Gene fusion encodes a chimeric. Medical search. Frequent questions

Anaplastic large cell lymphomas are associated with chromosomal aberrations involving the anaplastic lymphoma kinase (ALK) gene, resulting in the expression of novel chimeric ALK proteins with transforming properties. (signalchem.com)
TRKA, B, and C are encoded by the genes NTRK1, NTRK2, and NTRK3.Chromosomal rearrangements involving in-frame fusions of these genes with various partners can result in constitutively-activated chimeric TRK fusion proteins that can act as an oncogenic driver, promoting cell proliferation and survival in tumor cell lines. (ptmasterguide.com)

A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors. (escholarship.org)
Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain capable of activating T-cells. (escholarship.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. (atlasgeneticsoncology.org)
Whole-genome sequencing revealed that the fusion resulted from a ∼400-kilobase (kb) deletion on chromosome 19 (chr19). (medscape.com)
[ 19 ] The apparent lack of a second-hit mutation in the genome of FLCs supports the role of DNAJB1-PRACA fusion protein as a major driver of this tumor and as a key diagnostic and therapeutic target. (medscape.com)
HJ3/QL H77/JFH1 chimeric genome was kindly provided by Lemon and co-workers (47). (tam-receptor.com)
The rNDV-18HL selectively replicated in orthotopic HCC xenografts resulting in cHAb18 manifestation with a poor non-segment solitary strand RNA genome which encodes six proteins including nucleocapsid proteins (NP) phosphoprotein (P) matrix proteins (M) fusion proteins (F) haemagglutinin-neuraminidase (HN) and RNA reliant RNA polymerase (L). NDV strains are categorized into velogenic (extremely virulent) mesogenic (intermediate virulence) and lentogenic (nonvirulent) predicated on the virulence in the organic sponsor [2]. (immune-source.com)
At this institution, 2 fecal samples with high genome load, as determined by 2 independent, published ( 8 , 9 ) reverse transcription quantitative PCRs selective for PEDV nucleocapsid (N) and spike (S) genes, were chosen for routine virologic testing and next-generation sequencing. (cdc.gov)

In this study, we demonstrated that the conditional deletion of both the forkhead box p3 (Foxp3) and B-cell lymphoma 6 (Bcl6) genes induced the spontaneous development of AD-like skin inflammation with hyperactivation of type 2 immunity, skin barrier dysfunction, and pruritus, which were not induced by the single deletion of each gene. (bvsalud.org)
In in vitro and in vivo tumor models, larotrectinib demonstrated anti-tumor activity in cells with constitutive activation of TRK proteins resulting from gene fusions, deletion of a protein regulatory domain, or in cells with TRK protein overexpression. (ptmasterguide.com)
1q23.1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia. (cancerindex.org)
This plasmid was used as a template to prepare HVR1 deletion mutants using standard fusion PCR, followed by insertion into phCMV vector. (tam-receptor.com)
This plasmid was used as a template to amplify the E1E2 sequence by PCR, and the E1E2 sequences with HVR1 deletion mutations using fusion PCR and the resulting fragments were inserted into the phCMV vector. (tam-receptor.com)
HVR1 deletion mutants were generated by deleting the indicated sequences in the genomic cDNA backbone using fusion PCR together with endonuclease digestion and ligation. (tam-receptor.com)

Ph+ acute lymphoblastic leukemia (Ph+ ALL) is a high-risk acute leukemia with poor prognosis, in which the specific t(9;22)(q34;q11) translocation results in a chimeric bcr-abl (e1a2 breakpoint) and in a 190 KD protein (p190) with constitutive tyrosine kinase activity. (hindawi.com)
Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. (novusbio.com)
Expression of ALK in malignant T cells is typically due to the t(2;5) translocation resulting in formation of the fusion gene which encodes a 80-kDa hybrid protein that contains portion of the nuclear protein nucleophosmin (NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase ALK. (upenn.edu)
A rearrangement (translocation) of genetic material between chromosomes 22 and 11, written as t(11;22), fuses part of the EWSR1 gene with part of the FLI1 gene, creating the EWSR1/FLI1 fusion gene. (medlineplus.gov)
Bailly RA, Bosselut R, Zucman J, Cormier F, Delattre O, Roussel M, Thomas G, Ghysdael J. DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. (medlineplus.gov)
Gene amplification, Chromosome Translocation, and Retroviral Insertion all create cancer. (pbworks.com)

Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
Among these candidates were the paralogous proteins encoded by FTT0918 and FTT0919. (encyclopedia.pub)

Cell entry by measles virus: long hybrid receptors uncouple binding from membrane fusion. (1library.net)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)

A recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. (bcm.edu)

Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. (novusbio.com)
Sequence analysis showed that the result of the inversion/fusion generated a chimeric USP16-RUNX1 transcript. (atlasgeneticsoncology.org)
The USP16-RUNX1 fusion transcript did not have an open reading frame using the canonical start codons of USP16 or RUNX1. (atlasgeneticsoncology.org)
The break/fusion was not present in the germline since we did not find the USP16-RUNX1 transcript in buccal smear cells of the patient. (atlasgeneticsoncology.org)
In 2014, Honeyman and colleagues discovered a novel, chimeric transcript that is present in all studied samples of FLC, DNAJB1-PRKACA . (medscape.com)
In these rare tumors, the DNAJB1-PRKACA fusion transcript is expressed at high levels. (medscape.com)
In 2014, Honeyman et al reported that FLC tumor samples from 11 patients expressed a novel fusion transcript, DNAJB1-PRKACA . (medscape.com)
The fusion transcript encodes a chimeric protein that couples a segment of the heat shock protein, DNAJB1, with the catalytic domain of protein kinase A (PKA) and exhibits full retention of PKA activity. (medscape.com)
Almost half of the genes expressed in adults showed reduced expression, supporting a broad role for the three tested genes in steady-state transcript abundance. (sdbonline.org)

Recombinant human fusion TFG (1-193)-ALK (1058-end) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. (signalchem.com)
As a result, we prepared a recombinant protein composed of the benzo[a]pyrene immunomimetic peptide and pIII-encoding sequences. (actanaturae.ru)
The present invention relates to a chimeric protein of recombinant human granulocyte colony stimulating factor comprising of hG-CSF fused to an affinity fusion tag at its amino terminus. (allindianpatents.com)
One way to produce recombinant human G-CSF in soluble form is to produce chimeric protein formed by expression of a hybrid gene made by splicing together two gene sequences, In this approach, ideally GCSF would be operationaffy finked to an affinity tag so as to give chimeric protein with better solubility. (allindianpatents.com)
The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. (justia.com)
The pro-peptide-polypeptide fusion protein can be cleaved and the recombinant polypeptide released under the appropriate conditions. (justia.com)
The preparation of valuable recombinant (genetically engineered) polypeptides, for example pharmaceutical proteins, relies frequently on techniques which involve the production of these polypeptides as fusion or hybrid proteins. (justia.com)
Finally, the use of a fusion partner may enable the production of a peptide which would otherwise be too small to accumulate and recover efficiently from a recombinant host cell system. (justia.com)

[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
Transfection of mRNAs encoding the chimeric constructs achieved functional expression of the proteins able to act on their targets. (unav.edu)
Brewery quality control programs rely on selective microbial growth media and molecular detection of the STA1 gene, however there is a wide functional range of diastatic activity that remains unresolved by these current methods. (omegayeast.com)
Surface (S)-layer proteins and S-layer fusion proteins incorporating functional sequences, self-assemble into monomolecular lattices on solid supports and on various lipid structures. (2medicalcare.com)
The abnormal fusion creates an Chimeric Gene whose functional over activity leads to Luekemia. (pbworks.com)
This demonstration opens up new avenues for identifying functional genes, and novel therapeutic strategies against F. tularensis infections. (encyclopedia.pub)
Spiller B. O., Blackbourne, D., Mark L, Proctor D. and * Blom A. M. , (2003) Functional activity of the complement regulator encoded by Kaposi's sarcoma associated herpesvirus. (lu.se)

Gain-of-function alleles of the Drosophila gene Bearded ( Brd ) cause sensory organ multiplication and loss pheno-types indistinguishable at the cellular level from those caused by loss-of-function mutations in the genes of the Notch pathway (Leviten, M. W. and Posakony, J. W. (1996). (biologists.com)
In humans, mutations affecting the genes of this family are associated with specific diseases. (sdbonline.org)
Mutations can cause two basic things to a gene. (pbworks.com)

