• Systematic analysis and nomenclature of mammalian F-box proteins. (nih.gov)
  • Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)
  • Mutations in these genes affect proteins involved in the signaling pathway for pigment production and explain a large amount of the color variation in mammals. (creation.com)
  • Multiple transcript variants encoding different proteins have been found for this gene. (unige.ch)
  • Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
  • Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the embryo and adult. (deathbase.org)
  • These proteins have largely been considered to be specificaly expressed in the respiratory tract, and we have recently shown that they exhibit differential expression in the epithelium of the proximal airways. (revoluciondelosgladiolos.org)
  • Both proteins exhibit limited expression outside of these regions. (revoluciondelosgladiolos.org)
  • Knowledge of the complex expression patterns of BPIF proteins in these regions will allow the use of tractable mouse models of disease to dissect their function. (revoluciondelosgladiolos.org)
  • 2002). PLUNC proteins are encoded by genes in a single locus on human chromosome 20q11, and conserved loci are found in all mammals. (revoluciondelosgladiolos.org)
  • PLUNC proteins encoded by these genes were originally grouped into short (SPLUNC1 etc.) and long (LPLUNC1 etc.) proteins on the basis of structural homology to the domains of BPI, with SPLUNCs having structural similarity to the N-terminal domain name of BPI, and LPLUNCs having structural similarity to both domains (Bingle and Craven. (revoluciondelosgladiolos.org)
  • DSB sites are preferentially located within chromatin loops, while several proteins that are required for DSB formation (Rec114, Mei4, and Mer2) localize on the chromosome axis (Blat et al. (springer.com)
  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. (maayanlab.cloud)
  • Membrane trafficking defects caused by mutation in OCRL may explain renal tubular defects observed in Lowe syndrome, including the inability of proximal tubular cells (PTC) to reabsorb low-molecular weight (LMW) proteins and other solutes such as phosphorus and bicarbonate from the glomerular filtrate. (medscape.com)
  • Although the optimal treatment strategy continues to evolve, three agents that target angiogenesis (sunitinib, bevacizumab, and pazopanib) and a mammalian target of rapamycin (mTOR)-targeted therapy (temsirolimus) have been approved as front-line agents. (medscape.com)
  • FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer. (nih.gov)
  • Our recent work demonstrated that TPM cancers are a unique subset characterized by distinct gene and protein expression profiles dominated by epithelial-mesenchymal transition (EMT) markers and elevated RAS/BRAF/MAPK signaling. (uab.edu)
  • Several recent studies reported that TERT mRNA expression in TPM cancers is supported by mitogen activated protein kinase (MAPK) signaling through the Ras pathway (Vallarelli et al. (uab.edu)
  • In adult mouse hippocampus, Tbr2 protein and Tbr2-GFP (green fluorescent protein) transgene expression were specifically localized to intermediate-stage progenitor cells (IPCs), a type of transit amplifying cells. (jneurosci.org)
  • especially, in localization, Nonetheless small lipid requires purified digested to the protein of the most TSLC1 random expression to be the two figures. (scoutconnection.com)
  • This complex gene codes for a complex protein important in a number of pathways. (creation.com)
  • This complex organization of the gene reflects the complex nature of the protein receptor it produces. (creation.com)
  • This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. (unige.ch)
  • VIGR--a novel inducible adhesion family G-protein coupled receptor in endothelial cells. (unige.ch)
  • Genes contributing to the similarity include ribosomal protein (RP) genes as well as genes involved in transcription, translation and cell division. (karger.com)
  • We applied a range of molecular and cellular techniques to measure cell survival, cell cycle progression, protein expression and DNA damage combined with a transcriptomic micro-array approach in D283-MED cells, for global gene expression analysis in acute and chronic hypoxic conditions. (biomedcentral.com)
  • Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. (deathbase.org)
  • This gene encodes a 39S subunit protein. (maayanlab.cloud)
  • Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
  • RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)
  • For each IP, 500μg of protein (measured with BCA assay) from the cell lysate, 30uL protein G Dynabeads, and 5μg-10ug of antibody or IgG (Pierce 31235) were used. (nih.gov)
  • Lowe syndrome is caused by an inherited mutation in the OCRL gene, mapped to chromosome Xq 26.1, which encodes the OCRL1 protein. (medscape.com)
  • To better understand the cellular components controlling alphavirus vector specificity, a cell culture model system of the anopheline restriction of CHIKV was developed along with a protein expression strategy. (cdc.gov)
  • [ 35 ] Expression of the Birt-Hogg-Dubé syndrome protein has been widespread in a variety of tissues, including the kidneys, lungs, and skin. (medscape.com)
  • One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)
  • By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)
  • During my graduate studies, I used a systems biology approach to demonstrate that chromatin environments at different genomic loci decouple transcription factor mediated initiation of gene expression from subsequent gene activation 6 . (confex.com)
  • 1 Some of these, such as the MC1R 2 and ASIP 3 genes, have been fairly well studied and useful information has been obtained by examining mutation patterns at these loci. (creation.com)
  • This identified approximately 140 chromosome loci where nucleotides deviated from the reference sequence GRCh37 hg19 comprising the three genes TRPV1, LTB4R and LTB4R2. (researchgate.net)
  • Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)
  • The TERT gene encodes the catalytic sub-unit of telomerase, which polymerizes telomeric DNA. (uab.edu)
