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  • patterns
  • By using strand-specific RNA sequencing, researchers from the Shanghai Center for Plant Stress Biology profiled the expression patterns of lincRNAs in Arabidopsis, rice and maize, and identified 47, 611 and 398 TE-associated lincRNAs (TE-lincRNAs), respectively. (lncrnablog.com)
  • For trait-associated lincRNAs, they also investigated synteny and conservation relative to mouse, expression patterns in five cardiometabolic-relevant tissues, and allele-specific expression in RNA sequencing data for adipose tissue and leukocytes. (lncrnablog.com)
  • conservation
  • Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. (ox.ac.uk)
  • We identify some of the first lncRNA orthologs present in birds (chicken), marsupial (opossum), and eutherian mammals (mouse), and investigate whether they exhibit conservation of brain expression. (ox.ac.uk)
  • Instead, their preservation across diverse amniotes, their apparent conservation in exon structure, and similarities in their pattern of brain expression during embryonic and early postnatal stages together indicate that these are functional RNA molecules, of which some have roles in vertebrate brain development. (ox.ac.uk)
  • promoter
  • Repressors bind to the Operator, coding sequences on the DNA strand that are close to or overlapping the promoter region, impeding RNA polymerase's progress along the strand, thus impeding the expression of the gene.The image to the right demonstrates regulation by a repressor in the lac operon. (wikipedia.org)
  • A recent study of about 40 histone modifications across human gene promoters found over 4000 different combinations used, over 3000 occurring at only a single promoter. (wikipedia.org)
  • In a normal cell, the bulk genome is highly methylated at CpGs whereas CpG islands (CPI) at gene promoter regions remain highly methylated. (wikipedia.org)
  • Aberrant DNAm is the most common type of molecular abnormally in cancer cells, where the bulk genome because globally 'hypomethylated' and CPIs in promoter regions become 'hypermethylated', usually leading to silencing of tumour suppressor genes. (wikipedia.org)
  • genome
  • In multicellular organisms, gene regulation drives cellular differentiation and morphogenesis in the embryo, leading to the creation of different cell types that possess different gene expression profiles from the same genome sequence. (wikipedia.org)
  • Lon protease binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription. (wikipedia.org)
  • Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). (wikipedia.org)
  • This fact suggests that genome-size reduction could give advantages for flying animals, such as rapid gene-expression regulation, which is required in powered flight. (wikipedia.org)
  • The presence of functional restrictions in genome self-regulation can be studied by comparing the genomes of species whose last common ancestor is more ancient. (wikipedia.org)
  • RGD is responsible for attaching biological information to the rat genome via structured vocabulary, or ontology, annotations assigned to genes and quantitative trait loci (QTL), and for consolidating rat strain data and making it available to the research community. (wikipedia.org)
  • In addition, the site imports GO annotations for mouse and human genes from the GO Consortium, rat electronic annotations from UniProt and mouse phenotype annotations from the Mouse Genome Database/Mouse Genome Informatics (MGD/MGI). (wikipedia.org)
  • pathways
  • Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways , respond to environmental stimuli, or adapt to new food sources. (wikipedia.org)
  • After being produced, the stability and distribution of the different transcripts is regulated (post-transcriptional regulation) by means of RNA binding protein (RBP) that control the various steps and rates cripts: events such as alternative splicing, nuclear degradation (exosome), processing, nuclear export (three alternative pathways), sequestration in P-bodies for storage or degradation and ultimately translation. (wikipedia.org)
  • After costimulation from CD28 the optimal activation of expression of IL-2 and these pathways is induced. (wikipedia.org)
  • RGD curators review the literature and manually curate GO, diseases, phenotypes and pathways for rat genes, diseases and pathways for mouse genes, and diseases, phenotypes and pathways for human genes. (wikipedia.org)
  • Introns
  • Although introns are sometimes called intervening sequences, the term "intervening sequence" can refer to any of several families of internal nucleic acid sequences that are not present in the final gene product, including inteins, untranslated sequences (UTR), and nucleotides removed by RNA editing, in addition to introns. (wikipedia.org)
  • Introns are now known to occur within a wide variety of genes throughout organisms and viruses within all of the biological kingdoms. (wikipedia.org)
  • The fact that genes were split or interrupted by introns was discovered independently in 1977 by Phillip Allen Sharp and Richard J. Roberts, for which they shared the Nobel Prize in Physiology or Medicine in 1993. (wikipedia.org)
  • transcripts
  • The term intron refers to both the DNA sequence within a gene and the corresponding sequence in RNA transcripts. (wikipedia.org)
  • While RT-PCR is used to qualitatively detect gene expression through creation of complementary DNA (cDNA) transcripts from RNA, qPCR is used to quantitatively measure the amplification of DNA using fluorescent dyes. (wikipedia.org)
  • transcript
  • In order to determine the functionality of certain AMOs, the AMO/miRNA binding expression (transcript concentration) must be measured against the expressions of the isolated miRNA. (wikipedia.org)
  • Data imported during this process includes the Gene ID, Genbank/RefSeq nucleotide and protein sequence identifiers, HomoloGene group IDs and Ensembl Gene, Transcript and Protein IDs. (wikipedia.org)
  • upstream
  • A region a few hundred nucleotides 'upstream' of the gene (toward the 5' end). (le.ac.uk)
  • For instance, the blood disorder Beta thalassemia is inherited and caused by mutations within the upstream of the β-globin gene. (wikipedia.org)
  • Drosophila
  • For Drosophila RBPs associated with splicing or nonsense mediated decay, analyses of protein-protein and protein-RNA interaction profiles have revealed ubiquitous interactions with RNA and protein products of the same gene. (wikipedia.org)
  • citation needed] A particularly extreme case is the Drosophila dhc7 gene containing a ≥3.6 Mb intron, which takes roughly three days to transcribe. (wikipedia.org)
  • inhibition
  • Enzyme inhibition can refer to the inhibition of the expression of the enzyme by another molecule interference at the enzyme-level, basically with how the enzyme works. (wikipedia.org)
  • humans
  • Lon protease homolog, mitochondrial is an enzyme that in humans is encoded by the LONP1 gene. (wikipedia.org)
  • citation needed
  • citation needed] Regulation of transcription thus controls when transcription occurs and how much RNA is created. (wikipedia.org)
  • citation needed] Junctional diversity includes the process of somatic recombination or V(D)J recombination, during which the different variable gene segments (those segments involved in antigen recognition) of TCRs and immunoglobulins are rearranged and unused segments removed. (wikipedia.org)
  • human
  • Given the crucial role of LON protease in maintaining the control of mitochondrial function, its dynamics in expression under stress conditions has been found associating with human diseases and aging. (wikipedia.org)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • diseases
  • This volume presents a didactic approach to the understanding of the basic processes of gene expression and their involvement in certain brain diseases, such asAlzheimer's disease and schizophrenia. (springer.com)
  • occurs
  • These interactions, within the body between miRNA and AMOs, can be for therapeutics in disorders in which over/under expression occurs or aberrations in miRNA lead to coding issues. (wikipedia.org)