• Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
  • Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. (frontiersin.org)
  • In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
  • However, most of our knowledge about cell proliferation comes from studies that average data from large and mixed cell populations. (frontiersin.org)
  • miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. (hindawi.com)
  • Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis. (hindawi.com)
  • It has been shown that inflammation caused by oxidized low-density lipoprotein (ox-LDL) contributes to the occurrence and development of AS [ 1 ], which can promote vascular smooth muscle cell (VSMC) migration, proliferation, and transformation from a contractile to a synthetic phenotype [ 2 - 6 ]. (hindawi.com)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • In the present study, we analyzed the proliferation and apoptosis of trophoblasts and human decidual cells in patients with recurrent spontaneous abortion and the related cellular pathway mechanism. (spandidos-publications.com)
  • The mechanism of recurrent abortion is considered to be related to the proliferation and apoptosis of human decidual cells and cytotrophoblasts ( 4 ). (spandidos-publications.com)
  • BRAF is a protein kinase and part of the MAP kinase signalling cascade which involves transduction of a growth signal from the cell membrane to the nucleus via a chain of protein kinases and is responsible for cellular proliferation and survival. (hindawi.com)
  • Nucleolar protein 2 (NOP2) is evolutionarily conserved from yeast to human, and has been found to play an important role in accelerating cell proliferation, cell-cycle progression, and tumor aggressiveness. (umass.edu)
  • Purified cannabinoids have been reported to prevent proliferation, metastasis, and induce apoptosis in a variety of cancer cell types. (nih.gov)
  • We performed genome-scale loss-of-function screens in 33 cancer cell lines to identify genes essential for proliferation/survival and found a strong correlation between increased gene copy number and decreased cell viability after genome editing. (broadinstitute.org)
  • Within regions of copy-number gain, CRISPR/Cas9 targeting of both expressed and unexpressed genes, as well as intergenic loci, led to significantly decreased cell proliferation through induction of a G2 cell-cycle arrest. (broadinstitute.org)
  • MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
  • In addition, we studied the effect of WSC on the proliferation and cell cycle of alveolar type II cells and vascular endothelial cells. (who.int)
  • Tumor suppressor genes encode proteins that normally keep cell growth and division in check, preventing excess cell proliferation and the formation of tumors. (pewtrusts.org)
  • Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
  • At the same time, we found an increase in the expression of ElrC, a marker of cells as they undergo a transition from proliferation to differentiation. (xenbase.org)
  • 10] Interestingly, this analysis found no differences in expression of proliferation markers between these subsets of CD207+ cells, consistent with the hypothesis that LCH may be a disease of abnormal cellular accumulation. (medscape.com)
  • Taken together, our study provides a detailed functional and molecular characterization of HSCs at different phases of regeneration and identifies a gene set associated with the transition from proliferation to quiescence. (lu.se)
  • The mechanism, which is based on the synthesis and degradation of three ''master regulator'' proteins (CtrA, GcrA, and DnaA), is converted into a quantitative model, in order to study the temporal dynamics of these and other cell cycle proteins. (ebi.ac.uk)
  • Since many of the proteins involved in regulating the cell cycle of C. crescentus are conserved among many genera of a-proteobacteria, the proposed mechanism may be applicable to other species of importance in agriculture and medicine. (ebi.ac.uk)
  • This allows the proteins to follow a cycle of activation and deactivation necessary for cell function. (unige.ch)
  • By disrupting interactions with cell membrane proteins, these mutations modify the ability of neurons to communicate with their environment. (unige.ch)
  • What you actually find in the genome are coding genes that produce proteins, coupled to regulatory elements that switch the coding genes off and on using a kind of sophisticated boolean logic. (scienceblogs.com)
  • T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
  • Here, we analyze the expression signature associated with all 687 RNA-binding proteins (RBPs) and identify 39 that significantly correlate with cell cycle mRNAs. (iric.ca)
  • HCF-1 interacts with proteins called transcription factors, which attach (bind) to specific regions of DNA and help control the activity of particular genes. (medlineplus.gov)
  • These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
  • Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)
