• UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. (wikipedia.org)
  • Fatty acids are released by the following signaling cascade: Sympathetic nervous system terminals release Norepinephrine onto a Beta-3 adrenergic receptor on the plasma membrane. (wikipedia.org)
  • The lipase converts triacylglycerols into free fatty acids, which activate UCP1, overriding the inhibition caused by purine nucleotides (GDP and ADP). (wikipedia.org)
  • During the termination of thermogenesis, thermogenin is inactivated and residual fatty acids are disposed of through oxidation, allowing the cell to resume its normal energy-conserving state. (wikipedia.org)
  • Both proteins are integral membrane proteins, localized to the inner mitochondrial membrane, and they have a similar pattern of salt bridges, proline residues, and hydrophobic or aromatic amino acids that can close or open when in the cytoplasmic or matrix state. (wikipedia.org)
  • In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). (hmdb.ca)
  • Palmitic acid, or hexadecanoic acid, is one of the most common saturated fatty acids found in animals, plants, and microorganisms. (hmdb.ca)
  • Palmitic acid is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. (hmdb.ca)
  • Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. (thermofisher.com)
  • Fatty acid-binding proteins are low molecular weight (100-130 aa) chaperones for long chain fatty acids, fatty acyl CoA esters, eicosanoids, retinols, retinoic acids and related metabolites and are usually regarded as being responsible for allowing the otherwise hydrophobic ligands to be mobile in aqueous media. (guidetoimmunopharmacology.org)
  • A process for microbial hydrocarbon synthesis: Overproduction of fatty acids in Escherichia coli and catalytic conversion to alkanes. (research.com)
  • In general, the uncoupling proteins dissipate the proton electrochemical gradient generated in respiration as heat, being dependent on fatty acids and sensitive to purine nucleotides. (unesp.br)
  • The lipidomic analysis showed that disruption of NcACBP caused no obvious changes in the overall abundance and turnover of fatty acids while knockout resulted in the accumulation of triacylglycerol. (biomedcentral.com)
  • Fatty acids provide the acyl skeleton for lipid synthesis. (biomedcentral.com)
  • Before entering lipid synthesis pathways, different kinds of acyl-CoA transporters which acts as the major carrier of acyl-CoAs, such as fatty acid binding protein (FABP), sterol carrier protein 2 (SCP2) and acyl-CoA-binding protein (ACBP), would activate and convert fatty acids to fatty acyl-CoA esters via a reaction catalyzed by fatty acyl-CoA synthetase and transported to various metabolic locations [ 11 ]. (biomedcentral.com)
  • Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. (smpdb.ca)
  • Oleic acid, also known as oleate or 18:1 N-9, belongs to the class of organic compounds known as long-chain fatty acids. (ymdb.ca)
  • These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms. (ymdb.ca)
  • belongs to the class of organic compounds known as long-chain fatty acids. (ymdb.ca)
  • Fatty acid desaturases play a key role in producing polyunsaturated fatty acids by converting single bonds to double bonds. (springeropen.com)
  • This study provided a better understanding of the evolution and functions of the fatty acid desaturases gene family in the four Aspergillus species, and would be useful for seeking methods to improve the production of unsaturated fatty acids and enhance efforts for the genetic improvement of strains to adapt to the complex surrounding environment. (springeropen.com)
  • Unsaturated fatty acids, which contain one or more double bonds, are the major structural components of cell membranes. (springeropen.com)
  • 2003 ). Unsaturated fatty acids are synthesized by individual fatty acid desaturases via introducing double bonds into the hydrocarbon chains of fatty acids (Chi et al. (springeropen.com)
  • The membrane-bound fatty acid desaturases, which include Δ5-, Δ6-, Δ9-, Δ12- and Δ15-desaturase in the mammals, fungi, insects, higher plants and cyanobacteria, use fatty acids esterified to complex lipid as the substrate, and use cytochrome (cyt) b5 oxidoreductase and cyt b5 as electron donors. (springeropen.com)
  • However, some researches revealed that the cytochrome b5 domain play a key role in the synthesis of unsaturated fatty acids as an electron donor to activate desaturase (Pereira et al. (springeropen.com)
  • reported that the cytochrome b5 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans (Zhang et al. (springeropen.com)
