Gene expression cdk6 inhibits transcriptional. Medical search. Frequent questions

Cyclin D1 also binds to histone acetylases and histone deacetylases to regulate cell proliferation and cell differentiation genes in the early to mid-G1 phase. (wikipedia.org)
As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)
EIF5B promotes HCC proliferation and invasion by increasing ASAP1 expression [ 5 ]. (techscience.com)
AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
The miR-128-5p mimic promoted the migration and proliferation of VSMCs and suppressed p21, p27, and SM22ɑ expression. (hindawi.com)
The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and proliferation of VSMCs. (hindawi.com)
miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. (hindawi.com)
Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis. (hindawi.com)
Several studies have shown that miRNAs play multiple roles in the phenotypic transformation, migration, and proliferation of VSMCs by inhibiting ERK1/2 activation [ 11 , 12 ], partly by regulating the tissue inhibitor of metalloproteinases (TIMPs)-MMPs and p21-cyclins interactions [ 13 - 18 ]. (hindawi.com)
This study aimed to explore adipogenic transcriptional dynamics before (proliferation) and after (differentiation) initial preadipocyte differentiation in ducks. (biomedcentral.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Finally, we manually assembled a proposed regulation network model of subcutaneous preadipocyte differentiation base on the expression data, and suggested that E2F1 may serve as an important link between the processes of duck subcutaneous preadipocyte proliferation and differentiation. (biomedcentral.com)
A, B) Cell proliferation and colony formation assays in HLECs cultured in conditioned medium come from ZR75-1 or MDA-MB-231 cells stably infected with lentivirus carrying ZKSCAN5 shRNA or ZKSCAN5 shRNA plus ZKSCAN5-R. The representative Western blot displays the expression of ZKSCAN5. (bms-911543.com)
A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
Knockdown of CASP5 greatly inhibited GBM proliferation and resulted in G1 cell cycle arrest along with higher apoptosis ratios in vitro and in vivo, while overexpression led to the opposite phenomenon. (cancerindex.org)
Proliferation of BC cells was suppressed by ectopic expression of BCRC-3 in vitro and in vivo. (biomedcentral.com)
overexpression of these genes decreased proliferation or induced apoptosis of human MLL-AF4 + ALL cell lines, respectively. (ashpublications.org)
HIV-1 expression induces cyclin D 1 and phospho-pRb (Ser780) expression in infected podocytes, suggesting that HIV-1 activates cyclin D1-dependent cell-cycle mechanisms to promote proliferation of infected renal epithelium. (biomedcentral.com)
In comparison to the two general alternative mechanisms utilized by known transforming viruses to promote cell-cycle progression, namely, by activating or bypassing endogenous D-type cyclins (herein, referred to as "cyclin D"), it has not been established whether HIV-1 gene products trigger either cyclin D-dependent or cyclin D-independent proliferation in non-lymphoid tissues [ 15 ]. (biomedcentral.com)
Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
For example, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in GBM tissues and perturbed expression of NEAT1 suppresses cell proliferation and invasion ( 10 ). (spandidos-publications.com)
In fact, many studies have demonstrated the oleuropein and its derivative have proved pharmacological activity against proliferation of cancer cells and several tumor cell lines by different mechanisms such arrest cell cycle and cause apoptosis in cancerous cells, by modulation of miRNA expression and upregulation and downregulation of several genes. (springer.com)

In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), are ubiquitously expressed in eukaryotic cells during post-transcriptional processes. (ijbs.com)
ncRNAs play important roles in controlling gene expression at both transcriptional and post-transcriptional levels. (ijbs.com)
HIV-1-infected podocytes showed markedly elevated cyclin D 1 mRNA and cyclin D 1 protein, the latter of which did not down-regulate during cell-cell contact or differentiation, suggesting post-transcriptional stabilization of cyclin D 1 protein levels by HIV-1. (biomedcentral.com)
They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)

