Gene encoding cleavage. Medical search. Frequent questions

Proteins/genes with a putative catabolic role and bacterium adaptation mechanisms during OPP degradation were identified via genomic and proteomic analysis. (nature.com)
Composed of 2 major components, the C. difficile S-layer has high and low molecular weight proteins (HMW and LMW, respectively), which are formed from the posttranslational cleavage of a single precursor, surface layer protein A (slpA) ( 6 ). (cdc.gov)
This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. (cancerindex.org)
The env gene maintained an ORF coding for a 538-amino acid polypeptide that has all the characteristic features of env proteins and mediates intercellular fusion in vitro [ 11 - 13 ]. (ecancer.org)
Charles J.-P., Chihara C., Nejad S., Riddiford L.M. (1998) Identification of proteins and developmental expression of RNAs encoded by the 65A cuticle protein gene cluster in Drosophila melanogaster , Insect Biochem. (apidologie.org)
Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680-685. (apidologie.org)
these proteins are also important in regulating gene transcription. (biomedcentral.com)
The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. (nih.gov)
In this strain, 1 putative cleavage site of the viral polyprotein responsible for processing of structural proteins was changed. (cdc.gov)

Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. (thermofisher.com)
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. (thebiogrid.org)
Are there any known genetic variations or mutations in the ANXA3 gene? (creativebiomart.net)
Yes, genetic variations and mutations in the ANXA3 gene have been reported. (creativebiomart.net)
Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
Mutations in the PNKD gene can cause familial paroxysmal nonkinesigenic dyskinesia. (medlineplus.gov)
How mutations in the PNKD gene lead to the signs and symptoms of familial paroxysmal nonkinesigenic dyskinesia is also unknown. (medlineplus.gov)
Researchers suspect that mutations in one or more other genes that have not been identified can cause the condition. (medlineplus.gov)
In all reported cases caused by PNKD gene mutations, an affected person has inherited the mutation from one parent. (medlineplus.gov)
The unique synonymous mutations detected in the E and Non-structural 2a genes of Usutu-BONN strains may suggest an adaptive evolution. (cdc.gov)
Deletions or mutations of the genes encoding the enzymes involved in the synthesis or impaired function of the enzymes involved in the steroid hormones pathway (eg, autoantibodies) leads to deficiency of different hormones. (medscape.com)
Some mutations in the S gene may lead to changes in the spike protein which result in inhibition of contact and entry of the virus into human cells, however in the case of the VOC, they contain mutations in the S gene that enhance the process of contact and entry into human cells, increasing transmissibility of the virus. (who.int)
Currently, manufacturers are focusing on and targeting assays to mutations in the S gene. (who.int)

Different variants of the slp A gene have been identified in C. difficile ( 7 ). (cdc.gov)
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. (cancerindex.org)
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (nih.gov)
Alternative splicing of this gene results in two transcript variants that encode the same protein. (thermofisher.com)
Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (utsouthwestern.edu)
About 30 pathogenic variants have been reported throughout the PYGL gene. (medscape.com)

It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. (thermofisher.com)
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. (nih.gov)
Cleavage of the precursor generates alpha and beta subunits. (utsouthwestern.edu)
AD is characterized diagnostically by two histologic findings: (1) extracellular amorphus eosinophilic deposits of amyloid consisting of Aβ peptides (a cleavage product of amyloid precursor protein [APP]), which are referred to as amyloid plaques, and (2) intraneuronal aggregates of abnormally modified microtubule-associated protein tau (neurofibrillary tangles) (see the image below). (medscape.com)