  • 4 It encodes a receptor tyrosine kinase involved in the development and homeostasis of several cell lines including melanocytic (pigment), hematologic (blood), mast, and germ cells. (creation.com)
  • The recently isolated bcl-w gene encodes a pro-survival member of the Bcl-2 family, which is widely expressed. (deathbase.org)
  • This phenomenon, termed genomic imprinting, is highlighted by the neighboring Igf2 and H19 genes, which are monoallelically expressed on opposite parental chromosomes. (kb.se)
  • By means of laser-dissection and bisulfite genomic sequencing, it was observed that de novo methylation of CTCF target sites occurred in BORIS-expressing spermatocytes that exhibit repression of CTCF gene. (kb.se)
  • In conclusion, this work is the first report of sex-biased miRNAs expression in the budgerigar, and provides additional sequences to the avian miRNAome database which will foster further functional genomic research. (peerj.com)
  • replicating the CAPTCHA uses you are a genomic and proves you available shop Manual del Parrillero Criollo to the scan expression. (scoutconnection.com)
  • On the molecular level, it is well known that CpG methylation leads to X-chromosome inactivation, genomic imprinting, and suppression of transposable elements. (biomedcentral.com)
  • Lactase is encoded by a single genetic locus on chromosome 2. (wikipedia.org)
  • However, the full promise of regenerative medicine has been difficult to achieve so far, partly due to our incomplete understanding of the genetic and epigenetic mechanisms regulating differentiation of stem cells to specific lineages and tissues. (confex.com)
  • Because tissues are composed of several cell-types and even cells within the same cell-type have been shown to display dramatic cell-to-cell variability in gene expression, bulk measurements obscure quantification of how genetic or epigenetic features directly influence the function of individual cells. (confex.com)
  • To resolve misconfigured cells we include a Bayesian fitted online artificial that is a different restriction to perform the genetic and the yeast genes, Qbeing P-splines. (scoutconnection.com)
  • Together our results demonstrate a new mechanism explaining hypoxia-induced resistance involving the alteration of the response to DSB in D283-MED cells, but also highlight the cell type to cell type diversity and the necessity to take into account the differing tumour genetic make-up when considering re-sensitisation therapeutic protocols. (biomedcentral.com)
  • As a postdoc in Manoj Duraisingh's lab at Harvard School of Public Health she performed a genetic screen to identify critical host factors for Plasmodium falciparum malaria using red blood cells derived from hematopoietic stem cells. (stanford.edu)
  • Population genetic studies dating back to the mid-20th century first proposed that erythrocytes (red blood cells), the host cell for P. falciparum, have been under natural selection due to malaria. (stanford.edu)
  • Although the notion that malaria has helped shape the human genome is well- accepted, the lack of a nucleus in human erythrocytes has hindered our ability to study genetic interactions between these unusual host cells and P. falciparum parasites. (stanford.edu)
  • Genetic studies of the families at high risk for developing renal cancer led to the cloning of genes whose alteration results in tumor formation. (medscape.com)
  • Although the genome-wide DNA demethylation is believed to be a hallmark of mammalian embryogenesis, previous study also indicated that the somatic form of dnmt1 ( dnmt1s ) is actually expressed at each stage of pre-implantation embryos and plays a role in the maintenance of DNA imprinting 8 . (nature.com)
  • In somatic mammalian cells, the majority of CpG sites are methylated. (biomedcentral.com)
  • Mature spermatozoa were obtained from epididymides of adult mice, and contaminating cell types were eliminated by incubating in somatic cell lysis buffer (0.1% SDS, 0.5% Triton X-100 in DEPC H2O) on ice for 20 minutes. (nih.gov)
  • Twenty years have passed since Dolly the sheep was born by cloning (somatic cell nuclear transfer, SCNT) but the results of non-human mammalian cloning are very poor, and cause animal diseases and huge biological losses. (sibi.org)
  • So far the reprogramming of somatic cells shows very low rates of efficiency (~0.0006-1%) that have not improved in the last two decades of continuous research. (sibi.org)
  • I believe that the reprogramming errors are not the only cause of these low rates of cloning: the mammalian SCNT fails with a very high frequency mainly due to the damage that the technique itself inflicts in the egg and the somatic nucleus, and the very few successful cases occur only when the damage is not significant. (sibi.org)
  • True cloning performed by nuclear transfer from an adult and differentiated somatic cell to a previously enucleated egg (somatic cell nuclear transfer, SCNT), gives rise to a new cell, the nuclovulo (nucleus+ovum), distinct from the zygote because the sperm is not involved in its creation, while both can develop as embryos and give rise to offspring. (sibi.org)
  • Prior to SCNT, the somatic cell (differentiated) must be reprogramed to a similar state of a pluripotent embryonic cell (undifferentiated) before the nucleus is extracted and transferred. (sibi.org)
  • Despite immense promise, somatic cell reprogramming still faces a critical challenge. (sibi.org)
  • TERT is transcriptionally silent in most adult cells and its expression is tightly regulated during cellular and organism development (Counter et al. (uab.edu)
  • Conversely, the continued expression of telomerase in stem cells and cancer cells allows them to counteract this deficiency and enables their indefinite cellular growth. (uab.edu)
  • Notably, the Tbr2+ IPCs formed cellular clusters, the average size of which (Tbr2+ cells per cluster) likewise more than doubled in runners. (jneurosci.org)
  • Similarly, in specific cases, such as cancers, viral infections and in certain cell-types during normal development, mutations and other structural variations within the genome also influences cellular functions. (confex.com)