  • RNA profiling identified 2283 differentially expressed genes in F7+F3 treatment, among them genes related to the Wnt signaling pathway and apoptosis-related genes. (nih.gov)
  • We found that the total transcript level per cell and the expression of most individual genes correlated with progression through the cell cycle, but not with cell size. (frontiersin.org)
  • The molecular processes behind cell cycle progression have been dissected by numerous morphological studies on live or fixed single cells using a plethora of techniques to visualize components and processes during cell division. (frontiersin.org)
  • A total of 513 genes have been identified as being required for cell cycle progression, 276 of which have not been previously described as cell cycle genes. (uzh.ch)
  • Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. (nih.gov)
  • Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome replication and partitioning to daughter cells. (ebi.ac.uk)
  • This pathway describes progression of a serrated precursor lesion, often followed by the onset of epigenetic instability involving promoter methylation and silencing of key tumour suppressor genes, and accounts for 15%-20% of sporadic colorectal cancer [ 1 , 2 ]. (hindawi.com)
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (caslab.com)
  • Using this system, we have been modeling glioma, medulloblastoma, breast cancer, and ovarian cancer and have revealed highly intricate cell-cell relationships that are critical for tumor progression and should inspire paradigm-shifting strategies for cancer prevention and treatment. (pewtrusts.org)
  • Tumor progression in current mouse models tends to be driven by mutations in specific genes. (pewtrusts.org)
  • HCF-1 helps regulate genes that are important in other cellular processes, such as progression of cells through the step-by-step process it takes to replicate themselves (called the cell cycle). (medlineplus.gov)
  • The most relevant articles summarising existing knowledge on RCC genomics, including tumour cell evolution and progression, were selected for this review. (springer.com)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • The most common function is found during the cell cycle when mutations occur because it becomes activated without phosphorylation and turns on Cds1. (wikipedia.org)
  • By deciphering mutations in the GNAO1 gene, which cause severe mental and motor disabilities, a UNIGE team is showing how zinc could improve the brain defects at stake. (unige.ch)
  • One of these diseases, first identified in 2013, is caused by mutations in the GNAO1 gene. (unige.ch)
  • Children with mutations in the GNAO1 gene show significant clinical disorders: delayed intellectual and motor development, uncontrollable movements, as well as more or less severe epilepsy, sometimes accompanied by brain damage and atrophy. (unige.ch)
  • Mutations in the GNAO1 gene lead to the replacement of one amino acid in Gαo by another. (unige.ch)
  • These mutations are found to indirectly affect a crucial amino acid for GTP hydrolysis: glutamine 205. (unige.ch)
  • Combining expertise from Stukenberg's work in chromosomal biology and Zong's development of cutting-edge cancer models, the pair will engineer a novel mouse model of triple negative breast cancer that incorporates both specific gene mutations and aneuploidy. (pewtrusts.org)
  • Several HCFC1 gene variants (also known as mutations) have been identified in people with methylmalonic acidemia with homocystinuria, cblX type, which is one form of a disorder that causes developmental delay, eye defects, neurological problems, and blood abnormalities. (medlineplus.gov)
  • Mutations in TP53 can lead to the loss of these functions, inducing uncontrolled cell growth and the promotion of tumor development ( 11 , 12 ). (spandidos-publications.com)
  • These studies reveal that recurrent somatic mutations occur in only a handful of genes, with an overall mutational burden of roughly 1-2 per Mb. (springer.com)
  • This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
  • TP53 protein can induce cell growth arrest, apoptosis, differentiation and DNA repair, and activate or inhibit the expression of downstream genes such as Bax and CDKN1A ( 5 ). (spandidos-publications.com)
  • In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
  • Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
  • This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
  • Depletion of the cell-cycle inhibitor p27 ( Xic1 ) impairs neuronal differentiation and increases the number of ElrC (+) progenitor cells in Xenopus tropicalis. (xenbase.org)
  • To investigate whether p27(Xic1) is necessary for cell cycle exit and/or neuronal differentiation, we used antisense morpholino oligos (MO) to knockdown the protein levels in vivo. (xenbase.org)
  • These differences were found in genes involved in cell cycle regulation, apoptosis, cell signaling, metastasis, and myeloid differentiation. (medscape.com)
  • With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
  • In the present study, we comparatively analyzed the cell apoptosis and cell signaling pathways of healthy patients and those with recurrent spontaneous abortion, providing a theoretical basis for clinical treatment. (spandidos-publications.com)
