and validated by qRT-PCR to study the impact of microRNAs on the host genes. (hindawi.com)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
These findings indicate miR-34a along with its putative target genes could play a role in RCC tumorigenesis and progression. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)

A similar coiled-coil domain is present in several putative human proteins and in the mitotic phosphoprotein 43 ( MP43 ) of X. laevis. (xenbase.org)
Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)

Bayesian evolutionary tree of Influenza A(H9N2) virus based on the nucleotide sequence of the HA gene. (cdc.gov)
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)
Within amino acids 131-217, human Cbx2 shares 94% and 92% aa sequence identity with mouse and rat Cbx2, respectively. (rndsystems.com)
Full-length human BATF3 (aa 1-127) shares 80% aa sequence identity with mouse BATF3. (rndsystems.com)
NUDF protein, the product of the nudF gene, displays 42% sequence identity with the human protein LIS1 required for neuronal migration. (xenbase.org)
The regions between arrowheads were used in sequence exchange experiments to test if human or X. laevis coiled-coil regions can substitute for the NUDE coiled-coil. (xenbase.org)
Characterization of the dead ringer gene identifies a novel, highlyconserved family of sequence-specific DNA-binding proteins. (embl.de)
Gelretardation and optimal binding site screens revealed that the in vitrosequence specificity of DRI is strikingly similar to that of manyhomeodomain proteins, although the sequence and predicted secondarystructure do not resemble a homeodomain. (embl.de)
The reference sequence was derived from Ensembl Human sequence AC007637.9.1.175870 . (lu.se)
The proposed method is novel because it works independently of protein sequence databases and without any prior knowledge about modifica- tions. (lu.se)
The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)
PTMs from this list in conjunction with a protein sequence and a few precursor masses. (lu.se)
CRISPR-Cas9 gene editing ( c lustered r egularly i nterspaced s hort p alindromic r epeats-CRISPR-associated protein 9) involves editing the deleterious DNA sequence of a gene. (msdmanuals.com)

3419. M.A. Mancini, D. He, I.I. Ouspenski, B.R. Brinkley, 'Dynamic continuity of nuclear and mitotic matrix proteins in the cell cycle,' J. Cell Biochem. (nanomedicine.com)

A fusion gene is an abnormal gene consisting of parts from two different genes that form as a result of a large scale gene mutation such as a chromosomal translocation, interstitial deletion, or inversion. (wikipedia.org)
A novel initiation codon mutation in the ribosomal protein S17 gene (RPS17) in a patient with Diamond-Blackfan anemia. (medlineplus.gov)
2) lilli mutation strongly suppresses the rough eye phenotype of ectopically expressed phyllopod (Tang, 2001), and (3) lilli was identified in a screen for genes that enhance the embryonic lethal phenotype of dpp alleles (Su, 2001). (sdbonline.org)
We screened for multicopy suppressors of a mutation in the nudF gene. (xenbase.org)
A new mutation has been reported, making a total of 15 different mutations that can cause premature stop codons in the alpha-L-iduronidase gene (IDUA), and the biochemistry of these mutations has been investigated. (medscape.com)

This antibody was raised against a peptide within the C-terminal region of human TRIM24. (fishersci.com)
Cbx2 was detected in immersion fixed iPS2 human induced pluripotent stem cells, differentiated with 0.2 µM retinoic acid for 4 days (panels A and C) or undifferentiated (panels B and D), using Mouse Anti-Human Cbx2 Monoclonal Antibody (Catalog # MAB8098) at 10 µg/mL for 3 hours at room temperature. (rndsystems.com)
Human peripheral blood mononuclear cell (PBMC) monocytes were stained with Mouse Anti-Human CD11c PE-conjugated Monoclonal Antibody (Catalog # FAB1777P ) and either (A) Mouse Anti-Human BATF3 Monoclonal Antibody (Catalog # MAB7437) or (B) Mouse IgG 2B Flow Cytometry Isotype Control (Catalog # MAB0041 ) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B ). (rndsystems.com)
12 - 15 These studies focused mainly on major histocompatibility complex (MHC) class II genes, and found evidence that class II alleles such as HLA-DRB1*03:01 are associated with auto-antibody production. (cdc.gov)