  • Compared with unsaturated fatty acids production in animals and plants, microbes possess many advantages in the production of polyunsaturated fatty acids. (springeropen.com)
  • For instance, unsaturated fatty acids production in microbes has a short production cycle and is unaffected by sites, climates and seasons. (springeropen.com)
  • Moreover, transcripts representing fatty acid degradation were up-regulated indicating that fatty acids might be degraded to feed the increased need to channel carbons into fatty acid synthesis creating a futile cycle. (biomedcentral.com)
  • The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
  • It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. (nih.gov)
  • Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids. (genebiosystems.com)
  • In hepatoma cell lines, fatty acids increase Hilpda expression and protein levels. (wur.nl)
  • Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. (fn-test.com)
  • 5) Intralipid therapy was utilized because the syndrome is associated with low levels of vitamin A and essential fatty acids. (aad.org)
  • In the gut, NT is secreted after fat ingestion and promotes the absorption of fatty acids. (lu.se)
  • However, like many bacteria and plants, its metabolism does depend upon the type II fatty-acid synthesis (FAS) pathway for lipogenesis, whereas the predominant form of fatty-acid biosynthesis in humans is via the type I pathway. (rcsb.org)
  • 2010). ACP and fatty acyl-coA transferases may also be needed at multiple levels of microbial polyketide synthesis. (exposed-skin-care.net)
  • Lipid synthesis requires bulk carbon skeleton acyl-CoAs, the transport of which depends on the acyl-CoA binding protein (ACBP). (biomedcentral.com)
  • 3-Oxo-acyl-acyl carrier protein (ACP) reductase (FabG) plays a key role in the bacterial fatty acid synthesis II system in pathogenic microorganisms, which has been recognized as a potential drug target. (dundee.ac.uk)
  • To be available for TAG synthesis, carbons from sucrose must first be converted to pyruvate through cytosolic or plastidic glycolytic pathways and at some point be imported into the plastid to yield acetyl-coenzyme A (CoA) which feeds fatty acid (FA) synthesis with carbon backbones. (biomedcentral.com)
  • Gene expression analyses using microarrays have further revealed that some of the down-regulated genes in seeds of the wri1 mutant are involved in glycolysis and FA synthesis, rather than in TAG assembly [ 7 ]. (biomedcentral.com)
  • Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (genebiosystems.com)
  • Our results support the major role of PPARα in regulating hepatic lipid metabolism, highlight the more modest effect of PPARα activation on gene regulation in human liver compared to mouse liver, and indicate that PPARα may have a suppressive effect on DNA synthesis in human liver. (wur.nl)
  • This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. (fn-test.com)
  • Here, transcriptome analysis and fatty acid profiling from developing V. galamensis seeds were integrated to uncover the critical metabolic pathways responsible for high EFA accumulation and identify the targets that could be used in assembly of EFA biosynthesis pathway in existing oilseed crops. (researchsquare.com)
  • Transcriptome data were further confirmed by quantitative real-time PCR for twelve key genes in EFA biosynthesis. (researchsquare.com)
  • Brian F. Pfleger focuses on Metabolic engineering, Biochemistry, Escherichia coli, Biosynthesis and Fatty acid. (research.com)
  • His Biosynthesis research incorporates elements of SOXS, Regulon, Phage shock and Unsaturated fatty acid. (research.com)
  • Built YchM deletion exhibited artificial lethality with multiple fatty acidity biosynthesis genes, as well as the YchM polypeptide bodily interacted numerous proteins from the fatty acidity biosynthetic pathway. (exposed-skin-care.net)
  • Certainly, STAS domain-encoding SulP genes have already been found as the different parts of antibiotic operons, like the BLM bleomycin biosynthesis operon of (Du et al. (exposed-skin-care.net)
  • FabG catalyzes reduction of a 3-oxo-acyl-ACP intermediate during the elongation cycle of fatty acid biosynthesis. (dundee.ac.uk)
  • Transcriptome sequencing revealed that all homologs induced the same general patterns with a drastic shift in gene expression profiles of leaves from that of a typical source tissue to a source-limited sink-like tissue: Transcripts encoding enzymes for plastid uptake and metabolism of phosphoenolpyruvate, fatty acid and oil biosynthesis were up-regulated, as were also transcripts encoding starch degradation. (biomedcentral.com)