  • Some genes, such as RELA and GADD45B , were predicted to extensively involve these critical pathways, indicating their potential functions in OA mechanisms. (frontiersin.org)
  • In conclusion, this study identified the significant modules, signaling pathways, and hub genes relevant to OA and highlighted the potential clinical value of anisomycin and MG-262 as novel therapies in OA management. (frontiersin.org)
  • GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)
  • We shall consider each subtype in turn describing genes and pathways of oncogenesis and how these relate to prognosis and treatment response. (springer.com)
  • Immune checkpoint inhibitors (ICIs) are monoclonal antibody antagonists, which can block cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1/ligand-1 (PD-1/PD-L1) pathways, and other molecules exploited by tumor cells to evade T cell-mediated immune response. (bvsalud.org)
  • Furthermore, annotation discrepancy can be found among different bioinformatic and genomic databases. (nature.com)
  • This is not to imply that the genomic information is unimportant, only that understanding it requires complementing it with an understanding of cell:cell interactions, signaling, signal transduction, induction, and molecular patterning…all stuff that developmental biologists love. (scienceblogs.com)
  • Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. (broadinstitute.org)
  • By examining single-guide RNAs that map to multiple genomic sites, we found that this cell response to CRISPR/Cas9 editing correlated strongly with the number of target loci. (broadinstitute.org)
  • The most common non-clear cell renal cancers have also undergone genomic profiling and are characterised by distinct genomic landscapes. (springer.com)
  • We report the isolation of a p27(Xic1) genomic clone and we identify a 5' region capable of driving reporter gene expression specifically in the neural tube and the eye. (xenbase.org)
  • and regulation of cell cycle process. (nih.gov)
  • MicroRNAs (miRNAs) are small noncoding sequences involved in the negative regulation of gene expression. (hindawi.com)
  • Intriguingly, some of the top-ranked transcripts are noncoding splicing isoforms, which imply diverse gene regulation mechanisms. (nature.com)
  • gene loci structures and their regulation. (nature.com)
  • A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation. (ebi.ac.uk)
  • To develop a data-driven model of cell cycle regulation, we used contiguous, dynamic measurements over two time scales (minutes and hours) calculated from static multiparametric cytometry data. (ebi.ac.uk)
  • The rat HMGCS2 gene contains elements that control its multihormonal regulation and tissue specificity ( 11 - 14 ). (aacrjournals.org)
  • 1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
  • 1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
  • These modifications have been shown to be important in gene regulation. (neb.com)
  • Although some of these genes are controlled by specific transcriptional programs, very little is known about their post-transcriptional regulation. (iric.ca)
  • This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)
  • Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
  • Principles for regulation of gene expression through intercellular signalling. (lu.se)
  • Gene regulation in developmental biology and the cell cycle. (lu.se)
  • We investigated the expression of genes of interest using quantitative reverse transcription PCR. (molvis.org)
  • We also assessed the effect of WSC on the expression of genes involved in cell cycle arrest and inflammation. (who.int)
  • The role of intracellular glutathione on the Cr(VI)-induced alterations in the expression of genes was further investigated using heme oxygenase 1 (HO-1) as the model gene. (cdc.gov)
  • and the cellular glutathione level appears to be an important factor influencing Cr(VI)'s effects on the expression of genes. (cdc.gov)
  • We have also attempted to verify a series of differentially expressed candidate susceptibility genes to lung tumours in our previous microarray analysis with semiquantitative reverse transcriptase PCR (RT-PCR). (bmj.com)
  • In general, genes involved in stress response, cell cycle control, drug metabolism, apoptosis and growth were differentially expressed in response to Cr(VI) exposure. (cdc.gov)
  • Differential expression of six of seven candidate genes were confirmed. (bmj.com)
  • A total of 330 significantly differential genes were identified through large-scale transcriptome sequencing, among which 103 genes were upregulated and 227 genes were downregulated. (mdpi.com)
  • 687 genes differentiated tumor samples before and after treatment, among which 310 genes did not show the same differential expression in the placebo group or normal samples. (karger.com)
  • In order to better understand the molecular mechanisms responsible for the dermal toxicity of chromium , differential gene expression profiles of human skin fibroblasts exposed to a cytotoxic concentration of hexavalent potassium dichromate [Cr(VI)] were studied. (cdc.gov)
