• An expression system refers to the factors that work together to yield a particular gene product such as a protein, ribozyme or RNA particle. (news-medical.net)
  • They then looked at the gene levels of immune signals and cytokines (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses. (redorbit.com)
  • Acute manipulation of gene and protein function in the brain is essential for understanding the mechanisms of nervous system development, plasticity and information processing. (nature.com)
  • The NIH-sponsored GENSAT (Gene Expression Nervous System Atlas) project has created close to 1,500 transgenic mouse lines expressing green fluorescent protein (GFP) reporters or DNA recombinases in specific neural and glial cell populations. (nih.gov)
  • Expression of the Ppp1-r17 protein in postnatal day 7 mouse cerebellum. (nih.gov)
  • 5. A method according to claim 3, wherein the first gene encodes ribosomal inhibitor protein (RIP). (google.com)
  • These products are often proteins, but in non-protein coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes, the product is a functional RNA. (wikipedia.org)
  • RNA polymerase II (Pol II) transcribes all protein-coding genes but also some non-coding RNAs (e.g., snRNAs, snoRNAs or long non-coding RNAs). (wikipedia.org)
  • αComplementationEnabled T7 Expression Vectors and Their Use for the Expression of Recombinant Polypeptides for Protein Transduction Experim. (google.co.uk)
  • Topics covered include multiple sequence alignments, phylogenetics, gene expression data analysis, and protein interaction networks, in two separate parts. (coursera.org)
  • part determines how much protein of that gene is present in the cell. (coursera.org)
  • For example, the reporter gene green fluorescent protein can be visualized by stimulating it with blue light and then using a digital camera to record green fluorescent emission. (wikipedia.org)
  • Immunohistochemistry involves preparing an antibody with specific affinity for the protein associated with the gene of interest. (wikipedia.org)
  • 29. Expression of myelin proteolipid protein in oligodendrocytes and transfected cells. (elsevier.com)
  • An operon includes a special segment of genes that are regulators of the protein synthesis, but do not code for protein, called the promoter and operator. (factmonster.com)
  • This type of overall control of protein synthesis is regulated by genes that control the packing density of histones. (factmonster.com)
  • The ability to switch protein-coding genes 'on' and 'off' is a fundamental process shared by all cell types. (le.ac.uk)
  • All DNA is wrapped up into a protein straight-jacket, whose basic repeat, the 'nucleosome', must be countered in order to activate a gene. (le.ac.uk)
  • The 20,000 protein coding genes in the human cell produce a repertoire of ~100,000 proteins through the process of alternative splicing. (le.ac.uk)
  • To allow in vitro to in vivo extrapolation of the contribution of MRP2 toward hepatic disposition of its substrates, data on the interindividual variability of hepatic MRP2 protein expression are required. (biomedsearch.com)
  • one has been identified as the myosin VIIa gene on chromosome 11q, and a second is a novel basement membrane protein called Usherin. (boystownhospital.org)
  • At least two genetic pathways regulating organism longevity act by modifying gene expression. (hindawi.com)
  • While the paper is not terribly conclusive in its definition of genes or pathways involved, (partially I suspect because of the limited time points examined and the late point in the examinations), this paper does however point in a direction that is useful to the retinal degeneration community. (utah.edu)
  • State-of-the-art and forward looking, Recombinant Gene Expression: Reviews and Protocols, Second Edition offers investigators seeking an overview of this critically important field not only the understanding, but also the tools needed to begin producing nonprotein products and altering the central metabolic pathways of cells to enhance heterologous gene expression. (google.co.uk)
  • Now, in the most comprehensive genetic analysis to date, researchers from the Massachusetts Institute of Technology (MA, USA) have identified each of the genes expressed in individual brain cells of patients with AD, allowing them to determine the distinctive cellular pathways that are disturbed in each neuron or glial cell. (biotechniques.com)
  • The researchers say their study is the largest of its kind, and conclude that it "may shed light on the biological mechanism by which environmental influences regulate the activity of certain genes and in turn contribute to the development of ASD and related behavior traits. (psychcentral.com)
  • The mutation(s) in cancer cells and the change to the expression of those genes regulate how rapidly the tumor grows, its likelihood of metastasizing and moving throughout the body, whether or not its growth is supported by the hormones estrogen or progesterone, whether it over-expresses certain proteins such as HER2 , and how responsive it will be to different treatments. (labtestsonline.org)