  • Here, the structure of the third enzyme in the FAS pathway, 3-ketoacyl-(acyl-carrier-protein) reductase, is reported at a resolution of 2.25 Å. (rcsb.org)
  • The substrate comes in to the half open UCP1 protein from the cytoplasmic side of the membrane, the protein closes the cytoplasmic side so the substrate is enclosed in the protein, and then the matrix side of the protein opens, allowing the substrate to be released into the mitochondrial matrix. (wikipedia.org)
  • The opening and closing of the protein is accomplished by the tightening and loosening of salt bridges at the membrane surface of the protein. (wikipedia.org)
  • Substantiation for this modelling of UCP1 on ANT is found in the many conserved residues between the two proteins that are actively involved in the transportation of substrate across the membrane. (wikipedia.org)
  • He studied Fatty acid and Membrane that intersect with Acyl carrier protein. (research.com)
  • to a membrane-scaffolded organic of fatty acidity biosynthetic enzymes (Babu et al. (exposed-skin-care.net)
  • Transcriptional analysis of ACBP-deficient parasites revealed differentially expressed genes involved in a wide range of biological processes such as lipid metabolism, posttranslational modification, and membrane biogenesis. (biomedcentral.com)
  • Membrane enclosed crystal proteins from slime mold. (expasy.org)
  • According to localization and cofactor requirements, fatty acid desaturases have been broadly classified into two evolutionary groups: soluble and membrane-bound desaturases. (springeropen.com)
  • Zinc is also an antioxidant and can directly protect cell membrane lipids and proteins and mercaptan-dependent macromolecules (tubulin and enzyme) from oxidative damage [ 6 ]. (nature.com)
  • 5%) of dystrophin, a protein in the muscle cell membrane. (msdmanuals.com)
  • His Escherichia coli study combines topics from a wide range of disciplines, such as Gene expression, Computational biology and Growth medium. (research.com)
  • His primary areas of study are Biochemistry, Metabolic engineering, Escherichia coli, Gene and Fatty acid. (research.com)
  • By adding genes from a variety sources - including other microorganisms and the camphor tree - researchers have coaxed Escherichia coli to produce diesel , Scientific American 's David Biello reports. (genomeweb.com)
  • Beta-ketoacyl-ACP synthase I of Escherichia coli: nucleotide sequence of the fabB gene and identification of the cerulenin binding residue. (genebiosystems.com)
  • Owing to its small genome (about 800 protein-coding genes), it relies on the host for many basic biosynthetic processes, hindering the identification of potential antipathogenic drug targets. (rcsb.org)
  • Homologs of CylC are also found in other characterized cyanobacterial secondary metabolite biosynthetic gene clusters. (biomedcentral.com)
  • Genes encoding CylC homologs are widely distributed throughout the cyanobacterial tree of life, within biosynthetic gene clusters of distinct architectures (combination of unique gene groups). (biomedcentral.com)
  • These enzymes are found in a variety of biosynthetic contexts, which include fatty-acid activating enzymes, type I or type III polyketide synthases, dialkylresorcinol-generating enzymes, monooxygenases or Rieske proteins. (biomedcentral.com)
  • Open up in another window Physique 1 Phylogenetic romantic relationship of BIIE 0246 supplier human being SLC26 polypeptides generated with Jalview (http://www.jalview.org) using NCBI proteins sequences listed in Desk 1. (exposed-skin-care.net)
  • We have identified a cytosolic acyl-CoA binding protein, with highly conserved amino acid residues and a typical acyl-CoA binding domain in N. caninum . (biomedcentral.com)
  • Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (smpdb.ca)
  • In addition, most of fatty acid desaturases share three highly conserved histidine boxes: ʻHXXXXHʼ, ʻHXXHHʼ and ʻQXXHHʼ included in the fatty acid desaturases domain. (springeropen.com)
  • The loss of NcACBP resulted in global changes in the expression of multiple genes. (biomedcentral.com)
  • 1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. (guidetopharmacology.org)
  • 2. Matsufuji T, Ikeda M, Naito A, Hirouchi M, Kanda S, Izumi M, Harada J, Shinozuka T. (2013) Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. (guidetopharmacology.org)
