Gene encoding cyclic. Medical search. Frequent questions

The PAC produces the molecule cyclic adenosine monophosphate (cAMP) when exposed to blue light, which in turn cranks up the glucose-stimulated production of insulin in the beta cell. (newswise.com)
The locus of Rubinstein-Taybi syndrome is located on band 16p13.3, which includes a gene encoding a binding protein for cyclic adenosine monophosphate-response element binding protein (CBP) ( CREBBP or CBP gene) that is responsible for the phenotype of Rubinstein-Taybi syndrome. (medscape.com)
Cyclic adenosine monophosphate ( cAMP , cyclic AMP , or 3',5'-cyclic adenosine monophosphate ) is a second messenger , or cellular signal occurring within cells, that is important in many biological processes. (wikipedia.org)
Earl Sutherland of Vanderbilt University won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers (such as cyclic adenosine monophosphate, cyclic AMP). (wikipedia.org)
Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. (antibodypedia.com)
Keywords: Soluble adenylyl cyclase cAMP Microdomain Cancer Diagnostics 1 Introduction Cyclic adenosine monophosphate (cAMP) is one of the most ancient CDCL1 signaling molecules present from bacteria to man. (bioinf.org)
CFTR is a cyclic adenosine monophosphate (cAMP)-regulated chloride channel, regulating chloride, sodium, and bicarbonate transport across epithelial membranes. (msdmanuals.com)

In the X-linked recessive form, the gene defect lies in the DKC1 gene (located at Xq28), which encodes for the protein dyskenin. (medscape.com)
Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)
The hang gene encodes a large, approximately 210-kDa nuclear zinc finger protein that is expressed in most, if not all, neurons in the adult brain (Scholz, 2005). (sdbonline.org)
However, this particular gene is expressed exclusively in the brain, and its activity has been linked to memory and learning, which lends some plausibility to the link between protein activity and the generation of AP. (jax.org)
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. (creativebiomart.net)
Here we report biallelic variants in CACNA2D1, encoding the α2δ-1 protein, in two unrelated individuals showing a developmental and epileptic encephalopathy (DEE). (stanford.edu)
The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). (thermofisher.com)
The EP300 gene on band 22q13 encodes a protein, p300, that is highly similar to CREBBP. (medscape.com)
In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase ). (wikipedia.org)
Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the regulatory and catalytic subunits, thus enabling those catalytic units to phosphorylate substrate proteins. (wikipedia.org)
Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which acts as a chloride channel activated by cyclic AMP (cAMP). (biomedcentral.com)
The NPR2 gene encodes the natriuretic peptide receptor B (NPR-B) protein, also called guanylate cyclase B (GC-B). NPR-B is expressed in many tissues, including cells in the growth plates of growing bones. (childrenshospital.org)
NPR-B is activated by a small protein called CNP (C-type natriuretic peptide) and it, in turn, activates other proteins including PRGK2 (cyclic GMP dependent protein kinase 2). (childrenshospital.org)
The Tax protein has pleiotropic effects on host-cell gene expression and activates several pathways such as the cyclic AMP responsive binding protein (CREB), the nuclear factor kappa-B (NF-κB), the cyclin-dependant kinases (CDKs), and the Akt pathways. (nih.gov)
The Tax protein has pleiotropic effects on host-cell gene expression and activates several pathways such as the cyclic AMP responsive binding protein (CREB), the nuclear factor kappa-B, the cyclin-dependant kinases (CDKs), and the Akt pathways. (nih.gov)
Encodes a putative RING-H2 finger protein RHA1a. (or.jp)
CD38 is a gene providing instruction of making a protein named ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (also abbreviated as ADPRC1 or CD38) in human and belongs to ADP-ribosyl cyclase family. (cusabio.com)
The CFTR protein is a membrane-bound, cyclic adenosine 3′,5′-monophosphate-regulated chloride channel that is thought to regulate other cell membrane ion channels. (rcjournal.com)
The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. (utsouthwestern.edu)
Regulatory genes which encode a cyclic AMP receptor protein required for L-arabinose utilization in E. coli. (nih.gov)
The kinesin- homologous protein encoded by the Chlamydomonas FLA10 gene is associated with basal bodies and centrioles. (bio.net)
The cyclic AMP-dependent protein kinase A signaling pathway plays a major role in regulating plant infection from the rice blast fungus and or are both necessary for development of spores and appressoria by and play roles in cell wall differentiation, regulating melanin pigmentation and cell surface hydrophobicity during spore formation. (bio2009.org)
which encodes a putative G-protein-coupled receptor may be involved in regulating Mac pc1 activities, because is required for surface acknowledgement and virulence and exogenous cAMP restores appressorium formation and pathogenicity in deletion mutants [55]. (bio2009.org)
It encodes a membrane-associated protein called the cystic fibrosis transmembrane conductance regulator (CFTR). (msdmanuals.com)
A highly expressed protein in tumor cells, encoded by Tpt1 gene. (bvsalud.org)