  • Through gene expression, breast tumor genes regulate the timing and quantity of production of gene-specific RNA and proteins. (labtestsonline.org)
  • Our primary interest is the genes that regulate how people respond to medicines, such as cancer chemotherapy," senior study author Eileen Dolan, a professor of medicine at the University of Chicago, said in a prepared statement. (drugs.com)
  • Interestingly, when valproic acid was administered, the neurons showed increased gene activation, including increased levels of LEF1 . (medscape.com)
  • The gene expression of individual neurons can be examined following patch clamp experiments by performing single cell PCR on the cytosol aspirated from the patched cell. (epfl.ch)
  • Our results point to the fact that the gene expression pattern is one of the most reliable ways to map the cellular identity of individual neurons, since classification based on morpho-electrical properties fails to capture all the neuronal subtypes. (epfl.ch)
  • 4. Gene expression of serotonergic neurons in the central nervous system: molecular and developmental analysis. (elsevier.com)
  • For example, Olson and his colleagues realized that one fifth of the genes altered in Huntington's seem to be regulated by retinoids, molecules that modulate the development and maturation of neurons. (genomenewsnetwork.org)
  • Then the researchers sequenced RNA from these neurons to find out which genes were misregulated when compared to untreated neurons. (genengnews.com)
  • A publicly available dataset containing gene expression data of 42 tumor tissues of the embryonal central nervous system (CNS) is used for this example. (mathworks.com)
  • Researchers in the laboratory of Mikhail Shapiro, assistant professor of chemical engineering and Heritage Medical Research Institute Investigator, have invented a new method to link magnetic resonance imaging (MRI) signals to gene expression in cells--including tumor cells--in living tissues. (innovations-report.com)
  • Previously developed reporter genes for MRI have been much more limited in their capabilities, requiring the use of specific metals that are not always available in some tissues. (innovations-report.com)
  • For each such gene, the investigators then compared expression of the two alleles head-to-head in 52 different tissues. (eurekalert.org)
  • Expression of Neanderthal alleles tended to be especially low in the brain and the testes, suggesting that those tissues may have experienced more rapid evolution since we diverged from Neanderthals approximately 700,000 years ago. (eurekalert.org)
  • Different tissues express different sets of genes based on their role in the body. (labtestsonline.org)
  • We have attempted to detect cells committed to the melanocytic lineage, in human tissues, by means of tyrosinase gene expression. (nih.gov)
  • Therefore, it appears likely that cells expressing the tyrosinase gene are present in a wide range of human tissues. (nih.gov)
  • When and where genes are expressed (active) in tissues or cells is one of the main determinants of what makes that tissue or cell the way it is, both in terms of morphology and in terms of response to external stimuli. (coursera.org)
  • Several different methods exist for generating gene expression levels for all of the genes in the genome in tissues or even at cell-type-specific resolution. (coursera.org)
  • Spatiotemporal gene expression is the activation of genes within specific tissues of an organism at specific times during development. (wikipedia.org)
  • Reporter genes can be visualized in living organisms, but both immunohistochemistry and in situ hybridization must be performed in fixed tissues. (wikipedia.org)
  • To determine the metabolism location of the extra-cellular matrix proteins in fugu (Takifugu rubripes), we cloned the cDNAs of the fugu gelatinases, matrix metalloproteinase-2 (MMP-2) and MMP-9, and examined their expressions in various adult tissues using a quantitative real-time PCR. (biomedsearch.com)
  • The expression profiles of fugu gelatinases were different among tissues. (biomedsearch.com)
  • Expression targeting involves the use of tissue‐specific enhancer/promoter elements to target the expression of therapeutic transgenes to tissues of interest. (els.net)
  • From the expression data of all 42 samples in the dataset, extract the data of the 10 MD samples and the 10 Mglio samples. (mathworks.com)
  • We tested our method on a collection of yeast expression profiles and on a human cancer dataset. (psu.edu)
  • We present algorithms for time-series gene expression analysis that permit the principled estimation of unobserved time points, clustering, and dataset alignment. (psu.edu)
