This variation in gene expression among species occurs early in the developmental programme for dental patterning. (biomedcentral.com)
These data show how a complex multi-rowed vertebrate dentition is organized and how developmental tinkering of conserved gene networks during iterative pattern formation can impact upon the evolution of trophic novelty. (biomedcentral.com)
What is the most common type of developmental odontogenic cyst? (easynotecards.com)
Odontogenesis3
Identification of gene expression profiles, RNA interactions, gene regulation patterns, and single nucleotide polymorphisms (SNPs) is important for determining the molecular mechanisms underlying the normal odontogenesis and the pathology of oral and dental disorders. (ac.ir)
Therefore, this in silico study aimed to identify novel proteins, RNA interactions, and deleterious SNPs related to four major genes ( MSX2 , SHH , SMAD7 , TFAP2 ) involved in the odontogenesis process. (ac.ir)
More than 300 genes have been known to be expressed in teeth that are responsible for odontogenesis 72 . (bvsalud.org)
Differentiation3
In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
showed that knocking out Mage-D1 can induce the expression of autophagy-related genes by enhancing the activity and differentiation of osteoclasts, thereby accelerating the process of periodontitis 23 . (researchsquare.com)
Protein expression1
Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
Patterns1
Coordinated patterns of gene expression differ among Malawi species and prefigure the future-ordered distribution of functional teeth of specific size and spacing. (biomedcentral.com)
Expression3
We investigate the expression of conserved gene networks (involving bmp2 , bmp4 , eda , edar , fgf8 , pax9 , pitx2 , runx2 , shh and wnt7b ) known to pattern iterative structures and teeth in other vertebrates. (biomedcentral.com)
GDF-5 also increased the gene expression and enzyme activity of alkaline phosphatase. (ispub.com)
Moreover, the hsa-miR-134-5p regulated the SHH and TFAP2A gene expression. (ac.ir)
Interactions1
After pathway enrichment and gene ontology analysis, the protein-protein, microRNA (miRNA)-mRNA, and miRNA-long noncoding RNA (lncRNA) interactions and networks were determined for the selected genes using integrated bioinformatics analyses. (ac.ir)
Teeth1
Studies have shown how gene networks are employed to pattern butterfly eyespots, fly bristles and vertebrate epithelial appendages such as teeth, feathers, hair and mammary glands. (biomedcentral.com)
Type1
Structurally, Mage-D1 possesses the N-terminal sequence Mage homology domain 2 (MHD2), which is a highly conserved structure of the type II Mage gene family. (researchsquare.com)
Activity1
MSX2 in ameloblast cell fate and activity. (ac.ir)
Structure3
Moreover, the potential deleterious SNPs in the selected genes were identified and finally, their validation and implications on the structure of proteins were investigated by specific bioinformatics tools. (ac.ir)
We also identified various SNPs in the investigated genes that changed the normal structure and thus the function of their related proteins. (ac.ir)
The role of genes in determining the shape and form of a specific tooth has already been defined, the alterations in which can lead to a variety of anomalies in regards to number, size, form, shape, structure, etc. (bvsalud.org)
Cells3
All slides and records proliferating odontogenic epithelial cells of which were diagnosed as ameloblastoma were palisading peripheral tall columnar to cuboidal included and analyzed. (bvsalud.org)
2002). It has also been reported that the GDF-5 gene is expressed in dental sac, periodontal ligament, dental pulp cells, and odontoblasts during tooth development (Morotome et al. (ispub.com)
Reasons1
Defects in these genes have been found to be one of the reasons for alteration of the morphology of tooth 72 . (bvsalud.org)
Human1
2016. In silico analysis of deleterious single nucleotide polymorphisms in human BUB1 mitotic checkpoint serine/threonine kinase B gene. (ac.ir)
Important1
Purpose: Gene fusions are important oncogenic drivers and many are actionable. (researchgate.net)
Calcifying epith1
Cells inside the proliferating epithelial cell public had been positive for Notch I and acquired an appearance similar to calcifying epithelial odontogenic tumor with amyloid-like debris. (cancer8.info)
Epithelial odontogenic1