Due to bcr-abl fusion, the corresponding p190 joint region contains an amino acid sequence unique to the oncoprotein in addition to a novel amino acid, not belonging to either BCR or ABL sequences, created at the exact fusion point. (hindawi.com)
Moreover, the 3′ UTRs of Brd and of the m4 transcription unit of the Enhancer of split gene complex [E(spl)-C] exhibit an unusually high degree of sequence identity that includes not only Brd box sequences but also a second motif we refer to as the 'GY box' (GTCTTCC). (biologists.com)
All the envelope encoding sequences were confirmed by DNA sequencing. (tam-receptor.com)
In addition to unbiased de novo detection of canonical junctions, STAR can discover non-canonical splices and chimeric (fusion) transcripts, and is also capable of mapping full-length RNA sequences. (nih.gov)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831673/ Gene fusions are frequently found in prostate cancer and may result in the formation of unique chimeric amino acid sequences (CASQs) that span the breakpoint of two fused gene products. (iedb.org)

ELISA assays using several different monoclonal antibodies to CD19 demonstrated dose-related specific binding by the fusion molecule CD19sIg1-4, but no binding by CD19sIg1-3. (escholarship.org)
Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. (unav.edu)
Chimeric monoclonal antibodies activate antigen-presenting cells (APCs) and T cells more effectively than murine monoclonal antibodies but can still induce production of human anti-chimeric antibodies. (msdmanuals.com)
Fully human monoclonal antibodies are produced using transgenic mice that contain human immunoglobulin genes or using phage display (ie, a bacteriophage-based cloning method) of immunoglobulin genes isolated from human B cells. (msdmanuals.com)

q11) resulting in a chimeric bcr-abl (e1a2 breakpoint) fusion gene that encodes a 190 KD protein (p190) with constitutively active tyrosine kinase activity that can alter multiple signaling pathways, contributing to tumor growth and proliferation. (hindawi.com)
If the epitope is derived from fused gene products and spans the breakpoint, it is considered a fusion neoepitope. (iedb.org)

2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)

3. Mechanisms of malignant cell transformation by the chimeric NPM/ALK kinase. (upenn.edu)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
His team has characterized more than 25 different translocations and found that the majority result in fusion genes encoding chimeric proteins with an N-terminal region derived from a partner gene fused in frame to the C-terminal region of tyrosine kinase such as ABL, PDGFRα, PDGFRß, JAK2, KIT or FGFR1. (cml-foundation.org)

In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Oncogenes and Tumor suppressor genes are very important when it comes to this cancer topic. (pbworks.com)
Than once those proto-onco genes change to oncogenes, cancer starts. (pbworks.com)

Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Tumor suppressor genes are the opposite. (pbworks.com)
Background Oncolytic disease which hands the therapeutic gene to improve anti-tumor activity is a common technique to improve oncovirotherapy of tumor. (immune-source.com)
Viral replication and virulence weren't attenuated from the incorporation of cHAb18 gene ICOS which considerably improved the suppression of relict tumor cell migration. (immune-source.com)
It has been proved to have a beneficial treatment effect on BIBX 1382 prevention of tumor recurrence in individuals with HCC [23 24 We generated a mouse-human chimeric cHAb18 antibody that derived from murine HAb18 and showed inhibition of HCC cell. (immune-source.com)

Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML. (cancerindex.org)

Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. (bcm.edu)
Aberrant cell signaling and epigenetic regulation of gene expression in human lymphomas. (upenn.edu)
Our most recent work focuses on the molecular mechanisms of the aberrant gene silencing in the malignant lymphoid cells. (upenn.edu)

This fusion molecule is a sensitive reagent for detection of anti-CD19 CAR derived from any monoclonal antibody present in CAR-modified T-cells. (escholarship.org)
The resultant DNA is placed in a mammalian cell culture, which then expresses the resultant gene, producing the desired antibody. (msdmanuals.com)
After four years of research and validation, GemPharmatech's independently developed fully antibody gene humanized mouse model, NeoMab™, is officially entering the market to serve the therapeutic antibody development needs of biotechnology companies and pharmaceutical enterprises. (gempharmatech.us)
GemPharmatech's NeoMab™, a fully antibody gene humanized model, along with its advanced technical platform, not only facilitates but expedites the preclinical discovery and validation processes for forward-thinking pharmaceutical enterprises. (gempharmatech.us)
NeoMab™, our fully antibody gene humanized model, serves as a pivotal addition to the GemPharmatech family. (gempharmatech.us)
The rNDV-18HL-encoded cHAb18 antibody kept affinity for CD147 and showed inhibiting the invasion and migration of HCC cells. (immune-source.com)