  • Gene expression is the process by which DNA is used to make proteins, which then go on to perform various important functions in the body. (news-medical.net)
  • Further, the genes themselves did not control the levels of their own expression, rather noncoding regions adjacent to them determined whether to ratchet up or down the proteins or other functional end products the genes encoded. (scientificamerican.com)
  • Gene expression is the process of making specific proteins from the information contained in the genes . (labtestsonline.org)
  • Gene expression tests evaluate the RNA in a person's tissue sample to determine which genes are actively making proteins. (labtestsonline.org)
  • These are tests that evaluate the products (RNA) of specific groups of genes in malignant tumor tissue from the breast in order to determine which genes are making proteins in the tumor tissue. (labtestsonline.org)
  • Postdoctoral Research Associate: Isolation and characterization of sperm-expressed genes and proteins from Zea mays Despite the crucial role of sperm in fertilization, virtually nothing is known about sperm cell gene expression, largely because sperm cells in the quantities necessary for molecular and biochemical characterization could not be obtained, and because partially purified sperm cells are often highly contaminated with the cytoplasm of the vegetative cell. (bio.net)
  • Once sperm-surface proteins are identified, homologs of these genes will be obtained via PCR and/or database searches of other plant genomes. (bio.net)
  • Gene expression is an active ongoing process that maintains a functional CNS, as proteins are being made on a continual basis. (elsevier.com)
  • A regulatory gene , located before the operon, continually makes repressor proteins that bind with the operator and prohibit the function of RNA polymerase. (factmonster.com)
  • We'll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability. (coursera.org)
  • After analyzing some of the nearly 1,100 genes in detail, Cheung and Spielman believe that the expression level discrepancies were due to nucleotide differences in noncoding regions around the genes, and not the genes themselves. (scientificamerican.com)
  • Sex differences in muscle gene expression were further reduced with long-term endurance exercise, an international research team found. (genomeweb.com)
  • We can infer that maybe the greatest differences in gene regulation exist in the brain and testes between modern humans and Neanderthals," says Akey. (eurekalert.org)
  • For this study, McCoy and his colleagues had to develop a new statistical approach to sift through the immense amount of RNA data, but the same technique could be used to compare gene expression differences between modern human alleles. (eurekalert.org)
  • The study to be published on March 22 in PLoS Genetics uncovered differences in gene expression between brain tissue from young (2 to14 years old) and adult individuals with autism syndrome disorder, providing important clues why brain growth and development is abnormal in this disorder. (ucsd.edu)
  • What causes spatial and temporal differences in the expression of a single gene? (wikipedia.org)
  • THURSDAY, Feb. 28 -- People of European and African ancestry have differences in gene expression levels that affect how they respond to certain kinds of drugs and fight off specific types of infections, says a new U.S. study. (drugs.com)
  • But they also made some unexpected findings of major differences in expression levels of genes involved in a communication system that governs basic cellular activities and coordinates cell actions. (drugs.com)
  • Population differences in gene expression have only recently begun to be investigated. (drugs.com)
  • By performing single-cell analysis on around 8000 cells taken from 48 post-mortem human brains, half with distinctive AD pathology and half with no signs of the disease, the researchers were able to analyze all cell types and differentiate between them, showing the distinct gene expression differences that can occur in the disease . (biotechniques.com)
  • Gene expression differences in two groups of samples are discovered and quantificated by comparison of signal intensity values in microarray spots. (srce.hr)
  • July 19 (UPI) -- Most of the science looking at gender differences among mammals have focused on physiological differences, but new research suggests many of those more outward-facing differences -- like height and facial hair -- are rooted in differences in the way males and females express their genes. (upi.com)
  • Discovering contributions of sex biased gene expression to height is exciting because identifying the determinants of height is a classic, century-old problem, and yet by looking at sex differences in this new way we were able to provide new insights," David Page, director of the Whitehead Institute at MIT, said in a news release . (upi.com)