The nucleotide and deduced amino acid sequences of the phnA gene showed no significant homology with any data bank accessions. (embl-heidelberg.de)
An unusual finding is that one of the repetitive extragenic palindromic sequences actually overlaps with the reading frame of the phnE gene. (embl-heidelberg.de)
One of the potential effects of TEs is the generation of new gene sequences [ 3 , 6 , 7 ] such as the envelope (env) genes of retroviral origin found in several mammals. (ecancer.org)
Translated partial amino acid sequence of pln A gene in MCC4246 displayed 48 amino acid sequences showing 100% similarity with plantaricin A of Lactobacillus plantarum (WP_0036419). (researchsquare.com)
The homologies of nucleotide and amino acid sequences of S1 gene between CK/CH/LDL97Ⅰ/97 and 27 reference IBV strains ranged from 60.6% to 99.6%, and 50.5% to 99.1%, respectively. (virosin.org)
In conclusion, the authors detected and genetically characterized a putative novel Usutu virus strain (Usutu-BONN) by determining its complete genome sequence and comparing it with Usutu virus strains for which complete polyprotein-encoding sequences are available. (cdc.gov)
Although an sgRNA design consisting of a truncated crRNA and tracrRNA had been previously shown to mediate efficient cleavage in vitro 12 , it failed to achieve detectable cleavage at several loci that were efficiently modified by crRNA-tracrRNA duplexes bearing identical guide sequences 1 . (cdc.gov)
We performed northern blot analyses for the guide RNA truncations and found increased levels of expression for the longer tracrRNA sequences, suggesting that improved target cleavage was at least partially due to higher sgRNA expression or stability ( Fig. 1c ). (cdc.gov)
Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)

Cloning of the phosphonoacetate hydrolase gene from Pseudomonas fluorescens 23F encoding a new type of carbon-phosphorus bond cleaving enzyme and its expression in Escherichia coli and Pseudomonas putida. (embl-heidelberg.de)
The phnA gene encoding a novel carbon-phosphorus bond cleavage enzyme, phosphonoacetate hydrolase, from Pseudomonas fluorescens 23F was cloned and expressed in Escherichia coli and Pseudomonas putida. (embl-heidelberg.de)
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. (joplink.net)
Several lines of evidence have suggested that UL33, along with the UL15 and UL28 gene products, forms part of a terminase enzyme responsible for catalysing this process. (gla.ac.uk)
In autoimmune adrenal disease, serum antibodies against several steroidogenic enzymes-including P450scc (CYP11A1, side-chain cleavage enzyme), P450c17 (CYP17, 17-alpha-hydroxylase), and P450c21 (CYP21A2, 21-hydroxylase)-are present. (medscape.com)
GSD VI is caused by deficient activity of hepatic glycogen phosphorylase, an enzyme encoded by the PYGL gene, which is located on chromosome 14q21-q22. (medscape.com)
The investigators used enzyme-linked immunosorbent assay (ELISA) methods to measure Htt protein in the saliva of 178 individuals, including patients with manifest Huntington's disease, gene-positive patients with pre-manifest Huntington's disease, and age- and sex-matched normal controls. (medscape.com)

The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. (nih.gov)
A pseudogene of this gene is located on the long arm of chromosome 3. (nih.gov)
The best known of the human env-derived genes is syncytin-1, or ERVWE1, which originated from a human endogenous retrovirus (HERV) of the HERV-W family inserted on chromosome 7q21 in human-pre-hominoids 40-45 million years ago [ 11 , 10 ]. (ecancer.org)
Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23. (nih.gov)
This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. (nih.gov)

Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene. (wikipedia.org)
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. (wikipedia.org)
This gene encodes the 68kD subunit. (wikipedia.org)
Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization" (PDF). (wikipedia.org)
As such it will recognize pro Caspase-3 and the large subunit cleavage fragment. (thermofisher.com)
Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of ribulose-1,5-bisphosphate carboxylase. (wikidata.org)
The nucleotide sequence, expression, and evolution of one member of a multigene family encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean. (wikidata.org)

The cleavage factor complex is composed of four polypeptides. (wikipedia.org)
Sixteen distinct mutants, encoding polypeptides with 5 aa insertions located at 14 separate positions throughout the protein, were generated. (gla.ac.uk)
Light-stimulated transcription of genes for two chloroplast polypeptides in isolated pea leaf nuclei. (wikidata.org)

Human CPSF6 genome location and CPSF6 gene details page in the UCSC Genome Browser. (wikipedia.org)