These results suggest that transcriptional elongation control is especially important for rapidly expressed genes to support digestion and metabolism, many of which have sex-biased function. (sdbonline.org)
WRN protein is thought to be involved in optimization of various aspects of DNA metabolism, including DNA repair, recombination, replication, and transcription. (amrita.edu)
NR1I3) is expressed primarily in liver and regulates the expression of genes involved in xenobiotic metabolism as well as hormone, energy, and lipid homeostasis. (aspetjournals.org)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
3424. P.T. Moen Jr., K.P. Smith, J.B. Lawrence, 'Compartmentalization of specific pre-mRNA metabolism: an emerging view,' Human Mol. (nanomedicine.com)

Three transcript variants encoding the same protein have been identified for this gene. (origene.com)
It is caused by pathogenic variants in the WRN gene, which encodes a multifunctional nuclear protein with exonuclease and helicase activities. (amrita.edu)
Here, we discover a previously unknown type of SBD in four independent families caused by bi-allelic loss-of-function pathogenic variants in TMEM53 , which encodes a nuclear envelope transmembrane protein. (nature.com)
Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. (fishersci.com)
Multiple transcript variants encoding different isoforms have been found for this gene. (thermofisher.com)
Strains were transformed with nudE variants in pAid vector and grown at 43°C. Numbers refer to amino acid residues of NUDE protein expressed by the constructs (see Fig. 3 for detailed amino acid sequences). (xenbase.org)

NUTM1 gene) encodes (i.e. directs the synthesis of) a 1,132-amino acid protein termed NUT that is expressed almost exclusively in the testes, ovaries, and ciliary ganglion (i.e. a parasympathetic ganglion of nerve cells located just behind the eye). (wikipedia.org)
Synthesis of the nuclear protein cyclin and DNA in quiescent mouse fibroblasts is coordinately induced by serum and purified growth factors. (ihcworld.com)
Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication. (ihcworld.com)
Zinc, an essential micronutrient, is required by many enzymes involved in gene expression and, therefore, is vital in maintaining DNA, RNA, and protein synthesis in cells. (usda.gov)
matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)
Protein synthesis, folding, and tertiary and quaternary. (msdmanuals.com)

Homozygous loss of band 9p21, the site for the tumor suppressor gene P16, is a known early genetic event in the development of papillary carcinoma and urothelial carcinoma in situ (CIS). (medscape.com)
The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. (thermofisher.com)
William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)

Gene expression is regulated by proteins known as transcription factors. (ku.edu)
One of the largest transcription factor families is the nuclear receptor (NR) superfamily. (ku.edu)
Loss of FMR2 gene transcription causes mental retardation. (sdbonline.org)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (gentaur.com)
Furthermore, by integrating large amounts of biochemical data and evolutionary analysis, we would like to eventually understand the impact of anti-transposon/virus strategies on the way genes themselves evolve, from transcription start sites to the evolution of new exon-intron boundaries and termination sites, which altogether determine the complete mRNA molecule as an expression of its underlying gene. (mpg.de)
Influenza virus NS1- C/EBPβ gene regulatory complex inhibits RIG-I transcription. (cdc.gov)

The RPS17 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. (medlineplus.gov)
The specific functions of the RPS17 protein and the other ribosomal proteins within these subunits are unclear. (medlineplus.gov)
Some ribosomal proteins are involved in the assembly or stability of ribosomes. (medlineplus.gov)
Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis). (medlineplus.gov)
The RPS17 gene mutations that cause Diamond-Blackfan anemia are believed to cause problems with ribosomal function. (medlineplus.gov)
Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome. (medlineplus.gov)
Cmejla R, Cmejlova J, Handrkova H, Petrak J, Pospisilova D. Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. (medlineplus.gov)
Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (medlineplus.gov)
Identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein S17. (medlineplus.gov)

Gene, 2019 Mar 10. (nih.gov)

Intrinsic antiviral resistance is a branch of antiviral defence that involves constitutively expressed cellular proteins that act within individual infected cells. (mdpi.com)
During Adv DNA replication, host cellular proteins such as nuclear factor I and POU2F1 are used by Adv [ 13 , 14 ]. (hindawi.com)
Although patients may differ in their clinical manifestations, patients do share a propensity to develop autoantibodies directed against nucleic acids and associated nuclear and cellular proteins. (cdc.gov)