  • We're not saying to avoid animal models in sex differences research, only not to take for granted that the sex biased gene expression behind a trait or disease observed in an animal will be the same as that in humans," said Sahin Naqvi, former MIT graduate student, now a postdoctoral researcher at Stanford. (upi.com)
  • A non-radioactive in situ hybridization assay will be used to look at the spatial and developmental pattern of expression of rhodopsin and other retinal genes in retinal whole mounts. (hopkinsmedicine.org)
  • By exploring evolutionary histories of gene regulation with particular reference to developmental and behavioural genes in humans, you will gain a comprehensive understanding of the role that evolution plays in the diversity and maintenance of different life forms. (le.ac.uk)
  • For example, a recent study found that forms of a gene associated with schizophrenia are over-expressed in the fetal brain, adding to evidence implicating this critical developmental period. (isi.edu)
  • This project will allow us to document which individual genes and sets of genes are turned on and off in different brain regions through the whole developmental time period," said Knowles, the principal investigator on the project. (isi.edu)
  • April 11, A communiqué from Michael Hoffman of Rosetta Inpharmatics reports on the development of GEML - an open-standard XML format for DNA microarray and gene expression data. (coverpages.org)
  • November 29, "On behalf of the GEML Community, Rosetta Inpharmatics has submitted to the Object Management Group (OMG) a proposed DTD based on the new version of Gene Expression Markup Language - GEML 2.0. (coverpages.org)
  • November 29, Rosetta Inpharmatics' Initial Submission regarding the OMG's Gene Expression RFP -- XML DTD for GEML 2.0. (coverpages.org)
  • A study from 2012 showed that in the brain's microvessels alone, there can be up to 2000 genes with altered expression in the brains of AD patients. (biotechniques.com)
  • Steinwaerder D and Lieber A (2000) Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo. (els.net)
  • Stone D, David A, Bolognani F, Lowenstein PR and Castro MG (2000) Viral vectors for gene delivery and gene therapy within the endocrine system. (els.net)
  • Their results, reported in this week's Nature Genetics, were that different ethnic groups not only carried different genes, but there were greater disparities than previously believed in the degrees to which genes that were the same among ethnic groups were expressed. (scientificamerican.com)
  • In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, i.e. observable trait. (wikipedia.org)
  • Now, a Swedish study published in Human Molecular Genetics shows that drinking tea can affect gene expression in women. (healthcentral.com)
  • Moreover, use of the ordering relationships for a small collection of genes has potential for identification of gene-gene interactions with plausible biological interpretation and direct clinical applicability [ 4 ]. (hindawi.com)
  • The spatiotemporal pattern of wingless gene expression is determined by a network of regulatory interactions consisting of the effects of many different genes such as even-skipped and Krüppel. (wikipedia.org)
  • Differential gene expression controls variation in numerous plant traits, such as flowering time and plant/pest interactions, but little is known about the genomic distribution of the determinants of transcript levels and their associated variation. (genetics.org)
  • Our TaqMan® Assays are primer and probe sets based on 5' nuclease chemistry using TaqMan® MGB (minor groove binder) probes, the most quantitative gene expression technology available. (appliedbiosystems.com)
  • Along with graduate student Yun Zhang and professor of veterinary medicine Gregory J. Phillips, Yeung used the chemiluminescence technique to perform quantitative studies of gene expression in two bacterial lines. (photonics.com)
  • An alga that seems healthy from a physiological point of view appears altered when its gene's expression is examined. (eurekalert.org)
  • In each mouse line, expression of the reporter or recombinase is controlled by promoter elements derived from a bacterial artificial chromosome (BAC) containing a specific gene of interest, in order to mimic the gene's expression pattern. (nih.gov)
  • The two-year Grand Opportunity grant, funded through the National Institutes of Mental Health, will allow researchers to use DNA sequencing and profiling technologies to create an atlas of when and where thousands of genes are expressed during key periods of development. (isi.edu)
  • The team used gene chips, which reveal the activities of thousands of genes at once, to monitor approximately 6,000 genes in the striatum, a brain region particularly damaged by Huntington's. (genomenewsnetwork.org)
  • Major and well-known drawback of RXA is a high computational complexity, which grows exponentially with the size of the collection of genes. (hindawi.com)