  • Skin fibroblasts were exposed to 5 uM Cr(VI) for time intervals up to 24- hr and their differential gene expression profile was studied using the Toxicology and Drug Resistance Microarray (Super Array Inc.). Of the 280 genes represented on the array, the expression levels of 32 genes were found to be differentially affected in the fibroblasts exposed to Cr(VI). (cdc.gov)
  • A 2010 study comparing gene expression of cells expressing CD207 (a marker of Langerhans cells) in LCH lesions with epidermal CD207+ control cells identified differential expression of more than 2000 genes between these 2 subsets. (medscape.com)
  • Diagnosis is by white blood cell count with a differential count, and evaluation requires identification of the cause. (msdmanuals.com)
  • To identify near complete sets of genes required for the cell cycle and cell shape, we have visually screened a genome-wide gene deletion library of 4843 fission yeast deletion mutants (95.7% of total protein encoding genes) for their effects on these processes. (uzh.ch)
  • Here, we provide the first eukaryotic resource of gene deletions, which describes a near genome-wide set of genes required for the cell cycle and cell shape. (uzh.ch)
  • Resisting cell death', 'genome instability and mutation' and 'deregulating cellular energetics' refine breast cancer classification with their predictive values. (jcancer.org)
  • With the release of a genome wide SNPs database, it has become feasible to analyse these genetically determined QTLs for genes polymorphic in these strains. (bmj.com)
  • We modified the genome of flies to replicate the mutation of the GNAO1 gene, retaining a normal copy of the gene as in humans'', explains Mikhail Savitskiy, a researcher in Vladimir Katanaev's laboratory and a specialist in the modelling of diseases in Drosophila. (unige.ch)
  • I have a bit of a peeve with a common analogy for the human genome: that it is the blueprint of the body, and that we can find a mapping of genes to details of our morphological organization. (scienceblogs.com)
  • For instance, there is no code anywhere in the genome that commands the forelimbs to make five and only five digits: instead, a cascade of genes and cell movements produce a patterned tissue that in us contains sufficient mass and is of a size to generate five nuclei of condensing tissue that produce fingers. (scienceblogs.com)
  • The unfortunate consequence of those properties, though, is that you'll never be able to look at a single gene from the genome and sort out what it does in the embryo. (scienceblogs.com)
  • The CRISPR/Cas9 system enables genome editing and somatic cell genetic screens in mammalian cells. (broadinstitute.org)
  • These observations indicate that genome targeting by CRISPR/Cas9 elicits a gene-independent antiproliferative cell response. (broadinstitute.org)
  • The Fanconi Anemia (FA) pathway genes maintain genome stability and play important roles in human diseases, including cancer. (pulsus.com)
  • Clear cell, papillary cell, and chromophobe renal cell carcinomas (RCCs) have now been well characterised thanks to large collaborative projects such as The Cancer Genome Atlas (TCGA). (springer.com)
  • This small gland in the brain produces melatonin, a hormone that helps regulate sleeping and waking cycles. (nih.gov)
  • NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay. (iric.ca)
  • The HCFC1 gene provides instructions for making a protein, called HCF-1, that helps regulate the activity of other genes. (medlineplus.gov)
  • The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
  • In addition, STARD12/14 could regulate the ferroptosis related genes. (medsci.org)
  • The ability to regulate transgene expression will be crucial for development of gene therapy to the brain. (lu.se)
  • An aspect of gene delivery to the brain that is currently being regulate the endogenous GFAP expression in a lesioned brain. (lu.se)
  • Mechanisms that regulate development from single cell to multicellular organisms. (lu.se)
  • In the process called quantitative trait loci (QTL) mapping, attempts are made to find significant correlations between marker alleles and the phenotypic variation, or disease state. (bmj.com)
  • This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. (caslab.com)
  • The Stukenberg lab found that human breast tumors with a high degree of aneuploidy overexpress key transcriptional regulators of the cell cycle, which they hypothesize drives aneuploidy in these tumors. (pewtrusts.org)
  • Methods: In this study, the ONCOMINE, UCSC Xena, UALCAN, Kaplan Meier plotter, cBioPortal, GEPIA, GeneMANIA, DAVID and TIMER databases were used to investigate the transcriptional and survival data of FA pathway genes in patients with breast cancer. (pulsus.com)
  • This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
  • Results: Most of the FA pathway genes were found to be significantly upregulated in breast cancer tissues when compared to normal tissues. (pulsus.com)
