• Although Pae displays anti-neoplastic activity and increases the efficacy of chemotherapeutic drugs in various cell lines and in animal models, studies related to the effect of Pae on ER stress-induced resistance to chemotherapeutic agents in hepatocellular carcinoma (HCC) are poorly understood. (nih.gov)
  • During this process, environmental conditions can rapidly fluctuate, following local changes in oxygen, pH or nutrient gradients, and can become extremely harsh for the transformed cell, which must become capable of tackling sudden shortages in blood supply or exposure to anti-neoplastic treatments. (frontiersin.org)
  • One of the main components of frankincense oil is boswellic acid, a component known to have anti-neoplastic properties. (biomedcentral.com)
  • Here we report the whole-genome sequencing of probands from several melanoma families, which we performed in order to identify other genes associated with familial melanoma. (edu.au)
  • These data indicate that MITF is a melanoma-predisposition gene and highlight the utility of whole-genome sequencing to identify novel rare variants associated with disease susceptibility. (edu.au)
  • Epigenetic perturbations are increasingly described in cancer cells where they are thought to contribute to deregulated gene expression and genome instability. (cnrs.fr)
  • We screened the genome for further potential MIA-regulated genes carrying the element in their promoter regions. (uni-regensburg.de)
  • Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs. (nih.gov)
  • METHODS: Genome-wide expression profiles were obtained from tumor biopsies from 81 ER(+) postmenopausal patients, before and after 2 weeks' anastrozole treatment. (ox.ac.uk)
  • For the majority of samples, clinical and biological information, such as age at diagnosis, sex, Rai stage, presence/absence of treatment, ZAP-70 expression, and IgV H gene mutation status were available (see Table 4, which is published as supporting information on the PNAS web site). (pnas.org)
  • Mutation of the p38 MAPK target site in KSRP blocked the resveratrol effect on pro-inflammatory gene expression. (jove.com)
  • We found that breast tumors from BRCA1 and BRCA2 mutation carriers display characteristic RNA expression patterns, allowing them to be distinguished from sporadic tumors. (forskningsdatabasen.dk)
  • So far, two genes associated with familial melanoma have been identified, accounting for a minority of genetic risk in families. (edu.au)
  • GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2. (uchicago.edu)
  • Mice with endothelial cell-specific loss of G13 showed reduced VEGFR-2 expression at sites of angiogenesis and attenuated VEGF effects, resulting in impaired retinal angiogenesis and tumor vascularization. (mpg.de)
  • Haeberle H, Kuziel W, Dieterich H, Casola A, Gatalica Z, Garofalo R. Inducible expression of inflammatory chemokines in respiratory syncytial virus-infected mice: role of MIP-1alpha in lung pathology. (labome.org)
  • Activation of YFP, ablation of p53, and expression of an oncogenic form of K-ras was achieved by the delivery of an adenovirus expressing Cre-recombinase into the mammary duct of sexually mature, virgin female mice. (jove.com)
  • Gene expression in surgically resected and microdissected samples of non-small-cell lung cancers (18 squamous cell carcinomas and nine adenocarcinomas), matched normal bronchial epithelium, and peripheral lung tissue from both smokers (n = 22) and non-smokers (n = 5) was studied using the Affymetrix U133A array. (uni-regensburg.de)
  • Glut-1 may be a useful biomarker to validate tissue microarrays for use in studies of hypoxia-regulated genes in cancer. (surrey.ac.uk)
  • Altered subcellular localization and isoform distribution in malignant glioma indicate that tumor-specific changes in DRBP76-related gene products and their regulatory functions may contribute to the formation and/or maintenance of these tumors. (nih.gov)
  • In NPC, EBV infection is predominantly latent and viral gene expression is restricted, similar to other EBV-associated malignant tumors. (pnas.org)
  • Recently, our laboratory and others (11 , 12 , 13 , 14 , 15 , 16 , 17) have used expression arrays to subclassify breast tumors into categories possessing distinct biological and clinical properties. (aacrjournals.org)
  • The Int6 gene was originally identified as a common insertion site for the mouse mammary tumor virus in virally induced mouse mammary tumors. (aacrjournals.org)
  • Expression was rare in breast (6/40) and prostate (1/57) tumors, and in normal tissue, was restricted to spleen, tongue, and CNS endothelium. (surrey.ac.uk)
  • Many oncogenes, tumour suppressor genes, and altered signalling pathways have been identified [ 7 - 11 ]. (hindawi.com)
  • An approach emphasizing both principles and methodology provides the scientist with the essential fundamentals needed for gene cloning and for an appreciation of the strategies of recombinant DNA technology as well as other molecular techniques. (faes.org)
  • This text then examines the molecular mechanism by which steroid hormones regulate specific gene expression. (elsevier.com)
  • E-cadherin acts as an invasion-suppressor gene ( 5 - 7 ) and, consequently, knowledge of the molecular mechanism that controls its expression or function is of primary importance in understanding the process of tumor invasion. (pnas.org)
