Gene family expression. Medical search. Frequent questions

The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
A total of 285 R2R3-MYB genes as well as genes encoding three other classes of MYB proteins containing multiple MYB repeats were identified and characterised with respect to structure and chromosomal organisation. (uni-bielefeld.de)
GRFs are a large gene family with highly conserved proteins. (biomedcentral.com)
2003). The COR413 gene family can be divided into two groups: plasma membrane proteins ( COR413-PM ) and thylakoid membrane proteins ( COR413-TM ), which target the plasma membrane and thylakoid membrane, respectively ( Breton et al. (bioscipublisher.com)
Melko M, Douguet D, Bensaid M, Zongaro S, Verheggen C, Gecz J, Bardoni B. Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability. (medlineplus.gov)
92623-83-1 supplier Computational analysis of genome-wide CArG boxes (CArGome) in mice and humans has identified many SRF-dependent genes that encode for cytoskeletal/contractile or adhesion proteins suggesting that SRF is an ancient master regulator of the actin cytoskeleton [2]. (informationalwebs.com)
Immunohistochemical staining was performed to confirm the expression of related proteins in OA and non‑OA tissue samples. (spandidos-publications.com)
Bioinformatics analysis showed that the proteins encoded by the four genes were hydrophilic proteins. (cnjournals.org)
However, biochemical analysis of the fractions have shown that they contain multiple members of nematode protein families, such as metallopeptidases, cysteine proteinases and activation associated secreted proteins. (europa.eu)
It is unclear whic h proteins of each family are necessary for the protection. (europa.eu)
In this study, we observed that the expression of anti-apoptotic BCL2 family genes, such as BCL2, BCL2L1, and MCL1, is highly varied in T-ALL patients, and inhibitors targeting proteins coded by these genes display differential. (lu.se)
Annotation of Selaginella moellendorffii major intrinsic proteins and the evolution of the protein family in terrestrial plants. (lu.se)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
The prin2.2 and csp41b-2 single mutants displayed pale phenotypes, abnormal chloroplasts with reduced transcript levels of photosynthesis genes and defects in embryo development. (frontiersin.org)
These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
Many factors can affect gene expression (and thus phenotypes). (msdmanuals.com)

Spatio-temporal expression pattern showed that these genes were expressed in many tissues with different levels, and they had distinct expression pattern during adventitious root formation and development. (biomedcentral.com)
We identified BnPP2C genes with tissue specificity , using ramie transcriptome data from different tissues , in rhizome leaves and bast fibers. (bvsalud.org)
Results show that 18 genes are specifically or preferentially expressed in the male gametophyte, and six genes are highly expressed in sporophytic tissues. (umn.edu)
Based on the available public RNA-Seq data, the expression patterns of PgGRF and PgGIF genes were analysed from 14 different tissues. (biomedcentral.com)
GRF genes are usually expressed at higher levels in young tissues but at lower levels in mature tissues [ 6 ]. (biomedcentral.com)
Furthermore, the relative expression level of SsLRRII-RLK genes varied in different tissues of sugarcane. (chinacrops.org)
A total of 61 transcriptomes across different tissues and conditions were selected to identify the novel splicing event and expression profile within 80 WRKY genes of the tea plant. (isical.ac.in)
Almost half of the total WRKY genes differentially expressed and 37.5% genes are alternatively spliced across tissues and stress responses. (isical.ac.in)
The extensive tissues expression profiling of each Dmrt family gene revealed typical characteristics. (researchsquare.com)
The RT-PCR method was used to detect the expression patterns of polyphenol oxidase in different developmental stages and different tissues. (cnjournals.org)

Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. (nih.gov)
Gene TNNI1, troponin I type 1 (skeletal muscle, slow), also known as TNN1 and SSTNI, is located at 1q31.3 in the human chromosomal genome, encoding the slow twitch skeletal muscle isoform of troponin I (ssTnI), the inhibitory subunit of the troponin complex in striated muscle myofilaments. (wikipedia.org)
cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I". Genomics. (wikipedia.org)
A total of 12 potential MTP candidate genes in the M. truncatula genome were successfully identified and analyzed for a phylogenetic relationship, chromosomal distributions, gene structures, docking analysis, gene ontology, and previous gene expression. (uaeu.ac.ae)
It is generally hypothesized to be related to aging, trauma, inflammation, obesity, metabolism and genetics, and may also be related to genetic factors, chromosomal abnormalities and gene fusion ( 5 , 6 ). (spandidos-publications.com)