This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. (antibodypedia.com)
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. (genemedi.net)

all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes. (medscape.com)
The Popeye domain containing (POPDC) genes encode sarcolemma-localized cAMP effector proteins. (imperial.ac.uk)
Polycomb group (PcG) proteins are chromatin-associated factors involved in the repression of gene transcription. (sdbonline.org)
Both genes are highly conserved, and their proteins are thought to have 2 functions: (1) formation of a bridge or scaffold between the DNA-binding transcription factors and the RNA polymerase II complex and (2) serving as histone acetyltransferases that open the chromatin structure, a process essential for gene expression. (medscape.com)
immunogenic differences in their surface M proteins and polymorphisms in the emm gene ( 1 ). (cdc.gov)
In addition, cAMP binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2 . (wikipedia.org)
This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)
ACs 1-9 encode for proteins with a fairly similar structure in that all of them are transmembrane proteins (tmACs) and reside principally at the plasma membrane and endosomes making these ACs well suited to respond to extracellular signals. (bioinf.org)

It is located in the sperm head rather than the flagellum and is controlled by intracellular pH, but not cyclic nucleotides. (elifesciences.org)
This channel is activated by signalling molecules inside cells, called 'cyclic nucleotides', and its activity ultimately leads to calcium ions flowing into the sperm cell's tail. (elifesciences.org)
Electrophysiological experiments then revealed that the fish version of CNGK is not activated by cyclic nucleotides, but is activated when the inside of the cell becomes more alkaline. (elifesciences.org)
It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. (genemedi.net)
Cyclic nucleotides, like other nucleotides, are composed of three functional groups: a ribose sugar, a nitrogenous base, and a single phosphate group. (pancreapedia.org)
A cyclic nucleotide, unlike other nucleotides, has a cyclic bond arrangement between the ribose sugar and the phosphate group. (pancreapedia.org)
There are two main groups of cyclic nucleotides: the canonical or well-established and the non-canonical or unknown-function cyclic nucleotides. (pancreapedia.org)
The two well-established cyclic nucleotides are adenosine-3',5'-cyclic monophosphate (cyclic AMP) and guanine-3',5'-cyclic monophosphate (cyclic GMP). (pancreapedia.org)
The non-canonical cyclic nucleotides include the purines inosine-3',5'-cyclic monophosphate (cyclic IMP), xanthosine-3',5'-cyclic monophosphate (cyclic XMP) and the pyrimidines cytidine-3',5'-cyclic monophosphate (cyclic cCMP), uridine-3',5'-cyclic monophosphate (cyclic UMP), and thymidine-3',5'-cyclic monophosphate (cTMP) (145). (pancreapedia.org)
An overview of the non-canonical cyclic nucleotides is provided in Section V. (pancreapedia.org)
Cyclic nucleotides form when the phosphate group of the molecule of nucleotide triphosphate (ATP or GTP) is attacked by the 3' hydroxyl group of the ribose, forming a cyclic 3',5'-phosphate ester with release of pyrophosphate. (pancreapedia.org)

Pancreatic beta cells were engineered with a gene that encodes a photoactivatable adenylate cyclase (PAC) enzyme. (newswise.com)
Genes of interest in this area include ADCY8 (adenylate cyclase 8), which encodes a membrane bound enzyme that catalyzes the formation of cyclic AMP from ATP, a pretty basic cellular process. (jax.org)
Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. (wikipedia.org)
Deletion of the gene encoding adenylate cyclase resulted in mutants that cannot form appressoria and were defective in the growth of aerial hyphae and conidiation [12]. (bio2009.org)

