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  • beta-catenin
  • Finally we review the evidence showing that ablation of NM II-C (which also localizes to the intercalated disc) in mouse hearts deficient in NM II-B expression results in destabilization of N-cadherin and beta-catenin in the intercalated disc. (biomedsearch.com)
  • genetic
  • Despite great advances in the genetic regulatory networks responsible for tissue and organ development, it is not yet clearly understood how specific gene functions are linked to the specific morphogenetic processes underlying the internal organ asymmetries found in vertebrate animals. (biomedsearch.com)
  • Analysis of variance of gene expression separated the samples by genetic background and by the developmental stage before or after vernalization saturation was reached. (biomedcentral.com)
  • drug
  • Interestingly, the epigenetic state of ADME genes, at least in rodent livers, can change in response to xenobiotic exposure [ 16 , 17 ], thus opening the perspective for epigenetics-mediated drug-drug interactions. (biomedcentral.com)
  • embryonic
  • At E12.5, embryonic hearts lacking A1AR expression (A1AR-/-) had elevated heart rates compared to A1AR+/- littermates, A1AR-/- heart rates failed to decrease to levels comparable to those of controls. (biomedsearch.com)
  • patterns
  • Furthermore, we provide evidence that Ta.Vrn-A1 and Ta.Vrt1 originally hypothesized to encode for the same gene showed different patterns of expression and therefore are distinct. (biomedcentral.com)
  • differentiation
  • We demonstrate that RGCs express Shh soon after differentiation, and cells at the optic disc in close proximity to the Shh-expressing RGCs upregulate Hh target genes, which suggests they are responding to RGC-derived Shh signaling. (biomedsearch.com)
  • target
  • GSE10341), hypoxia-inducible factor-1 target genes are induced to a greater extent in null fetuses than in wt siblings, supporting the notion that mutants experience lower oxygen tension or have an enhanced response to hypoxia. (biomedsearch.com)
  • We found that miR-30 family microRNAs target mesenchymal gene transcripts and maintain them in a translationally inactive state. (biomedsearch.com)
  • cell
  • An interesting feature of these domains of Noggin expression is that they lie between territories of Bmp-4 expression, suggesting that Noggin is acting to protect from Bmp-4-mediated cell death. (biomedsearch.com)
  • activity
  • The disposition of paired organs along the left-right body axis has been shown to be regulated by the activity of the homeobox containing gene pitx2. (biomedsearch.com)