The OA subchondral bone dataset GSE51588 was downloaded from the GEO database, and the differentially expressed genes (DEGs) were screened. (spandidos-publications.com)
Based on differentially expressed genes, possible mechanisms of SWCNT-associated apoptosis resistance and oncogenesis were identified, which included activation of pAkt/p53/Bcl-2 signaling axis, increased gene expression of Ras family for cell cycle control, Dsh-mediated Notch 1, and downregulation of apoptotic genes BAX and Noxa. (cdc.gov)

Transcriptome sequencing data provided evidence for their transcription and tissue-specific expression. (ncl.res.in)
Serial analysis of gene expression (SAGE) is really a widely used way of large-scale transcriptome analysis in mammalian systems. (colinsbraincancer.com)
We have previously built the Smooth Muscle Genome Browser linked to the UCSC Genome Browser (UCSC Smooth Muscle Genome Browser) that shows genome scale transcriptional expression data and SRF binding sites (CArG boxes) obtained from mouse jejunal and colonic SMC: http://med.unr.edu/physio/transcriptome. (informationalwebs.com)
A full-length gonad transcriptome database was exploited to identify Dmrt gene orthologs. (researchsquare.com)
Method】The genes containing tyro sinase domains were found out through transcriptome sequencing, and their primers were designed according to the obtained sequences. (cnjournals.org)

In this study, 23 HD-Zip genes distributed on 6 chromosomes were identified from the peach ( Prunus persica ) genome, and named PpHDZ01-23 according to their positions on the chromosomes. (biomedcentral.com)
In this study, 20 GRF gene members of ginseng were systematically identified and found to be distributed on 13 chromosomes. (biomedcentral.com)
The ginseng GIF gene family has only ten members, which are distributed on ten chromosomes. (biomedcentral.com)
Here, we identified 27 LRRII-RLK genes in Saccharum spontaneum, which were distributed on 17 chromosomes. (chinacrops.org)
Here, we profile eight genomes of the bivalve mollusc family of Pectinidae in a phylogenetic context and show 350 million years sex-chromosome homomorphy, which is the oldest known sex-chromosome homomorphy in the animal kingdom, far exceeding the ages of well-known heteromorphic sex chromosomes such as 130-200 million years in mammals, birds and flies. (nature.com)
The long-term undifferentiation of molluscan sex chromosomes is potentially sustained by the unexpected intertwined regulation of reversible sex-biased genes, together with the lack of sexual dimorphism and occasional sex chromosome turnover. (nature.com)
The pleiotropic constraint of regulation of reversible sex-biased genes is widely present in ancient homomorphic sex chromosomes and might be resolved in heteromorphic sex chromosomes through gene duplication followed by subfunctionalization. (nature.com)
The evolutionary dynamics of sex chromosomes suggest a mechanism for 'inheritance' turnover of sex-determining genes that is mediated by translocation of a sex-determining enhancer. (nature.com)
Some tests look for changes in chromosomes rather than gene changes. (cdc.gov)
An allele with incomplete (low) penetrance may not be expressed even when the trait is dominant or when it is recessive and the gene responsible for that trait is present on both chromosomes. (msdmanuals.com)