The human gene encoding cGAS is MB21D1 on chromosome 6. (wikipedia.org)
In humans, the STAT3 gene is located on the q arm of chromosome 17. (thermofisher.com)
Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)
1 The condition is caused by mutations in a single gene on chromosome 7, which encodes the CF transmembrane conductance regulator (CFTR). (rcjournal.com)
The responsible gene has been localized on the long arm of chromosome 7. (msdmanuals.com)

Sperm intracellular cAMP levels depend on the activity of adenylyl cyclases, mostly SACY, though transmembrane-containing adenylyl cyclases are also present, and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5'-AMP. (plos.org)
Parasites loaded with intracellular Ca 2+ chelators displayed significantly decreased infectivity and cyclic GMP level. (ias.ac.in)

two of them play a dual role in cyclic guanosine monophosphate (cGMP) and cAMP signaling, whereas only Dunce (Dnc) is cAMP specific. (sdbonline.org)

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. (cusabio.com)
Both cyclic AMP and cyclic GMP are second messengers. (pancreapedia.org)

Nucleotide sequence of the PetM gene encoding a 4 kDa subunit of the cytochrome b6f complex from Chlamydomonas reinhardtii. (bio.net)
A family of genes, including (also referred as is controlled by Tpk2 (a catalytic subunit of PKA) in [23]. (bio2009.org)
However, these problems in mutants could be complemented by adding exogenous cAMP or by spontaneous mutations in the regulatory subunit of PKA gene [44]. (bio2009.org)
The CNGA3 gene provides instructions for making one part (the alpha subunit) of the cone photoreceptor cyclic nucleotide-gated (CNG) channel. (medlineplus.gov)
The CNGA3 gene mutations that underlie complete achromatopsia affect the production or function of the alpha subunit. (medlineplus.gov)

In sea urchin sperm, a cyclic nucleotide-gated K + channel (CNGK) mediates a cGMP-induced hyperpolarization that evokes Ca 2+ influx. (elifesciences.org)
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. (taconic.com)

Through APA, a single gene containing multiple PAS can generate a considerable number of transcript isoforms, thereby producing a highly diversified transcriptome ( Tian and Manley, 2013 ). (frontiersin.org)
The dnc gene encodes for at least eight isoforms with high homology to the human phosphodiesterase 4 class of PDEs. (sdbonline.org)
Alternatively spliced transcript variants encoding different isoforms have been described for this gene. (creativebiomart.net)
Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. (thermofisher.com)
Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. (genemedi.net)

A dual gene reporter system was used to determine the gentamicin-induced readthrough level of the most frequent stop mutations within the CFTR in the French population. (biomedcentral.com)
Suppression of stop mutations in the CFTR gene with parenteral gentamicin can be predicted in vitro and is associated with clinical benefit and significant modification of the CFTR-mediated Cl - transport in nasal and sweat gland epithelium. (biomedcentral.com)
Pharmacologic suppression of stop mutations within the CFTR gene may therefore be of benefit to a significant number of patients. (biomedcentral.com)

The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. (antibodypedia.com)
A cyclase enzyme (lyase) catalyzes the formation of the cyclic nucleotide from its nucleotide triphosphate precursor ( Figure 1 ). (pancreapedia.org)

In cyclic neutropenia, a rare form of congenital neutronia, the primary finding is a periodic severe decrease in the levels of neutrophils. (rarediseases.org)
A novel mutation Ala57Val of the ELA2 gene in a Korean boy with severe congenital neutropenia. (lu.se)
Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene. (lu.se)
Molecular screening of the neutrophil elastase gene in congenital neutropenia. (lu.se)
A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia. (lu.se)
Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register. (lu.se)
Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease. (lu.se)
Mutations in the gene encoding neutrophil elastase (ELA2) are not sufficient to cause the phenotype of congenital neutropenia. (lu.se)
Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. (lu.se)

The hangover gene defines a cellular stress pathway that is required for rapid ethanol tolerance in Drosophila melanogaster. (sdbonline.org)
The Drosophila genome contains two genes( CG8422 and CG1237 0) orthologous to Manduca and Acheta DH-Rs. (silverchair.com)

