InhibitorDifferentially expressed genesGLS1InhibitionMitochondrialMutationsMetabolicGlutamineEnzymeOrganismRegulationProteinEpigeneticOXPHOSMonoclonalGenotypeAssociated gene expressionInhibitorsGenomeChemotherapyDetectionPromotersPathogenTranscriptsCancersProteinsTranscriptionLiverPhosphorylationResearchersPolyadenylationPredictsPathwaysTumorResultsResistanceInteractionStrainDemonstrateCellsActivityStudyMemberPatientsSearchHumanCellStudiesDataIdentifyMatterDiseaseLevels
Inhibitor5
- Additionally, treatment of the cells with Compound 968, a glutaminase inhibitor, depleted the cells from the CD133 marker, slowed proliferation and limited growth on soft agar. (tmc.edu)
- Treatment with BPTES, a glutaminase inhibitor, reversed LPS-induced microglial activation and inflammation. (shengsci.com)
- IACS-010759 treatment and treatment with the novel glutaminase inhibitor CB839 significantly improved the survival of mice bearing High-OXPHOS, MAPKi-resistant ICr xenografts. (tmc.edu)
- New data from the Phase III EMBRACA trial led by researchers at The University of Texas MD Anderson Cancer Center found the PARP inhibitor talazoparib did not demonstrate a statistically significant overall survival (OS) benefit for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes. (mdanderson.org)
- In a first-time disclosure of IPN60090, a small-molecule inhibitor of the metabolic enzyme glutaminase (GLS1), researchers. (mdanderson.org)
Differentially expressed genes2
- This study provides a detailed overview of differentially expressed genes between BRAF wt vs. BRAF mut conventional PTCs using whole transcript, high-density microarrays. (biomedcentral.com)
- However, when the tilapia is affected by pathogen, the differentially expressed genes of T-cells are mainly concentrated in the metabolic pathways, and large-scale metabolic reorganization occurs. (ecnu.edu.cn)
GLS13
- Twenty-four hours post-treatment, TNBS-induced colitis results in DNA hypermethylation of CpG dinucleotides in the promoter region of glutaminase (GLS1) gene. (okstate.edu)
- MeCP2 protein has been shown to interact with corepressors to suppress or turn off gene transcription, however, in TNBS-induced colitis recruitment of MeCP2 to GLS1 promoter results in increased gene expression indicating interaction with coactivators rather than corepressors. (okstate.edu)
- whereas the glutamine deprivation or inhibition of the glutaminase GLS1 results in impairment of T-cell proliferation and effector function. (ecnu.edu.cn)
Inhibition3
- KEAP1/NFE2L2 mutations predict lung cancer radiation resistance that can be targeted by glutaminase inhibition. (stanford.edu)
- scRNA-seq analysis revealed that many fibroblasts expressed Hk2 along with Gls with several genes including Ptgs2 , Hif1a , Timp1 , Cxcl5 , and Plod2 only associated with double-positive fibroblasts, suggesting that dual inhibition can be an attractive target for fibroblasts. (biomedcentral.com)
- However, specific analyses of the regulation of major immediate early (MIE) gene expression reveal that the HATi C646, which targets p300/CBP, transiently repressed MIE gene expression via inhibition of the MIEP but by 24 h post-infection MIE gene expression was rescued due to compensatory activation of an alternative IE promoter, ip2. (bvsalud.org)
Mitochondrial2
- Glutaminase liver isoform, mitochondrial is a protein in humans that is encoded by GLS2 gene. (cusabio.com)
- We find a circadian rhythm in antigen processing that correlates with rhythms in both mitochondrial morphology and metabolism, dependent on the molecular clock gene, Bmal1. (biomed.news)
Mutations5
- Most commonly, such mutations are in the BRCA2 gene. (pcf.org)
- Over a decade ago, Dr. Wang co-discovered there are mutations of the PIK3CA gene (which is critical for cell division and movement) in 20 to 30 percent of colorectal cancers, suggesting the mutations play a role in the formation of colorectal cancer. (case.edu)
- These mutations account for 30% of all missense mutations in the TP53 gene. (encyclopedia.pub)
- Moreover, we show that aminooxyacetate (AOA), a compound that inhibits enzymatic activity of aminotransferases, suppresses xenograft tumour growth of CRCs with mutations, but not with wild-type (WT) mutations and that targeting glutamine metabolism may be an effective approach to treating CRC patients harbouring tumour mutations of this gene. (bibf1120.com)
- Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
Metabolic1
- Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)
Glutamine2
- Here we show that CD40 activation triggers fatty acid oxidation (FAO) and glutamine metabolism to promote ATP citrate lyase-dependent epigenetic reprogramming of pro-inflammatory genes and anti-tumorigenic phenotypes in macrophages. (acir.org)
- To enter the TCA cycle, glutamine is first deaminated by glutaminases (GLSs) to glutamate4. (bibf1120.com)
Enzyme1
- The glutaminase enzyme in A. sojae is important to the taste of the soy sauce that it produces. (wikipedia.org)
Organism1
- Also, the genes an organism possesses. (nih.gov)
Regulation2
- The rat HMGCS2 gene contains elements that control its multihormonal regulation and tissue specificity ( 11 - 14 ). (aacrjournals.org)
- Following infection, the human cytomegalovirus (HCMV) genome becomes rapidly associated with host histones which can contribute to the regulation of viral gene expression. (bvsalud.org)
Protein6
- This study revealed that the Ca2+ influx and the expression of immediate early genes (IEGs) encoding transcription factors such as early growth responses (EGRs) and activator protein-1 (AP-1) were greatly increased in HSC-2 cells incubated with the culture supernatant of SLS-producing ß-hemolytic S. anginosus subsp. (bvsalud.org)
- Our goals were twofold: 1) to characterize the gene expression, protein expression, and activity of key synthesizing and regulating enzymes of energy metabolism in the whole mouse retina, retinal compartments, and/or cells and 2) to provide an integrative analysis of the results related to function. (molvis.org)
- This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (thermofisher.com)
- The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
- What does this gene/protein do? (cancerindex.org)
- What pathways are this gene/protein implicaed in? (cancerindex.org)
Epigenetic1
- We developed 'epigenetic expression inference from cell-free DNA-sequencing' (EPIC-seq), a method that uses targeted sequencing of promoters of genes of interest. (stanford.edu)
OXPHOS3
- We recently showed via RNA-sequencing (RNA-seq) analysis of clinical samples that melanoma brain metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including PPARGC1A or PGC1α ) than patient-matched extracranial metastases (ECMs). (tmc.edu)
- RNA-seq analysis identified increased expression of OXPHOS genes in intracranial (ICr) vs. subcutaneous (SQ) xenografts of 4 different human melanoma cell lines. (tmc.edu)
- Hierarchical clustering analysis of surgically resected MBMs by OXPHOS genes identified subsets of MBMs particularly enriched (High-OXPHOS) and depleted (Low-OXPHOS) in OXPHOS. (tmc.edu)
Monoclonal2
- Genetic ablation of Ldha (encoding lactate dehydrogenase) and Gls (encoding glutaminase 1) impaired anti-CD40 monoclonal antibody-induced antitumor responses and re-education of tumor-associated macrophages. (acir.org)
- These Mouse monoclonal to Myostatin molecules will probably add powerful Glutaminase-IN-1 matches to standard chemotherapy. (sdfca.org)
Genotype1
- Genotype -- The specific allelic composition of a cell, either of the entire cell or more commonly for a certain gene or a set of genes. (nih.gov)
Associated gene expression1
- The presence of HK2 and GLS across various cell types and associated gene expression in human synovial cells and a murine model of arthritis was evaluated by scRNA-seq. (biomedcentral.com)
Inhibitors1
- Applying EPIC-seq to serial blood samples from patients treated with PD-(L)1 immune-checkpoint inhibitors, we show that gene expression profiles inferred by EPIC-seq are correlated with clinical response. (stanford.edu)
Genome3
- We have found a way to scan the genome of a wild relative of a crop plant and pick out the resistance genes we need: and we can do it in record time. (phys.org)
- The tumor suppressor p53, encoded by the TP53 gene and known as "the guardian of the genome", performs a variety of functions in cancer prevention. (encyclopedia.pub)
- A remarkable genomic feature is that the number of glycoside hydrolase (GH) genes in the genome of G. flava JLT2011 is more than 2-fold higher than that of other Gramella species. (unl.edu)
Chemotherapy1