This research has great significance for the functional characterisation of the tobacco bZIP family and our understanding of the bZIP family in higher plants. (biomedcentral.com)
This functional classification and expression analysis of the MYB gene family in banana establishes a solid foundation for future comprehensive functional analysis of MaMYBs and can be utilized in banana improvement programmes. (uni-bielefeld.de)
In addition, we observed that the functional differentiation of the BnPP2C family of genes was restricted and that fragment replication played a major role in the amplification of the BnPP2C gene family . (bvsalud.org)
Conclusion: The results of this study will be useful in selecting candidate genes related to disease resistance in grapevine and pave the way for further functional verification of the VvPLD genes. (eurekaselect.com)
This data provides a preliminary theoretical basis for the functional study of LRRII-RLK gene during photosynthesis, growth and development, and disease conditions in sugarcane. (chinacrops.org)
Taken together, these findings demonstrate how transcriptional diversification and functional redundancy of a miRNA family along with PWR-mediated co-regulation of miRNA and transcription factor genes contribute to the robustness of the floral determinacy network. (elsevierpure.com)
Theories predict that the long-term survival of duplicated genes requires their functional diversification, which can be accomplished by either subfunctionalization (the partitioning of ancestral functions among duplicates) or neofunctionalization (the acquisition of novel function). (syr.edu)
Thus, the CDY-related family offers an instructive example of how duplicated genes undergo functional diversification in both expression profile and protein sequence. (syr.edu)
Functional consequences of the WRKY gene spliced variants are predicted to play an important role through compensation or competition with their corresponding full-length transcripts. (isical.ac.in)
Overall, our study provides a novel insight into the evolution of the MTP gene family in M. truncatula and paves the way for additional functional characterization of this gene family. (uaeu.ac.ae)
This browser offers a new perspective into the alternative expression of genes in the context of SRF binding sites in SMC and provides a valuable reference for future functional studies [6]. (informationalwebs.com)
Our proposed model offers new insight into how loss of SRF expression can lead to functional Mouse monoclonal to GFI1 changes in SMC in the pathogenesis of GI motility disorders. (informationalwebs.com)
Functional enrichment analysis was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and then Gene Set Enrichment Analysis (GSEA) was used to formulate the molecular functions and pathways based on the results of GO and KEGG analyses. (spandidos-publications.com)
Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)

The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)
Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
The M. acuminata R2R3-MYB genes were functionally categorised, leading to the identification of seven clades containing only M. acuminata R2R3-MYBs. (uni-bielefeld.de)
The R2R3-MYB gene family in banana (Musa acuminata): Genome-wide identification, classification and expression patterns", PLoS One , vol. 15, 2020, : e0239275. (uni-bielefeld.de)
Genome-Wide Identification and Expression Analysis of BnPP2C Gene Family in Response to Multiple Stresses in Ramie ( Boehmeria nivea L. (bvsalud.org)
Up till now, there is no systematic identification and analysis of the LRRII-RLK gene family in sugarcane. (chinacrops.org)
Genome-wide identification of multifunctional laccase gene family in cotton (Gossypium spp. (ttu.edu)
2001). Exhaustive sequencing of portrayed series tags (ESTs) was the initial technique SB-408124 used for speedy identification of portrayed genes and gene appearance profiling (Adams et al. (colinsbraincancer.com)
Identification of the gene FMR2, associated with FRAXE mental retardation. (medlineplus.gov)
In silico analysis of Sorghum bicolor genome resulted in the identification of a total of 42 NF-Y genes, among which 8 code for the SbNF-YA, 19 for SbNF-YB and 15 for the SbNF-YC subunits. (icrisat.org)

Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others. (nih.gov)
To provide valuable information on the efficacy and safety of diabetes medications (metformin and gliclazide), we evaluated how they affected the expression level and mutations of the SLC2A2 gene in the liver of T2DM patients. (geneticsmr.com)
Our findings identified mutations of the SLC2A2 gene and a positive correlation between SLC2A2 gene expression and the effects of gliclazide and metformin in the liver of T2DM patients. (geneticsmr.com)
Mutations in the AFF2 gene cause fragile XE syndrome, a condition characterized by mild intellectual disability and learning difficulties. (medlineplus.gov)
[ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
The various forms of Waardenburg syndrome (WS), a neurocristopathy, arise from mutations in multiple genes. (medscape.com)
[ 6 ] Therefore, mutations in the PAX3 gene could affect regulation of the MITF gene, leading to abnormalities of melanocyte differentiation. (medscape.com)
Most, if not all, cases of WS1 are caused by mutations in the PAX3 gene located on chromosome band 2q35. (medscape.com)
Novel mutations of PAX3 , MITF , and SOX10 genes have been described in Chinese patients with WS1 or WS2. (medscape.com)
Mutations in the MITF gene, located on chromosome band 3p14.1-p12.3, cause some cases of WS2. (medscape.com)
Hereditary angioedema in Greek families caused by novel and recurrent mutations. (lu.se)
Normal C1 inhibitor mRNA expression level in type I hereditary angioedema patients: newly found C1 inhibitor gene mutations. (lu.se)
Five novel mutations in the C1 inhibitor gene (C1NH) leading to a premature stop codon in patients with type I hereditary angioedema. (lu.se)
A review of the reported defects in the human C1 esterase inhibitor gene producing hereditary angioedema including four new mutations. (lu.se)
Frequent de novo mutations and exon deletions in the C1inhibitor gene of patients with angioedema. (lu.se)