  • since the identity of a cell is specified by the collection of genes actively expressed within that cell, if gene expression was uniform spatially and temporally, there could be at most one kind of cell. (wikipedia.org)
  • Dr. Josh Dubnau introduces a technique for examining gene expression in the brains of fruit flies. (curriki.org)
  • Until now, few studies have been able to investigate whole-genome gene expression and genotype variation in the brains of young patients with autism, especially in regions such as the prefrontal cortex that display the greatest growth abnormality. (ucsd.edu)
  • Past studies have investigated the gene expression profile of the brain of an Alzheimer's patient, with each additional study increasing understanding of how the affected brains differ. (biotechniques.com)
  • One of these groups of chemicals altered the levels of many of the same genes that are altered in the brains of people with autism or Alzheimer's disease. (genengnews.com)
  • Cardiac Gene Expression: Methods and Protocols presents both cutting-edge and established methods for studying cardiac gene expression. (springer.com)
  • The concluding section, Gene Overexpression and Targeting in the Myocardium, highlights methods that facilitate overexpression or cardiac-specific targeted gene deletion. (springer.com)
  • The ExpressionSet class is designed to contain data from a microarray gene expression experiment, including expression values, sample and feature metadata, and information about experimental methods and conditions. (mathworks.com)
  • The ExpressionSet class includes properties and methods that let you access, retrieve, and change data, metadata, and other information about the microarray gene expression experiment. (mathworks.com)
  • GeneLab undertakes specific research and training projects, which require expertise in gene cloning, PCR, DNA sequencing, cDNA library construction, gene expression and other molecular methods. (lsu.edu)
  • The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene. (google.com)
  • Systemic analysis of data gathered in microarray gene expression measurement is performed by various bioinformatic methods such as group analysis, annotation analysis as well as network and pathway analysis. (srce.hr)
  • Future research will be centered on the causes of variation in the expression of the Usher genes, on the development of animal models (with Dominic Cosgrove, Ph.D.) and on methods of gene therapy. (boystownhospital.org)
  • Prostate tumor samples were taken from the patients at the time of surgery and subjected to a microarray gene expression analysis as described in Methods. (jci.org)
  • The researchers were able to analyse the transcriptome of the microalgae -- i.e. the set of all RNA molecules that controls the expression of their genes -- using molecular biology tools. (eurekalert.org)
  • Researchers developed a highly multiplexed screen to quantify the co-expression of 351 molecules on the surfaces of millions of human B cells. (genomeweb.com)
  • We thought that if we could link signals from water molecules to the expression of genes of interest, we could change the way the cell looks under MRI," says Arnab Mukherjee, a postdoctoral scholar in chemical engineering at Caltech and co-lead author on the paper. (innovations-report.com)
  • The review articles survey new directions in recombinant gene expression research, technique, and application, and point the way to using recombinant gene expression for metabolic engineering and the production of nonprotein molecules. (google.co.uk)
  • Microarray gene expression analysis is high-throughput method in which many different sized DNA molecules are attached to solid surface in designated spots. (srce.hr)
  • The complex nature of mitochondrial gene expression that relies on two different genomes calls for a multidisciplinary approach in which different teams of researchers join forces. (eurekalert.org)
  • Here, we…observed that the Wnt/ß-catenin signaling pathway is profoundly affected, with a significant decrease in expression of LEF1 ," the researchers write. (medscape.com)
  • Mutations in key genes may result in changes to how a step proceeds (or doesn't) and may cause a change to the end product or any intermediate product along the pathway. (labtestsonline.org)
  • His current research interests include rate control and noise in the eukaryotic gene expression pathway, and a range of synthetic biology projects. (uv.es)
  • A team from King's College London, UK, looked at so-called "epigenetic changes" involved in ASD, in which the environment affects the expression of genes without changing the underlying DNA. (psychcentral.com)
  • Because identical twins share the same genes, the fact that ASD can occur in one twin and not the other suggests that epigenetic factors may be involved. (psychcentral.com)
  • An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. (coursera.org)