  • UCP1 belongs to the UCP family which are transmembrane proteins that decrease the proton gradient generated in oxidative phosphorylation. (wikipedia.org)
  • In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). (hmdb.ca)
  • This protein shuttles fatty molecules between cholesterol carrier molecules, ultimately facilitating the transport of cholesterol from blood vessels to the liver. (iflscience.com)
  • The TGF-β signaling pathway is also involved in bone and blood vessel development and the formation of the extracellular matrix, an intricate lattice of proteins and other molecules that forms in the spaces between cells and defines the structure and properties of connective tissues. (medlineplus.gov)
  • Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)
  • Recent multi-omics studies have revealed the heterogeneity and complexity of tumor features such as their genetic mutations, transcriptome, proteins, and signaling pathways. (rsc.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Rapid whole-genome sequencing identifies a homozygous novel variant, His540Arg, in HSD17B4 resulting in D-bifunctional protein deficiency disorder diagnosis. (nih.gov)
  • A genome-wide association study identified variants in the ferredoxin fd ), apicoplast ribosomal protein S10 ( arps10 ), multidrug resistance protein 2 ( mdr2 ), and chloroquine resistance transporter ( crt ) genes as additional factors contributing to ART resistance, in which a missense fd mutation fd -D193Y) was the most frequent variant among resistant parasites [ 8 ]. (biorxiv.org)
  • The disrupted mouse gene is Slc27a4 (solute carrier family 27 [fatty acid transporter], member 4), ortholog of human SLC27A4. (mmrrc.org)
  • Fatty acid transporter proteins (FATPs) are a family (SLC27) of six transporters (FATP1-6). (guidetopharmacology.org)
  • Dogs with CE and protein-losing enteropathy had the greatest number of differentially expressed genes. (avma.org)
  • Targeted or gene trap mutations are generated in strain 129/SvEvBrd-derived embryonic stem (ES) cells. (mmrrc.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • nonetheless, mutations of Fd gene ( fd ) may modulate ART resistance and Fd would be an important target for antimalarial drugs. (biorxiv.org)
  • PSS localized to the extremities is termed acral PSS and usually caused by mutations in the TGM5 gene encoding transglutaminase 5 (although mutations in the CSTA gene, encoding cystatin A, have also been shown to be causative). (aad.org)
  • PSS type1 (PSS1, OMIM 270300) is a rare autosomal recessive disorder caused by nonsense mutations or complete deletion of the CDSN gene encoding for CDSN. (aad.org)
  • At least 23 SLC2A10 gene mutations have been identified in people with arterial tortuosity syndrome, a connective tissue disorder characterized by abnormal curving and twisting (tortuosity) of the blood vessels that carry blood from the heart to the rest of the body (arteries) and other health problems. (medlineplus.gov)
  • They are caused by mutations of the dystrophin gene, the largest known human gene, at the Xp21.2 locus. (msdmanuals.com)
  • The phylogenetically ancient SLC26 gene family encodes multifunctional anion exchangers and anion channels transporting a wide selection of substrates, including Cl? (exposed-skin-care.net)
  • The corresponding gene, AtWRINKLED1 ( AtWRI1, At3g54320), encodes a protein with two APETALA2-ethylene responsive element-binding protein (AP2/EREBP) motifs that is a signature for plant-specific transcription factors involved in a wide range of developmental processes [ 5 , 6 ]. (biomedcentral.com)
  • This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2) , as a result of transcription initiation from 2 independently regulated promoters. (fn-test.com)
  • The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. (fn-test.com)
  • It has been determined that VPS13A encodes for a protein called chorein. (medscape.com)
  • Our data suggests that TMEM106B is one of a growing list of major dementia risk genes that affect glial lipid metabolism. (biomedcentral.com)
  • Abnormal lipid metabolism has been associated with a wide range of chronic and infectious diseases including non-alcoholic fatty liver disease, viral hepatitis C infection, atherosclerosis, diabetes, and cancer. (wur.nl)
  • Ultimately, we sought to identify the physiological function of the liver-specific mitochondrial carrier Slc25a47 in liver lipid metabolism and energy expenditure. (wur.nl)
  • Duck acyl-[acyl-carrier protein] hydrolase, medium chain (EC 3.1.2.14 ), an enzyme that may be associated with peroxisome proliferation and may play a role in the production of 3-hydroxy fatty acid diester pheromones. (expasy.org)