Results: Ten PLD coding sequences (CDS) and two PLD genes segments were isolated from grape berry suspension cells. (eurekaselect.com)
Five Dmrt family genes with full-length transcript sequences were identified in Amur sturgeon. (researchsquare.com)
The reports on base sequences of spider silk protein genes have gained importance as the mechanical properties of silk fibers have been revealed. (bioone.org)
The cDNAs were used as the template to amplify the polyphenol oxidase gene sequences. (cnjournals.org)
Result】A total of four CDS sequences of PPO genes were cloned from V. volvacea, named as VvPPO1, VvPPO2, VvPPO3 and VvPPO4. (cnjournals.org)

Quantitative real-time polymerase chain reaction analysis identified that expression patterns of bZIP s differed, including in different organs and under various abiotic stresses. (biomedcentral.com)
Organ- and development-specific expression patterns were determined from RNA-Seq data. (uni-bielefeld.de)
For 280 M. acuminata MYB genes for which expression was found in at least one of the analysed samples, a variety of expression patterns were detected. (uni-bielefeld.de)
The mRNA expression patterns of VvPLDs were examined by quantitative real-time PCR. (eurekaselect.com)
Analyses of phylogenetic relationships and selection pressure were performed, and tissue expression profiles and spatiotemporal expression patterns in gonads were then analyzed using real-time PCR. (researchsquare.com)
Objective】The study is presented to obtain the sequence information of polyphenol oxidase gene family in Volvariella volvacea, and identify their characteristics and expression patterns. (cnjournals.org)
Some cause the expression of traits to deviate from the patterns predicted by Mendelian inheritance. (msdmanuals.com)

Thus the inhibitory effects of SLTM on gene expression appear to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis consequent upon overexpressing the protein. (bris.ac.uk)
The promoter cis-regulatory elements of BnPP2C genes were mainly involved in light response regulation , phytohormone synthesis, transport and signaling, environmental stress response and plant growth and development regulation . (bvsalud.org)
Next, we characterized the cis -regulatory elements, which identified 32 different types of cis elements in the gene promoters, primarily involved in light response, stress response, regulation of hormone mechanism, and plant growth. (chinacrops.org)
Additionally, some genes expressed differently during distinct periods of day and night, suggesting that they were associated with plant growth regulation and photosynthesis. (chinacrops.org)
The study regarded also roots to understand whether the invariance of root ET emission might relate to unchanged transcription of the biosynthetic genes or to a balance between up- and down-regulation of different isoforms. (unipi.it)
In this study, we characterized the interaction between p53 family-dependent signaling pathways and the regulation of AFP at the gene and protein levels as essential determinants of therapeutic response and prognosis in HCC. (jgld.ro)
Underlining the importance of the crosstalk between the p53 family-dependent pathways and AFP regulation we identified eight novel putative binding sites for the members of the p53 family within the introns 1, 2, 3, 4, 7, 8, 11, and 12 of the AFP gene. (jgld.ro)
Here we show that AFP gene regulation occurs via a combined action of the p53 family members p53, p63 and p73. (jgld.ro)
Thus, our findings reveal a novel interaction of p53 family-dependent signaling pathways and AFP regulation at the gene and protein levels in HCC. (jgld.ro)
In order to study the function of peach COR413 in the regulation of postharvest chilling injury in peach 'Beijing No. 9', four COR413 gene family members were identified based on the peach genome database, namely PpCOR1 ~ PpCOR4 . (bioscipublisher.com)
Interestingly, the expression of PpCOR3 was positively correlated with the change of H 2 O 2 content in peach, which indicated that PpCOR 3 was involved in the regulation of postharvest chilling injury in peach fruit. (bioscipublisher.com)
PageMan analysis revealed several significantly enriched categories altered by MeJA+NaCl treatment, compared with NaCl treatment alone, including genes involved in secondary metabolism, glutathione-based redox regulation, cell cycle, transcription factors (TFs), and other signal transductions (such as calcium and ROS). (frontiersin.org)
We observed a different trend of regulation in terms of BCL2 family gene expression and global gene expression profile including genes reported to be expressed in cancer stem cells. (lu.se)