  • From an engineering perspective, gene expression regulation can be viewed as the output of a network of complex chemical and physical processes, and understanding how these processes interact and integrate to govern cellular phenotypes has been a major focus of my graduate and postdoctoral research. (confex.com)
  • To understand how the genome and epigenome regulates cellular function, development of high-throughput sequencing methods, known as next-generation sequencing, are beginning to unravel genome-wide correlations between the genome, epigenome and transcriptome within a large population of cells or tissues. (confex.com)
  • Thus, my research interests are to develop novel single-cell genomics methods to better understand how changes in the epigenetic landscape during normal development regulates cellular differentiation, information that is critical towards realizing the full potential of regenerative medicine. (confex.com)
  • Cellular identity is now accepted to be the result of the expression of specific combinations of genes (Fig. 1 ). (nature.com)
  • Cellular immunology, T cell immunity, autoimmune diseases: The immune system plays a fundamental role in the defense against microbial pathogens. (utsa.edu)
  • Methylation of cytosine (5 mC) residues in CpG dinucleotides across the genome is an epigenetic modification that plays a pivotal role in the establishment of cellular identity by influencing gene expression during development [ 1 ]. (biomedcentral.com)
  • However, biologically a gene or a sample could participate in multiple biological pathways, and a cellular process is generally active only under a subset of genes or experimental conditions. (columbiagypsy.net)
  • Nowhere is that clearer on a cellular level than in the case of epithelial sheets, single layers of cells that line every body cavity from the gut to mammary glands. (stowers.org)
  • As long as epithelial cells pack tightly and adhere to their neighbors, the cellular business of building tissue barriers and constructing ducts goes smoothly. (stowers.org)
  • When investigating the causes of this failure via cellular and molecular analysis of 2-cell zygotes and the successive cell divisions (blastomeres), all kinds of abnormalities were found. (sibi.org)
  • Temporal distribution studies identify hnRNPA1 and NP co-localize in the same cellular milieu in both nucleus and mitochondria in NP-transfected and IAV-infected mammalian cells. (cdc.gov)
  • Mutations in genes for telomerase cause a wide spectrum of disorders including, premature aging syndromes. (uab.edu)
  • These heterozygous mutations drive monoallelic expression and are common in many cancer types, but are especially prevalent in glioblastomas, melanomas, myxoid liposarcomas, liver cancers, and bladder cancers. (uab.edu)
  • TPM tend to occur in slower growing cell types and are associated with older age at least in glioblastoma, thyroid cancer, and melanoma (4) suggesting that molecular features in certain cell types and older patients may drive the acquisition of these mutations. (uab.edu)
  • While most cancers drive TERT expression without requiring these mutations, it appears in cells with mesenchymal features and elevated RAS pathway signaling, the acquisition of TERT promoter mutations provides a selective advantage. (uab.edu)
  • Via positional cloning, we show that mutations in a zebrafish LTCC encoding gene, cav1.3a , underlie the auditory-vestibular defects of gemini ( gem ) circler mutants. (jneurosci.org)
  • Interrupted aortic arch and complete common atrioventricular canal can be observed in the context of coloboma, heart disease, atresia choanae, retarded growth and development and/or CNS anomalies, genital hypoplasia, and ear anomalies and/or deafness (CHARGE) syndrome , which is usually caused by mutations in CHD7 on chromosome 8q12.1. (medscape.com)
  • Several mutations in the OCRL gene have been described, including truncation mutations, missense mutations, and large deletions. (medscape.com)
  • Failure of mammalian cells to regulate their proliferation cycle leads to cancer. (nih.gov)
  • This enzyme drives the indefinite proliferation of most cancer cells as well as normal stem cells (Greider and Blackburn 1989). (uab.edu)
  • Animal miRNA are involved in neuronal cell fate, cell proliferation and differentiation, metabolism, aging, apoptosis and organ morphogenesis, suggest that miRNAs are particularly critical in the development, health, and aging of animals ( Ameres & Zamore, 2013 ). (peerj.com)
  • GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression. (unige.ch)
  • By the 8-cell stage, remethylation becomes more pronounced than demethylation, resulting in an increase in global DNA methylation. (nature.com)
  • The methylation plasticity of the H19 ICR was nevertheless tolerated without affecting the imprinted status of either Igf2 or H19 genes. (kb.se)
  • It was also observed that some human cancer cell lines possess strong de novo methylation activities. (kb.se)
  • Although the H19 ICR was initially protected from being methylated by JEG3 cells, progressive waves of de novo methylation generated a heavily methylated H19 ICR in later passages, with concomitant loss of its insulator function. (kb.se)
  • Third, we identified subtype-specific differential methylation in promoter and enhancer regions that were strongly correlated with gene expression. (biomedcentral.com)
  • In the present study we provide a comprehensive, genome-wide map of de novo DNA methylation changes in ALL cells at diagnosis and relapse by interrogating the methylation levels of 435,941 CpG sites distributed genome-wide in a large collection of pediatric ALL cells of diverse cytogenetic backgrounds. (biomedcentral.com)
  • In 1-cell and 2-cell embryos Dnmt1s is derived from the oocyte, whereas from the 2-cell stage onward the embryo starts to synthesize its own Dnmt1s 8 . (nature.com)
  • Our goal is therefore to understand how the hypothalamus develops in the embryo and how the proper embryonic assembly of the hypothalamus holds the key to robust adult function. (sheffield.ac.uk)
  • Whilst U87MG shared the same dampened p53 activity, upon chemotherapeutic drug treatment in chronic hypoxic conditions, these cells used a different mechanism, independent of the DNA damage pathway. (biomedcentral.com)
  • Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)
  • Although the mechanisms of gene activation are still unclear, ceramide's role as a messenger of cytotoxic response to chemotherapy might be linked to the MDR pathway. (sphingolipidclub.com)
  • The maintenance phase often involves a plethora of non-DNA sequence specific chromatin cofactors that set up and maintain chromatin states through cell division and for extended periods of time-sometimes in the absence of the initial transcription factors 3 . (nature.com)
  • Chromatin immunoprecipitation (ChIP) experiments revealed that the active chromatin mark trimethylation of lysine 4 of histone 3 (H3K4me3), was significantly enriched in areas associated with interferon-stimulated genes in STAT1 GOF cells in comparison to cells from healthy donors. (kb.se)
  • This suggests that the chromatin binding of GOF STAT1 variant promotes epigenetic changes compatible with higher gene expression and elevated reactivity to type I interferons, and possibly predisposes for interferon-related autoimmunity. (kb.se)
  • It was also shown, by chromatin immunopurification analyses of adult mouse testes, that CTCF and BORIS were associated with H19 ICR. (kb.se)
  • 2009 ). At a larger scale, DSB formation occurs in the context of a specific chromosome architecture that consists of chromatin loops anchored to a proteinaceous axis (Zickler and Kleckner 1999 ). (springer.com)
  • 2015). Importantly, the long isoform, GABP b 1L, regulates a restricted subset of genes, and in a mouse xenograft model of glioblastoma regulates expression from mutant TERT promoters (Mancini et al. (uab.edu)
  • Drugs that block DNA replication can arrest the spread of cancer cells and eliminate viral pathogens. (nih.gov)
  • In the past, our research focused on viral genomes as models for DNA replication in mammalian cell nuclei. (nih.gov)
  • We used isolated nuclei from virus infected cells supplemented with cytoplasm, and discovered that viral replicating chromosomes could continue replication in the absence of a nucleus. (nih.gov)
  • My graduate and postdoctoral research has focused on investigating how the genome and epigenome regulates the dynamics of gene expression in viral and mammalian systems 8 . (confex.com)
  • KIT has also gone by several other names including c-kit , v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, stem cell factor receptor, mast cell growth factor receptor, and CD117 . (creation.com)
  • Here we report that human hnRNPA1 physically interacts with the nucleoprotein (NP) of IAV in mammalian cells at different time points of the viral replication cycle. (cdc.gov)
  • Therefore, the overall goal of our work is to discover how DNA replication is regulated both in the large chromosomes of cells and in the "mini-chromosomes" of viruses and small extrachromosomal DNA molecules. (nih.gov)
  • MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that can post-transcriptionally regulate gene expression and play a critical role in gonadal differentiation as well as early development of animals. (peerj.com)
  • In this review, we focused on the molecular mechanisms of ovarian sex determination and on understanding mutual cross-talks between central molecules in sex development which might impact fertility later in adult life. (lidsen.com)
  • In some longitudinal phytochemicals, respectively, we are both CD4 data in the non-terminal % and sure population in expression molecules. (scoutconnection.com)
  • Blood cells, molecules & diseases. (rochester.edu)
  • small molecule perturbations changing expression of MRPL39 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. (maayanlab.cloud)
  • My laboratory has developed new technologies and applied them towards understanding the molecular biology and enzymology of DNA replication in animal cells and viruses (SV40, polyomavirus, papillomavirus, and herpes simplex virus), and at the beginning of animal development (mouse preimplantation embryos and frog eggs). (nih.gov)
  • suggesting that progenitor cells in the embryonic and adult brain may share similar molecular phenotypes. (jneurosci.org)
  • To overcome this limitation, recent advances in molecular biology have enabled genome-wide single-cell measurements of the transcriptome, genome or certain epigenetic marks that capture this cell-to-cell heterogeneity. (confex.com)
  • Here especially highlighted variations of FISH are molecular combing, chromosome orientation-FISH (CO-FISH), telomere-FISH, parental origin determination FISH (POD-FISH), FISH to resolve the nuclear architecture, multicolor-FISH (mFISH) approaches, among other applied in chromoanagenesis studies, Comet-FISH, and CRISPR-mediated FISH-applications. (frontiersin.org)
  • We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes. (lidsen.com)
  • The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is known for paediatric brain tumours. (biomedcentral.com)
  • Molecular analysis indicates that the gene mutated is Bclw, a death-protecting member of the Bcl2 family. (deathbase.org)
  • As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis. (springer.com)
  • Our research focuses on characterising the stem and progenitor cells that build the hypothalamus and characterising the molecular networks that direct hypothalamic morphogenesis, growth and differentiation. (sheffield.ac.uk)
  • Using high resolution fluorescence imaging to look inside dividing cells in developing wing discs, they observed that the two poles of the spindle were always near the septate junctions, specific regions of close molecular contact between neighboring cells. (stowers.org)
  • However, robust and large-scale genome-wide reprogramming of DNA methylome occurs during two critical developmental processes: (1) development of primordial germ cells and (2) pre-implantation embryogenesis. (nature.com)
  • DEAF-1 recognizes several TTCG motifs within the portion of the Dfd autoregulatory region termed 'module E.' In addition, DEAF-1 binds several similar motifs within a Dfd response element ( DRE ) from the 1.28 gene that enhances maxillary gene expression during embryogenesis (Pederson, 2000). (sdbonline.org)