Binding of BMP2/4 to their receptors initiates the signal transduction cascade by inducing phosphorylation of SMAD1/5/9, which can then form hetero-complexes with SMAD4 followed by translocation into the nucleus to upregulate osteogenesis-related genes. (nature.com)
3409. V.C. Cordes, H.R. Rackwitz, S. Reidenbach, 'Mediators of nuclear protein import target karyophilic proteins to pore complexes of cytoplasmic annulate lamellae,' Exp. (nanomedicine.com)
Protein-protein interaction (PPI) sites play a key role in the formation of protein complexes, which is the basis of a variety of biological processes. (bvsalud.org)

trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression. (nih.gov)

It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
Methods: Protein physical interactions were screened using the yeast two-hybrid system. (lu.se)
NUDF protein interacts with the Aspergillus NUDE coiled-coil in a yeast two-hybrid system, while human LIS1 interacts with the human homologue of the NUDE/RO11 coiled-coil and also the Xenopus MP43 coiled-coil. (xenbase.org)
Other proteins containing the conserved motifinclude yeast SWI1, two human retinoblastoma binding proteins, and othermammalian regulatory proteins. (embl.de)

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. (fishersci.com)
However, the proteins needed for transcriptional control have been reported to be immunogenic and there is often a substantial leakage in the systems (Clackson, 2000). (lu.se)

Human BAFT3 is 127 amino acids (aa) in length. (rndsystems.com)

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (nih.gov)
E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays, E05 478 566 350 170 or Enzyme-Linked Immunosorbent Assays, Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. (gentaur.com)

Predicted to enable ubiquitin protein ligase activity. (nih.gov)

Certain aspects of the aforementioned diseases have been linked to the aberrant expression and activity of selected gene-expression-programs. (ku.edu)
In humans, mutations affecting the genes of this family are associated with specific diseases. (sdbonline.org)
Mutations in mtDNA occur mainly in the 24 non-coding genes, with specific mutations implicated in early death, neuromuscular and neurodegenerative diseases, cancer, and diabetes. (ca.gov)
His lab discovered the mechanisms that clear away toxic proteins in young, healthy brains - mechanisms that, Dillin found, break down with age and lead to protein aggregate build-up, the hallmark of age-related neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. (salk.edu)
Nuclear membrane irregularities are a hallmark of many diseases, including cancer and neurodegenerative disorders, and thus his work is relevant for diverse aspects of human health. (salk.edu)
In the end, building such an accurate model can be used to design and evaluate artificial genetic circuits, to predict outcomes of clinically important mutations in RNA-binding proteins or RNA sequences, to develop possible solutions to reverse those outcomes, to treat genetic diseases and to understand how different cellular strategies against transposons/viruses might have shaped our genes and genomes over the course of our evolution. (mpg.de)
Its human ortholog, melanocyte proliferating gene 1, is linked to developmental processes and dermatological diseases. (bvsalud.org)

Small RNAs include microRNA (miRNA), siRNA, tRFs, piRNA, and rasiRNAs, which regulate gene expression in a wide range of processes such as viral replication and host immune response. (hindawi.com)
miRNAs regulate gene expression in a wide range of physiological and pathological processes such as in immune response and viral replication [ 18 ]. (hindawi.com)
Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. (cdc.gov)

2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)

To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. (lu.se)
Here, we used biolayer interferometry and pulldown assays to identify regions of RAG1 necessary for interaction with RAG2 and to measure the RAG1-RAG2 binding affinity (KD ∼0.4 μM) (where RAG1 and RAG2 are recombination activating genes 1 or 2). (nih.gov)
Quantitative Western blotting allowed us to estimate that mouse thymocytes contain on average ∼1,800 monomers of RAG1 and ∼15,000 molecules of RAG2, implying that nuclear concentrations of RAG1 and RAG2 are below the KD value for their interaction, which could help limit off-target RAG activity. (nih.gov)
BATF3 accomplishes this by heterodimerizing with Jun and binding to AP-1 consensus binding sites, thus precluding a Jun/Fos interaction with gene activation. (rndsystems.com)
Through this interaction, mRNAs and their associative proteins form messenger ribonucleoprotein particles (mRNPs) that are actively transported along the cytoskeleton to intracellular destinations. (frontiersin.org)
Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. (embl.de)
Unfortunately, in circumstances where its validity condition is not satisfied, especially so in protein interaction networks, the MM rate law has frequently been misused. (bvsalud.org)