These Ras-mediated pathways lead to the increase in transcription of cyclin D1, and inhibit its proteolysis and export from the nucleus. (wikipedia.org)
The objective of this study was to explore gossypol's toxicity and its effect on gene expression involved in the inflammatory response, glucose transport and insulin signaling pathways in mouse macrophages. (bvsalud.org)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
These observations raise the possibility that HIV-1 gene products may interact with mitogenic pathways in infected renal epithelium to cause aberrant cell-cycle engagement. (biomedcentral.com)
Ensartinib targets ALK, inhibiting downstream malignant pathways that contribute to tumorigenesis and disease progression. (bettapharma.com)
Potential molecular pathways through which PPP2CA may be involved in HCC were determined using miRWalk 2.0 as well as analysis of Gene Ontology categories, Kyoto Encyclopedia of Genes and Genomes pathways, and protein-protein interaction networks. (xiahepublishing.com)
Future studies should examine whether PPP2CA contributes to HCC through the candidate microRNAs, pathways and hub genes identified in this study. (xiahepublishing.com)
HCC involves the actions and interactions of numerous genes, 1 , 2 and increasingly powerful bioinformatics tools and datasets, such as the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA), have facilitated explorations of how specific proteins and pathways contribute to the disease. (xiahepublishing.com)
Together, these results illustrate the co regulation of EGF receptors, their downstream signaling pathways, and their transcriptional targets. (hdac-inhibitors.com)
A plausible mechanism for how signaling from these pathways is integrated into a transcriptional response is offered by the remaining module, six. (hdac-inhibitors.com)

In this study, we identified BARX1 as a common differentially expressed gene in lung squamous cell carcinoma and adenocarcinoma. (bvsalud.org)
Using the GSE2223 and GSE59612 datasets, and RNA sequencing data of GBM from The Cancer Genome Atlas, differentially expressed (DE) genes including DE messenger RNAs (DEmRNAs) and DElncRNAs between GBM and normal controls were identified. (spandidos-publications.com)
The GSE3467 , GSE3678 , GSE33630 and GSE53157 were obtained from the GEO database, including 100 thyroid tumors and 64 normal tissues to obtain the intersection of differentially expressed genes, and a protein-protein interaction network was constructed to obtain the HUB gene. (peerj.com)
With the development of RNA sequencing and microarray technology, the study of differentially expressed genes (DEGs) between cancer and normal tissues has improved our understanding of the molecular mechanism of PTC. (peerj.com)

Comparative transcriptomic analysis of tumor cells from diseased mice revealed the expression of several well-known MLL-rearranged leukemia-associated target genes, including Meis1 , Runx1 ( pMIRH-128a mice), HoxA9 , Flt3 ( pMIRH-130b mice), Cdk6 , and Bcl2 . (ashpublications.org)
Malouf et al also identified several candidate target genes that may mediate the leukemic activity of miR-128 (including the nuclear orphan receptor NR2F6 gene), miR-130b, or both (including the sphingomyelin synthase 1 [ SGMS1 ] gene). (ashpublications.org)
These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)
Strikingly, we located enrichment of genes which might be transcriptionally regulated by two AP 1 family members members, FOSL1 and FOSL2, in M1 enrichment of NF B target genes involved during the regula tion of apoptosis in M4 enrichment of targets of AP 1 in M7 and enrich ment of predicted NF B targets in M6 itself. (hdac-inhibitors.com)

Cyclin D1-CDK4 inhibits pRb through phosphorylation, allowing E2F transcription factors to transcribe genes required for entry into the S phase. (wikipedia.org)
Therefore, imatinib was a paradigm of targeted therapies, which due to that imatinib inhibits the phosphorylation of BCR-ABL then suppress the activation of BCR-ABL tyrosine kinase [ 6 ]. (jcancer.org)
The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. (molcells.org)
This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (thermofisher.com)
Al though it has been shown that EPO induces tyrosine phosphorylation of Stat3 in addition to a likely purpose for this gene continues to be inferred in fetal definitive erythropoi esis through pathway examination, activation of Stat3 is uncommon in hematopoietic cell lines. (hdac-inhibitors.com)

Cyclin D1 overexpression can also down-regulate Fas expression, leading to increased chemotherapeutic resistance and protection from apoptosis. (wikipedia.org)
A significant enrichment for apoptosis genes, including MCL-1 , was found among the mRNAs inversely correlated with miR-29b expression in 45 primary AML samples. (ashpublications.org)