  • Additionally, the elevated expression levels of FA pathway genes were significantly associated with poor survival outcomes in breast cancer patients. (pulsus.com)
  • Modulating the intracellular glutathione level by pre-treating the cells with either BSO (buthionine- Sulfoximine) or glutathione significantly influenced the potential of Cr(VI) to induce expression of the HO-1 gene. (cdc.gov)
  • The Cr-induced overexpression of the HO-1 gene in the BSO-treated cells was significantly higher than in those cells without BSO treatment. (cdc.gov)
  • CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. (who.int)
  • The model accounts for important details of the physiology, biochemistry, and genetics of cell cycle control in stalked C. crescentus cell. (ebi.ac.uk)
  • AX-0810 for Cholestatic Diseases targeting NTCP is designed to introduce a loss of function (LOF) variant that has been found in human genetics to prevent re-uptake of bile acids in liver. (globenewswire.com)
  • The INK and CIP/KIP families of cyclin dependent kinase inhibitors (CDKis) protect cells from oncogenic signals-initiated cellular transformation. (sigmaaldrich.com)
  • INK4a and INK4b are induced by oncogenic Ras and are involved in cell cycle G1 arrest and cellular senescence. (sigmaaldrich.com)
  • In this manuscript, we report the in vitro mutagenicity of waterpipe smoke condensate (WSC), the alteration in cellular parameters of lung alveolar cells in response to WSC exposure and discuss the implication of cellular responses in the pathophysiology of chronic obstructive pulmonary disease (COPD). (who.int)
  • However, WSC induced cell cycle arrest and cellular senescence mediated by the p53-p21 pathway. (who.int)
  • Other cellular structures are duplicated during G2, such that each replicated daughter cell produced during mitosis will have all necessary organelles (such as mitochondria, endoplasmic reticulum, etc. (coursehero.com)
  • The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
  • TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
  • 1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
  • The Von Hippel-Lindau ( VHL ) tumour suppressor gene undergoes bi-allelic knockout in the vast majority of clear cell RCCs. (springer.com)
  • We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
  • Histone H3.3, an H3 variant that is found in all eukaryotes from yeast to human, is replication and cell cycle phase-independent and is the most common H3 in non-dividing cells. (neb.com)
  • This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • Interphase is characterized by cell growth and DNA replication , while M is the phase of the cell cycle in which the chromosomes of the cell prepare for the cell to divide into two new cells. (coursehero.com)
  • Mechanisms for maintaining genetic information during cell division and the generation of genetic variation: replication, mitosis, meiosis, recombination. (lu.se)
  • In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
  • Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
  • also known as CDK4I, Cyclin-dependent kinase 4 inhibitor A, Multiple tumor suppressor 1, MTS-1, p16-INK4, p16-INK4a, p16INK4A) is encoded by the CDKN2A (also known as CDKN2, MTS1) gene (Gene ID 1029) in human. (sigmaaldrich.com)
  • Gene ID: 5925, OMIM 614041 ) gene, which encodes a tumor suppressor protein. (molvis.org)
  • The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. (thermofisher.com)
  • In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans. (ed.ac.uk)
  • Some forms of cancer are initiated when both copies of tumor suppressor genes are lost in single or a few cells, and the cells begin to divide unchecked. (pewtrusts.org)
  • Previously, we developed and tested a mouse genetic model system that sporadically shuts down tumor suppressor genes in cells and labels the resulting mutant cells so that they can be visualized within hours of their formation. (pewtrusts.org)
  • Tumor protein 53 ( TP53 ) is a recognized tumor suppressor gene located on chromosome 17q13.1. (spandidos-publications.com)
  • In this study, we employed the weighted gene co-expression network (WGCNA) method and the connectivity map (CMap) database to identify the candidate target genes and potential compounds. (frontiersin.org)
  • We find frequent somatic nuclear transfers of mitochondrial DNA, some of which disrupt therapeutic target genes. (lu.se)
  • The Regulator of Chromosome Condensation 1 (RCC1) was identified over 20 years ago as a critical cell cycle regulator. (nih.gov)
  • The MATR3 gene is found on chromosome 5 . (medlineplus.gov)
  • The higher incidence of ccRCC in male patients may partially be accounted by mono-allelic inactivation of the chromatin remodelling gene, KDM5C on the X chromosome [ 6 ]. (springer.com)
  • A centromere , the point on a chromosome that attaches to the spindle fibers with a kinetochore during cell division, attaches the sister chromatids. (coursehero.com)
  • Researchers are working to find a way to use this gene to create anti-cancer drugs. (wikipedia.org)
  • The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