- The observation of total medical recovery of individuals after effective chemotherapy in the absence of significant reduction of amyloid deposits indicates Glutaminase-IN-1 the mass action caused by the deposits is not the only, and possibly not the main, determinant of organ dysfunction in AL amyloidosis. (sdfca.org)
Detection2
- cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. (systemsbiology.net)
- B) Luciferase reporter gene detection in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with expression in ZR75-1 and MDA-MB-231 cells, which were transfected with ZKSCAN5 shRNA, control shRNA, or ZKSCAN5 shRNA plus shRNA-resistant ZKSCAN5 (ZKSCAN5-R). The representative Western blot further showed the expression of ZKSCAN5. (bms-911543.com)
Promoters1
- FAO generated acetyl-CoA and increased histone acetylation at promoters and enhancers of pro-inflammatory marker genes. (acir.org)
Pathogen1
- The research published today in the journal Nature Biotechnology reveals that AgRenSeq has been successfully trialled in a wild relative of wheat-with researchers identifying and cloning four resistance genes for the devastating stem rust pathogen in the space of months. (phys.org)
Transcripts1
- Hundred eighty transcripts from annotated genes were significantly differentially expressed between BRAF wt and BRAF mut PTCs and unsupervised cluster analysis was able to separate both groups. (biomedcentral.com)
Cancers3
- Deregulation of the lncRNA taurine upregulated gene 1 (TUG1) predicts poor prognosis and is implicated in the development of several cancers. (oncotarget.com)
- TP53 is the most frequently mutated gene in cancers. (encyclopedia.pub)
- Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)
Proteins1
- Numerous cellular proteins detect DNA damage and induce senescence , a permanent change of state characterized by morphological and gene expression changes. (massgenomics.org)
Transcription1
- To achieve this, p53 mainly functions as a transcription factor (TF) targeting hundreds of genes, but it also has TF-independent roles in the nucleus and cytoplasm [ 6 ]. (nature.com)
Liver2
- HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)
- The Affymetrix data revealed varied gene expression patterns of the ATP synthesizing and regulating enzymes found in the muscle, liver, and brain. (molvis.org)
Phosphorylation1
- This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (thermofisher.com)
Researchers4
- Researchers have pioneered a new method which allows them to rapidly recruit disease resistance genes from wild plants and transfer them into domestic crops. (phys.org)
- It enables researchers to search a genetic "library" of resistance genes discovered in wild relatives of modern crops so they can rapidly identify sequences associated with disease fighting capability. (phys.org)
- From there researchers can use laboratory techniques to clone the genes and introduce them into elite varieties of domestic crops to protect them against pathogens and pests such as rusts, powdery mildew and Hessian fly. (phys.org)
- What we have now is a library of disease resistance genes and we have developed an algorithm that enables researchers to quickly scan that library and find functional resistance genes," explains Dr. Sanu Arora, first author of the paper. (phys.org)
Polyadenylation2
- Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders. (rochester.edu)
- Multiple polyadenylation sites of the gene have been reported. (thermofisher.com)
Predicts1
- Here we describe promoter fragmentation entropy as an epigenomic cfDNA feature that predicts RNA expression levels at individual genes. (stanford.edu)
Pathways1
- Valuable candidate genes shall be assessed further to identify molecular pathways and molecular biomarkers which distinguish BRAF wt from BRAF mut PTCs. (biomedcentral.com)
Tumor2
- The tumor suppressor TP53 (also called p53) has been among the most extensively studied genes since its discovery in 1979 [ 1 , 2 ]. (nature.com)
- Chromatin fragmentation features have previously been explored to infer gene expression profiles from cell-free DNA (cfDNA), but current fragmentomic methods require high concentrations of tumor-derived DNA and provide limited resolution. (stanford.edu)
Results2
- Our results demonstrate that AgRenSeq is a robust protocol for rapidly discovering resistance genes from a genetically diverse panel of a wild crop relative," he says. (phys.org)