The 3' regulatory regions have a great diversity of cis -regulatory elements directly involved in polyadenylation, stability, transport and mRNA translation, essential to achieve the desired levels of gene expression. (frontiersin.org)
Although a small number of 3' regulatory regions have been identified and validated so far, many studies have shown that plant 3' regulatory regions have a higher potential to regulate gene expression in plants compared to widely used 3' regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. (frontiersin.org)
In this review, we discuss the role of 3' regulatory regions in gene expression, and the superior potential that plant 3' regulatory regions have compared to NOS, OCS and 35S 3' regulatory regions. (frontiersin.org)

Diagnosis is by sweat test or identification of 2 cystic fibrosis-causing gene variants in patients with a positive newborn screening test result or characteristic clinical features. (msdmanuals.com)

Because those patients retain some cone function, we reasoned that mutant alleles encode functional channel subunits that alter the human cone visual pathway in characteristic ways. (jneurosci.org)

Mutations in the genes encoding the CNGA3 and CNGB3 subunits of the cyclic nucleotide-gated (CNG) channel of cone photoreceptors have been associated with autosomal recessive achromatopsia. (jneurosci.org)
The α2δ subunits are encoded in mammals by four genes, CACNA2D1-4. (stanford.edu)

Eukaryotes have a mechanism termed alternative polyadenylation (APA), which allows the selective use of PAS in genes containing multiple PAS. (frontiersin.org)
As part of nitric oxide-cyclic GMP transduction signaling operative in higher eukaryotes and involved in the long-term potentiation, a soluble guanylyl cyclase has also been detected in this lower eukaryote. (ias.ac.in)

Rubisco in marine symbiotic dinoflagellates: Form II enzymes in eukaryotic oxygenic phototrophs encoded by a nuclear multigene family. (bio.net)

Genetics, phenotype, and natural history of autosomal dominant cyclic hematopoiesis. (lu.se)
Upon detection of environmental alterations, bacteria adjust their gene expression in order to obtain a phenotype that is suitable for the environment to which they are exposed ( Federle, 2012 ). (frontiersin.org)
PHENOTYPE: Mice homozygous for disruptions in this gene experience embryonic lethality between E9.5 and E11.5. (utsouthwestern.edu)
The pc-1 phenotype of Chlamydomonas reinhardtii results from a deletion mutation in the nuclear gene for NADPH:protochlorophyllide oxidoreductase. (bio.net)

Members of both the SLC4 and SLC26 mammalian gene families encode Na + -independent Cl - -HCO3 - exchangers. (tcdb.org)

In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. (plos.org)
Within these neurons, two cyclic AMP (cAMP)-dependent mechanisms balance the degree of tolerance. (sdbonline.org)
In neuronal cell lines, ethanol exposure reduces cyclic AMP (cAMP) levels, which results in cellular tolerance. (sdbonline.org)
cAMP-dependent phosphodiesterases (PDEs) are essential components of the cAMP signaling cascade and fine-tune cyclic nucleotide signaling. (sdbonline.org)
cAMP is synthesized from ATP by a class of enzymes called adenylyl cyclases (ACs) which are encoded by 10 different genes (ADCY1-10) [1]. (bioinf.org)

STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. (thermofisher.com)
Transcriptional regulators enable the microbes to sense and respond to environmental stimuli, by altering gene expression. (frontiersin.org)

Discovering human diabetes-risk gene function with genetics and physiological assays. (nature.com)

Patients with congenital forms of SCN are at greater risk of developing leukemia than are other people, especially in cases associated with certain gene mutations and cases that require higher medication doses. (rarediseases.org)

Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage. (thermofisher.com)

The gene encoding the soluble guanylyl cyclase was cloned, sequenced and over expressed in bacterial system. (ias.ac.in)
Once inside, it activated adenyl cyclase, causing the concentration of cyclic-AMP to increase. (kenyon.edu)

Autosomal Recessive Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)

Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. (wikipedia.org)

Polyadenylation is essential for the stability of the transcript, preventing the mRNA from being the target of posttranscriptional gene silencing (PTGS) via RNA-dependent RNA polymerase 6 (RDR6) in plants ( Luo and Chen, 2007 ). (frontiersin.org)

To overcome the host plant defense response, M. phaseolina encodes a significant number of P450s, MFS type membrane transporters, glycosidases, transposases, and secondary metabolites in comparison to all sequenced ascomycete species. (biomedcentral.com)
Cyclic lipopeptides (CLiPs) constitute a unique and major class of microbial amphiphilic secondary metabolites. (fems-microbiology.org)
Zettner MA, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster v79 cells. (who.int)

