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  • distinct
  • Partitional clustering of the transcription factor binding site composition within these promoter segments reveals a small number of gene groups that are selectively enriched for gene ontology terms consistent with distinct aspects of cellular function. (biomedcentral.com)
  • commonly
  • Using ProSpector, a web-based promoter search and annotation tool, we have applied an unbiased approach to analyze the transcription factor binding site frequencies of 1400 base pair genomic segments positioned at 1200 base pairs upstream and 200 base pairs downstream of the transcriptional start site of 7298 commonly studied human genes. (biomedcentral.com)
  • mice
  • Intrasplenic administration of a colon adenocarcinoma cell line, colon 26, induced tumor necrosis factor (TNF) α protein expression around the central and portal veins of the liver at 3 days, and liver metastases by 24 days after the tumor injection, in 90% of wild-type (WT) mice. (aacrjournals.org)
  • The intrasplenic tumor injection induced mRNA expressions of vascular endothelial growth factor, heparin-binding epidermal growth factor, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 at similar levels in the livers of both WT and TNF-Rp55 KO mice. (aacrjournals.org)
  • These results show that PlagL2 expression activates expression of Mpl in hematopoietic progenitors, and that upregulation of wild-type Mpl provides an oncogenic signal in cooperation with CBFbeta-SMMHC in mice. (umassmed.edu)
  • Mice with a targeted mutation in the TGF beta 1 gene were examined to determine the cause of prenatal lethality, which occurs in 50% of homozygous TGF beta 1 null (TGF beta 1−/−) conceptions. (biologists.org)
  • Orthologs of most of these ATG genes have now been identified in higher eukaryotes ( Table 1 ), and genetic analyses have begun to decipher the functions of autophagy in multicellular organisms, such as nematodes, flies and mice. (biologists.org)
  • factor
  • Significance ranking of the class-determining transcription factor binding sites within these clusters show substantial overlap between the gene ontology terms of the transcriptions factors associated with the binding sites and the gene ontology terms of the regulated genes within each group. (biomedcentral.com)
  • These findings demonstrate that the transcription factor binding site composition is non-randomly distributed between gene promoters in a manner that reflects and partially defines general gene class function. (biomedcentral.com)
  • specific
  • We have demonstrated that CR1 has the ability to direct reporter gene expression in a cell-specific manner. (plos.org)
  • This is the first report on the association between low-frequency and common variants in the chitinases- related genes CHIA and CHI3L1 with the intensity of specific IgE to ABA-1 in a population naturally exposed to Ascaris and with Bet v 1 in a Swedish population. (diva-portal.org)
  • role
  • We also confirmed that TNFSF13B has an important and conserved role in the regulation of total IgE levels, which supports potential evolutionary links between helminth immunity and allergic response. (diva-portal.org)
  • analysis
  • Microarray technology has become popular for gene expression profiling, and many analysis tools have been developed for data interpretation. (biomedcentral.com)
  • Using transposon mutagenesis, polypeptide analysis and expression of subfragments of DNA, the genes encoding the first four enzymatic steps of the pathway have been individually mapped and found to lie adjacent to each other. (diva-portal.org)
  • High
  • Two low-frequency coding variants in the gene encoding the Acidic Mammalian Chitinase (CHIA rs79500525, rs139812869, tagged by rs10494133) were found enriched in high IgE responders to ABA-1 and confirmed by genetic association analyses. (diva-portal.org)
  • The SNP rs4950928 in the Chitinase 3 Like 1 gene (CHI3L1) was associated with high IgE to ABA-1 in Colombians and with high IgE to Bet v 1 in the Swedish population. (diva-portal.org)
  • transgenic
  • Here we present a model of peripheral ALCL pathogenesis where the malignancy is initiated in early thymocytes, before T-cell receptor (TCR) β-rearrangement, which is bypassed in CD4/NPM-ALK transgenic mice following Notch1 expression. (cancerindex.org)
  • blasts
  • Association of SNPs within MCC with cytarabine sensitivity in LCLs and in leukemic blasts. (nih.gov)
  • MCC SNPs plotted against log2 AUC in LCLs for (A) rs7729269 and (B) rs13171482, and MCC SNPs plotted against IC 50 (dose required to inhibit growth of 50% of cells) in leukemic blasts for (C) rs7729269 and (D) rs13171482. (nih.gov)
  • Cells
  • The expression of CTSL was examined in HCC tissue and MHCC-97H cells by Western-blotting, Real-time PCR and immunohistochemical staining. (cancer-genetics.org)
  • Its expression is lower in oligodendrocyte progenitor cells than in mature oligodendrocytes. (wikipedia.org)
  • Elevated expression of L-selectin ligand in lymph node-derived human prostate cancer cells correlates with increased tumorigenicity. (unmc.edu)
  • These results suggest that modulated expression of selective glycogenes correlates with altered tumorigenicity of cancer cells. (unmc.edu)
  • Erythroid differentiation of parental TF-1 cells and variants was determined by flow cytometry for GPA expression after 2 initial days of DOX treatment and 8 days of EPO and DOX treatment. (nih.gov)
  • C) Expression of fetal hemoglobin was determined by qRT-PCR for cells treated as in (B). Values normalized to No DOX controls. (nih.gov)