- p 0.01 versus the control shRNA group (A, B). (C, D) Wound healing assays for HLECs cultured in conditioned medium from ZR75-1 or MDA-MB-231 cells, which were Glutaminase-IN-1 stably infected as in (A). The image shown is one of the representative results (C, D). Scale bar: 100 m. (bms-911543.com)
Resistance3
- Re-introducing disease resistance genes from wild relatives is an economic and environmentally sustainable approach to breeding more resilient crops. (phys.org)
- By correlating this information with the DNA sequences of the plants, they were able to reveal the identity of functional resistance genes across the population. (phys.org)
- Investigating gene expression profiles associated with clinical radiation resistance in KEAP1/NFE2L2 wildtype lung cancer. (stanford.edu)
Interaction1
- Strikingly, a long noncoding RNA (lncRNA) GATA3-AS, transcribed from the antisense strand of the GATA3 gene, functioned as a cis -acting element for the preferential interaction of KIAA1429 with GATA3 pre-mRNA. (biomedcentral.com)
Strain1
- ASNase genes from each strain amplified by polymerase chain reaction PCR were inserted into Nde I and Xho I sites of pET28a-(+) and cloned in E. coli BL21(DE3). (fortunepublish.com)
Demonstrate2
- Previous studies demonstrate abnormal elevation of glutaminase C (GAC) in HIV-infected or immune-activated microglia. (shengsci.com)
- We further demonstrate that mutant p110 increases GPT2 gene expression through an AKT-independent signalling pathway. (bibf1120.com)
Cells3
- In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
- Moreover, GBM stem cells showed an increase in the expression of genes related to the mevalonate pathway. (tmc.edu)
- A) Luciferase reporter genes were determined in ZR75-1 and MDA-MB-231 breast cancer cells co-transfected with Glutaminase-IN-1 different concentrations of reporter and myc-ZKSCAN5. (bms-911543.com)
Activity1
- However, their intrinsic glutaminase activity, which could cause serious side effects like neurotoxicity, hepatitis and other dysfunctions, restricts their clinical applications [7]. (fortunepublish.com)
Study2
- Tumour Growth and Metastasis Analysis The animal study was approved and Glutaminase-IN-1 monitored by the Ethics Committee of Harbin Medical University Cancer Hospital (the ID of animal experiment ethical approval: SYDW2021-056). (bms-911543.com)
- Informed consent was obtained from the patients, and all study protocols were approved by the Institutional Review or Glutaminase-IN-1 Committees of Harbin Medical University Cancer Hospital. (bms-911543.com)
Member2
- The main module page also shows the location of these motifs within the upstream sequences of the module member genes. (systemsbiology.net)
- cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. (systemsbiology.net)
Patients2
- It has been recognized that 50% of cancer patients acquire certain types of TP53 gene alterations [ 9 ] [ 10 ] . (encyclopedia.pub)
- A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
Search1
- Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Human1
- Rusinek D, Szpak-Ulczok S, Jarzab B: Gene expression profile of human thyroid cancer in relation to its mutational status. (biomedcentral.com)
Cell1
- Inferring gene expression from cell-free DNA fragmentation profiles. (stanford.edu)
Studies1
- Previous lncRNAs profile studies have demonstrated aberrant expression of a series of lncRNAs, including taurine upregulated gene 1 (TUG1), in ICC specimens [ 5 ]. (oncotarget.com)
Data1
- mRNA expression data of energy-related genes were extracted from our whole retinal Affymetrix microarray data. (molvis.org)
Identify1
- MeRIP-seq, RIP-seq and RNA-seq were performed to identify the target genes of KIAA1429. (biomedcentral.com)
Matter2
- Now we can clone these genes in a matter of months and for thousands of pounds instead of millions. (phys.org)
- It's not that genes don't matter at all, but it turns out that your microbes have this very important role in shaping you and the food that you eat. (pullquote.com)
Disease1
- AgRenSeq -- new rapid gene cloning method will protect domestic crops from disease. (phys.org)
Levels1
- The factors responsible for the postnatal and starvation-associated induction of HMGCS2 gene expression have been identified and shown to involve changes in circulating hormone and fatty acid levels. (aacrjournals.org)