  • The researchers found that changes in histone modification at HPV integration events were correlated with upregulation of nearby genes and endogenous retroviruses. (genomeweb.com)
  • The protocols provide a template for solid research, and cover the process through screening, analysis, characterization, and functional confirmation of novel genes or known genes with a new function. (springer.com)
  • Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. (wikipedia.org)
  • The genes that control the number of brain cells did not have the normal functional expression, and the level of gene expression that governs the pattern of neural organization across the prefrontal cortex is turned down. (ucsd.edu)
  • The postdoc will prepare cDNA libraries from highly purified maize sperm (available via our collaboration with the RDP, Lyon, France) and sequence large numbers of clones, in order to obtain a representation of sperm -expressed genes. (bio.net)
  • Now researchers from North Carolina State University have found a way to use naturally occurring hydrogen peroxide inside cells to switch on gene expression. (redorbit.com)
  • Researchers have been conducting studies such as the International HapMap Project--a global effort to catalogue common single-nucleotide variations, such as the addition, deletion or substitution of a base in the code of a gene--to get to the bottom of long-observed correlations between ethnicity and common complex diseases. (scientificamerican.com)
  • When the researchers then compared the Asian populations with the Caucasian sampling, they noted that 1,097, more than 25 percent, of the genes had differing expression levels. (scientificamerican.com)
  • Researchers have developed a method, called MemorySeq, to identify genes transcriptome-wide whose expression fluctuations persist for several cell divisions. (genomeweb.com)
  • A team of researchers in Germany investigated gene expression in airway cells of SARS-CoV-2 patients, finding increased interaction between epithelial and immune cells. (genomeweb.com)
  • The researchers showed that this technique was successful in monitoring gene expression in a brain tumor in mice. (innovations-report.com)
  • Neanderthal genes' effects on gene expression likely contribute to traits such as height and susceptibility to schizophrenia or lupus, the researchers found. (eurekalert.org)
  • For their newly reported study, the researchers initially conducted a systematic review of published gene signatures identified in blood samples from people with TB, compared with healthy individuals. (genengnews.com)
  • Researchers studied 30 white families from Utah and 30 Yoruban families from Nigeria, and found significant variations in nearly 5 percent of the 9,156 genes they analyzed. (drugs.com)
  • In support of this, the researchers found that there is a significant change in the genes associated with axon regeneration and myelination . (biotechniques.com)
  • Researchers determined that sex-biased gene expression accounts for 12 percent of the difference in average height between males and females. (upi.com)
  • Ultimately, the researchers found that commonly used chemicals produced gene expression changes similar to those in people with autism and neurodegenerative conditions, including Alzheimer's disease and Huntington's disease. (genengnews.com)
  • In the course of their work, the researchers created hundreds of data sets of gene expression. (genengnews.com)
  • Cross validation results show high specificity in assigning function to genes based on their biclusters, and we are able to annotate in this way 196 uncharacterized yeast genes. (psu.edu)
  • We demonstrate that our algorithm produces stable low-error alignments on real expression data and further show a specific application to yeast knock-out data that produces biologically meaningful results. (psu.edu)
  • The technique, which eventually could be used in humans, would allow gene expression to be monitored non-invasively, requiring no surgical procedures such as biopsies. (innovations-report.com)
  • They can, however, look to gene expression in modern humans who possess Neanderthal ancestry. (eurekalert.org)
  • Next steps may include investigating whether Denisovans--another species of hominins that crossbred with modern humans--are contributing to gene expression, as well as applying the side-by-side method of expression analysis more broadly. (eurekalert.org)
  • In gene expression programming the linear chromosomes work as the genotype and the parse trees as the phenotype, creating a genotype/phenotype system. (wikipedia.org)
  • The exciting aspects of this synthetic gene switch are that you can use it not only as a way to detect the presence of hydrogen peroxide within cells, in this case, by making cells containing hydrogen peroxide glow, but also to express any gene of interest in response to the presence of hydrogen peroxide," Deiters says. (redorbit.com)