Phylogenetic analysis points to their diversification into two families namely TIR-NBS-LRR and non-TIR-NBS-LRR. (ncl.res.in)
In the present study, a total of 13, 12, 8 and 8 candidate fatty acid desaturases genes were identified in the Aspergillus oryzae , Aspergillus flavus , Aspergillus fumigatus and Aspergillus nidulans genomes through database searches, which were classified into five different subfamilies based on phylogenetic analysis. (springeropen.com)
Phylogenetic analysis showed that these genes were clustered into clades corresponding to the doublesex/Mav-3 (DM) genes of vertebrates. (researchsquare.com)
According to phylogenetic analysis of specific genes, the family Alloherpesviridae seems to be subdivided into 2 clades ( 6 ) ( Figure 2 , panel B). The first clade comprises anguillid and cyprinid herpesviruses, which possess the largest genomes in the order Herpesvirales (245-295 kb). (cdc.gov)

they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)
1995). It really is an effective incredibly, effective, and global strategy for examining gene expression information, novel gene breakthrough, revealing book pathways, and metabolic circuits. (colinsbraincancer.com)
Collectively, our data suggest that venetoclax resistance can be mediated through the enrichment of distinct gene signatures and cytokine signaling pathways. (lu.se)

They bind to the CCAAT box in the promoter regions of the target genes and regulate gene expressions. (icrisat.org)

Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)
Four cis-regulatory elements namely WBOX, DRE, CBF, and GCC boxes, that commonly occur in resistance genes, were present in the promoter regions of these genes. (ncl.res.in)

2003). Weighed against microarrays, serial evaluation of gene appearance (SAGE) enables both qualitative and quantitative evaluation of a large number of genes without the prior details (Velculescu et al. (colinsbraincancer.com)
In silico analysis of available array data showed that a large number of genes traditionally classified as PEP dependent genes are transcribed during early embryo development from the pre-globular stage to the mature-green-stage. (frontiersin.org)

Most PgGRF and PgGIF gene promoters contain some hormone- and stress- related cis-regulatory elements. (biomedcentral.com)
The PEP enzyme recognizes the -10 and -35 cis -elements, similar to those found in bacterial promoters whereas the NEP enzyme recognizes the YRTA-motif, which can also be found upstream of several genes with PEP promoters indicating that these genes can be transcribed by both polymerases ( Pfannschmidt and Liere, 2005 ). (frontiersin.org)
SRF transcriptionally activates the expression of SMC-specific genes by binding to CArG [CC (A/T)6 GG] boxes in promoters and introns of most SMC-restricted genes [1]. (informationalwebs.com)
It then homodimerizes and translocates to the nucleus where it binds with high affinity to STAT-binding elements (SBE) in the promoters of various IL-10-responsive genes. (nih.gov)

Total RNA was isolated on P16, and the relative abundance of mRNA of the crystallin structural genes, redox components, and apoptotic cascade were ascertained with real-time PCR with reference to the internal control β-actin . (molvis.org)
Real-time PCR analysis showed the crystallin genes ( αA- , βB1- , γD- ) and redox cycle components ( Cat , SOD-1 , Gpx ) were downregulated, the apoptotic components were upregulated, and antiapoptotic Bcl-2 was downregulated in Group II. (molvis.org)
C-PC treatment possibly prevented cataractogenesis triggered by sodium selenite, by regulating the lens crystallin, redox genes, and apoptotic cascade mRNA expression and thus maintains lens transparency. (molvis.org)
The expression of the anti-apoptotic protein BCL2 has been shown to be deregulated in T-cell acute lymphoblastic leukemia (T-ALL), where different T-ALL cells display a differential response to the BCL2-specific inhibitor venetoclax. (lu.se)

These 77 genes were then divided into eleven subfamilies according to their homology with Arabidopsis thaliana . (biomedcentral.com)
2020). The COR413 gene family was first identified when the model plant Arabidopsis thaliana was subjected to low temperature stress ( Breton et al. (bioscipublisher.com)
Phylogenetic relationships and ortholog predictions displayed that sorghum has additional NF-YB genes with unknown functions in comparison with Arabidopsis. (icrisat.org)

