• Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
  • Senescence cells display a phenotype like increase of cell size, distinctive flat morphology, changes in gene expression and activity of senescence-associate ß-galactosidase (SA-ß-gal). (easylab.ae)
  • Senescent cells have been identified in the aging prostate, and the senescence-associated secretory phenotype might be linked to prostate cancer (PCa). (biomedcentral.com)
  • The features of the senescence phenotype usually consist of the activation of a chronic DNA damage response, the involvement of various cyclin-dependent kinase inhibitors, increased secretion of proinflammatory and tissue-remodeling factors, induction of antiapoptotic genes, altered metabolic rates, and endoplasmic reticulum stress [ 13 ]. (biomedcentral.com)
  • SnCs exhibit irreversible growth arrest accompanied by increased expression of cyclin-dependent kinase inhibitors (CDKi) such as p16 INK4a , and p21 Cip1 , accumulation of DNA damages, and secretion of diverse bioactive molecules known as the senescence-associated secretory phenotype (SASP). (aging-us.com)
  • Similarly, aging has long been known to be associated with the accumulation of mutations, leading to cellular dysfunction and, ultimately, to a senescent phenotype (Lee 2018). (ernolaszlo.com)
  • Nuclear DNA damage can contribute to aging either indirectly (by increasing apoptosis or cellular senescence) or directly (by increasing cell dysfunction). (wikipedia.org)
  • Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
  • The rationale of this Program Project is that spontaneous DMA damage drives major components of the aging process, through direct adverse effects, but more likely by inducing genome maintenance responses, resulting in senescence, apoptosis and/or genomic and epigenomic errors. (elsevierpure.com)
  • In fact, the previous work of Kazuko Nishikura, Ph.D., professor in the Gene Expression & Regulation Program at Wistar's Ellen and Ronald Caplan Cancer Center - and a pioneer in ADAR1 biology - showed that stressed cells utilize ADAR1 as protection from apoptosis, programmed cell death. (thincb2b.com)
  • As senescent cells are stressed cells and are resistant to apoptosis, the first question we set out to ask was whether ADAR1 is related to cellular senescence and secondly, how does it regulate senescence and what is its' potential implication in tissue aging. (thincb2b.com)
  • The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
  • RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF- κ B, hence alleviating infarction area, fibrosis, and cell apoptosis. (hindawi.com)
  • In in vitro experiment, RSV prevented hypoxia-induced NRCM senescence and apoptosis. (hindawi.com)
  • The p53-associated signaling pathway has been demonstrated to regulate hypoxia-induced apoptosis and senescence [ 5 ]. (hindawi.com)
  • The 'cancer platform' concept proposes that most oncogenic molecules also have the inherent ability to activate tumor suppressor genes or pathways through oncogene-induced apoptosis or senescence, thus limiting their oncogenic effects in a homeostatic fashion. (biomedcentral.com)
  • Loss of telomeres typically triggers cellular apoptosis in the process referred to as telomeric crisis. (biomedcentral.com)
  • Senescence Detection Kit is a Fast, Convenient & Easy-to-use kit that measures activity of SA-B-Gal in cells cultures by hydrolysis of X-gal, which results in the accumulation of a distinctive blue color in senescent cells. (easylab.ae)
  • Cellular senescence is one of the root causes of aging, and there are at present serious, well-funded efforts underway to produce rejuvenation therapies based on the selective destruction of senescent cells in old tissues. (fightaging.org)
  • Human tissue samples characterized and collected through the Biospecimen Core (BIO) will be analyzed using the tools and techniques developed through the Biological Analysis Core (BAC) and Data Analysis Core (DAC), leading to detailed maps of senescent cells and their effects on human tissues at single-cell resolution. (columbia.edu)
  • The ultimate goals of the BAC are to identify and validate a panel of robust senescence biomarkers for each cell type in our target tissues and their spatial context at the single-cell level and to assess the cell-autonomous and cell non-autonomous effects of senescent cells on the cellular composition and molecular signatures of the tissue microenvironment. (columbia.edu)