  • J:64018 Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP, Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. (jax.org)
  • From its microarray, the team measured 4,197 genes expressed by cells. (scientificamerican.com)
  • Genes tell cells what to do -- for example, when to repair DNA mistakes or when to die--and can be turned on or off like a light switch. (innovations-report.com)
  • Now, for the first time, Caltech scientists have developed a simple way to visualize gene expression in cells deep inside the body using a common imaging technology. (innovations-report.com)
  • After implanting the tumor, they gave the mice a drug to trigger the tumor cells to express the aquaporin reporter gene, which made the tumor look darker in MRI images. (innovations-report.com)
  • This paper by Karin Roesch , Michael B. Stadler and Constance L. Cepko looks at gene expression changes in the Müller cells, one of the glial cells of the retina as the rd1 mouse retina degenerates. (utah.edu)
  • Approximately 3 to 5 percent of genes are active in a particular cell, even though all cells have the same information contained in their DNA. (uptodate.com)
  • books.google.co.uk - In this updated and expanded second edition of an established classic, the editors have added critical reviews to a fresh collection of cutting-edge protocols for gene expression in bacteria, fungi, plants, plant cells, animals, and animal cells. (google.co.uk)
  • Loss of ACL in cultured mouse 3T3-L1 cells diminished the increase in histone acetylation normally associated with hormone-stimulated differentiation of these cells and inhibited the increase in expression of specific genes, such as that encoding the Glut4 glucose transporter. (sciencemag.org)
  • Because gene expression within a cell population fluctuates randomly, investigators must monitor individual cells if they want to follow the activity as genes switch on and off. (photonics.com)
  • Expression of NAPEPLD and PLA2G4E, coding for eCB anabolic enzymes, was higher in the tumour tissue than in non-malignant tissue. (diva-portal.org)
  • Among genes coding for eCB catabolic enzymes, expression of MGLL was lower in tumour tissue while PTGS2 was increased. (diva-portal.org)
  • This study aims to investigate the expression of metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in chronic doxorubicin cardiomyopathy in a rabbit model and to evaluate the effects of bone marrow-derived mesenchymal stem cell (MSC) transplantation in this disease. (biomedsearch.com)
  • With the development of in vivo delivery vectors, these selective expression cassettes can now be used for preclinical assessment of their therapeutic potential for the treatment of inherited diseases or cancers. (els.net)
  • You can now compare the gene expression values between two groups of data: CNS medulloblastomas (MD) and non-neuronal origin malignant gliomas (Mglio) tumor. (mathworks.com)
  • LEF1 commonly pairs with beta-catenin, which typically leads to the activation of other genes for regulating neuronal activity levels. (medscape.com)
  • We have successfully used this approach to correlate the expression of more than 30 genes coding for ion channels and neuronal markers with the electropysiological and morphological properties [1- (epfl.ch)
  • Studies on the regulation of expression of retina-specific genes, in addition to their importance at the basic level, will also have implications for the understanding and treatment of human disease. (hopkinsmedicine.org)
  • A decrease in activation of a specific gene may explain why many patients with bipolar disorder (BD) do not respond to lithium , new research suggests. (medscape.com)
  • You want to be more specific, either activating LEF1 on a targeted basis or activating downstream genes that are relevant for lithium nonresponsiveness," Marchetto said. (medscape.com)
  • 7. A method according to claim 3, wherein the sequence that causes male sterility is the RIP gene linked to an anther specific promoter. (google.com)
  • Extracting accurate and simple rules that exploit marker genes is crucial in understanding and identifying casual relationships between specific genes. (hindawi.com)
  • This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. (waterstones.com)
  • 1997) Efficient muscle‐specific transgene expression after adenovirus‐mediated gene transfer in mice using a 1.35 kb muscle creatine kinase promoter/enhancer. (els.net)
  • Rothmann T, Katus HA, Hartong R, Perricaudet M and Franz WM (1996) Heart muscle‐specific gene expression using replicative defective recombinant adenovirus. (els.net)
  • A gene expression-based recurrence predictor algorithm was informative in predicting the outcome in patients with early-stage disease, with either high or low preoperative prostate-specific antigen levels and provided additional value to the outcome prediction based on Gleason sum or multiparameter nomogram. (jci.org)