Analyses of the molecular pathophysiology using the primary cells from the Tmem53 -/- mice and the TMEM53 knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins. (nature.com)
Martin Hetzer , who like Dillin and Karlseder is a member of the Molecular and Cell Biology Laboratory, is interested in how the organization of the nucleus influences gene activity and how disruption of its three-dimensional architecture can cause developmental defects, cancer and aging. (salk.edu)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)

These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)

Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. (lu.se)
A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)
In addition, by South-western blotting analysis of nuclear extracts using the 95-bp probe or MRE oligonucleotide probe, we detected a Zn-dependent DNA-binding protein with a molecular mass of 116 kDa, which is likely to be ZRF. (go.jp)
3405. D. Stoffler, B. Fahrenkrog, U. Aebi, 'The nuclear pore complex: From molecular architecture to functional dynamics,' Curr. (nanomedicine.com)

However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)
To study the interactions between these sequences and regulatory factors, HeLa cell nuclear proteins were analyzed by band-shift assay using a 95-base pair (bp) DNA probe containing a part of the human MT-IIA gene upstream sequences. (go.jp)
namely, this protein is activated only by Zn, and requires not only MRE but also its flanking sequences for optimal DNA-binding. (go.jp)
The other protein appears to be Spl, based on its recognition sequences specificity. (go.jp)

However, the mechanism by which nuclear translocation is regulated remains unclear. (nature.com)

This study identified SNPs mapping to the HERC2, CDH17, and ODZ3 genes as potential susceptibility loci for DA. (cdc.gov)

3406. H. Ris, 'High-resolution field-emission scanning electron microscopy of nuclear pore complex,' Scanning 19(August 1997):368-375. (nanomedicine.com)
3407. S.A. Rutherford, M.W. Goldberg, T.D. Allen, 'Three-dimensional visualization of the route of protein import: the role of nuclear pore complex substructures,' Exp. (nanomedicine.com)
Work of the Hetzer lab has established nuclear pore proteins as a new class of gene regulators and showed that nuclear membrane integrity declines with age and during tumorigenesis. (salk.edu)

DNA-protein bundles) by histone acetyltransferase EP300 in testicular spermatids (cells that mature into sperms). (wikipedia.org)

CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia. (nih.gov)

This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. (nih.gov)
Almost half of the genes expressed in adults showed reduced expression, supporting a broad role for the three tested genes in steady-state transcript abundance. (sdbonline.org)
Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in the dendrites contain cis -elements and trans -acting factors such as RNA-binding proteins and microRNAs to convey stimulus-, transcript-specific local translation. (frontiersin.org)

Chemical cross-linking (CX) of proteins in vivo or in cell free extracts followed by mass spectrometric (MS) identification of linked peptide pairs (CXMS) can reveal protein-protein interactions (PPIs) both at a proteome wide scale and the level of cross-linked amino acid residues. (bvsalud.org)
Consequently, a lot of effort is put into identifying the constituent proteins using mass spectrometric methods. (lu.se)

Human mitochondria produce ATP and metabolites to support development and maintain cellular homeostasis. (ca.gov)
Earlier that week, he'd read about them in his pathology class, for which the definitive textbook included just a single, brief reference suggesting that mutations in mitochondria might lead to a human muscle disease. (harvardmagazine.com)
Mitochondria produce metabolic energy by oxidizing carbohydrates, protein, and fatty acids. (harvardmagazine.com)
Techniques are based on the fact that mitochondria are derived entirely from the mother and that mitochondria contain their own DNA separate from nuclear DNA. (msdmanuals.com)

Efimov VP and Morris NR (2000), The LIS1-related NUDF protein of Aspergillus ni. (xenbase.org)
Efforts have therefore, designed a study to compare the expression of green ¯uor- been made to develop systems based on different drugs or hormones escent protein (GFP) and GDNF under the control of the hGFAP including tetracycline, rapamycine and progestrone (Clackson, 2000). (lu.se)