The histologic results had been much like that observed in individual calcifying epithelial odontogenic tumors (CEOT) that are uncommon harmless epithelial odontogenic tumors that are usually produced from stratum intermedium Sclareol which may be the cell level next to the ameloblasts (11 12 The introduction of a tooth depends upon sequential and reciprocal connections between epithelial and mesenchymal levels (13). (cancer8.info)
ODAM1
Odontogenic ameloblast-associated protein is a protein that in humans is encoded by the ODAM gene. (wikipedia.org)
Tumors2
Ameloblastoma is one of the most common tumors from odontogenic epithelium. (ijofr.org)
Global gene expression profiles clearly distinguished tumors from normal healthy epithelium. (gsea-msigdb.org)
Epithelium2
Chick epithelium combined with mesenchyme from mouse molartooth produced dental structures with differentiated ameloblasts depositing enamel matrix. (ehu.eus)
However, controversy persists regarding the ability of avian epithelium to express the ameloblast phenotype and to secrete enamel protein. (ehu.eus)
Ameloblastoma3
Background: Keratocystic odontogenic tumour and ameloblastoma are classified under tumours by WHO. (journalcra.com)
Aims and Objectives: To investigate the involvement of apoptosis inhibition in these lesions, expression of Bcl-2 was examined in 10 cases of KCOT (keratocystic odontogenic tumour) and ameloblastoma each. (journalcra.com)
Results: : The intensity varied among the layers from intense to weak in basal / peripheral ameloblast- like cells and parabasal layers respectively and negative staining was seen only in superficial layer of KCOT but not in Ameloblastoma-central stellate reticulum-like cells in qualitative assessment. (journalcra.com)
Tooth4
Some authors have suggested that genes involved in tooth formation, which have remained silent in birds for more than 200 million years, can be activated by appropriate signals. (ehu.eus)
History Amelogenins are highly conserved protein secreted by ameloblasts in the teeth body organ of developing tooth. (cancer8.info)
The role of genes in determining the shape and form of a specific tooth has already been defined, the alterations in which can lead to a variety of anomalies in regards to number, size, form, shape, structure, etc. (bvsalud.org)
Defects in these genes have been found to be one of the reasons for alteration of the morphology of tooth 72 . (bvsalud.org)
Inhibition2
Among the human genes whose inhibition was most strongly correlated with increased EBV gene expression were multiple MHC class I HLA genes involved in regulating immune response via antigen presentation. (gsea-msigdb.org)
The association between EBV gene expression and inhibition of MHC class I HLA expression implies that antigen display is either directly inhibited by EBV, facilitating immune evasion by tumor cells, and/or that tumor cells with inhibited presentation are selected for their ability to sustain higher levels of EBV to take maximum advantage of EBV oncogene-mediated tumor-promoting actions. (gsea-msigdb.org)
Enamel1
The purpose of our research was to judge Notch 1 in the ameloblast/stratum intermedium cell levels during enamel advancement in KO mice and in TgP70TKO proliferating epithelial public and developing molars to recognize the potential function of Notch in the forming of these abnormal buildings. (cancer8.info)
Tissues1
To identify the molecular mechanisms by which EBV-associated epithelial cancers are maintained, we measured the expression of essentially all human genes and all latent EBV genes in a collection of 31 laser-captured, microdissected nasopharyngeal carcinoma (NPC) tissue samples and 10 normal nasopharyngeal tissues. (gsea-msigdb.org)
Positive2
When KO females had been mated with TgM180 men male offspring had been either Sclareol positive or detrimental for the transgene on the KO background due to the location from the gene exclusively over the X-chromosome in mice. (cancer8.info)
Genes up-regulated in nasopharyngeal carcinoma (NPC) positive for LMP1 [GeneID=9260] , a latent gene of Epstein-Barr virus (EBV). (gsea-msigdb.org)
Matrix2
Treatment of HDPCs with 1α,25(OH) 2 D 3 at a concentration of 10 nM or 100 nM significantly upregulated the expression of dentin sialophosphoprotein (DSPP) and dentin matrix protein1 (DMP1), the odontogenesis-related genes. (molcells.org)
Our data clearly reflect such tumor promotion, showing that deregulation of key proteins involved in apoptosis (BCL2-related protein A1 and Fas apoptotic inhibitory molecule), cell cycle checkpoints (AKIP, SCYL1, and NIN), and metastasis (matrix metalloproteinase 1) is closely correlated with the levels of EBV gene expression in NPC. (gsea-msigdb.org)