  • Other genes affecting coloration are involved in pigment production or development (i.e. regulating the development and migration of pigment cells during embryogenesis). (creation.com)
  • One locus important in embryogenesis, KIT , has been associated with white coat patterns in several mammalian species and piebaldism in humans. (creation.com)
  • SSCs are adult-tissue stem cells in the mammalian testis that balance self renewing and differentiating fate decisions to give rise to and sustain the entire spermatogenic lineage. (utsa.edu)
  • Previous data has reported similarity between human brain and testis gene expression patterns. (karger.com)
  • Hence, it means that human testis could also play a crucial role in human speciation if these two tissues exhibit similar gene expression patterns. (karger.com)
  • Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
  • Present results provide evidence to support the proposal that human testis and brain share the highest similarity of gene expression patterns. (karger.com)
  • Expression of Bclw in the testis appears to be restricted to elongating spermatids and Sertoli cells. (deathbase.org)
  • STAT1 gain-of-function (GOF) variants lead to defective Th17 cell development and chronic mucocutaneous candidiasis (CMC), but frequently also to autoimmunity. (kb.se)
  • Variants in blood pressure genes and the risk of Accardi R, Rubino R, Scalise M et col . (2011). (who.int)
  • Until recently, it was unknown how sexual differences in the behavior, physiology, and development of organisms are regulated by differential gene expression. (peerj.com)
  • Mature human lactase consists of a single 160-kDa polypeptide chain that localizes to the brush border membrane of intestinal epithelial cells. (wikipedia.org)
  • Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells. (unige.ch)
  • For over 50 years, glucose has been recognised to cross the lung epithelial barrier and be transported by lung epithelial cells. (ersjournals.com)
  • In vitro studies in resistive human lung epithelial cell monolayers grown at an air-liquid interface have supported these in vivo observations. (ersjournals.com)
  • In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)
  • Recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) normally expressed at low levels in epithelial cells. (spandidos-publications.com)
  • RON was found to be primarily expressed in cells of epithelial origin such as colon, breast and skin ( 9 ). (spandidos-publications.com)
  • But if epithelial cells fail to hold together, they die, or worse, produce jumbled masses resembling tumors known collectively as carcinomas. (stowers.org)
  • Stowers Institute for Medical Research Associate Investigator Matt Gibson, Ph.D., and his team use simple animal systems like fruit flies and sea anemones to investigate how epithelial cells maintain order while getting jostled by cell division. (stowers.org)
  • New findings from his lab published in the July 21 advance online issue of Nature demonstrate that the way the mitotic spindle-the machinery that separates chromosomes into daughter cells during cell division-aligns relative to the surface of the cell layer is essential for the maintenance of epithelial integrity. (stowers.org)
  • Our work is addressing how epithelial tissues maintain structural integrity, even during the extreme events of cell division. (stowers.org)
  • In other words, if you pointed a tiny camera in your gut toward dividing epithelial cells of its lining, you would "see" the mitotic spindle looking like a symmetrical web, exactly like it did in your high school biology textbook. (stowers.org)
  • Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. (rochester.edu)
  • Finally, higher-order 3D chromosome folding is also thought to modulate gene expression and might contribute to inheritance 15 . (nature.com)
  • This laboratory pursues several lines of investigation to understand how T cells contribute to autoimmune diseases and protection from infection, and how to modulate T cell immunity for therapeutic purposes in humans. (utsa.edu)
  • Methods A next-generation sequencing (NGS) panel was created for the human TRPV1 gene and in addition, for the leukotriene receptors BLT1 and BLT2 recently described to modulate TRPV1 mediated sensitisation processes rendering the coding genes LTB4R and LTB4R2 important co-players in pharmacogenetic approaches involving TRPV1. (researchgate.net)
  • Starting from the zygotic genome, stage- and cell-type-specific transcription factors initiate regulatory cascades that induce cell differentiation. (nature.com)
  • Altered epigenomes can lead to changes in programmed cell differentiation or, when accidental, to disease (bottom right). (nature.com)
  • We are testing the hypothesis that specific transcription factors form regulatory networks to execute gene expression programs important for SSC fate decisions (self-renewal and differentiation), and ultimately, spermatogenesis. (utsa.edu)
  • Second, networks of genes and hormones regulate the advancement of sex determination and gonad differentiation, known as the gonadal sex phase. (lidsen.com)
  • An error during these developmental steps in females may lead to defective gonads, affecting the differentiation and/or function of the gonads and the development, differentiation, and maturity of the germ cells. (lidsen.com)
  • Promoters of genes associated with oxidative phosphorylation are preferentially remethylated at the 8-cell stage, suggesting that this mode of energy metabolism may not be favored. (nature.com)
  • different online artificial receptor, longitudinal property and 0K1hisds+∫ backbone of sequence restriction of areas,4,368 data: pFlpBtM-II for expression Steroid, 2000 Mol. (scoutconnection.com)
  • The sre Gene( ORF469) has a Site-Specific Recombinase Responsible for Integration of the R4 Phage Genome, 1996 J. Transgene approximating by the online artificial photosynthesis receptor functionality: substances for the cytoplasm of several IntechOpen data in promoters and bacteria, 2000 Plant Mol. (scoutconnection.com)
  • However, over recent years, it became clear that RTKs cannot be sufficiently activated by growth factors or receptor agonists in the adult and aging brain to exert significant neuroprotective or neurorestorative effects. (springer.com)
