• Each of these three categories is dominated by groups of genes where all transcript levels increase and/or decrease at similar times, suggesting a common mode of regulation. (nih.gov)
  • Together these findings extend the complexity of regulation and function of Hox genes in C. elegans and demonstrate the importance of their tissue-specific expression for correct development and response to infection. (ox.ac.uk)
  • While BRCA2 expression is involved in cell cycle checkpoints and DNA repair, the mechanisms of cell cycle-dependent regulation of BRCA2 gene expression remains elusive. (biomedcentral.com)
  • No apparent role for the Wari insulator in transcriptional regulation of the endogenous white gene of Drosophila melanogaster. (unibas.ch)
  • Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
  • Expression complexity of the Otx2 locus: transcriptional, post-transcriptional and translational regulation of Otx2 mRNA isoforms control specification and maintenance of forebrain and midbrain regional identities. (cnr.it)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl.de)
  • The comparative expression analysis of Ms4 and Ms4_homologs across the soybean developmental and reproductive stages showed significantly higher expression of Ms4 in early flowering (flower bud differentiation) stage than its homolog. (biomedcentral.com)
  • Throughout this paper I will detail the early career of Dr. Nusslein-Volhard and the ways in which her research helped to revolutionize the field of developmental biology as it pertains to embryonic development and gene analysis/function. (wepapers.com)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)
  • One of the most enduring concepts in the field of developmental biology is the idea that expression gradients contain multiple thresholds that control and position different cell fates. (nyu.edu)
  • One-third of the 471 genes predicted to encode transcription factors are differentially expressed during sexual development of S. commune . (nature.com)
  • Members of the Hox gene family encode transcription factors that specify positional identity along the anterior-posterior axis of nearly all metazoans. (ox.ac.uk)
  • Homeobox genes that encode transcription factors play important roles in development and differentiation of both plant and animal systems. (elsevierpure.com)
  • Most of these genes encode transcription factors that are expressed in bands or stripes at specific positions along the anterior posterior axis. (nyu.edu)
  • The EMX2 gene encodes for a transcription factor that is a homolog to Drosophila melanogaster "empty spiracles" gene. (wikipedia.org)
  • We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. (ntnu.edu.tw)
  • Comparative analyses of its 38.5-megabase genome, which encodes 13,210 predicted genes, reveal the species's unique wood-degrading machinery. (nature.com)
  • From a cDNA library of 3-day after-pollination (DAP) rice embryos we cloned a HAZ1 cDNA that encodes a protein with a PHD-finger domain and a homeodomain. (elsevierpure.com)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
  • We have isolated a murine cDNA encoding a 9-kD protein, Chisel (Csl), in a screen for transcriptional targets of the cardiac homeodomain factor Nkx2-5. (ox.ac.uk)
  • While extensive work has emphasized the importance of the HIF-1 alpha transcription factor on controlling hypoxia gene expression, less is known about other transcriptional mechanisms. (thegallolab.com)
  • The Engrailed homeodomain protein is an 'active' or dominant transcriptional repressor in cultured cells. (biologists.com)
  • The current examine focuses on the definition of the minimal transcriptional regulatory area of this gene in HeLa cells and the mechanism(s) underlying the lack of PCFT expression within the methotrexate-resistant HeLa R1-11 cell line. (inacj.com)
  • and +96 bases from the transcriptional begin web site utilizing a luciferase-reporter gene system. (inacj.com)
  • Hypermethylation at CpG websites inside the minimal transcriptional regulatory area was proven in HeLa R1-11 cells as in contrast with the parental PCFT-competent HeLa cells, utilizing bisulfite conversion and sequence evaluation. (inacj.com)
  • This protein belongs to the rel proto-oncogene and NF-KB transcriptional factor family and acts by controlling zygotic gene expression. (silverchair.com)
  • As master transcriptional regulators, Hox proteins recognize DNA through the homeodomain (HD) and interact with a multitude of proteins, including general transcription factors and other cofactors. (biomedcentral.com)
  • HD binding specificity increases by protein-protein interactions with a diversity of cofactors that outline the Hox interactome and determine the transcriptional landscape of the selected target genes. (biomedcentral.com)