The ER-resident protein fat-inducing transcript 2 (FIT2) catalyzes acyl-CoA cleavage in vitro and is required for endoplasmic reticulum (ER) homeostasis and normal lipid storage in cells. (sdsc.edu)
Hiruma K., Hardie J., Riddiford L.M. (1991) Hormonal regulation of epidermal metamorphosis in vitro: control of expression of a larval-specific cuticle gene, Dev. (apidologie.org)
Cadi, R. dc.description.abstract: Background: The success of in vitro-fertilization (IVF) cycles is determined in large part by the quality of embryo cleavage, which in turn, is dependent on the quality of the embryo culture media (CM). Many factors can influence the quality of embryo CM, one of which is the levels of Cell Free Deoxyribonucleic acid (DNA). (who.int)

MicroRNAs (miRNAs) are involved in sequence-specific cleavage, translational repression or deadenylation of specific target mRNAs resulting in post-transcriptional gene silencing. (nih.gov)
All PCR-ribotype 027 strains showed the same slp A gene nucleotide sequence. (cdc.gov)
This enabled the full sequence of the protein to be deduced and the cleavage site of the transit peptide for chromoplast import to be predicted. (lancs.ac.uk)
The complete nucleotide sequence of 15,611 bases has been determined, and the gene structures were examined. (embl-heidelberg.de)
A Pho box-like promoter sequence is also found upstream of the gene cluster starting at phnA, which is consistent with the observation of phosphate regulation of the Phn+ response. (embl-heidelberg.de)
It has been suggested that TEs are a source of variation as a result of the insertion of fragments of their sequence into functioning genes elsewhere in the genome. (ecancer.org)
The cleavage site sequence was RRTGR. (virosin.org)

sgRNAs with +67 or +85 nucleotide (nt) tracrRNA tails mediated DNA cleavage at all target sites tested, with up to fivefold higher levels of indels than the corresponding crRNA-tracrRNA duplexes ( Fig. 1b and Supplementary Fig. 1a ). (cdc.gov)

The incumbent in this position plays a critical role in data annotation and curation for the Gene Ontology (GO) and Protein Ontology (PRO) programs at The Jackson Laboratory in Bar Harbor Maine, through diverse activities to gather, analyze, evaluate and integrate information and analysis results using biomedical ontologies. (bytesizebio.net)
Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes. (nih.gov)

The second ben/cat operon was located in a 92-kb scaffold along with (i) an operon ( opp ) comprising genes for the transformation of OPP to BA and 2-hydroxypenta-2,4-dienoate (and genes for its transformation) and (ii) an incomplete biphenyl catabolic operon ( bph ). (nature.com)
This protein family includes an uncharacterised member designated phnA in Escherichia coli, part of a large operon associated with alkylphosphonate uptake and carbon-phosphorus bond cleavage. (embl-heidelberg.de)

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. (cancerindex.org)

Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)

6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)

Genomic analysis identified two orthologous operons encoding the ortho -cleavage of benzoic acid (BA) ( ben/cat ). (nature.com)
Genomic Southern analysis indicates that the clone is homologous to a low-copy-number gene family. (lancs.ac.uk)
The Giardia lamblia vsp gene repertoire: characteristics, genomic organization, and evolution. (mbl.edu)
However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)
Genomic analysis revealed several unique amino acid substitutions among the polyprotein gene. (cdc.gov)

A handful of genes exempt themselves from this standard of immutability, however, most notably the loci that encode antigen receptors in B cells and T cells. (biomedcentral.com)

Transcription analysis of all putative catabolic genes established their role in the metabolism of OPP. (nature.com)

These guide the cleavage of target (SPL) mRNAs, thereby reducing SPL mRNA abundance, which has the effect of preventing vegetative phase change. (elifesciences.org)

C, in the translation initiation codon of the gene encoding kelch-like protein 24 (KLHL24) in 14 individuals with a distinct skin-fragility phenotype and skin cleavage within basal keratinocytes. (uzh.ch)