Comparative Toxicogenomics Database and TargetScan were used to identify the hub‑gene‑related diseases and the microRNAs that regulated the central hub genes. (spandidos-publications.com)
Pyruvate decar-boxylase (PDC) and RNA demethylase (ALKBH10B) were identified as the most central hub genes in these two modules. (frontiersin.org)

Here, we further examined the gene expression profile by using genome microarrays to profile molecular mechanisms of SWCNT oncogenesis. (cdc.gov)

This will be done by combinatorial RNAi, i.e. simultaneously interfering with the expression of multiple genes by RNAi. (europa.eu)

Although the PP2C gene family has been identified in many species, systematic analysis was still relatively lacking in ramie ( Boehmeria nivea L.). In the present study, we identified 63 BnPP2C genes from the ramie genome , using bioinformatics analysis , and classified them into 12 subfamilies, and this classification was consistently supported by their gene structures and conserved motifs. (bvsalud.org)
Interestingly, SsLRRII-RLK genes were detected to be conserved with 35 collinear gene pairs and multiple conserved motifs. (chinacrops.org)
Furthermore, a comprehensive analysis was performed to characterize conserved motifs and gene structures, which could provide an intuitive comprehension to learn the relationship between structure and functions of the fatty acid desaturases genes in different Aspergillus species. (springeropen.com)

A comprehensive bioinformatics analysis of the VvPLD family was then performed.To further investigate the function of the VvPLD genes during pathogen infection process, Botrytis cinerea was used to attack suspenson-cultured Cabernet Sauvignon cells. (eurekaselect.com)
Using bioinformatics approach, we identified and annotated 104 NBS-LRR genes in chickpea. (ncl.res.in)

The basic leucine zipper (bZIP) transcription factor (TF) is one of the largest families of transcription factors (TFs). (biomedcentral.com)
The R2R3-MYB genes comprise one of the largest transcription factor gene families in plants, playing regulatory roles in plant-specific developmental processes, defense responses and metabolite accumulation. (uni-bielefeld.de)
How the transcription factor and miRNA genes are coordinately regulated to achieve floral determinacy is unknown. (elsevierpure.com)
Some studies suggest that it acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of other genes, although the identity of these genes is unknown. (medlineplus.gov)
The doublesex and Mab-3-related transcription factor (Dmrt) gene family is known for its extensive roles in sex determination and differentiation across vertebrates. (researchsquare.com)
The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
[ 4 ] The 6 genes involved in WS are PAX3 (encoding the paired box 3 transcription factor), MITF (microphthalmia-associated transcription factor), EDN3 (endothelin 3), EDNRB (endothelin receptor type B), SOX10 (encoding the Sry bOX10 transcription factor), and SNAI2 (snail homolog 2), with different frequencies. (medscape.com)

The results suggested that BnPP2C1 and BnPP2C26 could be used as the candidate genes for drought and salt tolerance in ramie . (bvsalud.org)
These results provide a reference for further studies on the function of the PP2C gene and advance the development of the mechanism of ramie stress response, with a view to providing candidate genes for the molecular breeding of ramie for drought and salt tolerance . (bvsalud.org)

In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons, in part by repressing interneuron-specific gene expression. (jneurosci.org)
On the basis of recent vertebrate studies, the HB9/MNR2 gene family is a prime candidate for a general determinant of somatic motoneuron cell type. (jneurosci.org)
Thus, vertebrate HB9/MNR2 genes are expressed specifically in somatic motoneurons and are essential for distinguishing motoneuron/interneuron cell types. (jneurosci.org)

RNA-seq and gene ontology analysis revealed the significant role of MTP genes in the growth and development of M. truncatula. (uaeu.ac.ae)

In this study, we present a comprehensive, genome-wide analysis of the MYB genes from Musa acuminata DH-Pahang (A genome). (uni-bielefeld.de)

Here, we identify and characterize the single Drosophila ortholog of the HB9/MNR2 gene family. (jneurosci.org)
Here, we characterize the CDY-related mammalian gene family, focusing on three aspects of its evolution: gene copy number, tissue expression profile and amino acid sequence. (syr.edu)