  • The mutations of BRCA2 gene predispose the cells towards neoplastic development. (biomedcentral.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
  • Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
  • [ 3 ] Loss of function mutations in this gene are implicated in pediatric retinoblastoma. (medscape.com)
  • We report that boz mutations disrupt the homeobox gene dharma. (zfin.org)
  • By applying conservative filtering criteria and requiring 'sharp' transcript changes, we identified 1534 maternal genes, 792 transient zygotic genes, and 1053 genes whose transcript levels increase during embryogenesis. (nih.gov)
  • twist is one of the first zygotic genes necessary for mesoderm formation. (silverchair.com)
  • Genetic analysis of early development in the Drosophila embryo has revealed that embryonic pattern formation depends on both maternal and zygotic genes. (silverchair.com)
  • These studies provide genetic evidence for an essential function of a homeodomain protein in ß-catenin-mediated induction of the dorsal gastrula organizer and place boz at the top of a hierarchy of zygotic genes specifying the dorsal midline of a vertebrate embryo. (zfin.org)
  • At 4 and 5 DAPs, the expression of HAZ1 was concentrated at the ventral part of an embryo. (elsevierpure.com)
  • Maternal genes involved in dorsoventral (D/V) patterning of the Drosophila embryo interact to establish a stable nuclear concentration gradient of the Dorsal protein which acts as the morphogen along this axis. (silverchair.com)
  • In the ventral part of the embryo, dorsal specifically activates transcription of the gene twist and ventrally and laterally dorsal represses the expression of zerkn üllt , a gene involved in the formation of dorsal derivatives. (silverchair.com)
  • Hox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine the embryo body plan. (biomedcentral.com)
  • Bicoid is a homeodomain-containing transcription factor that is expressed in a long-range anterior gradient in the early embryo (Figure 2). (nyu.edu)
  • Here, we have defined a set of genes that help to understand the molecular mechanisms controlling reproduction in eels. (biomedcentral.com)
  • Molecular characterization of the male sterility genes will be the key to establish a sterility system for commercial application in hybrid seed production. (biomedcentral.com)
  • The molecular mass of the expressed protein was identical to that predicted by the cDNA sequence. (gc.ca)
  • Overall, when she began working in this lab with Wieschaus she discovered new ways of working on recombinant DNA and molecular biology with the focus to clone developmentally interesting genes. (wepapers.com)
  • Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals. (nih.gov)
  • This plethora of Hox protein-protein interactions clearly points to a Hox-driven transcription process in which every Hox homeoprotein could selectively recruit GTFs to achieve specificity and activate or repress target genes during Drosophila development, although the precise molecular mechanisms remain elusive [ 25 ]. (biomedcentral.com)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
  • Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. (nih.gov)
  • In this study, 23 HD-Zip genes distributed on 6 chromosomes were identified from the peach ( Prunus persica ) genome, and named PpHDZ01-23 according to their positions on the chromosomes. (biomedcentral.com)
  • These novel interactions open the possibility to analyze promoter function and gene expression to measure transcription factor binding dynamics at target sites throughout the genome. (biomedcentral.com)
  • The homeobox transcription factor HOXC13 upregulates human papillomavirus E1 gene expression and contributes to viral genome maintenance. (nih.gov)
  • The ms4 locus was fine mapped to a 216 kb region, which contains 23 protein-coding genes including Glyma.02G243200 , an ortholog of Arabidopsis MALE MEIOCYTE DEATH 1 ( MMD1 ), which is a Plant Homeodomain (PHD) protein involved in male fertility. (biomedcentral.com)
  • The reverse activity transcribes the ZAR2 mRNA with 966 nt coding sequence which codes for a 321 amino acid protein. (biomedcentral.com)
  • We also found that hypoxia suppresses the expression of genes involved in ribosome synthesis and egg production, and we showed that hypoxia suppresses tRNA synthesis and mRNA translation and reduces female fecundity. (thegallolab.com)
  • The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. (homeodomains.com)
  • NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. (homeodomains.com)
  • How Gene Expression (mRNA and protein synthesis) is spatially controlled in embryos. (albertkharris.com)