  • The Q-CABG study aims to explore the efficacy of quercetin to reduce inflammation, myocardial injury and senescence in patients undergoing CABG following an acute coronary syndrome. (frontiersin.org)
  • The primary endpoint examines the effects of quercetin on blood inflammatory cytokines and markers of myocardial injury and senescence in this patient population. (frontiersin.org)
  • For liver, a combination of whole liver gene expression analysis will be combined with laser capture microdissection for gene expression analysis for particular cellular components e.g. hepatocyte and biliary cells that can regenerate parenchyma when severe hepatocyte injury and senescence prevails. (mimah.org)
  • The current study investigated the role of dynamic methylation acting together with gene variants in an individual over time to gain insight into the evolving epigenome-genome interplay that affects biochemical pathways controlling physiological processes during aging. (fortuneonline.org)
  • These DEMs such as has-miR-1202 were mainly enriched in GO functions like histone acetyltransferase binding and KEGG pathways like cellular senescence. (biomedcentral.com)
  • Among the genes and pathways controlled by TET1, we found ribosomal biogenesis and translational control of protein synthesis highly enriched. (biomedcentral.com)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)
  • Oncogene activation is therefore generally only tumorigenic when it is coupled with inactivation or inhibition of oncogene-induced pro-apoptotic or senescence pathways [ 4 ]. (biomedcentral.com)
  • The specific effects that lead to inactivation of these pro-apoptotic or senescence pathways may impinge on major known tumor suppressors such as p53, but may also be due to effects on other genes and molecules within the p53 or other tumor suppressor pathways [ 5 ]. (biomedcentral.com)
  • Specific sessions will be dedicated to organelle evolution, their gene expression systems, the import of proteins and their assembly into functioning complexes, signaling pathways and stress response, disintegration of organelles during aging and senescence, and how all these are being translated to agriculture and medicine. (grc.org)
  • Chronic exposure to IL-1β induces only partial expression of senescence markers and does not allow us to conclude on its ability to induce senescence in chondrocytes. (aging-us.com)
  • They also found that downregulation of ADAR1 by a process called autophagy (the degradation and recycling of damaged or unneeded cell components) during senescence decreased the stability of SIRT1 mRNA, which in turn upregulated the translation of p16INK4a to induce senescence. (thincb2b.com)
  • Reversible epigenetic changes within the loci of genes that regulate critical cell processes have recently emerged as important biomarkers of disease pathology. (fortuneonline.org)
  • In addition to molecular and cellular factors, such as cellular senescence and telomere attrition, epigenetic changes that govern physiological processes comprise a significant component of the ageing process [2]. (fortuneonline.org)
  • In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
  • Methylation is a somewhat complex biochemical process in the body, the important thing to remember is that it is one of the ways epigenetic takes place and a process by which genes get turned on and off. (theepochtimes.com)
  • Epigenetic alterations, acting both independently and together with increasing mutational burden, genomic instability, and stem cell exhaustion, can influence gene expression in ways that promote aging (Saul 2021). (ernolaszlo.com)
  • Recent data show that these extrinsic environmental factors synergize with intrinsic age-related changes to influence epigenetic regulation of gene expression, ultimately contributing to the visible-and invisible-signs of skin aging (Chevalier 2019). (ernolaszlo.com)
  • Subsequent sections focus on the epigenetic regulation of gene expression and its relevance to skin aging. (ernolaszlo.com)
  • However, the detailed mechanisms phenomenon remains unclear. (bvsalud.org)
  • In the present review, we will focus on the role of cellular senescence and its related mechanisms in DN. (hindawi.com)
  • This pitfall may be due to the lack of understanding of the mechanisms underlying chondrocyte senescence. (aging-us.com)
  • Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. (harvard.edu)
  • We compared microRNA expression patterns in three cisplatin resistant sublines derived from paternal cisplatin sensitive germ cell tumor cell lines in order to improve our understanding of the mechanisms of cisplatin resistance. (biomedcentral.com)