Lampe D.J., Willis J.H. (1994) Characterization of a cDNA and gene encoding a cuticular protein from rigid cuticles of the giant silkmoth, Hyalophora cecropia , Insect Biochem. (apidologie.org)
LIU Xin, LIU Sheng-wang, KONG Xian-gang, ZHANG Qing-xia, RONG Jun-gong, HAN Zong-xi, SHAO Yu-hao.Characterization of Spike Gene of Infectious Bronchitis Coronavirus CK/CH/ LDL97Ⅰ/97 Isolated in China .VIROLOGICA SINICA, 2006, 21(1): 68-70. (virosin.org)

In some families with familial paroxysmal nonkinesigenic dyskinesia, the condition is not caused by a mutation in the PNKD gene. (medlineplus.gov)

In agreement with GSS activity localization in vivo , we identified six genes encoding arylsulfatase-like enzymes with a predicted C-terminal transmembrane domain, of which five showed GSS activity upon heterologous expression in insect cells. (nature.com)
In silico modeling of the folate biosynthesis pathway showed that these observations are consistent with the in vivo cleavage of 5,10-methylene-THF by a side-activity of PanB, with FolK-mediated recycling of the pterin cleavage product, and with regulation of folate biosynthesis by folates or their damage products. (ebi.ac.uk)

Isolation and characterisation of a melon cDNA clone encoding phytoene synthase. (lancs.ac.uk)
A cDNA clone (MEL5), encoding a protein homologous to phytoene synthase (PSY), has been isolated from a climacteric melon fruit cDNA library, using the tomato cDNA clone TOM5 [34] as a heterologous probe. (lancs.ac.uk)
Binger L.C., Willis J.H. (1994) Identification of the cDNA, gene and promoter for a major protein from flexible cuticles of the giant silkmoth Hyalophora cecropia , Insect Biochem. (apidologie.org)

This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. (creativebiomart.net)

The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. (cancerindex.org)

dc.title: Cell-free DNA in Embryo Culture Media as Non-invasive Biomarker of the Quality of Embryo Cleavage dc.contributor.author: Jamil, M. (who.int)
Understanding the association between Cell-free DNA levels in embryo CM and the quality of embryo cleavage could help improve the quality of IVF techniques. (who.int)
Methods: This prospective study was conducted with 96 spent CM from patients undergoing IVF cycle, in order to determine relationships of Cell-free DNA levels in embryo CM with embryo cleavage quality on day 3. (who.int)

The predominant genes encoding this miRNA- MIR156A and MIR156C -are transcribed to produce primary mRNA transcripts (pri-miR156 A/C), which are further processed to generate mature transcripts (miR156). (elifesciences.org)

Phylogenetic affiliations of mesopelagic acantharia and acantharian-like environmental 18S rRNA genes off the southern California coast. (mbl.edu)

Additionally, 193 cytochrome P450 (CYP450), 280 methyltransferase and 144 isomerase genes were identified, that are potential candidates for enzymes involved in RIN and IRN synthesis. (biomedcentral.com)

Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. (biomedcentral.com)
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. (wikidata.org)

Early in B- and T-cell development, site-specific cleavage and rejoining of V, D and J gene segments occurs to encode functional antigen receptors. (biomedcentral.com)
PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. (nih.gov)

The UL33 gene of herpes simplex virus type 1 (HSV-1) encodes a 130 amino acid (aa) protein that is essential for the cleavage of concatemeric viral DNA into monomeric genomes and their packaging into preformed capsids. (gla.ac.uk)
The viral S gene is important as it codes for the Spike protein which is the molecule that makes contact with, and allows entry of the virus into susceptible host cells, causing infection. (who.int)

The S gene is one of the structural genes of the virus which encodes for a protein that sits on the surface of the SARS CoV-2 virus. (who.int)

The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
Genetic and metabolic analyses of Escherichia coli strains showed that overexpression of PanB leads to accumulation of the likely folate cleavage product 6-hydroxymethylpterin and other pterins in cells and medium, and-unexpectedly-to a 46% increase in total folate content. (ebi.ac.uk)

The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. (joplink.net)
Insertions of TEs influence the transcriptional regulation of some genes as well as the termination of transcription. (ecancer.org)

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. (thermofisher.com)
Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. (appliedbioinfo.com)

UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. (nih.gov)
This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. (joplink.net)