  • Therapy with 5-aza-2′-deoxycytidine resulted in a considerable restoration of transport and PCFT mRNA expression and small however vital decreases in methylation within the promoter area. (inacj.com)
  • Identification and characterization of a stable male sterility gene will be highly beneficial for making hybrid seed production economically feasible. (biomedcentral.com)
  • Characterization of male sterility genes may facilitate the establishment of a stable male sterility system, highly desired for the viability of hybrid seed production in soybean. (biomedcentral.com)
  • Isolation and characterization of alternative messenger RNAs coding class I HLA genes. (cnr.it)
  • In humans, EMX2 shows high expression in the dorsal telencephalon, olfactory neuroepithelium, as well as the urogenital system. (wikipedia.org)
  • We describe a novel gene, mirror (mrr), which is expressed in the dorsal half of the eye and plays a key role in forming the equator. (nih.gov)
  • However, she had a breakthrough discovering a second gene that seemed to influence pattern formation in the embryos of flies, a gene later called dorsal. (wepapers.com)
  • The extent of dorsal action is closely related to the affinity and the number of dorsal response elements present in these zygotic gene promoters. (silverchair.com)
  • Each gene in the dorsal group displays a complete dorsalization as the lack-of-function phenotype: only elements that normally derive from the dorsalmost region of the egg are formed, while ventral and lateral elements are lacking ( Nüsslein-Volhard, 1979 ). (silverchair.com)
  • PHTF, a novel atypical homeobox gene on chromosome 1p13, is evolutionarily conserved. (nih.gov)
  • This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. (nih.gov)
  • In contrast, the Fushi Tarazu homeodomain protein is an activator, both in cultured cells and in Drosophila embryos, where it activates several known target genes, including its own gene. (biologists.com)
  • Normal Fushi Tarazu target genes are affected as they are in fushi tarazu mutants. (biologists.com)
  • In our first experiments, we have used genetic experiments to flatten the Bcd gradient, and then measured the amounts of Bcd required for activating specific target genes. (nyu.edu)
  • Surprisingly, we have found that all tested target genes can be activated by lower concentrations than those present in the wild type gradient where boundaries for those genes are formed. (nyu.edu)
  • Previous studies and our recent work have identified more than 50 target genes that are directly activated by Bicoid. (nyu.edu)
  • These enhancers direct expression patterns at different positions along the anterior posterior axis (Figure 3), and a major goal is to understand the cis-regulatory logic that controls the differential positioning of different target genes. (nyu.edu)
  • First, we use bio-informatics methods and published ChIP-Chip data to identify all clusters of Bicoid-binding sites that are similar to those in the known target genes. (nyu.edu)
  • Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
  • In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons, in part by repressing interneuron-specific gene expression. (jneurosci.org)
  • On the basis of recent vertebrate studies, the HB9/MNR2 gene family is a prime candidate for a general determinant of somatic motoneuron cell type. (jneurosci.org)
  • Thus, vertebrate HB9/MNR2 genes are expressed specifically in somatic motoneurons and are essential for distinguishing motoneuron/interneuron cell types. (jneurosci.org)
  • Names are often "whimsical" - mutants with no hearts might be called "Heartless", but the name "Tinman" (from The Wizard of Oz) was chosen for one of the best-characterized genes that can be mutated to produce embryos that fail to develop a heart. (albertkharris.com)
  • Expression analysis of several Hox genes in human embryos. (cnr.it)
  • Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
  • This gene belongs to the homeobox family of genes. (nih.gov)
  • It recognizes ATC sequences that consist of stretches of A's, T's, and C's on one DNA strand. (bdbiosciences.com)
  • Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals. (cnr.it)
  • Our understanding of the landscape of pediatric cancer genomics has improved markedly in the past 20 years with the advent of next generation sequencing and other high throughput genetic sequencing. (medscape.com)
  • It is the only mushroom-forming fungus for which genes have been inactivated by homologous recombination. (nature.com)
  • These gene sequences are conservative through evolution (for example have homologous sequences in flies and in vertebrates) although they don't necessarily have the same function. (albertkharris.com)
  • Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins. (bvsalud.org)