1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
MicroRNAs (miRNAs) are small noncoding sequences involved in the negative regulation of gene expression. (hindawi.com)
Recombinant HIPKs and DYRK1A are auto-activated and phosphorylate the negative elongation factor SPT5, the transcription factor c-Myc, and the C-terminal domain of RNA polymerase II, suggesting a direct function in transcriptional regulation. (nature.com)
However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
Furthermore, MJ significantly increased the expression of BCRC-3, resulting in an obvious up-regulation of p27. (biomedcentral.com)
1 MLL-AF4 binding upstream of the miR-128a and miR-130b transcriptional start sites suggested direct regulation. (ashpublications.org)
Transcriptional integration of upstream signaling Examination of M6 unveiled an enrichment for TFs together with other nuclear proteins involved in cell cycle regulation, chromatin modifications, and epigenetic regulation. (hdac-inhibitors.com)

We hypothesized that a high fat diet in non-human primates would induce changes in hepatic chromatin structure resulting in altered expression of fetal genes critical to the development of childhood and adult obesity. (nih.gov)

Mechanistically, we show that Cth2 protein limits the translation and promotes the decrease in the mRNA levels of these specific ERG genes, which contain consensus Cth2-binding sites defined as AU-rich elements (AREs). (bvsalud.org)
Indeed, HIV-1 virus deleted of nef failed to induce cyclin D 1 mRNA to the level of other single gene mutant viruses. (biomedcentral.com)
Correlation analysis revealed that mRNA TNF receptor associated factor 4 (TRAF4) was associated with DLEU1 expression. (spandidos-publications.com)
Based on the ceRNA hypothesis ( 15 ), the lncRNA-miRNA-mRNA network was constructed and Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway analysis of mRNAs in the network were performed. (spandidos-publications.com)

Circular RNAs (circRNAs) are a new member of noncoding RNAs (ncRNAs) that have recently been described as key regulators of gene expression. (biomedcentral.com)
Some circRNAs contain miRNA response elements (MREs) and function as competing endogenous RNAs (ceRNAs) to interact with miRNAs and regulate the expression of target mRNAs. (biomedcentral.com)

JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
38 Consistent together with the greater differentiation, G1 arrest also increases when QVD is utilised to inhibit HPK1 cleavage in DCS treated 40AF cells. (cox2-inhibitors.com)

In addition, the knockdown of BARX1 inhibited tumorigenicity in mouse xenograft. (bvsalud.org)

miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome proliferator-activated receptor (PPAR), and p21 genes, which are linked to the behaviours of VSMCs. (hindawi.com)
download history Thanks and genes Activation include the acid of and precursor between targets with exciting regulated students and SRC-phosphorylated types. (erik-mill.de)
Enthrallingly, HTLV-1 Tax expression also targets the functions of the centrosome, and this event is correlated with centrosome amplification, aneuploidy and transformation. (biomedcentral.com)
There is certainly also an over representation of the MAPK targets and nuclear occasions mediated by MAP kinases in this module, as well because the inclusion of all genes in Reactome annotated as acknowledged regulators of the AP 1 family TFs. (hdac-inhibitors.com)

Cyclin D1-CDK4 also associates with several transcription factors and transcriptional co-regulators. (wikipedia.org)
More importantly, circRNAs serve as microRNA (miRNA) sponges and crucial regulators of gene expression. (ijbs.com)

Based on a database search, we identified abemaciclib, an FDA-approved Cdk4/Cdk6 inhibitor used for the treatment of metastatic breast cancer, as potent inhibitor of HIPK2, HIPK3, and DYRK1A. (nature.com)
Mechanistically, overexpression of BCRC-3 induced the expression of cyclin-dependent kinase inhibitor 1B (p27). (biomedcentral.com)
download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
The selective suppression of HIV-1 transcription by the cyclin-dependent kinase inhibitor, flavopiridol, abrogated cyclin D 1 expression, underlying the requirement for HIV-1 encoded products to induce cyclin D 1 . (biomedcentral.com)
Vorolanib (CM082) is a novel next-generation of multi-target kinase inhibitor, which can inhibit tumor angiogenesis and growth, and can be used in the treatment of many kinds of cancer. (bettapharma.com)

Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes pathway analysis of DEmRNAs in the DElncRNA‑miRNA‑DEmRNA network was performed. (spandidos-publications.com)
The signature mechanism was studied by analyzing the gene ontology and the Kyoto Encyclopedia of Genes and Genome database. (peerj.com)

The cyclin D1-CDK4 complex promotes passage through the G1 phase by inhibiting the retinoblastoma protein (pRb). (wikipedia.org)

This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (wikipedia.org)
Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
Notably, circRNAs display cell-type, tissue-type and developmental-stage specific expression patterns in eukaryotic transcriptome, which reveals their significant regulatory functions in gene expression. (ijbs.com)

The Human Genome Project has revealed that protein-coding genes represent less than 2% of the total genome sequence [ 7 ], and the remaining greater portion of human genomes are regarded as "junk DNAs", for they do not encode any protein. (oncotarget.com)
A panel of genes has been identified whose cancer genome alterations may predict whether non-metastatic prostate cancer would go on to metastasize. (mdpi.com)
A comparison of immune associated genes amid insect species On this review, the genome and transcriptome broad ana lysis revealed an intact innate immune network current ing in N. lugens. (cox2-inhibitors.com)
Defensins will be the distinctive antibacterial peptide genes out there within the N. lugens genome. (cox2-inhibitors.com)
Studies of human genome demonstrate that protein-coding genes only occupy less than 2% of the entire genome [ 1 ]. (ijbs.com)
Data were analyzed from 2,545 patients with HCC and 1,993 controls without HCC indexed in The Cancer Genome Atlas database, the Gene Expression Omnibus database and our in-house RNA-Seq database. (xiahepublishing.com)

We determined the crystal structures of HIPK3 and DYRK1A bound to abemaciclib, showing a similar binding mode to the hinge region of the kinase as observed for Cdk6. (nature.com)
Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. (aging-us.com)
SnCs exhibit irreversible growth arrest accompanied by increased expression of cyclin-dependent kinase inhibitors (CDKi) such as p16 INK4a , and p21 Cip1 , accumulation of DNA damages, and secretion of diverse bioactive molecules known as the senescence-associated secretory phenotype (SASP). (aging-us.com)
Compared to controls, cultured podocytes expressing HIV-1 genes, and podocytes and tubular epithelium from hyperplastic nephrons in Tg26 kidneys, had increased levels of phospho-pRb (Ser780), a target of active cyclin D 1 /cyclin-dependent kinase-4/6 known to promote G 1 → S phase progression. (biomedcentral.com)
Recent reports demonstrate that the expression of protein kinase C alpha (PKCα) in triple-negative breast cancer (TNBC) correlates with decreased survival outcomes. (oncotarget.com)

Remarkably, DYRK1A is inhibited by abemaciclib to the same extent as Cdk4/Cdk6 in vitro, raising the question of whether targeting of DYRK1A contributes to the transcriptional inhibition and therapeutic activity of abemaciclib. (nature.com)

Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. (wikipedia.org)
The CCND1 gene encodes the cyclin D1 protein. (wikipedia.org)
The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). (wikipedia.org)
Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30-50%) pancreatic carcinomas (25%) bladder cancer (15%) pituitary adenomas (49-54%) breast carcinoma (13%) Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. (wikipedia.org)

Chemical compounds that inhibit histone deacetylases. (hdac-inhibitors.com)

1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. (ukessays.com)
As miRNAs proposed to control the expression up to one third of all genes and possibly utilised as diagnostic and prognostic marker for many genetic based diseases. (ukessays.com)
The expression levels of circRNAs, mRNAs and miRNAs in human tissues and cells were detected by quantitative real-time PCR (qRT-PCR). (biomedcentral.com)
MicroRNAs (miRNAs) are short (about 21 nucleotides long) strands of non-coding RNA that regulate the expression of multiple genes [ 1 ]. (biomedcentral.com)

However, off-target effects of targeting PKCα and limited understanding of the signaling mechanisms upstream of PKCα have hampered previous efforts to manipulate this ubiquitous gene. (oncotarget.com)

Also, expression verification and survival analysis of these candidate genes based on the TCGA database indicate the robustness of the above results. (peerj.com)