  • The receptor makes a single pass through the cell membrane and contains an intracellular kinase catalytic region divided by a hydrophilic insert. (creation.com)
  • gem homozygous receptor mutant HCs display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit strongly reduced extracellular potentials (∼50% of wild-type potentials). (jneurosci.org)
  • The gene, which is highly conserved between mouse and human, resides near the T-cell antigen receptor alpha gene within the central portion of mouse chromosome 14 and on human chromosome 14 at band q11. (deathbase.org)
  • Gene expression profiling of ErbB receptor and ligand-dependent transcription. (rochester.edu)
  • 2002). Due to the increasing complexity of this gene family and conflicting gene nomenclature, a new, comprehensive nomenclature has recently been developed. (revoluciondelosgladiolos.org)
  • Quantitative Biology of Development & Stem Cells, Hubrecht Institute, The Netherlands. (confex.com)
  • Project: Developing novel single-cell genomics methods to quantify cell-to-cell heterogeneity in cancers and stem cells. (confex.com)
  • More specifically, regenerative medicine has recently emerged as a promising therapeutic strategy for treating degenerating tissues using different types of stem cells. (confex.com)
  • Student projects in my lab will revolve around cell-fate decisions in Spermatogonial Stem Cells (SSC). (utsa.edu)
  • Medulloblastoma (MB) is a malignant embryonal brain tumour originating from neural stem cells or granule-cell progenitors of the cerebellum, due to a deregulation of signalling pathways involved in neuronal development such as Wnt or Sonic Hedgehog (SHH) [ 1 ]. (biomedcentral.com)
  • Pediatric acute lymphoblastic leukemia (ALL) originates from the malignant transformation of lymphocyte progenitor cells into leukemic cells in the B-cell and T-cell lineages. (biomedcentral.com)
  • It was shown that CTCF and its paralogue, BORIS, are expressed in reciprocal patterns during adult male germline development. (kb.se)
  • Determining the large scale anatomy of gene expression patterns of various human tissues could draw a more convincing conclusion, and better our understanding of the correlation/inter-correlation among different tissues. (karger.com)
  • Remarkably, the same TF cascade was found to be linked to stages of neuronal lineage progression in adult SGZ. (jneurosci.org)
  • The pluripotency of the initial cell and the establishment of cell types depend to a large extent on the coordinated deployment of hundreds of transcription factors that bind to specific DNA sequences to activate or repress the transcription of cell lineage genes 1 . (nature.com)
  • Such a review cannot be comprehensive due to space constraints and I focused on the commitment of the female cell lineage and avoided discussing the male cell lineage. (lidsen.com)
  • Humans are born with high levels of lactase expression. (wikipedia.org)
  • Also, although there were only two humans, Eve may have carried alleles in her egg cells that differed from those in her body. (creation.com)
  • Humans , or human beings , are bipedal primates belonging to the mammalian species Homo sapiens (Latin for 'wise man' or 'knowing man') under the family Hominidae (the great apes). (solarnavigator.net)
  • However, humans are particularly adept at utilizing systems of communication for self-expression and the exchange of ideas. (solarnavigator.net)
  • Humans also have a marked appreciation for beauty and aesthetics which, combined with the human desire for self-expression, has led to cultural innovations such as art , literature and music . (solarnavigator.net)
  • By present estimates, humans have approximately 20,000 25,000 genes and share 98.4% of their DNA with their closest living evolutionary relatives, the two species of chimpanzees. (solarnavigator.net)
  • Like other mammals, humans have an XY sex-determination system, so that females have the sex chromosomes XX and males have XY. (solarnavigator.net)
  • Further, while cell-to-cell heterogeneity in gene expression has been shown to drive dramatic phenotypic variations, the upstream epigenetic mechanisms regulating this heterogeneity remain largely unknown 8 . (confex.com)
  • Fig. 1: Epigenetic mechanisms that maintain cell identities during development and throughout life. (nature.com)
  • Their failures or incompletion (regulation and gene expression, epigenetic, etc.) are attributed to the inviability and losses detected in the laboratory as well as the pathologies observed during the animal´s pregnancy and offspring after birth or later. (sibi.org)
  • Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
  • See Renal Cell Carcinoma: Recognition and Follow-up, a Critical Images slideshow, to help evaluate renal masses and determine when and what type of follow-up is necessary. (medscape.com)
  • Renal cell carcinoma may remain clinically occult for most of its course. (medscape.com)
  • Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it is also used for palliation in metastatic disease. (medscape.com)
  • Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)
  • Go to Clear Cell Renal Cell Carcinoma and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
  • The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. (medscape.com)
  • Renal cell carcinoma develops in nearly 40% of patients with von Hippel-Lindau disease and is a major cause of death among these patients. (medscape.com)
  • Deletions of 3p occur commonly in renal cell carcinoma associated with von Hippel-Lindau disease. (medscape.com)
  • In summary, Birt-Hogg-Dubé syndrome is an autosomal dominant disorder clinically manifested by fibrofolliculomas, renal cell carcinoma, lung cysts, and spontaneous pneumothorax. (medscape.com)
  • E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
  • These results suggest that Tbr2+ IPCs play a major role in the regulation of adult hippocampal neurogenesis, and that a similar transcriptional program controls neurogenesis in adult SGZ as in embryonic cerebral cortex. (jneurosci.org)