  • Phenmedipham hydrolase (phenylcarbamate hydrolase), an Arthrobacter oxidans plasmid-encoded enzyme (gene pcd) that degrades the phenylcarbamate herbicides phenmedipham and desmedipham by hydrolyzing their central carbamate linkages. (expasy.org)
  • cAMP activates protein kinase A, causing its active C subunits to be freed from its regulatory R subunits. (wikipedia.org)
  • This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
  • Female carriers may have asymptomatic elevated creatine kinase levels and possibly calf hypertrophy. (msdmanuals.com)
  • Acanthocytosis has also been associated with the rare hypobetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP) syndrome, a disease of childhood akin to Hallervorden-Spatz disease and a defect in the gene for pantothenate kinase. (medscape.com)
  • While we found non-cyanobacterial homologs of these enzymes to be rare, we identified a large number of genes encoding CylC-like enzymes in publicly available cyanobacterial genomes and in our in-house culture collection of cyanobacteria. (biomedcentral.com)
  • Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid. (expasy.org)
  • By comparison, we found that various genes associated with acyl editing, fatty acid β-oxidation, triacylglycerol assembly and oil-body formation had greater expression levels at middle developmental stage (38 DAP), which are consistent with the fast accumulation of EFA in V. galamensis developing seed, implying their fundamental roles in EFA production. (researchsquare.com)
  • Objective -To characterize mucosal gene expression in dogs with chronic enteropathy (CE). (avma.org)
  • In this review, we discuss considerations of the study design for each data feature, the limitations in gene and protein abundance and their rate of expression, the current data integration methods, and microbiome influences on gene and protein expression. (rsc.org)
  • In addition to the host regulatory mechanisms response to disease, the microbiome can make changes to the expression of the host features such as their genes, proteins, and/or PTMs. (rsc.org)
  • The recombinant NcACBP protein was expressed to verify the binding activities of NcACBP in vitro , and the heterologous expression of NcACBP in Δacbp yeast in vivo . (biomedcentral.com)
  • Furthermore, transcriptome analysis was performed to compare the gene expression in different strains. (biomedcentral.com)
  • In addition, the expression pattern of 13 fatty acid desaturases genes of A. oryzae was tested in different growth stages and under salt stress treatment. (springeropen.com)
  • characterized 19 genes encoding fatty acid desaturases and analyzed their expression profiles in Gossypium raimondii under low temperature (Liu et al. (springeropen.com)
  • This yields important information about what effects WRI1 may exert on global gene expression during seed and embryo development. (biomedcentral.com)
  • Gene expression studies performed on PPARα null mice have shed light into a variety of genes regulated by PPARα. (wur.nl)
  • Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
  • If expression of a trait requires only one copy of a gene (one allele). (msdmanuals.com)
  • RESULTS: Six risk genes for SCZ (LINC01795, DDHD2, SBNO1, KCNG2, SEMA7A, and RUFY1) involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment response. (inra.fr)
  • Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial carrier protein found in brown adipose tissue (BAT). (wikipedia.org)
  • If uninformative deletion/duplication genetic tests have resulted, direct sequencing of the dystrophin gene is a viable option. (medscape.com)
  • This deletion did not affect the overall fatty acid composition but modified the abundance of TAG. (biomedcentral.com)
  • Here, we report gene deletion experiments that support the essentiality of this gene in P. aeruginosa and the identification of a number of small molecule FabG inhibitors with IC50 values in the nanomolar to low micromolar range and good physicochemical properties. (dundee.ac.uk)
  • In 2001, a deletion mutation in the gene (now known as VPS13A) localized to chromosome band 9q21 was identified as the site for the defect generating the autosomal recessive form of NA. (medscape.com)
  • An X-linked form (OMIM 300200) is caused by a mutation or deletion of the DAX1 gene (dosage-sensitive sex reversal adrenal hypoplasia congenita critical region of the X chromosome, also called the NR0B1 gene) on the X chromosome. (medscape.com)