High expression of lncRNA H19 promotes cell migration and enhances angiogenesis ( 11 , 12 ). (spandidos-publications.com)
Bevacizumab inhibits tumor angiogenesis by inhibiting the binding of VEGF to the vascular endothelial cell surface receptor (VEGFR), thereby cutting off tumor feeding to stop tumor growth.Bevacizumab was officially approved for marketing in November 2021 for the indications of metastatic colorectal cancer and advanced, metastatic or recurrent non-small cell lung cancer. (bettapharma.com)

Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. (wikipedia.org)
Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. (ayassbioscience.com)

On top of that, JUN, MYC, and RELA signify mem bers of every from the transcription factor households recognized inside the enhancer examination, which we implicate in our chromatin mediated transcriptional suggestions hypothesis. (hdac-inhibitors.com)

We recognized transcription elements inside of M6 which are also important hubs in the EMT network and therefore are likely to mediate the transcriptional response. (hdac-inhibitors.com)

We observed a downregulation in the expression of genes involved in host response, such as TNF signaling, IL-1β production, and phagosome formation in Mφ, and phosphatidylinositol signaling and TNF signaling in PMNs, being in line with the ability of the pathogen to survive within phagocytes. (frontiersin.org)

When lncHERG is highly expressed, cell multiplication, invasion and migration are inhibited in GBM ( 16 ). (spandidos-publications.com)

We identified 24 common genes that were significantly altered in both PMNs and PBMCs, including genes involved in IFN signaling that were downregulated after treatment in both cell populations, and IL1R1 that was upregulated. (frontiersin.org)
The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)
PPP2CA expression was significantly higher in HCC tissue than in non-cancerous tissues (standardized mean difference: 0.69, 95% confidence interval [CI]: 0.50-0.89). (xiahepublishing.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. (aacrjournals.org)

Notably, expressions of some lncRNAs undergo significant changes in the initiation and progression of cancers. (oncotarget.com)
Here, we ask whether the expression of HIV-1 genes in infected podocytes induces cyclin D 1 and phospho-pRb (Ser780) expression, hallmarks of cyclin D1-mediated G 1 → S phase progression. (biomedcentral.com)
High PPP2CA expression in HCC patients was associated with shorter overall, progression-free and disease-free survival. (xiahepublishing.com)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Although there is little knowledge about lncRNAs at present, their potential implications in gene transcriptomics have aroused great interest and attention in the most recent years [ 12 ]. (oncotarget.com)

Nonetheless, several observations from in vitro and in vivo models of HIVAN pathogenesis suggest that HIV-1 expression itself may be a key pathogenic factor. (biomedcentral.com)

This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. (wikipedia.org)

We knocked out these genes in myeloid cells in mice, singly and together. (bvsalud.org)
In contrast, mice with myeloid cell deficiency of all three genes developed severe inflammation, with a median survival of 8 wk. (bvsalud.org)
DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. (researchgate.net)
We assessed cyclin D 1 and phospho-pRb (Ser780) expression in two well-characterized models of HIV-associated nephropathy pathogenesis: HIV-1 infection of cultured podocytes and HIV-1 transgenic mice (Tg26). (biomedcentral.com)

Although the dysregulation of BARX1 expression has been shown to be associated with malignant cancers, including NSCLC, the underlying mechanism remains elusive. (bvsalud.org)

Based on the competing endogenous RNA hypothesis, DElncRNA‑micro RNA (miRNA)‑DEmRNA interactions were obtained by target gene prediction. (spandidos-publications.com)
However, this hypothesis has been recently challenged by Tsou and Stearns [ 5 ] who proposed that re-duplication is inhibited by a centrosome-intrinsic block [ 10 ]. (biomedcentral.com)

CiRS-7 has more than 70 miR-7 binding sites and thus acts as effective miR-7 suppressor to regulate the expression of miR-7 target mRNAs. (biomedcentral.com)

NF90/NF110 are also functional in inhibiting viral replication through binding to viral mRNAs. (ijbs.com)

Recent innovations have helped to develop prescription drugs against certain prostate cancer types, showing gene alterations that prevent the repair of damaged DNA or activate the body's anti-cancer natural immune defense. (mdpi.com)

The 3′UTR-binding sequence site of miR-128-5p on the p21 gene was predicted and assessed by luciferase assays. (hindawi.com)