  • Using a false discovery rate of 0.05, a total of 1,497 differentially expressed genes were identified. (biomedcentral.com)
  • A derivative that lacks this domain, while it cannot repress the endogenous fushi tarazu gene, can still reduce the activity of the fushi tarazu autoregulatory enhancer, suggesting that it competes with endogenous Fushi Tarazu for binding sites in vivo. (biologists.com)
  • Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl-s. (ntnu.edu.tw)
  • Glucose and GLP-1 also synergistically activated NFAT (nuclear factor of activated T-cells)-mediated transcription from a minimal promoter construct containing tandem NFAT consensus sequences. (diabetesjournals.org)
  • Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. (nih.gov)
  • NFAT binds to three distinct NFAT elements within the rat I insulin promoter and activates insulin gene transcription. (diabetesjournals.org)
  • One pathway results from the direct effect of increased [Ca 2+ ] i , which activates calcineurin, and in turn, it upregulates insulin gene transcription via NFAT. (diabetesjournals.org)
  • Overall, this is the first report, where map based cloning approach was employed to isolate and characterize a gene responsible for the male-sterile phenotype in soybean. (biomedcentral.com)
  • Huanga W., Wei Xinga W., Ryskampa D.A., Punzo C ., Križaj D. Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains. (umassmed.edu)
  • Christiane began examining a cohort of flies that did not have the bicaudal gene, therefore she was able to determine all the other genes that were involved in the mutant bicaudal phenotype (Resnik 2012). (wepapers.com)
  • The WUSCHEL (WUS)-related homeobox (WOX) gene family coordinates transcription during the early phases of embryogenesis. (gc.ca)
  • BRCA2 gene promoter has bi-directional activity, expressing BRCA2 and a novel C4-type zinc finger containing transcription factor ZAR2. (biomedcentral.com)
  • Among the downregulated genes, we discovered that FOXO was required for suppression of many ribosomal protein genes and genes involved in oxidative phosphorylation, pointing to a role for FOXO in limiting energetically costly processes such as protein synthesis and mitochondrial activity upon hypoxic stress. (thegallolab.com)
  • Role of unequal crossing-over in the evolution of ribosomal genes. (cnr.it)
  • Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)
  • Križaj D., Huang W., Furukawa T., Punzo C., Xing W.P. Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina. (umassmed.edu)
  • Currently there is intense interest to define the mechanism of action of glucagon-like peptide-1 (GLP-1) in regulating β-cell function, including insulin gene transcription. (diabetesjournals.org)
  • In this study, GLP-1 (100 nmol/l), in the presence of glucose (11 mmol/l), induced a ∼71-fold increase in insulin gene promoter activity in INS-1 pancreatic β-cells, an effect that was an order of magnitude larger than with either stimulant alone. (diabetesjournals.org)
  • While studying the activity of BRCA2 gene promoter in breast cancer cells, we discovered that this promoter has bi-directional activity and the product of the reverse activity (a ZAR1-like protein, we named ZAR2) silences the forward promoter at the G0/G1 phase of the cell. (biomedcentral.com)
  • Standard techniques like cell synchronization by serum starvation, flow cytometry, N-terminal or C-terminal FLAG epitope-tagged protein expression, immunofluorescence confocal microscopy, dual luciferase assay for promoter evaluation, and chromatin immunoprecipitation assay were employed during this study. (biomedcentral.com)
  • Human BRCA2 gene promoter is active in both the forward and the reverse orientations. (biomedcentral.com)
  • In the G0/G1 growth phase ZAR2 is predominantly located inside the nucleus of the breast cells, binds to the BRCA2 promoter and inhibits the expression of BRCA2. (biomedcentral.com)
  • Subcellular location of ZAR2 and its expression from the reverse promoter of the BRCA2 gene are stringently regulated in a cell cycle dependent manner. (biomedcentral.com)
  • ZAR2 binds to BRCA2/ZAR2 bi-directional promoter in vivo and is responsible, at least in part, for the silencing of BRCA2 gene expression in the G0/G1 phase in human breast cells. (biomedcentral.com)
  • Taken collectively, promoter silencing via methylation and gene copy loss accounted for the lack of PCFT exercise in antifolate-resistant HeLa R1-11 cells. (inacj.com)
  • Activation of each target gene involves direct binding of Bicoid to one or more enhancers that appear as rather tightly linked clusters of Bicoid-binding sites. (nyu.edu)
  • In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