Microarray data revealed that several AtCHX genes were developmentally regulated during microgametogenesis. (umn.edu)

Association study of single nucleotide polymorphism in tryptophan hydroxylase 1 gene with adolescent idiopathic scoliosis: A meta-analysis. (nih.gov)

Both jejunal and colonic SMC expressed genes into multiple transcriptional variants, of which most appeared to be specific to SMC [6]. (informationalwebs.com)
SMC express the 1C subunit of L-type Ca2+ channels (CACNA1C) [13], and a recent study showed that myotonic dystrophy protein kinase (DMPK) regulates transcriptional expression and alternative splicing of the 1S subunit of L-type Ca2+ channels (CACNA1S) in skeletal muscle [14]. (informationalwebs.com)
However, it is still unknown whether a transcriptional factor is involved in driving the muscle-specific expression of DMPK or whether DMPK regulates the excitation-contraction coupling. (informationalwebs.com)

This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. (nih.gov)

Three homologous genes have evolved in vertebrates, encoding three muscle type-specific isoforms of TnI. (wikipedia.org)

Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
1 % of alleles, expression is possible only from the paternal or maternal allele. (msdmanuals.com)

It is well-known that LRRII-RLK gene family widely exists in plants. (chinacrops.org)
Expression widely varies in different generations. (medscape.com)

Core genes were expressed differentially between OA subchondral bone and normal tissue samples. (spandidos-publications.com)

One of these genes, SOCS-3 (Suppressor of Cytokine Signaling-3) is a member of a newly identified family of genes that inhibit JAK/STAT-dependent signaling. (nih.gov)
Gene set enrichment analysis (GSEA) showed enrichment of cytokine signaling in all three cell lines which was supported by the phospho-kinase array where STAT5 phosphorylation was found to be elevated in resistant cells. (lu.se)

This study aimed to explore the dynamics of splicing and differential expression in tea plant WRKY genes under diverse conditions. (isical.ac.in)
Genomic imprinting is the differential expression of genetic material depending on whether it has been inherited from the father or mother. (msdmanuals.com)

Our results showed the roles of PpHDZs on root formation, which is helpful to better understand the classification and function of peach HD-Zip genes. (biomedcentral.com)
The predicted protein (85-95 kD) of 28 AtCHX genes after revision consists of an amino-terminal domain with 10 to 12 transmembrane spans (approximately 440 residues) and a hydrophilic domain of approximately 360 residues at the carboxyl end, which is proposed to have regulatory roles. (umn.edu)
Background: The phospholipase D genes have been identified to play critical roles in plant growth and stress responses. (eurekaselect.com)
Further, the findings will provide a strong background to use candidate disease resistance NBS-encoding genes and identify their specific roles in chickpea. (ncl.res.in)

In this study, the structures and functions of the bZIP family in tobacco were systematically explored. (biomedcentral.com)

The qRT- PCR results showed that the BnPP2C1, BnPP2C26 and BnPP2C27 genes had a strong response to drought , high salt and ABA, and there were a large number of stress-responsive elements in the promoter region of BnPP2C1 and BnPP2C26. (bvsalud.org)
Majority of the mannitol (drought)-inducible genes were also induced by salt, high temperature stresses and ABA. (icrisat.org)

This study aimed to identify new members of sturgeon Dmrt family genes and core actors in the gonadal differentiation of Amur sturgeon. (researchsquare.com)
In later stages, DmrtB1b expression continuously increased in testes and was significantly higher in testes than in ovaries at 24 months after hatching (M) and 36M, which strongly suggests that DmrtB1b is a core regulatory factor involved in sexual differentiation in sturgeon. (researchsquare.com)
This study provides a genetic resource of full-length Dmrt family genes and increases the understanding of Dmrt functions in sex differentiation in sturgeon. (researchsquare.com)
Evidence suggests that the MITF gene transactivates the tyrosinase gene, which is involved in melanocyte differentiation. (medscape.com)

Phylogenetic tree showed the classification of these genes into three different branches including NIK, SERK, and LRRII-C. Furthermore, we observed the significant amplification in the LRRII-C branch. (chinacrops.org)

Rapid detection by fluorescent multiplex PCR of exon deletions and duplications in the C1 inhibitor gene of hereditary angioedema patients. (lu.se)