  • Cellular senescence is one of the main mechanisms involved [ 5 , 6 ]. (hindawi.com)
  • This suggests that additional mechanisms must be acting to reduce expression of their remaining copy of the gene. (elifesciences.org)
  • this process often begins with mutations that inactivate normal cellular mechanisms for monitoring the fidelity of DNA replication, resulting in the rapid accumulation of mutations in genes involved in controlling the growth and death of cells. (ernolaszlo.com)
  • Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)
  • miR-1202 may regulate OA development via histone acetyltransferase pathway binding function and cellular senescence pathway. (biomedcentral.com)
  • Intriguingly, the team discovered that ADAR1 loss promotes p16INK4a expression through SIRT1, another protein known to regulate both senescence and tissue aging. (thincb2b.com)
  • Given this, it should not be a surprise to find that cellular senescence can be implicated in the way in which visceral fat accelerates aging: their presence in visceral fat tissue and the immune cells interacting with that tissue fits right in with the broader picture of inflammation and bad cellular behavior. (fightaging.org)
  • In a research paper published today in Nature Cell Biology , Rugang Zhang, Ph.D., deputy director of the Ellen and Ronald Caplan Cancer Center, Christopher M. Davis Endowed Professor, and program leader of the Immunology, Microenvironment & Metastasis Program, at The Wistar Institute, and his team revealed a novel ADAR1-SIRT1-p16INK4a axis in regulating cellular senescence and its potential implications in tissue aging. (thincb2b.com)
  • Understanding the basic mechanism underlying tissue aging is challenging and cellular senescence offers an angle into the complex biology that drives tissue aging. (thincb2b.com)
  • These mechanistic insights gained by studying senescence regulation during tissue aging can in turn be used to promote healthy aging and combat age-associated disorders. (thincb2b.com)
  • Central to this quest is a protein called p16INK4a because its expression both increases during tissue aging and it drives senescence. (thincb2b.com)
  • Zhang says, "Our study starts to reveal the missing link between ADAR1 and tissue aging through p16INK4a expression during senescence. (thincb2b.com)
  • One of the ways to potentially restore ADAR1 expression as a means to suppress p16INK4a and senescence observed during tissue aging is by inhibiting autophagy. (thincb2b.com)
  • In ischemic heart tissue, senescence-associated β -galactosidase (SA- β -gal) activity and proteins (such as p16, p19, and p53) are significantly upregulated [ 6 ]. (hindawi.com)
  • He uses a widely interdisciplinary approach ranging from dissection of biophysical regulation of gene expression to molecular control of pathology setting, epigenetics, classical tissue engineering models and so on. (edu.sa)
  • The Columbia University Senescence Tissue Mapping (CUSTMAP) Center comprises three scientific cores, which work together with the help of an Administrative Core. (columbia.edu)
  • The Data Analysis Core (DAC) is led by Vilas Menon, Ph.D., and plays a key role in all aspects of data processing and analysis, tissue mapping, and identification of markers of senescence, as well as data harmonization, coordination, and dissemination through the SenNet Consortium Data Coordination Center (CODCC). (columbia.edu)
  • These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
  • The term "epigenetics" was initially defined by Conrad Waddington in the 1940s, but in the modern context, it was formally defined in the 1990s by Wolffe and Matzkeset as "the study of heritable changes in gene expression that occur without a change in DNA sequence" (Alokail 2015). (ernolaszlo.com)
  • The last stage of leaf development in which the leaf cells undergo an ordered process of disassembly of organelles and changes in gene expression and metabolism. (bvsalud.org)
  • We found that cellular senescence and tumor regression upon MYC inactivation in T-ALL was associated with genome-wide changes in 5mC and 5hmC patterns. (biomedcentral.com)
  • Knockdown of TET1 or ectopic expression of TET2 in T-ALL was associated with genome-wide changes in 5mC and 5hmC enrichment and decreased cell proliferation, suggesting a tumor promoting function of TET1, and a tumor suppressing role for TET2. (biomedcentral.com)
