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  • metabolism
  • This gene encodes an essential enzyme of nucleotide metabolism. (wikipedia.org)
  • Since many chemotherapeutic agents such as 5-fluorouracil treat neoplastic diseases, including head and neck cancer, breast cancer, and gastrointestinal cancer, by targeting TS in thymidylate metabolism, DUT may protect against the cytotoxic side effects by countering dUTP accumulation. (wikipedia.org)
  • encodes
  • In humans, this gene encodes a homotrimeric enzyme with two isoforms characterized by their distinct subcellular localizations: the nuclear isoform (DUT-N) and mitochondrial isoform (DUT-M). Northern blot analysis reveals distinct mRNA transcripts for DUT-N (1.1 kb) and DUT-M (1.4 kb). (wikipedia.org)
  • This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. (wikipedia.org)
  • tissues
  • The PAX gene family has an important role in the formation of tissues and organs during embryonic development and maintaining the normal function of some cells after birth. (wikipedia.org)
  • It is postulated that high expression and secretion of elongation factors from tumor tissues, combined with altered levels of eEF1A-derived bacterial peptides in neoplastic disease, may lead to autoimmunity in breast cancer. (wikipedia.org)
  • Mice
  • SCID mice with tumour xenografts with inducible MT1h expression had lower tumour volumes as well as fewer metastases and deaths than uninduced controls. (biomedsearch.com)
  • A study on mice found that a specific subset of mouse genes (7%) was deregulated in the absence of HDAC1. (wikipedia.org)
  • chromosome
  • DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene on chromosome 15. (wikipedia.org)
  • The PTGER4 gene is located on human chromosome 5p13.1 at position p13.1 (i.e. 5p13.1), contains 7 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14). (wikipedia.org)
  • ING1 is located near the following genes on Chromosome 13 CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function) COL4A2: A2 Subunit of type IV collagen RAB20: Potential regulator of Connexin 43 trafficking. (wikipedia.org)
  • By copying and replacing the altered area with a very similar area on the sister homolog chromosome, the gene can be replicated as if nothing was ever wrong on the chromosome. (wikipedia.org)
  • Genetic
  • Genetic and epigenetic changes can occur at many levels, from gain or loss of entire chromosomes, to a mutation affecting a single DNA nucleotide, or to silencing or activating a microRNA that controls expression of 100 to 500 genes. (wikipedia.org)
  • Tumor suppressor genes are often disabled by cancer-promoting genetic changes. (wikipedia.org)
  • promoters
  • The isoforms are produced from alternative splicing at different 5' exons, with the first exon of DUT-N occurring 767 base pairs downstream of the first exon in DUT-M. Regulation at different promoters has been proposed to account for the differential expression of these isoforms. (wikipedia.org)
  • human
  • These expression changes, including increased PSMA expression in response to treatment with the antiandrogen MDV3100, can be quantitatively measured in vivo in human prostate cancer xenograft models through PET imaging with a fully humanized, radiolabeled antibody to PSMA, (64)Cu-J591. (biomedsearch.com)
  • Collectively, these results establish that relative changes in PSMA expression levels can be quantitatively measured using a human-ready imaging reagent and could serve as a biomarker of AR signaling to noninvasively evaluate AR activity in patients with CRPC. (biomedsearch.com)
  • Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • DISEASE
  • However, evidence of MTag encoding and expression has also recently been reported in at least one virus of unrelated lineage, the trichodysplasia spinulosa polyomavirus, which is a normally asymptomatic infection in humans that sometimes causes the rare disease trichodysplasia spinulosa in immunocompromised individuals. (wikipedia.org)
  • Cancer is fundamentally a disease of regulation of tissue growth. (wikipedia.org)
  • Thus
  • Thus the re-establishment of gene control by PRH is in part responsible for the therapeutic effects of dasatinib. (biomedsearch.com)
  • These expression patterns correspond with their roles in the DNA replication cycle of their respective genomes, and thus indicate different regulatory mechanisms affecting each isoform. (wikipedia.org)
  • promoter
  • We found that the promoter region of MT1h was hypermethylated in cancer and that demethylation of the MT1h promoter reversed the suppression of MT1h expression. (biomedsearch.com)
  • The sequences of their promoter regions are also highly similar, though that of the eEF1A2 gene contains an additional 81 bp SV40 small antigen sequence at the 5′-end. (wikipedia.org)
  • survival
  • As with breast cancer, upregulation of eEF1A expression is associated with prostate cancer and worsened metastasis-free and overall patient survival. (wikipedia.org)
  • induction
  • Gene expression analysis revealed the induction of interferon- and cell death-related genes that were associated with responsiveness of melanoma cell lines to BI-69A11. (biomedsearch.com)
  • Biweekly administration of BI-69A11 starting at 10 weeks or as late as 24 weeks after the induction of mutant Nras expression inhibited melanoma development (100 and 36%, respectively). (biomedsearch.com)
  • melanoma
  • Gene expression analysis revealed the induction of interferon- and cell death-related genes that were associated with responsiveness of melanoma cell lines to BI-69A11. (biomedsearch.com)
  • Biweekly administration of BI-69A11 starting at 10 weeks or as late as 24 weeks after the induction of mutant Nras expression inhibited melanoma development (100 and 36%, respectively). (biomedsearch.com)
  • Here we report the whole-genome sequencing of probands from several melanoma families, which we performed in order to identify other genes associated with familial melanoma. (edu.au)
  • effects
  • Thus the re-establishment of gene control by PRH is in part responsible for the therapeutic effects of dasatinib. (biomedsearch.com)