  • RARα takes part in regulation of VDR transcription, and unliganded RARα acts as a transcriptional repressor to VDR gene in acute myeloid leukemia (AML) cells. (mdpi.com)
  • This is why we decided to examine the effects of the combination of 1,25D and all- trans -retinoic acid (ATRA) on VDR gene expression in normal human and murine blood cells at various steps of their development. (mdpi.com)
  • We tested the expression of VDR and regulation of this gene in response to 1,25D or ATRA, as well as transcriptional activities of nuclear receptors VDR and RARs in human and murine blood cells. (mdpi.com)
  • Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells. (semanticscholar.org)
  • Glucocorticoids inhibit superoxide anion production and p22 phox mRNA expression in human aortic smooth muscle cells. (semanticscholar.org)
  • Regulation of the steady state level of Fc gamma RI mRNA by IFN-gamma and dexamethasone in human monocytes, neutrophils, and U-937 cells. (semanticscholar.org)
  • mutations
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. (cancerindex.org)
  • Because β-catenin activation and Myc translocations were previously found in murine T-cell acute lymphoblastic leukemias (T-ALLs) deficient for Pten, our results suggest that activation of the canonical Wnt pathway is associated with a subtype of Notch-independent T-ALLs that bear Myc gene rearrangements and Pten mutations. (ox.ac.uk)
  • Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. (wikipedia.org)
  • Leukemia
  • High Expression of CPT1A Predicts Adverse Outcomes: A Potential Therapeutic Target for Acute Myeloid Leukemia. (cancerindex.org)
  • In two independent cohorts of cytogenetically normal AML (CN-AML) patients, compared to low expression of CPT1A (CPT1A(low)), high expression of CPT1A (CPT1A(high)) was significantly associated with adverse outcomes, which was also shown in European Leukemia Network (ELN) Intermediate-I category. (cancerindex.org)
  • Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia. (rigshospitalet.dk)
  • significantly associated
  • By classifying mouse and human leukemias according to Evi1/EVI1 and Erg/ERG expression, reflecting aggressiveness and cell of origin, and performing comparative transcriptomics, we identified several EMT-related genes that were significantly associated with poor overall survival of AML patients. (ox.ac.uk)
  • ligand
  • Elevated expression of L-selectin ligand in lymph node-derived human p" by Prakash Radhakrishnan, Ming-Fong Lin et al. (unmc.edu)
  • clinical
  • To investigate the expression and role of Cathepsin L (CTSL) in Hepatocellular carcinoma (HCC) tissue and cell line (MHCC-97H), and to evaluate the clinical and prognostic significance of CTSL protein in patients with HCC. (cancer-genetics.org)
  • variants
  • Multiple transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)
  • Multiple variants of this gene have been described, but the full-length nature of only one has been determined. (wikipedia.org)
  • human
  • Carbohydrate kinase domain containing protein (abbreviated as CARKD), encoded by CARKD gene, is a human protein of unknown function. (wikipedia.org)
  • Expression data in the human protein, and the mouse ortholog, indicate its expression in almost all tissues. (wikipedia.org)
  • Interferon gamma induces in human neutrophils and macrophages expression of the mRNA for the high affinity receptor for monomeric IgG (Fc gamma R-I or CD64). (semanticscholar.org)
  • CEBPE is its human gene and is pro-apoptotic. (wikipedia.org)
  • suggest
  • These data suggest that the Bcrp/ABCG2 gene contributes importantly to the generation of the SP phenotype, which allows for the selection of immature, pluripotent HSCs. (wiley.com)
  • region
  • The bottom panel illustrates the chromosomal region and genes that these SNPs fall on. (nih.gov)
  • AML1
  • Fusion transcripts with upstream genes such as MDS1/EVI1 (ME), AML1/MDS1/EVI1 (AME), ETV6/MDS1/EVI1 have all been identified The MECOM is primarily found in the nucleus, either soluble or bound to DNA. (wikipedia.org)
  • glucose
  • Additionally, DPM down-regulated the mRNA and protein expression of jejunal Na(+)/glucose cotransporter, Na(+)/K(+)-ATPase and glucose transporter 2, and enhanced the activities as well as mRNA and protein levels of hepatic glycolysis enzymes (glucokinase, phosphofructokinase, private kinase and pyruvate decarboxylas E1). (jove.com)
  • Activity and expression of hepatic gluconeogenesis enzymes (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) were also found to be attenuated in diabetic mice treated with DPM. (jove.com)
  • Purified enzyme activity assays verified that the increased activities of glucose glycolysis enzymes resulted not from their direct activation, but from the relative increase in protein expression. (jove.com)
  • therapy
  • Our subsequent experimental work focused upon practical applications of BOEC: their use for gene therapy, tissue engineering, assessment of mutant gene effect, and discovery of heterogeneity in endothelial biology. (jci.org)
  • metastatic
  • This study is planned to evaluate margetuximab plus chemotherapy against trastuzumab plus chemotherapy in third-line metastatic breast cancer patients with HER2 expression at the 3+ level by immunohistochemistry (IHC) or 2+ level by IHC with gene amplification, subject to completion of further regulatory review. (macrogenics.com)
  • response
  • Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. (jci.org)
  • activity
  • Additionally, phytoceramide stimulated PPARα activity in HepG2 hepatocytes, suggesting that phytoceramide activates genes regulated by PPARα. (biomedcentral.com)