  • Our finding that MYC directly deregulates the expression of TET1 and TET2 in T-ALL provides novel evidence that MYC controls DNA (hydroxy)methylation in a genome-wide fashion. (biomedcentral.com)
  • The long-term objectives of Project 2 are to test the hypothesis that somatic DMA alterations, including genome rearrangements and epigenomic changes, causally contribute to aging by gradually dysregulating gene expression leading to cell functional decline and degeneration and eventually to age-related pathologies, including but not limited to cancer. (elsevierpure.com)
  • In Specific Aim 2 we will further study DMA double-strand breaks, as a potentially important intermediate in generating genome instability, dysregulated gene expression and cellular senescence in mouse and human primary fibroblast cultures (with projects 3, 4 and 5). (elsevierpure.com)
  • Successful pursuit of these Specific Aims should provide new insight into the role of genome maintenance as a determinant of aging, with a focus on the relationships among various molecular and cellular end points. (elsevierpure.com)
  • Gene set enrichment analysis (GSEA) is a method for analyzing microarray data of whole genome expression profiles, which compare genes with predefined gene sets. (biomedcentral.com)
  • Setting aside sporadic mutations, every somatic cell in the body contains an identical genome with an identical complement of genes, each of which encodes a specific protein. (ernolaszlo.com)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • This effect on longevity is apparently correlated with the midgut senescence phenotypes as a result of direct hormone action through both hormone receptors expressed in the enteroblasts or other midgut cell types. (bioone.org)
  • Furthermore, these senescence phenotypes appear to be independent of insulin signaling and manifest in an organ-specific manner. (bioone.org)
  • The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. (nih.gov)
  • If a cell retains DNA damage, transcription of a gene can be prevented and thus translation into a protein will also be blocked. (wikipedia.org)
  • At the cellular level, mutations can cause alterations in protein function and regulation. (wikipedia.org)
  • A rise in the levels of the p53 protein induces the expression of p21 cyclin-dependent kinase inhibitor. (reactome.org)
  • The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Upon aging, persistent NF-κB signaling promotes WMD in these mice as ultrastructural analysis revealed myelination deficits in the corpus callosum accompanied by impaired myelin protein expression. (biomedcentral.com)
  • It is important to have a fundamental understanding of how information flows from gene to protein to understand the role of epigenetics in aging. (ernolaszlo.com)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • Human population studies show that single-nucleotide polymorphisms in DNA repair genes, causing up-regulation of their expression, correlate with increases in longevity. (wikipedia.org)
  • This Collection showcases recent articles covering cellular to systemic metabolic regulation. (nature.com)
  • However, gut senescence does not appear to be the direct cause for longevity regulation, as knockdown of both hormone receptors did not affect adult lifespan. (bioone.org)
  • On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)
  • Considering the role of cellular senescence in age-related diseases including OA, the therapeutic potential of senolytic (drugs that induced SnCs death) and senomorphic (drugs that modulate the SASP) compounds have been contemplated with growing interest [ 15 ]. (aging-us.com)
  • RNA-Seq analysis of primary oligodendrocytes and microglia cells uncovers gene expression signatures associated with activated stress responses and increased post mitotic cellular senescence (PoMiCS) which was confirmed by elevated senescence-associated β-galactosidase activity and SASP gene expression profile. (biomedcentral.com)
  • This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. (nih.gov)
  • The gene, which is called MYBL2 , encodes a transcription factor that helps to control the cell division cycle. (elifesciences.org)
  • A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
  • The hsa-miR-371-373 cluster (counteracting cellular senescence and linked with differentiation potency), as well as hsa-miR-520c/-520h (inhibiting the tumor suppressor p21) were 3.9-16.3 fold up-regulated in two of the three cisplatin resistant cell lines. (biomedcentral.com)