  • He suggested to introduce the term chromosomics being equal to cytogenomics to bring the three-dimensional morphologically of chromosomes into the focus of research, as this is essential for gene regulation. (frontiersin.org)
  • In glioblastoma, liver cancer, and bladder cancer cell lines, mutant TERT promoters recruit the housekeeping transcription factors GABP a & GABP b 1 (Bell et al. (uab.edu)
  • Using transcriptomic analysis in D283-MED cells, we found a large transcriptional remodelling upon long term hypoxia, in particular the expression of a number of genes involved in detection and repair of double strand breaks (DSB) was altered. (biomedcentral.com)
  • To identify genes required for mammalian spermatogenesis, we screened lines of mutant mice created using a retroviral gene-trap system for male infertility. (deathbase.org)
  • Male 129S6/SvEvTac mice (Taconics, Germantown,NY) as well as Hrb-/- gene-disrupted mice (Kang-Decker 2001) were maintained according to the guidelines of the University of Pennsylvania Institutional Animal Care and Use Committee. (nih.gov)
  • Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12. (unige.ch)
  • The X chromosome is larger and carries many genes not on the Y chromosome, which means that recessive diseases associated with X-linked genes, such as hemophilia, affect men more often than women. (solarnavigator.net)
  • solitary shop Manual del Parrillero Criollo into time world col genotype( NSCLC) A549 inside FIG, and predicted that 60 cell of characteristics ended chromosome as TSLC1 manufactured, and led the R of survival 3 at the multilevel. (scoutconnection.com)
  • In fact, amplification of genes by over replication of certain regions of DNA is one of the primary mechanisms by which cancer cells become resistant to drug therapy. (nih.gov)
  • The Hsieh laboratory is a neural stem cell biology laboratory that focuses on 4 major areas: (1) epilepsy-in-a-dish, (2) 3D cerebral organoids, (3) patient recruitment, and (4) mechanisms of adult neurogenesis. (utsa.edu)
  • In the last four decades, transgenic and knockout mouse models have helped to understand the mechanisms of mammalian sex determination, germ cell development, and adult gonad functions. (lidsen.com)
  • In this review, we highlighted some of the main gene networks and regulatory mechanisms involved in the plasticity of sex-determining pathways that help to establish a functional ovary that can nurture the follicles to generate a good ovarian reserve, both in quantity and quality. (lidsen.com)
  • Following transfection of an episomal construct, which contains the H19 miningene with the core H19 ICR and its human counterpart, the H19 reporter gene became rapidly do novo methylated and eventually silenced in choriocarcinoma cells (JEG-3), but not in heptoma cells (HEP3B). (kb.se)
  • Gaussian online artificial photosynthesis in Human Cells Catalyzed by Phage polynucleotide Integrase Mutants, 2000 J. Maeser and Kahmann, The Gin model of event Mu can promote supernatant health in spline pairs, 1991 Mol. (scoutconnection.com)
  • At large, shop Manual del Parrillero Criollo Spanish 2004 methods do compared the clinical residuals to be the human orientations of survival cells. (scoutconnection.com)
  • The bcl-w-/- mouse provides a unique model of failed spermatogenesis in the adult that may be relevant to some cases of human male sterility. (deathbase.org)
  • The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. (deathbase.org)
  • The NGS workflow was based on a custom AmpliSeq™ panel and designed for sequencing of human genes on an Ion PGM™ Sequencer. (researchgate.net)
  • In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)
  • The human RON gene was originally cloned from keratinocytes ( 1 ). (spandidos-publications.com)
  • Conserved transcription factor-binding sites within promoter regions of human RON genes were then searched. (spandidos-publications.com)
  • In the present study we examined the relationship between ceramide, ceramide metabolites and expression of the MDR1 gene in human breast cancer cell lines. (sphingolipidclub.com)
  • Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
  • Why Cloning in Non-Human Mammalians Fail? (sibi.org)
  • Human males are typically larger than females: the average height and weight of a North American adult male is 175 centimeters (5 feet 9 inches) and 78 kilograms (172 pounds). (solarnavigator.net)
  • While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. (deathbase.org)
  • is usually regulated by inhibitors and activators, then Open in a separate window Figure 3 The Simulated dataset with realistic character types represents the abundance of the mRNA of gene are inhibitor concentrations, are activator concentrations, and is usually mRNA breakdown rate. (columbiagypsy.net)
  • 72 hours) to C8- ceramide (5 μg/ml culture medium), a cell-permeable analog of ceramide, enhanced MDR1 mRNA levels by 3- and 5-fold in T47D and inMDA-MB-435 cells, respectively, but did not affect MCF-7 cells.D-erythro-sphingosine exposure (5 μg/ml, 72 hr) increased MDR1 mRNA levels in MDA-MB-435 cells by 3.5-fold. (sphingolipidclub.com)
  • 72 hours) of MDA-MB-231cells to C8-ceramide enhanced MDR1 mRNA levels by 45- and 370-fold(real-time RT-PCR) at passages 12 and 22, respectively, and elicited expression of P-gp (Western blot). (sphingolipidclub.com)
  • Acute exposure ofMCF-7 and MDA-MB-231 cells to C8-glucosylceramide (10 μg/ml culture medium), a cell-permeable analog of glucosylceramide, increased MDR1 mRNA levels by 2- and 4-fold, respectively. (sphingolipidclub.com)
  • Gradual depletion of all stages of germ cells results in a Sertoli-cell-only phenotype by approximately six months of age. (deathbase.org)
  • Both Sertoli cells and germ cells of all types were reduced in number, the most mature germ cells being the most severely depleted. (deathbase.org)
  • Intragenic recombination among ospC genes is known, but the extent to which recombination extended beyond the ospC locus itself is undefined. (cdc.gov)
  • Deformed epidermal autoregulatory factor-1 (DEAF-1) is a transcription factor that was originally shown to bind the autoregulatory enhancer of the Deformed ( Dfd ) Hox gene, which is activated in embryonic head segments of Drosophila (Gross, 1996). (sdbonline.org)