The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

No. 4,743,679 which discloses a process for the production of human epidermal growth factor comprising cleavage of a fusion protein by Staphylococcus aureus V8 protease. (justia.com)
A particle according to claim 1, further comprising the nucleic acid sequence encoding die protease cleavage signal. (sumobrain.com)
This gene encodes a protein with protease activity and is expressed in the placenta. (cancerindex.org)

The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

A point mutation occurs when a single amino acid base pair of the gene gets effected. (pbworks.com)
A silent mutation changes the nucleotide sequence of a gene, but does not alter the amino acid sequence. (pbworks.com)
This mutation may not effect the function of the gene,as long as the substitute amino acid is has a chemistry similar to the original amino acid. (pbworks.com)

A driving force for the creation of eukaryotic genes encoding multienzymatic proteins such as CAD may be the advantage of coordinate expression of enzymes catalyzing steps in a biosynthetic pathway. (uky.edu)
A particle according to any one of the preceding claims, wherein heterologous polypeptide sterically hinders fusion of an enveloped viral particle with an eukaryotic cell to which it is bound. (sumobrain.com)

Translocations that fuse the EWSR1 gene with other genes that are related to the FLI1 gene can also cause these types of tumors, although these alternative translocations are relatively uncommon. (medlineplus.gov)
Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
In most of these tumors, the t(2;5)(p23;q35) generates the NPM-ALK fusion gene. (signalchem.com)

The efficacy of cellular or humoral immunotherapy has been demonstrated with the success of chimeric antigen receptor T-cell therapy and the bispecific engager blinatumomab in treating advanced disease. (haematologica.org)

Figure 1A: Genomic rearrangement involving USP16 and RUNX1 genes in a CMML. (atlasgeneticsoncology.org)
The CAD gene appears to have evolved through a process of gene duplication and DNA rearrangement, leading to an in‐frame gene fusion encoding a chimeric protein. (uky.edu)
However, for patients with a KMT2A rearrangement (KMT2A-r), the prognosis appears to depend on the fusion partner gene rather than the karyotype structure. (cancerindex.org)

2.Hernández L. et al: Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity. (signalchem.com)

For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)

The most common mutation that causes Ewing sarcoma involves two genes, the EWSR1 gene on chromosome 22 and the FLI1 gene on chromosome 11 . (medlineplus.gov)
The protein produced from the EWSR1/FLI1 fusion gene, called EWS/FLI, has functions of the protein products of both genes. (medlineplus.gov)
The EWS protein, produced from the EWSR1 gene, also regulates transcription. (medlineplus.gov)
The EWSR1/FLI1 fusion gene occurs in approximately 85 percent of Ewing sarcomas. (medlineplus.gov)

Exogenous control of mammalian gene expression via modulation of RNA self-cleavage. (bcm.edu)
By reverse genetics technology we shown that NDV Italien was able to carry exogenous genes without influencing computer virus replication [7]. (immune-source.com)

1. Role of the cytokine-signal transduction pathways and epigenetic gene silencing in pathogenesis of T-cell lymphoma. (upenn.edu)
1. Hernández L. et al: TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations. (signalchem.com)

Recurrent chimeric RNAs enriched in human prostate cancer identified by deep-sequencing. (bcm.edu)
A specific reagent for the detection of anti-CD19 CAR expression was developed, a fusion protein consisting of human CD19 extracellular domains and the Fc region of human IgG1 (CD19sIg). (escholarship.org)
Genes encoding CD19sIg fusion proteins were constructed by fusing either exons 1 to 3 (CD19sIg1-3) or exons 1 to 4 (CD19sIg1-4) of the human CD19 cDNA to a human IgG1Fc fragment. (escholarship.org)
Humans have a duplicate set of 23 chromosomes (or a total of 46 chromosomes) in any given cell that carries all of the human genes. (sarcomahelp.org)
If the mouse gene for the whole variable region is spliced next to the human constant region, the product is termed "chimeric. (msdmanuals.com)
Translocations between MLL (a human trithorax -related gene) and AF4 or AF5q31 are involved in acute lymphoblastic leukemia (Wittwer, 2001, Tang, 2001 and Su, 2001). (sdbonline.org)
It retains the native mouse constant region encoding genes while incorporating human variable gene repertoires at the endogenous loci. (gempharmatech.us)
NeoMab™ mice utilize human V(D)J genes to encode antibodies, exhibiting gene usage frequency and sequence diversity that closely resemble those of humans. (gempharmatech.us)