  • The autosomal recessive form is due to a mutation or deletion of the gene that codes for steroidogenic factor 1 (SF-1) on chromosome 9q33 (OMIM 184757). (medscape.com)
  • Patients with congenital adrenal hypoplasia due to a mutation or deletion of DAX1 or SF1 (gene name NR5A1) develop hypogonadotropic hypogonadism. (medscape.com)
  • X-linked congenital adrenal hypoplasia is due to mutation in, or deletion of, the DAX1 (AHCH) gene. (medscape.com)
  • There is new enthusiasm to consider newborn screening given the promise of earlier treatment with steroids, molecular therapy, or gene therapy. (medscape.com)
  • A comprehensive understanding of the physiological and molecular function of PPARα target genes is needed for the accurate development of therapeutical strategies. (wur.nl)
  • Then, we pursued to expand our understanding on the physiological and molecular function of two PPARα target genes, Hilpda and Slc25a47. (wur.nl)
  • The main module page also shows the location of these motifs within the upstream sequences of the module member genes. (systemsbiology.net)
  • cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. (systemsbiology.net)
  • Furthermore, a comprehensive analysis was performed to characterize conserved motifs and gene structures, which could provide an intuitive comprehension to learn the relationship between structure and functions of the fatty acid desaturases genes in different Aspergillus species. (springeropen.com)
  • The transient assay of selected genes resulted in a synergistic increase of EFA-enriched TAG accumulation in tobacco leaves. (researchsquare.com)
  • The accumulation of damaged, polyubiquitinated proteins rapidly induces lethal endoplasmic reticulum stress [ 1 ]. (biorxiv.org)
  • Peripheral artery disease is a condition in which an accumulation of fatty deposits and scar-like tissue in the lining of the arteries (atherosclerosis) reduces blood flow to the legs, causing pain when walking. (medlineplus.gov)
  • Neurotensin (NT) is a small protein implicated in the regulation of energy balance which acts as both a neurotransmitter in the central nervous system and as a gastrointestinal peptide. (lu.se)
  • Brian F. Pfleger combines subjects such as Amino acid substitution, Protein engineering and Strain engineering with his study of Computational biology. (research.com)
  • While UCP1 plays a key thermogenic role in wide range placental mammals, particularly those with small body size and those that hibernate, the UCP1 gene has lost functionality in several large-bodied lineages (e.g. horses, elephants, sea cows, whales and hyraxes) and lineages with low metabolic rates (e.g. pangolins, armadillos, sloths and anteaters). (wikipedia.org)
  • He interconnects Fermentation, Biochemical engineering, Fatty alcohol, Flux and Biofuel in the investigation of issues within Metabolic engineering. (research.com)
  • Biochemistry, Flux, Metabolic engineering, Computational biology and Gene are his primary areas of study. (research.com)
  • In conclusion, the NTS rs2234762 gene variant is a determinant of reduced circulating pro-NT levels in overweight and obese children, which predisposes this group to a more favorable metabolic profile and a reduced insulin resistance later in life, independently from metabolic confounders. (lu.se)
  • 2) Please refer to table 1 in Has's manuscript (reference 1) that elaborates the cutaneous features, associated features, and affected gene/protein for localized PSS, generalized noninflammatory PSS, and generalized inflammatory PSS. (aad.org)
  • Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)
  • Unusually low levels of triglycerides can be present in disease states, producing syndromes of malabsorption in addition to patients who carry genes for familial hypobetalipoproteinemia . (medscape.com)
  • Carriers of the rs2234762 variant showed lower pro-NT levels, after adjusting for sex, age, BMI, triglycerides and the Tanner stage. (lu.se)
  • The biological system is complex with many regulatory features such as DNA, mRNA, proteins, metabolites, and epigenetic features such as DNA methylation and histone post-translational modifications (PTMs). (rsc.org)
  • Results of quantitative reverse transcriptase PCR assay for select genes were similar to those for microchip array analysis. (avma.org)
  • Mechanistically, HILPDA interacts and increases DGAT1 protein level and activity as indicated by FRET-FLIM analysis, western blot and Dgat1 activity assay. (wur.nl)
  • Caenorhabditis gut esterase (gene ges-1). (expasy.org)