  • This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • The sequence consisted of 2045 bp, and contained an open reading frame (ORF), encoded 322 amino acids. (gc.ca)
  • The homeodomain domain is generally composed of about 60 amino acids encoded homeobox, which form three alpha helices. (biomedcentral.com)
  • mrr is similar to the Iroquois genes ara and caup and is located adjacent to them in this recently described homeotic cluster. (nih.gov)
  • NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.Peptides short amino acid chains or epitopes or blocking antagonists. (homeodomains.com)
  • This auto-activation has been shown to depend on targeting to a fushi tarazu enhancer by the Fushi Tarazu homeodomain. (biologists.com)
  • Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY, Kohwi-Shigematsu T. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. (bdbiosciences.com)
  • These twelve genes act in a complex way to establish the spatial coordinates of the D/V axis (for review see St Johnston and Nüsslein-Volhard, 1992 ). (silverchair.com)
  • Stacked bar graphs showing different patterns of enriched spatial expression based on RNA-seq of dissected gastrula tissues (Blitz et al. (xenbase.org)
  • To rigorously test this idea, we are carefully measuring the spatial relationships between potentially morphogenetic gradients and the positions of their target gene expression patterns. (nyu.edu)
  • Within the HIPK family, HIPK1 and HIPK2 are the most closely related members, sharing about 93% sequence identity in their kinase domains, while HIPK3 is slightly less conserved with 87% identity. (nature.com)
  • The most divergent member of the family is HIPK4, which shares only 50% sequence identity with the catalytic domains of the three other HIPKs. (nature.com)
  • In some cases, Sox17 and β-catenin synergistically activate transcription apparently independent of Tcfs, whereas on other enhancers, Sox17 represses β-catenin/Tcf-mediated transcription to spatially restrict gene expression domains. (xenbase.org)
  • Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl.de)
  • We've got studied this uncommon exon definition by making a assemble with the genomic fragment encompassing the entire gene from apoA-II and its regulatory areas. (inacj.com)
  • The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. (wikipedia.org)
  • For example, 34% of the transiently expressed genes fall into three groups, with increased transcript levels between 2.5-12, 11-20, and 15-20 h of development, respectively. (nih.gov)
  • The set of up-regulated genes includes genes involved in neuroendocrine processes, cell-cell signaling, neurogenesis and development. (biomedcentral.com)
  • The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum. (ox.ac.uk)
  • HD-Zips (Homeodomain-Leucine Zippers) are a class of plant-specific transcription factors that play multiple roles in plant growth and development. (biomedcentral.com)
  • Spatio-temporal expression pattern showed that these genes were expressed in many tissues with different levels, and they had distinct expression pattern during adventitious root formation and development. (biomedcentral.com)
  • The product of this gene may play a role in the development of hair, nail, and filiform papilla. (nih.gov)
  • Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
  • Combined expression analysis of Otx, Emx, Dlx and Otp during development and definition of brain segmentary identities. (cnr.it)
  • During lymphocyte development, the genes encoding immunoglobulins and T cell receptors are assembled from Variable (V), Diversity (D), and Joining (J) gene segments. (lu.se)
  • Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)
  • The Mnx homeobox gene class defined by HB9, MNR2 and amphioxus AmphiMnx. (ox.ac.uk)
  • In the chick, a related gene, MNR2, acts upstream of HB9 in this process. (ox.ac.uk)
  • Here we report an amphioxus homologue of these genes and show that it diverged before the gene duplication yielding HB9 and MNR2. (ox.ac.uk)
  • Here, we identify and characterize the single Drosophila ortholog of the HB9/MNR2 gene family. (jneurosci.org)
  • Interestingly, while genes involved in immune system function were down-regulated in the brains of mature males, changes in the expression levels of several receptors and channels were observed suggesting that some rewiring is occurring in the brain at sexual maturity. (biomedcentral.com)
  • Key genes are color coded based on regional expression from fate map in (E). (E) Enriched expression of Sox17 -regulated transcripts. (xenbase.org)
  • The functional complementation of Arabidopsis mmd1 mutant with the soybean Ms4 gene produced normal stamens, successful tetrad formation, fertile pollens and viable seeds, whereas the Ms4_homolog was not able to restore male fertility. (biomedcentral.com)