  • Differentiation subsequently occurs in leaf primordia basipetally, resulting in a gradient of easily distinguishable cellular morphologies of distal differentiated cells towards the tip of the leaf, basal progenitor proliferating cells adjacent to the shoot apical meristem, and all possible intermediate stages in between. (biomedcentral.com)
  • This study aimed to explore the molecular mechanism of osteoarthritis (OA) and provide information about new genes as potential targets for OA treatment. (biomedcentral.com)
  • The cellular and molecular features of the epithelial cells in the liver will be characterised and the non-parenchymal cells that help stimulate, control and impede regeneration will also be studied. (mimah.org)
  • Shirin Bahmanyar is an associate professor of molecular, cellular & developmental biology at Yale University, CT, USA. (nature.com)
  • Failure to execute these regulatory responses causes cell damage and inflammation or senescence, compromising cell survival and the ability to adapt to energetically demanding conditions. (nature.com)
  • Here, we report that in T cell acute lymphoblastic leukemia (T-ALL) the MYC oncogene controls the expression of TET1 and TET2 to maintain 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) patterns, which is associated with tumor cell-specific gene expression. (biomedcentral.com)
  • A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
  • Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. (aging-us.com)
  • Then, they experimentally altered ADAR1 expression in multiple cell types in petri-dish and mouse tissues to establish ADAR1 as a critical regulator of p16INK4a expression. (thincb2b.com)
  • Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
  • In June 2023, the International Society for Stem Cell Research (ISSCR) released a report detailing standards for human stem cell research . (nature.com)
  • However, cell types are differentiated by their program of gene expression. (ernolaszlo.com)
  • Thus, gene expression must be tightly regulated so that only appropriate genes are expressed in a particular cell type. (ernolaszlo.com)
  • This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
  • utilizes a combination of high-resolution comparative genomic hybridization, short hairpin RNA inhibition of target genes at the locations of focal genomic deletions, and a primed cell mosaic mouse model to identify novel tumor suppressors in hepatocellular carcinoma. (biomedcentral.com)
  • Taking advantage of the developmental gradient in the bread wheat leaf, we provide a simultaneous quantitative analysis for the development of mesophyll cells and of chloroplasts as a cellular compartment. (biomedcentral.com)
  • The second phase is marked by the development of photosynthetic chloroplasts which occupy the available cellular space. (biomedcentral.com)
  • Understanding the build-up of photosynthetic capacity requires detailed knowledge of how these cells, and chloroplasts within, are produced and develop. (biomedcentral.com)
  • Mitochondria and chloroplasts differ from other cellular compartments by their endosymbiotic origin, their semiautonomous genetic systems, their role in energy transduction, and their complex biology. (grc.org)
  • Freitas and de Magalhães presented a comprehensive review and appraisal of the DNA damage theory of aging, including a detailed analysis of many forms of evidence linking DNA damage to aging. (wikipedia.org)
  • Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)
  • If aging is not a stochastic process of attrition but is centrally orchestrated, it is reasonable to suspect that the timing of senescence is also influenced by one or more biological clocks. (karger.com)
  • Biological ages can be estimated by using the methylation profiles of aging-related genes. (theepochtimes.com)
  • In other words, scientists can focus on genes linked to aging and then look at how those genes are methylating and from this gauge how far along the person is in that process of degeneration and death. (theepochtimes.com)
  • I think that declaring cellular senescence to be the causal nexus of aging , as one research group did, is going overboard a little, as there are, after all, other independent causes of aging , forms of metabolic waste and damage that would cause death and disease even if cellular senescence did not exist. (fightaging.org)
  • Nonetheless, it is gratify to watch the spreading realization that cellular senescence plays a role in many areas of health and biology associated with aging. (fightaging.org)