In this study, the gene expression profile in GBM was analyzed using a microarray dataset and RNA-sequencing (RNA-Seq) datasets. (spandidos-publications.com)

In the present study, we investigated the expression profile and prognostic potential of EIF5B in HCC tissues and cell lines. (techscience.com)
We examined the expression level of lncRNA CASP5 in GBM tissues as well as GBM cell lines. (cancerindex.org)
We had analyzed circRNA high-throughout sequencing from human tissues and determined bladder cancer related circRNA-3 (BCRC-3, GenBank: KU921434.1) as a new candidate circRNA derived from PSMD1 gene. (biomedcentral.com)
RT‑PCR demonstrated that the expression levels of DLEU1 and TRAF4 were increased in GBM tissues. (spandidos-publications.com)
In the present study, bioinformatics and public databases were used to compare PPP2CA expression between HCC and non-cancerous tissues. (xiahepublishing.com)

The activity of these genes may help to guide treatment decision for non-metastatic cancer with the choice for non-aggressive versus debilitating aggressive options. (mdpi.com)
Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)

Of interest, we have observed in a rodent transgenerational model of intrauterine growth restriction (IUGR) that a diet supplemented with essential nutrients, yet unaltered in its caloric content, prevents adult metabolic disease and is associated with abrogation of reprogrammed gene expression. (nih.gov)

1 Mixed lineage leukemia (MLL) gene fusions are the molecular hallmark of infant acute lymphoblastic leukemia (ALL) and are present in tumor cells in up to 80% of patients. (ashpublications.org)
Recent developments in high-throughput sequencing technologies and microarray techniques enable scientists to conduct comprehensive analyses on the abundance, composition, expression profile and molecular function of circRNAs [ 16 ]. (ijbs.com)

Chronic exposure to IL-1β induces only partial expression of senescence markers and does not allow us to conclude on its ability to induce senescence in chondrocytes. (aging-us.com)
On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. (cancerindex.org)

qPCR analyzed the expression of anti-inflammatory tristetraprolin family (TTP/ZFP36), proinflammatory cytokine, glucose transporter (GLUT) and insulin signaling genes. (bvsalud.org)
DIM also enhanced glucose uptake by increasing expression of glucose transporter 4 in adipocytes. (researchgate.net)

We found that the acidic domain of MZF-1 and the heparin-binding domain of Elk-1 facilitate the heterodimeric interaction between the two genes before the complex formation binds to the PKCα promoter. (oncotarget.com)

The BIC gene is activated by promoter insertion at a retroviral integration site on chromosome 21q21 in B cell lymphomas induced by avian leukosis virus. (biomedcentral.com)

Gossypol is a complex plant polyphenol reported to be cytotoxic and anti-inflammatory, but little is known about its effect on gene expression in macrophages. (bvsalud.org)

Thus, expression of CTH2 leads to the accumulation of initial sterol intermediates, such as squalene, and to the drop of ergosterol levels. (bvsalud.org)
Changes in CTH2 expression levels disturb the response of yeast cells to stresses related to membrane integrity such as high ethanol and sorbitol concentrations. (bvsalud.org)
Finally, our hospital samples validated the expression levels of these genes. (peerj.com)
Stat3 is preferentially expressed in primitive erythropoiesis, with expression levels rising slowly for the duration of later maturation stages. (hdac-inhibitors.com)

Anatomy22

Organisms15

Diseases5

Chemicals and Drugs92

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes87

Disciplines and Occupations3

Information Science6

Health Care2

Proliferation23

Post-transcriptional5

Pathways11

Differentially expressed4

Target genes4

Phosphorylation5

Apoptosis2

Regulation7

Resulting in al1

MRNA4

RNAs2

Differentiation2

Knockdown1

Targets4

Regulators2

Inhibitor6

Ontology2

Retinoblastoma1

Regulatory3

Genome6

Kinase5

CDK41

CCND14

Histone1

MiRNAs5

Mechanisms1

Candidate genes1

Angiogenesis2

Overexpression2

Chromatin1

Mediate1

Downregulation1

Migration1

Significantly3

Mutations3

Progression3

Omnibus1

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Vitro1

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Mice4

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Hypothesis2

Regulate1

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Immune1

Assays1

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Tissues5

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Levels4