Dotson E.M., Cornel A.J., Willis J.H., Collins F.H. (1998) A family of pupal-specific cuticular protein genes in the mosquito Anopheles gambiae , Insect Biochem. (apidologie.org)

Cloning and sequencing of the phn (psiD) genes involved in alkylphosphonate uptake and C-P lyase activity in Escherichia coli B. (embl-heidelberg.de)
Genes from E. coli B that support growth on alkylphosphonates as the sole phosphorus source have now been cloned (B. L. Wanner and J. A. Boline, unpublished data). (embl-heidelberg.de)

Results showed that the S gene was 3501 bp encoding a polypeptide of 1167 amino acids. (virosin.org)

We also show that SpCas9-mediated cleavage is unaffected by DNA methylation and that the dosage of SpCas9 and sgRNA can be titrated to minimize off-target modification. (cdc.gov)

Izumi S., Tomino S. (1994) Structure and developmental expression of a larval cuticle protein gene of the silkworm, Bombyx mori , Biochim. (apidologie.org)

We analyzed the slp A gene of these strains by using the National Center for Biotechnology Information BLAST server ( www.ncbi.nlm.nih.gov/blast )and the European Bioinformatics Institute ClustalW server ( www.ebi.ac.uk/clustalw ). (cdc.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

Apple R.T., Fristrom J.W. (1991) 20-hydroxyecdys-one is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes, Dev. (apidologie.org)

The slp A genes of all strains were amplified by PCR mapping. (cdc.gov)

The positive samples were further subjected to PCRs for the amplification of a partial segment of the Usutu virus envelope and nonstructural 5 gene. (cdc.gov)

RIViT-seq technology could speed up associating transcription factors with their target genes. (doe.gov)

It was anticipated that a specific RNA target for AID would soon be identified, and would in all likelihood be found to encode a master regulator in the form of a critical nuclease or transcription factor [ 4 ]. (biomedcentral.com)
Gene symbols, accession ids and various other target identifiers. (nih.gov)
Huntington's disease, a fatal neurodegenerative disease, is known to be caused by a CAG repeat expansion in the gene that encodes Htt, making Htt a leading target in ongoing efforts to develop therapies. (medscape.com)

It reflects a neuroadaptation that is the likelihood of drug-seeking behav- mediated gene transfer as a tool for neuropsychi- .nature the result of a powerful psychological iors, whereas administration of small atric research. (lu.se)

A combination of de novo transcriptome assembly and DGE analysis was shown to be a powerful method for identifying genes encoding enzymes potentially involved in the biosynthesis of important secondary metabolites in a non-model plant. (biomedcentral.com)

Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24. (nih.gov)

The minigenome system is based on the S segment of CHAV or MACV genomes expressing the fluorescent reporter gene ZsGreen (ZsG). (cdc.gov)
We also generated recombinant CHAV and MACV with and without the ZsG reporter gene. (cdc.gov)

Furthermore, dual in situ hybridization detected positive signals for itr1 and cox2 at the same site, implying that ITR1 may regulate cox2 gene expression. (frontiersin.org)

Anatomy23

Organisms10

Chemicals and Drugs133

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes66

Disciplines and Occupations1

Information Science3

Health Care1

Proteins9

Mutations13

Variants6

Precursor4

Sequences9

Enzyme7

Chromosome5

Subunit7

Polypeptides3

UCSC Genome Browser1

Vitro3

Sequence7

Nucleotide1

Ontology2

Operon2

Genome1

PMID1

Cluster1

Genomic5

Loci1

Putative1

MRNAs1

Phenotype1

Characterization2

Mutation1

Vivo2

CDNA3

Inhibition1

Undergoes1

Embryo3

Predominant1

RRNA1

Enzymes involved1

Immunoglobulin2

Functional2

Viral2

Structural1

Genetic2

Regulation2

Caspase2

Catalyzes2

19981

Coli2

Polypeptide1

Methylation1

Developmental1

NCBI2

DataSets1

Drosophila1

Strains1

Envelope1

Transcription Factors1

Target3

Likelihood1

Transcriptome1

Protein gene1

Reporter gene2

Site1