  • transcription factor binding site profiles with transcription factor binding evidence at the promoter of MRPL39 gene from the CHEA Transcription Factor Binding Site Profiles dataset. (maayanlab.cloud)
  • transcription factors binding the promoter of MRPL39 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. (maayanlab.cloud)
  • Spermatogenic cell fractionation was performed by sedimentation of cells prepared from adult mouse testes through a BSA gradient as previously described (Bryant et al. (nih.gov)
  • The top category of Deaf1-regulated genes consists of glycolytic enzymes, which are suppressed by Deaf1 and Gsk3 but are upregulated by Deaf1 RNAi. (sdbonline.org)
  • The OCRL gene is located on Xq25-q26 and consists of 24 exons occupying 52kb. (medscape.com)
  • In EMT, clonal populations can display phenotypic heterogeneity, which when placed under therapeutic selection, facilitates the persistence of resistant cells that can eventually give rise to new populations. (uab.edu)
  • Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. (unige.ch)
  • We found that the distributions and frequencies of types of OspC genes differed between populations of B. burgdorferi in the Northeast, the Midwest, and California. (cdc.gov)
  • Applying the BBC algorithm to the yeast expression data, we noticed that most the biclusters we discovered are backed by significant biological evidences, such as for example enrichments of gene features and transcription aspect binding sites in the corresponding promoter sequences. (columbiagypsy.net)
  • However, the mechanism how the delayed dephosphorylation exactly causes the increased expression of STAT1-dependent genes, and how the intracellular signal transduction from cytokine receptors is affected, remains unknown. (kb.se)
  • Natural product anticancer agents enhance intracellular levels of ceramide, a sphingolipid that promotes cell apoptosis. (sphingolipidclub.com)
  • The impact of sphingolipids on MDR1 gene expression in cancer appears to reflect the myriad intracellular signaling pathways of ceramide and its metabolites. (sphingolipidclub.com)
  • Neurogenesis in the adult hippocampus is a highly regulated process that originates from multipotent progenitors in the subgranular zone (SGZ). (jneurosci.org)
  • The study employs live imaging of fruit fly imaginal discs, simple larval tissues that ultimately give rise to the adult wing. (stowers.org)
  • Initially, the group did not observe such dire consequences: Gibson says that delaminating cells generally "fall out of the epithelium" and are killed off by apoptosis, a mechanism healthy tissues use to eradicate damaged cells. (stowers.org)
  • Fractions were analyzed for purity based on cell and nuclear morphology (via DAPI staining) and pooled. (nih.gov)
  • BPIF genes are amongst the most rapidly evolving mammalian genes and there is significant interspecies diversity in the wider family, particularly within the branch (Bingle et al. (revoluciondelosgladiolos.org)
  • The seminiferous tubules of adult males, however, were disorganized, contained numerous apoptotic cells, and produced no mature sperm. (deathbase.org)
  • L-type Ca 2+ channels (LTCCs) drive the bulk of voltage-gated Ca 2+ entry in vertebrate inner ear hair cells (HCs) and are essential for mammalian auditory processing. (jneurosci.org)
  • It is expressed exclusively by mammalian small intestine enterocytes and in very low levels in the colon during fetal development. (wikipedia.org)
  • 2) What are the requirements for DNA replication and transcription at the beginning of mammalian development? (nih.gov)
  • The sex chromosome combination, particularly the presence of a Y chromosome, triggers a male pattern of development while its absence promotes female development. (lidsen.com)
  • Here, variation in a gene affecting the development and movement of pigment cells, KIT , is examined. (creation.com)
  • Unchecked, tumor cells divide unceasingly, and this is in large part why cancers are deadly. (uab.edu)
  • It also hints at a surprising way that cells initiate a gene expression program seen in invasive cancers when that process goes awry. (stowers.org)
  • Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)
  • DEAF-1 activates the expression of Mtk and Drs promoter-luciferase fusion genes in S2 cells. (sdbonline.org)
  • In 1973, I continued these studies on the replication and structure of SV40 chromosomes at Harvard Medical School where they culminated in promotion to Full Professor with tenure in 1985. (nih.gov)
  • Our current research now focuses on two basic, interrelated questions: (1) How do mammalian cells decide where and when to initiate DNA replication? (nih.gov)
  • Noteworthy, was our demonstration that although termination of DNA replication did not require specific DNA sequences, some DNA sequences did promote pausing of DNA replication forks in vivo (and DNA polymerase in vitro), and some sequences, such as thosewithin the termination region for SV40 DNA replication, did promote formation of catenated intertwines during separation of sibling chromosomes. (nih.gov)
  • Her PhD in Matthew Waldor's lab focused on defining essential replication factors for the two Vibrio cholerae chromosomes. (stanford.edu)
  • The genome within all cell-types of a multicellular organism is identical, yet different cell-types display varied functions within an organism due to differences in other factors, collectively termed as the epigenome. (confex.com)
  • Biologists have long sought to understand how a fertilized egg can form an organism composed of hundreds of specialized cell types, each expressing a defined set of genes. (nature.com)
  • But in an organism cell division must be reconciled with the broader structural context. (stowers.org)
  • online artificial photosynthesis 2016 cell and adjacent pLT42 transformed by Cre hash in general solutions, 2001 PNAS, 98:9209-14. (scoutconnection.com)
  • online artificial photosynthesis 2016: E22The applications for the complementary Building of fluid and resistive parameters are generally reasonably defined for a competing such indicator and a other construct cell. (scoutconnection.com)