  • As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
  • Ideal targets should be both specific to cancer cells and commonly found in cancer cells. (medscape.com)
  • Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
  • The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
  • 3 Identification of the genes predisposing to cancer could yield targets for treatment or chemoprevention. (bmj.com)
  • Genes for which associations or other plausible links with cancer have been published were deemed as final candidates. (bmj.com)
  • Identification of the genes predisposing to mouse lung cancer could have considerable implications for diagnosis, treatment, or chemoprevention of lung cancer in humans. (bmj.com)
  • In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
  • Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
  • Recent studies have found that they have clinical and molecular features of both the BRAF mutant/MSI and the conventional BRAF wild-type cancers and comprise a distinct colorectal cancer subgroup. (hindawi.com)
  • This study was aimed to specify the cytotoxic effect of C. sativa -derived extracts on colon cancer cells and adenomatous polyps by identification of active compound(s) and characterization of their interaction. (nih.gov)
  • Ethanol extracts of C. sativa were analyzed by high-performance liquid chromatography and gas chromatograph/mass spectrometry and their cytotoxic activity was determined using alamarBlue-based assay (Resazurin) and tetrazolium dye-based assay (XTT) on cancer and normal colon cell lines and on dysplastic adenomatous polyp cells. (nih.gov)
  • The unheated cannabis extracts (C2F), fraction 7 (F7), and fraction 3 (F3) had cytotoxic activity on colon cancer cells, but reduced activity on normal colon cell lines. (nih.gov)
  • This gene encodes the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a factor implicated in cell cycle, senescence, and cancer. (ed.ac.uk)
  • We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). (broadinstitute.org)
  • Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
  • These 12 genes are located at a region, which is frequently deleted in cancer. (ukessays.com)
  • However, the prognostic values and biological roles of FA pathway genes in breast cancer have not been clarified. (pulsus.com)
  • Conclusion: The FA pathway genes are potential prognostic biomarkers for breast cancer and may offer effective as well as new strategies for cancer management. (pulsus.com)
  • Therefore, identifying biomarkers related to the occurrence, development and prognosis of esophageal cancer is important for early diagnosis and treatment, as well as for finding new targets and treatment methods. (spandidos-publications.com)
  • The TP53 gene mutation is the most common gene alteration in many tumors, including esophageal cancer. (spandidos-publications.com)
  • Although the biological significance of TP53 gene mutation is well characterized, its clinical significance in esophageal cancer remains controversial, especially as a prognostic biomarker. (spandidos-publications.com)
  • This characteristic of the TP53 gene limits the use of IHC in TP53 gene research, which may be the cause of the conflicting results in the study of TP53 in esophageal cancer. (spandidos-publications.com)
  • Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
  • In this review, we consider what is currently known of the genetic landscape of the commonest subtypes of renal cell cancer (RCC). (springer.com)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • For example, in addition to promoting sleep, melatonin can also stop tumor growth and protect against the spread of cancer cells. (cdc.gov)
  • In most studies, an excess risk of breast cancer was found mainly among women who had worked night shifts for many years or at a high frequency, or who had worked a large number of night shifts over their lifetimes. (cdc.gov)
  • Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
  • All 11 selected SNPs within candidate genes were verified by polymerase chain reaction (PCR) sequencing. (bmj.com)
  • The BRAF (v-raf murine sarcoma viral oncogene homolog B) gene encodes a protein that belongs to the Raf family of serine/threonine protein kinases. (hindawi.com)
  • This gene encodes a protein that binds to matrix attachment regions. (thermofisher.com)
  • Recent studies have also found that presence of the BRAF mutation has direct implications for clinical management as along with TNM stage, BRAF mutational status was the only molecular variable that independently accounted for poor survival [ 13 ], and studies have found that BRAF mutant cancers are refractory to anti-EGRF therapy [ 14 , 15 ]. (hindawi.com)
  • Correlation with outcome needs to be more comprehensively furnished, particularly for small renal masses, rarer non-clear cell renal cancers, and for all tumours undergoing targeted therapy. (springer.com)
  • The Healthy Oregon Project (HOP) is a statewide effort that aims to build a large research repository and influence the health of Oregonians through providing no-cost genetic screening to participants for a next-generation sequencing 32-gene panel comprising genes related to inherited cancers and familial hypercholesterolemia. (cdc.gov)