This progenitor later duplicated to generate CDYL and CDYL2, two autosomal genes found in all extant mammals. (syr.edu)
Holt-Oram syndrome (HOS) (OMIM 142900) is a heart-upper limb malformation complex with an autosomal dominant inheritance and near-complete penetrance but variable expression. (medscape.com)

RNA interference knockdown of HB9 levels leads to defects in motoneuron ventral muscle target recognition, ectopic expression of a marker for dorsally projecting motoneurons (Even-skipped), and defects in serotonergic interneuronal projections. (jneurosci.org)

The results revealed that the fatty acid desaturases genes in A. oryzae were highly expressed in adaptive phase growth and up-regulated under salt stress treatment. (springeropen.com)

Examples of secondary findings are genes associated with a predisposition to cancer or rare heart conditions when you were looking for a genetic diagnosis to explain a child's developmental disabilities. (cdc.gov)

Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
Our data substantiates the Gimap5 frameshift mutation as the primary defect with only limited contributions to lymphopenia from the remaining Gimap genes. (hindawi.com)
Positional cloning of the lyp gene revealed a frame shift mutation in Gimap5 (previously known as Ian5 or Ian4L1 ). (hindawi.com)
Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
An Ancient Mutation in the TPH1 Gene is Consistent with the Changes in Mammalian Reproductive Rhythm. (nih.gov)
A mutation in POWERDRESS (PWR), a previously uncharacterized gene encoding a SANT-domain-containing protein, was isolated in this study as an enhancer of the weakly indeterminate ag-10 allele. (elsevierpure.com)
Nearly all cases are caused by a mutation called a CCG trinucleotide repeat expansion, in which the CCG trinucleotide is abnormally repeated more than 200 times, which makes this region of the gene unstable. (medlineplus.gov)
Single gene testing is also used when there is a known genetic mutation in a family. (cdc.gov)
Mutation screening of the C1 inhibitor gene among Hungarian patients with hereditary angioedema. (lu.se)
Hereditary angioedema with a de novo mutation of exon 8 in the C1 inhibitor gene showing recurrent edema of the hands around the peripheral joints: importance for the differential diagnosis of joint swelling. (lu.se)
A point mutation in exon 7 of the C1-inhibitor gene causing type I hereditary angioedema. (lu.se)
A mutation unique in serine protease inhibitors (serpins) identified in a family with type II hereditary angioneurotic edema. (lu.se)

Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
Prior to human-mouse divergence (and perhaps preceding the eutherian radiation), a processed CDYL transcript retroposed onto the Y chromosome to create CDY, the Y-linked member of the family. (syr.edu)

Rarely, small deletions of genetic material from the AFF2 gene are associated with fragile XE syndrome, although how these deletions affect the protein and lead to intellectual disability is unknown. (medlineplus.gov)

Gene architecture revealed intron gain/loss events in this resistance gene family during their independent evolution into two families. (ncl.res.in)
To understand how cells developed venetoclax resistance, we monitored the expression of BCL2, BCL2L1, and MCL1 over the treatment period and compared gene expression between resistant cells and parental sensitive cells. (lu.se)

Anatomy2

Chemicals and Drugs4

Phenomena and Processes7

Information Science5

Proteins12

Phenotypes5

Tissues10

Chromosomal5

Differentially expressed genes2

Transcriptome5

Chromosomes10

Functional14

Identification10

Mutations16

Sequences5

Patterns7

Regulation13

Phylogenetic analysis4

Pathways3

Regulate gene1

Promoter regions2

Large number of genes2

Promoters4

Apoptotic4

Arabidopsis3

Central hub genes2

Microarrays1

Multiple genes1

Motifs3

Bioinformatics2

Transcription factor7

Candidate genes2

Vertebrate3

Ontology1

Genome-Wide Analysis1

Characterize2

Developmentally regulated1

Nucleotide1

Transcriptional3

Segmental duplications1

Homologous1

Alleles2

Widely2

Tissue1

Cytokine2

Differential expression2

Roles4

Structures1

Drought2

Differentiation4

Classification1

Duplications1

Autosomal2

Defects1

Highly expressed1

Findings1

Mutation12

Chromosome2

Deletions1

Resistance2