Germline mutation of one TP53 allele is found in patients with Li-Fraumeni syndrome who generally inherit a mutated TP53 gene from an affected parent. (medscape.com)
2) lilli mutation strongly suppresses the rough eye phenotype of ectopically expressed phyllopod (Tang, 2001), and (3) lilli was identified in a screen for genes that enhance the embryonic lethal phenotype of dpp alleles (Su, 2001). (sdbonline.org)
A mutation is a small change in the DNA structure that alters a particular gene. (pbworks.com)
This includes peptides that overlap with the indel and those that are encoded downstream of the mutation. (iedb.org)

This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
The molecular cloning of GCSF gene (Nagata et al. (allindianpatents.com)
We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)

Through this harmonious fusion, we empower drug development enterprises with comprehensive support, propelling the process of uncovering and advancing new therapeutic agents. (gempharmatech.us)

and (iv) genes harboring germline non-silent variants presumed to confer a risk of sporadic ALL. (haematologica.org)

Two different ALK rearrangements involving the TRK-fused gene (TFG) in which the same portion of ALK was fused to different length fragments of the 5' TFG region. (signalchem.com)
These two rearrangements encoded chimeric proteins of 85 kd (TFG-ALK(S)) and 97 kd (TFG-ALK(L)), respectively. (signalchem.com)

Genes other than NPM have been demonstrated to fuse to the ALK gene. (signalchem.com)

These mutant phenotypes correlate with markedly reduced expression of the early zygotic genes serendipity alpha , fushi tarazu and huckebein , which are essential for cellularization and embryonic patterning (Tang, 2001). (sdbonline.org)

It has also been proposed to employ fusion partners as affinity peptides. (justia.com)

Some metabolic pathways are nearly ubiquitous among organisms: the genes encoding the enzymes for such pathways must therefore be ancient and essential. (uky.edu)
Genes showing reduced expression due to these RNAi treatments were short and enriched for genes encoding metabolic or enzymatic functions. (sdbonline.org)

Chromosomes are the cellular storage units for genes contained within the nucleus (which is the genetic center) of the cell and are analogous to a spool with the DNA or genetic message being the thread on the spool. (sarcomahelp.org)

Enzymes known to the prior art as "proteolytic enzymes" have been found to be particularly well suited for the cleavage of fusion proteins. (justia.com)
Direct Repair is when enzymes modify the base sequence if the gene, for it to be repaired. (pbworks.com)

The FLI protein controls the growth and development of some cell types by regulating the transcription of certain genes. (medlineplus.gov)
The GP64 envelope fusion protein is an essential baculovirus protein required for cell-to-cell transmission of infection. (1library.net)
Production of the fusion polypeptide involves the introduction of the hybrid gene into a biological host cell system, for example yeast cells, which permits the expression and accumulation of the fusion polypeptide. (justia.com)

These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
These results suggest that transcriptional elongation control is especially important for rapidly expressed genes to support digestion and metabolism, many of which have sex-biased function. (sdbonline.org)

We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)

These fusion proteins are intended to work in similar fashion as the MHC Tetramers used for identification of antigen-specific T-cells, and may also have other applications in studies of activation of anti-CD19 CAR bearing cells. (escholarship.org)
TFG can provide an alternative to NPM as a fusion partner responsible for activation of the ALK and the pathogenesis of ALCL. (signalchem.com)

This methodology facilitates the isolation and recovery of the fusion peptide from the host cells by exploiting the physico-chemical properties of the fusion partner. (justia.com)

Anatomy14

Organisms19

Diseases15

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes72

Technology, Industry, Agriculture1

Information Science4

Health Care1

Chromosomal2

Antigen Receptors3

Genome6

Deletion6

Translocation6

Proteins encoded3

Receptors2

Constitutively activated1

Transcript9

Recombinant8

Functional7

Mutations3

Sequences5

Monoclonal antibodies4

Breakpoint2

Oncoproteins2

Kinase3

Oncogenes4

Tumor5

Partner genes1

Aberrant3

Antibody6

Locus2

Protease3

Apoptosis2

Amino acid3

Eukaryotic2

Tumors3

Immunotherapy1

Rearrangement3

Genomic1

Nuclear protein2

EWSR14

Exogenous2

Lymphoma2

Human8

Mutation4

Molecular3

Therapeutic1

Confer1

Rearrangements2

Fuse1

Markedly1

Affinity1

Metabolic2

Cellular1

Enzymes2

Cell3

Transcriptional3

Regulation1

Activation2

Peptide1