  • It reproduces protein time courses in wild-type cells, mimics correctly the phenotypes of many mutant strains, and predicts the phenotypes of currently uncharacterized mutants. (ebi.ac.uk)
  • RESULTS: Within the range of tested doses, WSC did not elicit sufficient response to be considered mutagenic in any of the strains tested (TA98, TA100, TA102, and TA97a) but were found to be toxic for strains TA97a and TA102 at the highest tested doses. (who.int)
  • Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some variants has not been determined. (nih.gov)
  • Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (nih.gov)
  • Gene variants associated with ischemic stroke: the cardiovascular health study. (nih.gov)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (thermofisher.com)
  • Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (caslab.com)
  • Variants in the HCFC1 gene have also been found in individuals with X-linked intellectual disability. (medlineplus.gov)
  • The HCFC1 gene variants lead to production of an HCF-1 protein with reduced function. (medlineplus.gov)
  • Overall, we have identified 730 pathogenic/likely pathogenic variants in 710 participants in 24 of the 32 genes on the panel. (cdc.gov)
  • We also demonstrated that the −657 to +411 DCT promoter fragment efficiently directs RB cell-specific transcription of the luciferase reporter gene in cell lines. (molvis.org)
  • The regulatory elements required for this cell-specific gene expression are likely located within its proximal promoter. (molvis.org)
  • c-Myc transrepression is mediated by blockade of the transactivating activity of Miz-1, which occurs mainly through a Sp1-binding site in the proximal promoter of the gene. (aacrjournals.org)
  • There are a number of hypothesized that regulating the transgene with a GFAP promoter in a different vectors that transduce cells in the brain in a slightly different viral vector would give rise to a high transgenic expression in the manner (for a review see, e.g. (lu.se)
  • 2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)
  • Methods for analysis of gene expression: microarray, hybridisation, promoter analyses. (lu.se)
  • miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome proliferator-activated receptor (PPAR), and p21 genes, which are linked to the behaviours of VSMCs. (hindawi.com)
  • Matrin 3 as a key regulator of endothelial cell survival. (medlineplus.gov)
  • Co-expression analysis highlights the function of mitochondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connections with clinically actionable genes. (lu.se)
  • We find frequent somatic nuclear. (lu.se)
  • As miRNAs proposed to control the expression up to one third of all genes and possibly utilised as diagnostic and prognostic marker for many genetic based diseases. (ukessays.com)
  • One major difficulty confronted is complex alternatively spliced transcript isoforms in human protein-coding genes. (nature.com)
  • Genetic research suggests that the HLA-DRB1*0405 gene causes a 5-fold decrease in typhoid fever risk ( 7 ). (cdc.gov)
  • Interphase comprises the gap 1 (G1), synthesis (S), and gap 2 (G2) phases, in which the cell grows and replicates its genetic material. (coursehero.com)
  • Gene technology: basic and applied molecular genetic methods. (lu.se)
  • We reviewed published microarray and RNA sequencing studies in which gene expression profiles were compared between human RB and normal retina tissues. (molvis.org)
  • Therefore, we performed microarray analysis of adrenal medulla and kidney in order to identify other early gene expression changes elicited by SdhD deletion. (ed.ac.uk)
  • We tried several gene selection strategies, and built classifiers using the resulting cDNA microarray gene lists. (lu.se)
  • This mutation is heterozygous dominant, which means that one of the two copies of the gene is functional and the other is mutated'', explains Vladimir Katanaev, a professor in the Department of Cell Physiology and Metabolism at the UNIGE Faculty of Medicine, who led this research. (unige.ch)
  • Therefore, the overexpression of p53 does not always indicate a mutation in the TP53 gene. (spandidos-publications.com)
  • Similarly, TP53 mutation does not always lead to the accumulation of p53 protein in cells. (spandidos-publications.com)
  • At least one mutation in the MATR3 gene has been identified in people with distal myopathy 2, a condition characterized by muscle and vocal cord weakness. (medlineplus.gov)
  • The MATR3 gene mutation associated with distal myopathy 2 changes a single protein building block (amino acid) in the matrin 3 protein. (medlineplus.gov)
  • Researchers are working to determine how this gene mutation leads to the signs and symptoms of distal myopathy 2. (medlineplus.gov)
  • Our results establish a crucial role for E4F during early embryonic cell cycles and reveal an unexpected function for E4F in mitosis. (cnrs.fr)