CUSABIO synthesized the recombinant gene by integrating the C-terminal hFc tag sequence into the targeted gene encoding the 43-300aa of the human CD38. (cusabio.com)

It is unclear why some CNGA3 gene mutations cause achromatopsia and others result in progressive cone dystrophy. (medlineplus.gov)

The characterisation and cyclic production of a highly unsaturated homoserine lipid in Chlorella minutissima. (bio.net)

Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro. (who.int)

More than 100 mutations in the CNGA3 gene have been found to cause the vision disorder achromatopsia. (medlineplus.gov)
CNGA3 gene mutations have also been identified in a few individuals with incomplete achromatopsia, a milder form of the disorder associated with limited color vision. (medlineplus.gov)
A few mutations in the CNGA3 gene reduce but do not eliminate the function of CNG channels in cones. (medlineplus.gov)
Mutations in the CNGA3 gene have also been identified in a small percentage of cases of progressive cone dystrophy. (medlineplus.gov)

It is an example of positive control or regulation of gene expression in the bacterial operon. (nih.gov)

While this discovery is intriguing, making definitive links between the genome and AP are hampered by several factors, including the likelihood of multiple genes involved, the fact that not every family member has musical training, and the expectation of incomplete penetrance. (jax.org)

Age-dependent pancreatic gene regulation reveals mechanisms governing human β cell function. (nature.com)

GenePaint.org: an atlas of gene expression patterns in the mouse embryo. (taconic.com)
2006. An atlas of gene expression from seed to seed through barley development . (hutton.ac.uk)

Unusually low levels of triglycerides can be present in disease states, producing syndromes of malabsorption in addition to patients who carry genes for familial hypobetalipoproteinemia . (medscape.com)

Cyclic AMP (adenosine 3', 5'-cyclic monophosphate) is an important player in sperm function. (plos.org)

All three genes encode key components of the phototransduction cascade in cone photoreceptors. (jneurosci.org)

These genes collaborate in a complicated pathway (FA pathway), which is responsible for the repair of DNA damage. (medscape.com)

Disruption of the human CBP gene, either by gross chromosomal rearrangements or by point mutations, leads to Rubinstein-Taybi syndrome. (medscape.com)
RNA sequencing of single human islet cells reveals type 2 diabetes genes. (nature.com)
Koeppen K, Reuter P, Ladewig T, Kohl S, Baumann B, Jacobson SG, Plomp AS, Hamel CP, Janecke AR, Wissinger B. Dissecting the pathogenic mechanisms of mutations in the pore region of the human cone photoreceptor cyclic nucleotide-gated channel. (medlineplus.gov)

The synthesized gene was subsequently cloned into an expression vector. (cusabio.com)
Community level coordination of gene expression is known as quorum sensing (QS). (frontiersin.org)
Bone marrow & Lymphoid tissues Brain Breast and female reproductive system Connective & Soft tissue Endocrine tissues Eye Gastrointestinal tract Kidney & Urinary bladder Liver & Gallbladder Lymphoid Male reproductive system Muscle tissues Myeloid Pancreas Proximal digestive tract Respiratory system Skin * nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. (antibodypedia.com)
If expression of a trait requires only one copy of a gene (one allele). (msdmanuals.com)

Anatomy1

Organisms3

Chemicals and Drugs1

Phenomena and Processes2

Health Care1

Adenosine monophosphate7

Protein25

Nucleotide phosphodiesterase family2

Proteins8

Nucleotides11

Adenylate cyclase4

Chromosome5

Intracellular2

Guanosine monophosphate1

Second messengers2

Subunit5

CGMP2

Isoforms5

CFTR3

Enzyme2

Neutropenia9

Drosophila2

Regulatory3

Variants1

Functional1

Subunits2

Eukaryotes2

Eukaryotic1

Phenotype4

Mammalian1

CAMP5

Stimuli2

Genetics1

Congenital1

Deletion1

Cyclase2

Single gene1

Activates1

Transcript1

Metabolites3

Sequence1

Mutations cause1

Lipid1

Formation1

CNGA34

Regulation of gene ex1

Genome1

Pancreatic1

Atlas of gene expression2

Disease1

Sperm1

Cascade1

Collaborate1

Human3

Expression4