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  • Metabolism
  • Using promoter lacZ -fusions of genes involved in sulfur metabolism, we demonstrated the relief of l -methionine repression in the NCgl2640 mutant for cysteine synthase, o -acetylhomoserine sulfhydrolase ( metY ) and sulfite reductase. (springer.com)
  • tumors
  • In order to facilitate the shift, a "precision-medicine" approach where tests that predict the clinical outcome of patients on the basis of genes expressed by their tumors are likely to influence patient management and drug development. (biomedcentral.com)
  • 2 The microarray technique allows molecular classification of cancers, according to their expression profiles, as evidenced by the seminal work on lymphoid tumors ( 1 , 2 ). (aacrjournals.org)
  • In comparison to remotely located normal lung parenchyma, B, E, R, T mRNA expression was generally increased in matched tumors, as well as in the entire tumor series. (biomedcentral.com)
  • mutation
  • Very recently, a mutation of the ABCG8 gene, very rare in the general population, has been described in 4% of the Old Order Amish, a well-characterized founder population in Lancaster County, Pennsylvania. (clinicaltrials.gov)
  • pathway
  • Moreover, multiple variations in a gene or a set of genes within a pathway may all contribute to the phenotype, suggesting that the aggregation of variations found over the gene or pathway may be useful for improving the power to detect associations. (biomedcentral.com)
  • Approach
  • This pharmcogenomics approach supposed that genes with patterns of expression across the cell lines which are highly correlated with compound sensitivity are candidate clinical biomarkers of drug efficacy, potentially even direct effectors of drug action, or targets for novel drug development with existing compound leads. (biomedcentral.com)
  • With this approach, NSCLC patients with aberrant intratumoral TYMS expression will probably fare better with platinum-based treatments. (biomedcentral.com)
  • Genome
  • The Human Genome Project, which is nearing completion, is expected to lead to the identification of up to 50,000 human genes. (biomedcentral.com)
  • commonly
  • This study will determine if dietary supplements of sitosterol (a plant cholesterol commonly found in vegetables) can modify blood sugar and cholesterol levels and reduce the stiffness of the blood vessels in people with an abnormal copy of a gene that causes sitosterolemia. (clinicaltrials.gov)
  • methionine
  • C. glutamicum was randomly mutagenized by transposon mutagenesis and 7,000 mutants were screened for rapid growth on agar plates containing the methionine antimetabolite d , l -ethionine. (springer.com)
  • Methods
  • Hierarchical clustering analysis created at least three groups of genes, which were consistent with groupings by the other statistical methods. (nih.gov)
  • Also provided are methods of decreasing expression of an AKT gene in a cell or in a subject to treat an AKT-related disease. (patentsencyclopedia.com)
  • abnormal
  • People who carry only one copy of the abnormal gene are healthy but have increased blood levels of sitosterol. (clinicaltrials.gov)
  • People with two abnormal copies of the gene have increased levels of sitosterol and have an increased risk of heart attack. (clinicaltrials.gov)
  • Although extremely rare in the general population, up to 4% of the Amish carry an abnormal copy of this gene. (clinicaltrials.gov)
  • People of Amish background who are 18 years of age or older and in whom one person carries one copy of the abnormal gene that causes sitosterolemia and the other does not have an abnormal gene may be eligible for this study. (clinicaltrials.gov)
  • Proteins
  • Once released, type I interferons bind to specific receptors on target cells, which leads to expression of proteins that will prevent the virus from producing and replicating its RNA and DNA. (wikipedia.org)
  • cells
  • 9. An anticode oligomer as claimed in any one of the preceding claims wherein the cells expressing the human bcl-2 gene are human tumor cells. (google.com.au)
  • Treatment of prostate carcinoma cells in which TSPYL5 was absent or low (DU145 and LNCaP) with the demethylating agent 5-aza-2′-deoxycytidine upregulated its expression in these cells. (biomedcentral.com)
  • Furthermore, the cells also exhibited reduced CDKN1A expression with only marginal reduction in pAKT. (biomedcentral.com)
  • These samples were analyzed to determine the effects of the drug on GTP pools, and to correlate these changes to biomarkers examined in circulating cells using gene expression detection technologies. (aacrjournals.org)
  • Children who develop ALL in the first year of life have a very poor prognosis, especially if their leukemia cells contain a mutated gene called MLL. (yourcancercare.com)
  • Expression of type I and III IFNs can be induced in virtually all cell types upon recognition of viral components, especially nucleic acids, by cytoplasmic and endosomal receptors, whereas type II interferon is induced by cytokines such as IL-12, and its expression is restricted to immune cells such as T cells and NK cells . (wikipedia.org)
  • study
  • The aim of this study was to determine the prognostic/predictive impact of B, E, R, T in routinely-treated NSCLC patients by taking into account the expression of these genes in the normal lung parenchyma. (biomedcentral.com)
  • For instance, in one study gene profiling was used to identify eight types of pediatric ALL, representing 90% of all cases. (yourcancercare.com)
  • patients
  • 3 , 4 Gene profiling promises to be a significant method for identifying patients with aggressive or non-aggressive malignancies and should ultimately assist in disease management. (yourcancercare.com)