  • Through functional enrichment analysis, the FA pathway genes were positively associated with cell cycle and nucleoplasm and negatively correlated with SRP-dependent co-translational protein targeting to membrane and ribosome. (pulsus.com)
  • STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)
  • This effect has important practical implications for the interpretation of CRISPR/Cas9 screening data and confounds the use of this technology for the identification of essential genes in amplified regions. (broadinstitute.org)
  • These genes overlapped to a large extent with published gene sets associated with key aspects of HSC function, demonstrating the potential of this data set as a resource for identification of novel HSC regulators. (lu.se)
  • Methods for gene identification and analysis of gene structure: cloning, PCR, restriction mapping, in situ hybridisation, DNA sequencing. (lu.se)
  • We find that NF45 and NF90 play essential roles in mitosis, and transcriptome analysis reveals that they are necessary for the expression of a subset of mitotic mRNAs. (iric.ca)
  • We show that depletion of SMD components increases the binding of mitotic mRNAs to the NF45-NF90 complex and rescues cells from mitotic defects. (iric.ca)
  • Consistent with these observations, we found that E4F localizes to the mitotic spindle during the M phase of early embryos. (cnrs.fr)
  • We have previously shown that p27(Xic1) is expressed in the cells of the neural plate as they become post-mitotic (Development 127 (2000) 1303). (xenbase.org)
  • The protein encoded by this gene has sequence homology to members of the histone deacetylase family. (caslab.com)
  • Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. (lu.se)
  • Patients with prolonged neutropenia after hematopoietic stem cell transplantation or chemotherapy and patients receiving broad-spectrum antibiotics and high doses of corticosteroids are predisposed to fungal infections. (msdmanuals.com)
  • It is thought that changes in these regions prevent HCF-1 from interacting with transcription factors, which disrupts normal gene activity. (medlineplus.gov)
  • We used a decay rate model to fit the temporal transcription profiles of regenerating HSCs and identified genes with progressively decreased or increased expression after transplantation. (lu.se)
  • The Xenopus p27(Xic1) gene encodes a cyclin dependent kinase (CDK) inhibitor of the Cip/Kip family. (xenbase.org)
  • With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene transcript compositions. (nature.com)
  • In order to investigate representative mRNA transcript isoforms to be utilized as transcriptome analysis references, we utilized GTEx data to establish a top-ranked transcript isoform expression data resource for human protein-coding genes. (nature.com)
  • Protein-coding transcripts or genes do occupy much higher expression fraction in transcriptome data. (nature.com)
  • This signal transduction pathway is initiated by epidermal growth factor ligands binding to and activating receptor tyrosine kinases (RTK) at the cell membrane. (hindawi.com)
  • How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. (nature.com)
  • The findings help understand the adaptation and survival mechanisms of desert vegetation under the changing precipitation patterns and are important in exploring the impact of carbon cycling in desert systems under global environmental change. (bvsalud.org)
  • Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • 2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)
  • Furthermore, the expression levels of FA pathway genes exhibited a significant positive association with immune infiltration. (pulsus.com)
  • White blood cells of the immune system that are derived from the bone marrow and spleen. (cdc.gov)
  • succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. (ed.ac.uk)
  • In eukaryotic cells , DNA is found in structures called chromosomes. (coursehero.com)
  • The next most prevalent aberrations include a cohort of chromatin-modifying genes with diverse roles including PBRM1 , SETD2 , BAP1 , and KMD5C . (springer.com)
  • These studies provided us more information on the spliced transcript isoforms of protein-coding genes as well as more understanding on their expression profiles and translated protein products in human tissues and diseases. (nature.com)
  • We found that DCT was highly expressed in six of 13 samples microdissected from Thai RB tissues. (molvis.org)
  • Expression of DCT was absent or barely detected in retina tissues, various human ocular cells, and major organs. (molvis.org)
  • HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)
  • The analysis of the Hif1α pathway in SDHD-ESR tissues and in two newly derived cell lines after complete SdhD loss -a requirement for hereditary paraganglioma type-1 tumor formation in humans- partially recapitulated the "pseudo-hypoxic" response and rendered inconsistent results. (ed.ac.uk)
  • However, we found that the Cdkn1a gene was up-regulated in both tissues. (ed.ac.uk)
  • This protein also plays a role in the distribution of cells in developing tissues and organs, including the brain. (medlineplus.gov)