  • Cellular senescence has been described as one of the major drivers of aging [ 6 ] and has been implicated in the pathogenesis of many age-related diseases [ 7 ]. (aging-us.com)
  • To better understand how senescence is regulated is of high significance to promote healthy aging and treat age-associated disorders. (thincb2b.com)
  • Thus, approaches that prevent age-associated increase in p16INK4a expression may have important implications in designing intervention strategies to promote healthy aging. (thincb2b.com)
  • For example, what is the relative contribution of this mechanism to p16INK4a expression during aging of different tissues? (thincb2b.com)
  • I think, we've seen several hints that the cellular machinery of life is far more powerful and versatile than most believed, it certainly doesn't seem like something that would just decay, Multi-celled organisms seem quite capable of faithfully preserving their genes(even after going through aging several times, third gen clones) and seems to have vast innate regeneration potential. (fightaging.org)
  • Thus, we established a cellular senescence-related gene prognostic index (CSGPI) to predict metastasis and radioresistance in PCa. (biomedcentral.com)
  • In view of this, we developed and validated a cellular senescence-related gene prognostic index (CSGPI) to predict metastasis and tumor radioresistance and explored the related changes in the tumor immune microenvironment (TME) for PCa patients undergoing radical radiotherapy. (biomedcentral.com)
  • The bioinformatics method was used to investigate the expression patterns and prognostic value of MYST HATs. (biomedcentral.com)
  • To date, the significance of the expression of MYST HATs in relation to the clinicopathological and prognostic variables of patients with KIRC has not yet been fully revealed. (biomedcentral.com)
  • Our findings demonstrate an essential role of IKK/NF-κB signaling in mature, post-mitotic OLs in regulating stress-induced senescence in these cells. (biomedcentral.com)
  • Consequently, MYC inactivation led to an inverse expression pattern, decreasing TET1 , while increasing TET2 levels. (biomedcentral.com)
  • p21 and other tumor suppressor genes' inactivation are therefore most likely involved in the first steps of the cancer model, with later stages possibly involving protooncogene activation and inflammation. (medscape.com)
  • Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. (nih.gov)
  • Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. (nih.gov)
  • This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. (aging-us.com)
  • One technique that is garnering wide attention in this realm is the DNA array, in which a number of different genes from an individual can be processed to look at certain genotypes. (medscape.com)
  • These different genes produce pheochromocytomas with different ages of onset, secretory profiles, locations, and potential for malignancy. (medscape.com)
  • The exons 1, 2, 6, and 8 were the most common locations of gene variants, accounting for 78% of all variants, which will be promising targets of DNA sequencing for primary hyperoxaluria type 1. (bvsalud.org)
  • A fraction of the gene variants (242/24948) occurred within the CpG regions that were differentially methylated, with 67/247 exactly coincident with a CpG site. (fortuneonline.org)
  • Our analysis yielded a critical cluster of 10 genes that were each significantly methylated and had variants at the CpG site or the ±4 bp CpG region window. (fortuneonline.org)
  • Hao elaborates, "Our study revealed a novel ADAR1-SIRT1- p16 INK4a axis that plays an important role in cellular senescence at translational level, and this newly defined function of ADAR1 is independent of its RNA editing function. (thincb2b.com)
  • Successful translational research has allowed gene therapy trials to proceed. (medscape.com)
  • A previous bioinformatics analysis indicates that lncRNAs (such as uc.343) and predicted target homeobox gene C8 ( HOXC8 ) are promising therapeutic targets for OA [ 10 ]. (biomedcentral.com)
  • Furthermore, we will explore the potential therapeutic targets of cellular senescence and provide important clues for clinical strategies in the management of DN. (hindawi.com)
  • Etoposide-induced senescence model may help investigate the initiation of cellular senescence in chondrocytes, and provide a useful model to develop therapeutic approaches to target senescence in OA. (aging-us.com)