The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)

Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)

Ribosomes process the cell's genetic instructions to create proteins. (medlineplus.gov)
Together, these data demonstrate that human brain cells (both neurons and non-neuronal cells) can be aneuploid and that the resulting genetic mosaicism is a normal feature of the human CNS. (jneurosci.org)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)

Male mice that lacked the mouse Nutm1 gene using a gene knockout method had abnormally small testes, lacked sperm in their cauda epididymis (i.e. tail of the epididymis which contains sperm in fertile male mice), and were completely sterile. (wikipedia.org)
These findings indicate that Nutm1 gene is essential for the development of normal fertility in male mice and suggest that the NUTM1 gene may play a similar role in men. (wikipedia.org)
Tmem53 -/- mice recapitulate the human skeletal phenotypes. (nature.com)
MeCP2 is most highly expressed in neurons, and mice lacking this protein show symptoms that strikingly parallel those of Rett patients. (portlandpress.com)
In this fashion, mice or other laboratory animals that exhibit particular traits can be created for specialized studies, or herds of farm animals (such as goats, sheep or cows) can be created that produce pharmaceutically useful proteins in their milk. (who.int)

Alterations in genes with potential clinical utility are observed in more than three quarters of the cases and included members of the PI3-kinase and homologous DNA repair pathways. (nih.gov)
What pathways are this gene/protein implicaed in? (cancerindex.org)
The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (bvsalud.org)
The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)

Gene Accession No. (fishersci.com)
B) Alignment between coiled-coil regions of an ORF predicted from human EST with GenBank accession number AA424443, X. laevis MP43 (accession number U95097), A. nidulans NUDE (accession number AF085679), and N. crassa RO11 (accession number AF015560). (xenbase.org)

This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)

Detects human Cbx2 in ELISA. (rndsystems.com)
Depending on the epitopes used human ELISA kits can be cross reactive to many other species. (gentaur.com)
ELISA kit, ELISA, ELISAs Enzyme-linked immunosorbent assay 90320007 SNOMED code are used by the medical researcher for detection of human, mouse, … proteins are supplied in coated 96 well plates to be stored at +4°C. ELISA test kits can be sandwich ELISA. (gentaur.com)
ELISA tests are enzyme linked immunoassays to detect human, mouse or other proteins in serum, plasma, urine or biological fluids. (gentaur.com)

All four of these genes are oncogenes, i.e., genes that when overexpressed and/or overly active promote the development of certain types of cancers. (wikipedia.org)

Further studies are needed to confirm and expand these views and to determine if any of the overexpressed gene products of the BRD4-NUT protein contribute to the development and/or progression, or can serve as targets for the treatment, of the neoplasms associated with the BRD4-NUTM1 fusion gene. (wikipedia.org)
This review will highlight new discoveries regarding the mechanistic role of NRs and their associated protein cofactors in regulating gene activation and in the progression of cancer, diabetes, and obesity. (ku.edu)
microRNA-183-3p Inhibits Progression of Human Prostate Cancer by Downregulating High-Mobility Group Nucleosome Binding Domain 5. (cancerindex.org)

Anatomy5

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes12

Information Science3

Genome8

Regulation8

Chromosome13

Mutations in misma1

Mitochondrial protein1

Antigen4

Encodes a protein2

Signaling pathway2

Chromatin6

Subunit3

Target genes5

Putative3

Sequence13

Mitotic1

Mutation5

Antibody4

Metabolism5

Variants6

Synthesis6

Tumor4

Transcription7

Ribosomal9

20191

Cellular proteins3

Complexes3

Mammalian1

Yeast4

Transcriptional control2

Amino acids1

CDNA2

Ubiquitin protei1

Diseases7

Replication3

Different genes1

Interaction7

Nucleus3

Regulatory proteins1

Molecular4

Sequences4

Translocation1

Susceptibility1

Pore3

Histone1

Regulates1

Transcript3

Spectrometric2

Mitochondria4

20002

Embryonic development1

INTERACTIONS1

Genetic3

Mice5

Pathways4

Accession2

RNAs1

ELISA4

Oncogenes1

Progression3