  • Their gene expression profiles were used in the identification of potential molecular markers for GTD. (openthesis.org)
  • Comparison of global gene expression profiles between normal placenta and HM, and between regressive and persistent mole have provided new insights into the molecular events regulating behaviors of normal and abnormal trophoblasts. (openthesis.org)
  • Long noncoding RNAs (lncRNAs) interact with protein factors to regulate different layers of gene expression transcriptionally or posttranscriptionally. (jove.com)
  • It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. (zfin.org)
  • A series of genes of the four HOX gene clusters A, B, C, and D were reported to show aberrant expressions in oncogenesis, particularly in cutaneous malignant melanoma (CMM). (hindawi.com)
  • We describe the use of PI3Kβ protein and/or its encoding gene for the screening for substances useful in the treatment of cancers, preferably breast cancers, as well as a method for the diagnosis of malignant cell growth comprising the measuring the expression of PI3Kβ. (freepatentsonline.com)
  • In conclusion, tissue microarrays enable the observation of Glut-1 expression in peri-necrotic regions, which may be linked to hypoxia, and reflect previous studies showing differential Glut-1 expression across tumor types and non-malignant tissue. (surrey.ac.uk)
  • Uncorrected OCR) Abstract of thesis entitled GENE EXPRESSION PROFILE IN HUMAN TROPHOBLAST AND GESTATIONAL TROPHOBLASTIC DISEASE submitted by Feng Hui-Chen for the degree of Doctor of Philosophy at the University of Hong Kong in August 2004 Trophoblast in normal placenta is pseudo-malignant in nature. (openthesis.org)
  • In these studies we examine the effects of steroid hormones and cholcalciferol analogs on the expression of ectopically produced placental alkaline phosphatase and the eutopic breast-class isoenzyme in human breast cancer cell lines in which embryonic genes are ectopically (non-phenotype) expressed. (stanford.edu)
  • hTERT expression includes phenotype-specific RNA maturation and correlates with TA but not with TL. (ac.be)
  • We found that endothelial VEGFR-2 expression is strongly reduced in the absence of the G protein G13, resulting in an impaired responsiveness to VEGF-A, a phenotype that can be rescued by normalization of VEGFR-2 levels. (mpg.de)
  • However, the relationship between the expression of miR-101 in BTCC and a patient's prognosis has not yet been studied. (medscimonit.com)
  • A multivariate analysis confirmed that low Int6 expression was the only independent factor to predict poor prognosis, for both overall ( P = 0.0006) and disease-free ( P = 0.024) survival. (aacrjournals.org)
  • Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. (geneticsmr.com)
  • Additionally, high serum exosomal miR-106b-3p expression in patients was correlated with a poor prognosis. (portlandpress.com)
  • The ability to block the expression of these genes allows exploration of normal growth regulation. (eurekaselect.com)
  • Expression of enzymes involved in biosynthesis of oestrogens and prostaglandins (PG) is often higher in endometrial cancers when compared with levels detected in normal endometrium. (biomedcentral.com)
  • The candidate gene examined was the cadherin family expressed in normal placenta and HM using degenerated PCR. (openthesis.org)
  • MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program. (duke.edu)
  • Diffuse large B-cell lymphoma (DLBCL) is stratified into prognostically favorable germinal center B-cell (GCB)-like and unfavorable activated B-cell (ABC)-like subtypes based on gene expression signatures. (duke.edu)
  • aHCF were associated to aberrant spatial localization and deregulated expression of a novel 2p gene (GMCL1) that was found to have prognostic impact in diffuse large B cell lymphoma. (cnrs.fr)
  • Representational fragment amplification: Exponential amplification of fragmented cDNA enables multimillion-fold expression testing Sgarlato, G. D., Sussman, H. H. AMER ASSOC CLINICAL CHEMISTRY. (stanford.edu)
  • These data suggest that miRNA expression patterns have relevance to the biological and clinical behavior of this leukemia. (pnas.org)
  • Significantly, patients with low dyskerin expression were characterized by a better clinical outcome than those with a high dyskerin level. (unito.it)
  • This study indicated that down-regulation of TIMP3 in CCA may play a role in its pathogenesis, and may have potential application in clinical diagnosis and patient treatment in GTD. (openthesis.org)
  • Integrating our sequence data with expression data from human melanomas identified a list of 23 potential MIA-YBX1 targets in melanomas. (uni-regensburg.de)
  • We also describe non-human transgenic animals as models for studying human pathologies, preferably breast cancer, being transgenic for having altered PI3Kβ and Neu-T expression. (freepatentsonline.com)
  • Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer. (unito.it)
  • The B6hTERT is a newly established trophoblastic cell line immortalized with the hTERT (human telomerase reverse transcriptase) gene. (openthesis.org)
  • Dual-luciferase reporter gene assay was used to determine the targeting relationship between miR-30b and CCL22. (bvsalud.org)
  • Gene ontology analysis was used to highlight functionally distinct biological responses to different mitogens. (aacrjournals.org)