  • This approach will be further developed in the ISAIAH study where paired biopsy analysis will provide detailed transcriptional response patterns to therapeutic interventions. (mimah.org)
  • Methylation signatures specifically influence gene expression without altering the DNA sequence, connecting intrinsic and extrinsic signals. (fortuneonline.org)
  • Specifically, one common type of gene switch-DNA methylation-can change the expression of genes, shutting them down and making them non-functional. (theepochtimes.com)
  • As a result of DNA methylation, there are variations in whether the same genes can be expressed in different organs and at different ages, and the amount of expression. (theepochtimes.com)
  • It represents tumor suppressor mechanism for this reason cellular senescence has become an increasingly target in the development of novel therapeutics. (easylab.ae)
  • METHODS: The mRNA expression profiling dataset GSE37171 was taken from the Gene Expression Omnibus (GEO) database. (bvsalud.org)
  • The secondary endpoint is the assessment of endothelial (dys) function by looking at ex vivo vascular reactivity and mRNA expression of endothelial cells from the wall of discarded segments of internal mammary artery. (frontiersin.org)
  • The developmental gradient in monocot leaves has been exploited to uncover leaf developmental gene expression programs and chloroplast biogenesis processes. (biomedcentral.com)
  • The expression levels of KAT6A , KAT6B and KAT7 had significant positive correlations with cancer immune infiltrates such as B cells, CD4 + T cells and CD8 + T cells. (biomedcentral.com)
  • This allows us to generate the first biologically-informed gene expression map of this leaf, with the entire developmental gradient from meristematic to fully differentiated cells captured. (biomedcentral.com)
  • By 6 months post-transplantation, the reconstituted mice had developed a clonal myeloproliferative/myelodysplastic disorder originating from the cells with aberrantly reduced Mybl2 expression. (elifesciences.org)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • Because a specific marker for cellular senescence has yet to be identified, a combination of markers should be used to identify SnCs [ 14 ]. (aging-us.com)
  • Database of human genes associated with cellular senescence. (senescence.info)
  • Genes in the human body do not usually change after birth. (theepochtimes.com)
  • Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)
  • The team first examined the expression of ADAR1 in vitro in human fibroblasts and in vivo in multiple tissues from young and aged mice. (thincb2b.com)
  • Examining almost all known human micro-RNA species confirmed the miR-371-373 cluster as a promising target for explaining cisplatin resistance, potentially by counteracting wild-type P53 induced senescence or linking it with the potency to differentiate. (biomedcentral.com)
  • pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)
  • The lncRNA H19 is the first imprinted gene, which is expressed in the embryo and down-regulated at birth, and its role in tumors has long been a subject of controversy, however, in recent years, it has received increasing attention in kidney disease. (bvsalud.org)
  • BACKGROUND: Cellular senescence plays an essential role in the development and progression of end-stage renal disease (ESRD). (bvsalud.org)
  • Recently, the emerging role of cellular senescence in DN has attracted a broad attention. (hindawi.com)
  • Hence, this finding reveals a more general role for MYBL2 as it indicates that more patients are likely to be affected by altered expression of this gene. (elifesciences.org)
  • Although pheochromocytomas have classically been associated with 3 syndromes-von Hippel-Lindau (VHL) syndrome, multiple endocrine neoplasia type 2 (MEN 2), and neurofibromatosis type 1 (NF1)-there are now 10 genes that have been identified as sites of mutations leading to these tumors. (medscape.com)
  • In addition, higher expression of CD226 significantly increased the risk of metastasis (HR: 3.65, 95% CI 1.58-8.42, p = 0.006). (biomedcentral.com)
  • While the many functions of MYC were first attributed to its ability to both activate and repress transcription of a large number of genes through direct binding to their promoters, more and more reports challenge this dogma. (biomedcentral.com)
  • When a signal is sent to express a specific gene, the DNA sequence encoding that gene is used as a template to produce single-stranded RNA in a process called transcription. (ernolaszlo.com)